Andre Levchenko
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Neurosurgery
Secondary
About
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John C. Malone Professor of Biomedical Engineering
Appointments
Neurosurgery
ProfessorSecondary
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Research
Overview
Medical Subject Headings (MeSH)
Cell Communication; Microfluidics; Signal Transduction; Systems Biology
ORCID
0000-0001-6262-1222
Research at a Glance
Yale Co-Authors
Frequent collaborators of Andre Levchenko's published research.
Publications Timeline
A big-picture view of Andre Levchenko's research output by year.
Research Interests
Research topics Andre Levchenko is interested in exploring.
Michael Murrell
Jesse Rinehart, PhD
Stefania Nicoli, PhD
51Publications
4,125Citations
Signal Transduction
Cell Communication
Systems Biology
Publications
2024
Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12: rp89262. PMID: 38376371, PMCID: PMC10942579, DOI: 10.7554/elife.89262.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCell fate specificationFate specificationNotch signalingMorphogenic processesCell-cell communicationComplex morphogenic processesCell fateDynamics of spatial patternsDepletion of fibronectinTip cellsSprout extensionAngiogenic morphogenesisHypoxic micro-environmentCell plasticityCellsComputational analysisPre-existing onesCell patternMicro-environmentSpatial patternsLocal enrichmentMorphogenesisEndothelial cellsAngiogenesis modelFibronectinSpatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12 DOI: 10.7554/elife.89262.3.Peer-Reviewed Original ResearchConceptsCell fate specificationStalk cellsCell type-specificTip cellsNotch signalingFate specificationStalk cell differentiationMorphogenic processesDensity of fibronectinType-specificCell typesCell-cell communicationComplex morphogenic processesResponse to elevated levelsCell fateCell identityDynamics of spatial patternsDepletion of fibronectinEnvironmental cuesSignaling moleculesBlood vessel sproutingSprout extensionAngiogenic morphogenesisSignaling pathwayHypoxic micro-environment
2023
Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules
Emadi A, Lipniacki T, Levchenko A, Abdi A. Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules. Biology 2023, 12: 1461. PMID: 38132287, PMCID: PMC10740708, DOI: 10.3390/biology12121461.Peer-Reviewed Original ResearchSPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces.
Lee S, Yousafzai M, Mohler K, Yadav V, Amiri S, Szuszkiewicz J, Levchenko A, Rinehart J, Murrell M. SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces. Molecular Biology Of The Cell 2023, 34: ar122. PMID: 37672340, PMCID: PMC10846615, DOI: 10.1091/mbc.e23-03-0103.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells
Kshitiz, Afzal J, Suhail Y, Chang H, Hubbi M, Hamidzadeh A, Goyal R, Liu Y, Sun P, Nicoli S, Dang C, Levchenko A. Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells. Cell Systems 2022, 13: 1048-1064.e7. PMID: 36462504, PMCID: PMC10012408, DOI: 10.1016/j.cels.2022.11.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHIF-1α activityActivation of genesChaperone-mediated autophagyCancer cellsCell divisionIndividual cancer cellsRegulated processPatient-derived cancer cellsSubset of cellsMolecular mechanismsFluorescent reportersSingle-cell responsesCancer cell linesCell linesGenesHypoxic tumor cellsHIF-1αHypoxic conditionsCellsBroad suppressionAggressive growthTumor cellsHypoxic cellsOscillatory activityExtracellular lactate
2020
CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMA
Schiapparelli P, Meade P, Miranda-Herrera P, Bechtle A, Issacs F, Levchenko A, Rinehart J, Quinones-Hinojosa A. CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMA. Neuro-Oncology 2020, 22: ii29-ii29. PMCID: PMC7650317, DOI: 10.1093/neuonc/noaa215.120.Peer-Reviewed Original ResearchConceptsOxidative stress-responsive kinase 1Small molecule inhibitorsGBM cellsMolecule inhibitorsAggressive primary brain tumorCell migrationComplete surgical resectionMaximal safe resectionPrimary brain tumorsAdjacent brain parenchymaCell proliferationOrthotopic murine modelPatient-derived GBM cell linesDose-dependent reductionImportant therapeutic componentGBM cell linesCell cycle analysisGBM cell migrationSurgical resectionSafe resectionBrain parenchymaCell infiltrationCell cycle arrestMurine modelRadiation therapySignaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal Dynamics
Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Ling M, Trejo J, Levchenko A, Zhang J. Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal Dynamics. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00680.Peer-Reviewed Original ResearchConceptsERK activityTemporal regulationPrecise temporal regulationMembrane protrusion dynamicsSequence-specific motifsSpecific subcellular locationsControl cell morphologyDifferent subcellular compartmentsMultiple cellular processesERK enzymatic activityCAMP/PKAERK biosensorEGF inducesKinase cascadeCellular processesExtracellular signalsSubcellular compartmentsSubcellular locationProtrusion dynamicsSubcellular regionsPlasma membraneSpecific motifsEnzymatic activityCell morphologyRap1
2016
CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION
Shah S, David J, Tippens N, Mohyeldin A, Martinez J, Ganaha S, Levchenko A, Palena C, Quinones-Hinojosa A. CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION. Neuro-Oncology 2016, 18: vi41-vi41. DOI: 10.1093/neuonc/now212.166.Peer-Reviewed Original ResearchConceptsTranscriptional networksTranscriptional programsGenetic inhibitorsT-box transcription factorCell transcriptional programDirect transcriptional activationCell cycle progressionNew molecular insightsMalignant neoplasmsNegative feedback loopEarly embryogenesisTranscriptional activationHippo pathwayOrgan developmentTranscription factorsMaster regulatorProtein stabilityBioinformatics analysisGenetic stabilityPrevalent lung cancerCycle progressionMetastatic brain tumorsMolecular underpinningsMolecular insightsBrachyury217 YAP Is Ready to Rac and Rho
Shah S, Tippens N, Park J, Mohyeldin A, Vela G, Martinez-Gutierrez J, Margolis S, Schmidt S, Levchenko A, Quinones-Hinojosa A. 217 YAP Is Ready to Rac and Rho. Neurosurgery 2016, 63: 185. DOI: 10.1227/01.neu.0000489786.22041.2d.Peer-Reviewed Original ResearchCitationsAltmetricFundamental Limits to the Precision of Multicellular Sensing
Fancher S, Levchenko A, Nemenman I, Mugler A. Fundamental Limits to the Precision of Multicellular Sensing. Biophysical Journal 2016, 110: 350a. DOI: 10.1016/j.bpj.2015.11.1884.Peer-Reviewed Original Research
Links & Media
News
- July 27, 2023
Yale Scientists Develop a New Approach to Strengthen CAR-T Cell Therapy for Cancer Treatment
- April 04, 2023Source: Yale Daily News
Researchers explore the role of cellular plasticity in cancer
- February 23, 2023Source: Big Think
Cancer evolution is mathematical
- February 09, 2023Source: Yale West Campus
Study Reveals New Insight Into ‘Shape-shifting’ Cancer Cells
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