Edward Schrom, PhD
Associate Research ScientistDownloadHi-Res Photo
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I invent mathematical algorithms, build statistical models, and write robust software to maximize insights from data.
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Associate Research Scientist
Biography
Professionally, I am a data scientist in the most precise sense: I build quantitative algorithms, models, and inference tools with the utmost rigor and care to extract real understanding from data. My primary academic focus is the emergence of individual-scale immune functioning and its population-scale consequences from the dynamic interactions of cells and molecules. This broad theme has informed a variety of my study areas, including evolutionary processes, spatial tumor architecture, and vaccination response, as I have advanced from a Ph.D. student at Princeton University to a post-doctoral researcher at the NIH to a data scientist at the CDC to an Associate Research Scientist here at the Yale School of Medicine. Personally, my passions range more broadly, including my Christian faith, my family and community, the great outdoors, all things athletic, and much more.
Last Updated on December 02, 2025.
Appointments
Immunobiology
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Special Volunteer
- National Institute of Allergy and Infectious Disease (2025)
- Post-Doctoral Fellow
- National Institute of Allergy and Infectious Disease (2024)
- PhD
- Princeton University, Ecology and Evolutionary Biology (2020)
- MA
- Princeton University, Ecology and Evolutionary Biology (2017)
- BA
- University of Virginia, Mathematics (2015)
- BS
- University of Virginia, Biology (2015)
Research
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My recent work in immunobiology addresses immunological responses to vaccination, spatial architecture of solid tumors, and dynamic lymphocyte signaling circuits. My interests and past work vary more broadly, from clinical trial design to wildlife conservation genomics to cybersecurity.
Overview
Medical Research Interests
Computational Biology; Data Analysis; Immunoinformatics; Information Theory; Nonlinear Dynamics; Systems Biology
Public Health Interests
Bioinformatics; Cancer; Evolution; Immunology; Infectious Diseases; Modeling; Vaccines; Bayesian Statistics; Statistical Computing
ORCID
0000-0002-1793-6433
Research at a Glance
Publications Timeline
A big-picture view of Edward Schrom's research output by year.
14Publications
283Citations
Publications
2026
The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods
Yaniv Z, Anidi I, Arakkal L, Arroyo-Mejías A, Beuschel R, Börner K, Chu C, Clark B, Clatworthy M, Colautti J, Coscia F, Croteau J, Denha S, Dever R, Dutra W, Fritzsche S, Fullam S, Gerner M, Gola A, Gollob K, Hernandez J, Hor J, Ichise H, Jing Z, Jonigk D, Kandov E, Kastenmüller W, Koenig J, Kothurkar A, Kortekaas R, Kreins A, Lamborn I, Lin Y, Morais K, Lunich A, Luz J, MacDonald R, Makranz C, Maltez V, McDonough J, Moriarty R, Ocampo-Godinez J, Olyntho V, Oxenius A, Padhan K, Remmert K, Richoz N, Schrom E, Shang W, Shi L, Shih R, Speranza E, Stierli S, Teichmann S, Verse T, Vierhout M, Wachter B, Wade-Vallance A, Williams M, Zangger N, Germain R, Radtke A. The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods. ELife 2026, 14: rp105737. PMID: 41575186, PMCID: PMC12829988, DOI: 10.7554/elife.105737.Peer-Reviewed Original ResearchCitations
2025
Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells
Hor J, Schrom E, Wong-Rolle A, Vistain L, Shang W, Dong Q, Zhao C, Jin C, Germain R. Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells. Nature 2025, 649: 194-204. PMID: 41299179, PMCID: PMC12727512, DOI: 10.1038/s41586-025-09440-x.Peer-Reviewed Original ResearchCitationsAltmetricSingle-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML
Gui G, Bingham M, Herzog J, Wong-Rolle A, Dillon L, Goswami M, Martin E, Reeves J, Kim S, Bahrami A, Degenhardt H, Zaki G, Divakar P, Schrom E, Calvo K, Hourigan C, Hansen K, Zhao C. Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML. Science Advances 2025, 11: eadw4871. PMID: 40632867, PMCID: PMC12239967, DOI: 10.1126/sciadv.adw4871.Peer-Reviewed Original ResearchCitationsAltmetricThe IBEX Knowledge-Base: A central resource for multiplexed imaging techniques
Radtke A, Anidi I, Arakkal L, Arroyo-Mejias A, Beuschel R, Börner K, Chu C, Clark B, Clatworthy M, Colautti J, Coscia F, Croteau J, Denha S, Dever R, Dutra W, Fritzsche S, Fullam S, Gerner M, Gola A, Gollob K, Hernandez J, Hor J, Ichise H, Jing Z, Jonigk D, Kandov E, Kastenmüller W, Koenig J, Kortekaas R, Kothurkar A, Kreins A, Lamborn I, Lin Y, Morais K, Lunich A, Luz J, MacDonald R, Makranz C, Maltez V, McDonough J, Moriarty R, Ocampo-Godinez J, Olyntho V, Oxenius A, Padhan K, Remmert K, Richoz N, Schrom E, Shang W, Shi L, Shih R, Speranza E, Stierli S, Teichmann S, Veres T, Vierhout M, Wachter B, Wade-Vallance A, Williams M, Zangger N, Germain R, Yaniv Z. The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques. PLOS Biology 2025, 23: e3003070. PMID: 40106489, PMCID: PMC12135934, DOI: 10.1371/journal.pbio.3003070.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsSpatial Patterning Analysis of Cellular Ensembles (SPACE) finds complex spatial organization at the cell and tissue levels
Schrom E, McCaffrey E, Sreejithkumar V, Radtke A, Ichise H, Arroyo-Mejias A, Speranza E, Arakkal L, Thakur N, Grant S, Germain R. Spatial Patterning Analysis of Cellular Ensembles (SPACE) finds complex spatial organization at the cell and tissue levels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2412146122. PMID: 39903116, PMCID: PMC11831171, DOI: 10.1073/pnas.2412146122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2023
TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways
Chan W, Cao Y, Zhao X, Schrom E, Jia D, Song J, Sibener L, Dong S, Fernandes R, Bradfield C, Smelkinson M, Kabat J, Hor J, Altan-Bonnet G, Garcia K, Germain R. TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. Journal Of Experimental Medicine 2023, 220: e20231242. PMID: 37796477, PMCID: PMC10555889, DOI: 10.1084/jem.20231242.Peer-Reviewed Original ResearchCitationsAltmetricChallenges in cybersecurity: Lessons from biological defense systems
Schrom E, Kinzig A, Forrest S, Graham A, Levin S, Bergstrom C, Castillo-Chavez C, Collins J, de Boer R, Doupé A, Ensafi R, Feldman S, Grenfell B, Halderman J, Huijben S, Maley C, Moses M, Perelson A, Perrings C, Plotkin J, Rexford J, Tiwari M. Challenges in cybersecurity: Lessons from biological defense systems. Mathematical Biosciences 2023, 362: 109024. PMID: 37270102, DOI: 10.1016/j.mbs.2023.109024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2022
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells
Johansen K, Golec D, Huang B, Park C, Thomsen J, Preite S, Cannons J, Garçon F, Schrom E, Courrèges C, Veres T, Harrison J, Nus M, Phelan J, Bergmeier W, Kehrl J, Okkenhaug K, Schwartzberg P. A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells. Science Signaling 2022, 15: eabl9169-eabl9169. PMID: 35857633, PMCID: PMC9637254, DOI: 10.1126/scisignal.abl9169.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2021
The evolution of powerful yet perilous immune systems
Graham A, Schrom E, Metcalf C. The evolution of powerful yet perilous immune systems. Trends In Immunology 2021, 43: 117-131. PMID: 34949534, PMCID: PMC8686020, DOI: 10.1016/j.it.2021.12.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricUnderstanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*
Germain R, Radtke A, Thakur N, Schrom E, Hor J, Ichise H, Arroyo‐Mejias A, Chu C, Grant S. Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction*. Immunological Reviews 2021, 306: 8-24. PMID: 34918351, DOI: 10.1111/imr.13052.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
Academic Achievements & Community Involvement
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activity Spatial Patterning Analysis of Cell Ensembles: Discovering Spatial Relationships among Cell Types in Tissues
09/10/2024 - 09/12/2024Oral PresentationStanford Spatial Biology SummitDetailsPresented remotely.Collaboratorsactivity Spatial Patterning Analysis of Cell Ensembles: A General Framework for Characterizing Spatial Relationships Among Cell Types in Tissues
06/05/2023 - 06/05/2023LectureNorthwestern University Feinberg School of Medicine Division of Pulmonary and Critical Care Medicine Research-in-Progress SeminarDetailsPresented remotely.activity Spatial Patterning Analysis of Cell Ensembles: A General Framework for Characterizing Spatial Relationships Among Cell Types in Tissue
04/18/2023 - 04/21/2023Poster PresentationCold Spring Harbor Labs Meeting on Systems ImmunologyDetailsCold Spring Harbor, NY, United StatesCollaboratorsactivity Nautilus
2023 - 2023Media PresenceAuthoractivity Workshop Participant
06/08/2022 - 06/10/2022OtherDistributed Computing Perspectives on Theoretical ImmunologyDetailsSanta Fe, NM, United States
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