Clark Fisher, MD, PhD
Assistant ProfessorCards
About
Research
Publications
Featured Publications
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience
Raredon MSB, Fisher C, Heerdt PM, Schonberger RB, Nargi A, Nivison S, Fajardo E, Deshpande R, Akhtar S, Greaney AM, Belter J, Raredon T, Zinter J, McKee A, Michalski M, Baevova P, Niklason LE. Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia & Analgesia 2021, 134: 1094-1105. PMID: 34928890, DOI: 10.1213/ane.0000000000005825.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureClinical experienceIndividualized positive end-expiratory pressureIntensive care unitEnd-expiratory pressureCoronavirus disease 2019 (COVID-19) pandemicHealth care teamDisease 2019 pandemicVentilatory supportIll patientsCare unitCare teamVentilator sharingFuture clinical applicationsPatientsIndependent careVentilator capacityClinical applicationCOVID-19 pandemicVentilatorClinical environmentOutline recommendationsMass traumaPandemicHospitalOpioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2025, 140: 1016-1027. PMID: 39167548, PMCID: PMC11842693, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDose
2025
Association of Prophylactic Antibiotic Guideline Non-Adherence with Surgical Site Infections in Patients Receiving Perioperative Vancomycin: Results from a Multi-Institutional Combined NSQIP and MPOG Registry.
Bardia A, Lin H, Michel G, Fisher C, Zhao X, Shuster K, Colquhoun D, Mathis M, Anders M, Kheterpal S, Schonberger R. Association of Prophylactic Antibiotic Guideline Non-Adherence with Surgical Site Infections in Patients Receiving Perioperative Vancomycin: Results from a Multi-Institutional Combined NSQIP and MPOG Registry. Annals Of Surgery 2025 PMID: 40833154, DOI: 10.1097/sla.0000000000006903.Peer-Reviewed Original ResearchAssociated with surgical site infectionNational Surgical Quality Improvement ProgramSurgical site infectionInfectious Diseases Society of AmericaSociety for Healthcare Epidemiology of AmericaSociety for Healthcare EpidemiologySurgical Infection SocietyAntibiotic choiceSite infectionMulticenter Perioperative Outcomes GroupNon-adherenceIncidence of surgical site infectionTiming of vancomycin administrationOdds of surgical site infectionSurgical Quality Improvement ProgramIntraoperative antibiotic prophylaxisDose of vancomycinHealthcare Epidemiology of AmericaMulticenter observational studyNon-cardiac proceduresGuideline non-adherenceYears of agePerioperative vancomycinVancomycin prophylaxisAntibiotic prophylaxisAccounting for Healthcare Structures When Measuring Variation in Care
Colquhoun D, Janda A, Mentz G, Fisher C, Schonberger R, Shah N, Kheterpal S, Mathis M. Accounting for Healthcare Structures When Measuring Variation in Care. Anesthesiology 2025, 142: 793-805. PMID: 40197451, PMCID: PMC11981012, DOI: 10.1097/aln.0000000000005395.Peer-Reviewed Original ResearchConceptsHealthcare structuresOutcomes of clinical careFeatures of health systemsHealth services researchStructured healthcare systemHealth systemServices researchHealthcare systemClinical careQuality improvementOutcomes researchCarePatient outcomesAssessment of varianceClinical practiceInclusion of explanatory variablesHealthcareMixed-effects statistical modelOutcomesCliniciansPatientsPracticeHealthExplanatory variablesHospital
2024
Individual and System-level Factors Contributing to Guideline Nonadherent Surgical Antibiotic Prophylaxis at a Tertiary Healthcare System: A Qualitative Analysis
Bardia A, Melnick E, McCall T, Zhao X, Lin H, Fisher C, Burg M, Schonberger R. Individual and System-level Factors Contributing to Guideline Nonadherent Surgical Antibiotic Prophylaxis at a Tertiary Healthcare System: A Qualitative Analysis. Anesthesiology 2024, 142: 489-499. PMID: 39556527, PMCID: PMC11813683, DOI: 10.1097/aln.0000000000005302.Peer-Reviewed Original ResearchClinical decision supportCertified Registered Nurse AnesthetistsGuideline adherenceInfectious Diseases Society of AmericaQualitative studyTertiary health care systemClinical decision support toolSemi-structured interview formatSystem-level factorsHealth care systemRegistered Nurse AnesthetistsConstant comparison methodInfectious Diseases SocietyDecision supportAntibiotic guidelinesCare systemProvider needsNurse anesthetistsPerioperative pharmacistLimited familiarityPerceived benefitsNon-adherenceInterview formatLevel factorsResident traineesAssociation of Medicare eligibility with access to cardiac surgical care by patients identifying as other than non-Hispanic White: a regression discontinuity analysis
Arndt M, Lin H, Strand E, Fisher C, Schonberger R. Association of Medicare eligibility with access to cardiac surgical care by patients identifying as other than non-Hispanic White: a regression discontinuity analysis. British Journal Of Anaesthesia 2024, 133: 1341-1343. PMID: 39277456, DOI: 10.1016/j.bja.2024.07.031.Peer-Reviewed Original ResearchVariation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution
Burns M, Hilliard P, Vandervest J, Mentz G, Josifoski A, Varghese J, Fisher C, Kheterpal S, Shah N, Bicket M. Variation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution. JAMA Network Open 2024, 7: e2351689. PMID: 38227311, PMCID: PMC10792468, DOI: 10.1001/jamanetworkopen.2023.51689.Peer-Reviewed Original ResearchConceptsIntraoperative opioid administrationOral morphine equivalentsOpioid administrationSurgical proceduresHospital levelElectronic health record dataIntraclass correlationCohort studyAnalgesic categoriesSurgical categoriesHealth record dataQuality-improvement programHospital-level factorsPatient-level factorsNeuraxial analgesic techniquesCardiac surgical proceduresKnee surgical proceduresOpioid-reducing strategiesElective surgical proceduresMain OutcomesHospital contributionMorphine equivalentsOpioid exposureSurgical characteristicsOpioid prescriptions
2023
Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections
Bardia A, Michel G, Farela A, Fisher C, Mori M, Huttler J, Lang A, Geirsson A, Schonberger R. Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections. Journal Of Thoracic And Cardiovascular Surgery 2023, 167: 2170-2176.e5. PMID: 37075942, PMCID: PMC10579454, DOI: 10.1016/j.jtcvs.2023.03.031.Peer-Reviewed Original ResearchWeight-adjusted dosingPostoperative infectionAntibiotic guidelinesIncidence of nonadherenceCoronary artery bypassTertiary care hospitalAssociation of adherenceCohort of patientsRetrospective observational studyPost-operative infectionIntraoperative redosingValvular surgeryAntibiotic timingArtery bypassCoronary revascularizationPostoperative complicationsPostoperative sepsisAdult patientsFirst doseAntibiotic choiceCardiac surgeryCardiopulmonary bypassCare hospitalDose adjustmentPrimary outcome
2018
Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats.
Gorman A, Deh K, Schwiedrzik C, White J, Groman E, Fisher C, Gillen K, Spincemaille P, Rasmussen S, Prince M, Voss H, Freiwald W, Wang Y. Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats. Journal Of The American Association For Laboratory Animal Science 2018, 68: 139-147. PMID: 29663939, PMCID: PMC5897970.Peer-Reviewed Original ResearchConceptsSerum iron levelsHigh cumulative dosesWashout periodCumulative dosesIron levelsBrain ventriclesIron depositionMale Sprague-Dawley ratsUltra-small superparamagnetic iron oxide particlesQuantitative susceptibility mapsEnd of dosingSerum iron concentrationSprague-Dawley ratsBrain iron distributionGradient-echo MRIMultiple dosesBrain parenchymaSuperparamagnetic iron oxide particlesIron biodistributionFrequent administrationHistologic analysisParamagnetic iron oxideIron accumulationTime pointsDoses
2015
Whole-agent selectivity within the macaque face-processing system
Fisher C, Freiwald W. Whole-agent selectivity within the macaque face-processing system. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 14717-14722. PMID: 26464511, PMCID: PMC4664356, DOI: 10.1073/pnas.1512378112.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Teaching & Mentoring
Teaching
Didactic Resident Lectures
Clinical Faculty MemberLecture Setting8/1/2022 - PresentForHouse Staff2 Average Instructional Hours Per Year
Mentoring
Alexander Neilson, DO
Clinical Fellow2023 - 2024
Clinical Care
Overview
Clark Fisher, MD, PhD, is an anesthesiologist who specializes in cardiac anesthesiology. He focuses on providing anesthesia care for patients undergoing heart-related surgeries and procedures. Dr. Fisher uses advanced techniques to ensure patient safety and comfort during these complex operations.
As an assistant professor at Yale School of Medicine, Dr. Fisher is involved in research aimed at improving perioperative outcomes for cardiac patients. His work seeks to enhance patient care by developing new strategies for managing anesthesia in cardiac procedures.
Dr. Fisher received his medical training from Weill Cornell Medical College and his doctoral degree from The Rockefeller University. He completed his residency in anesthesiology and fellowship in adult cardiothoracic anesthesiology at Yale New Haven Hospital.
Clinical Specialties
Anesthesiology; Cardiac Anesthesiology
Board Certifications
Advanced Perioperative Transesophageal Echocardiography
- Certification Organization
- National Board of Echocardiography
- Original Certification Date
- 2023
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 2022
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