Santiago Clocchiatti-Tuozzo, MD, MHS
About
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Titles
Hospital Resident
Biography
Santiago Clocchiatti-Tuozzo, MD, MHS, is a Neurology Resident at Yale New Haven Hospital. He completed his medical degree at the University of Buenos Aires and a Master of Health Science in Bioinformatics at Yale. Before residency, he was a T32 Postdoctoral Fellow in Geriatric Clinical Epidemiology and Aging-Related Research in the Department of Neurology at Yale.
Dr. Clocchiatti-Tuozzo’s research lies at the intersection of neurology, aging, and data science, with a focus on genetic epidemiology and bioinformatics. His work explores how genetic variation and related phenotypes—such as cardiovascular and neurological risk factors—shape brain health and aging-related outcomes, including dementia and cognitive decline, besides vascular-related outcomes, like ischemic stroke, cerebral small vessel disease, and intracerebral hemorrhage. A central emphasis of his research is understanding heterogeneity of treatment effects and pharmacological responses in neurological disease. He integrates multiple data sources, including genomic datasets, neuroimaging, electronic health records, and other -omics technologies, to advance precision medicine approaches in neurology.
Departments & Organizations
Education & Training
- MHS
- Yale School of Public Health, Bioinformatics (2024)
- MD
- University of Buenos Aires (2021)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-5377-434X- View Lab Website
Falcone Labs
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Cyprien Rivier, MD, MSc
Guido J. Falcone, ScD, MPH
Kevin Sheth, MD, FAHA
Daniela Brenda Renedo, MD
Adam de Havenon, MD, MS
Charles Matouk, MD
Publications
Featured Publications
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionBrain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, PMCID: PMC11760050, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessmentAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseAPOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation
Renedo D, Rivier C, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Wu K, Torres-Lopez V, Huo S, Gunel M, de Havenon A, Sheth K, Matouk C, Falcone G. APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation. JAMA Network Open 2024, 7: e2355368. PMID: 38363572, PMCID: PMC10873768, DOI: 10.1001/jamanetworkopen.2023.55368.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsApolipoprotein E e4Participants of European ancestryRisk of intracerebral hemorrhageHigh risk of intracerebral hemorrhageCross-sectional studyUK BiobankEuropean ancestryHigh riskUs Research ProgramUK Biobank participantsInternational Classification of DiseasesAssociated with higher risk of ICHCross-sectional study of patientsAPOE e4 statusClassification of diseasesApolipoprotein ENinth Revision and Tenth RevisionAssociated with higher riskIndividual-level dataMultivariate logistic regressionIntracerebral hemorrhage riskBrain arteriovenous malformationsIntracerebral hemorrhageBiobank participantsTenth RevisionThe predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1373797. PMID: 39109366, PMCID: PMC11301016, DOI: 10.3389/fpsyt.2024.1373797.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIncident late-life depressionLate-life depressionBrain health outcomesCare scoresHealth outcomesHealthy lifestyle choicesOutcome of dementiaUK Biobank cohortRisk factorsComposite outcomeCox proportional hazards modelsCare providersBiobank cohortProportional hazards modelIncident casesMultivariate Cox proportional hazards modelRisk of strokeLifestyle changesClinical careLifestyle choicesDementiaBrain healthFuture depressionBaseline evaluationComplete data
2026
Improvements in Biological Age Acceleration Lead to Better Neuroimaging, Clinical, and Cognitive Markers of Brain Health (S10.003)
Rivier C, Huo S, Clocchiatti-Tuozzo S, Renedo D, Sheth K, Falcone G. Improvements in Biological Age Acceleration Lead to Better Neuroimaging, Clinical, and Cognitive Markers of Brain Health (S10.003). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000215890.Peer-Reviewed Original ResearchNeighborhood Deprivation and Disparities in Blood Pressure Monitoring in Patients with Intracerebral Hemorrhage (P4-4.018)
Namian S, Smith J, Constantinescu S, Tawaldemedhen Y, Rivier C, Clocchiatti-Tuozzo S, Huo S, Wu K, Forman R, Torres-Lopez V, Sunmonu N, Petersen N, Falcone G. Neighborhood Deprivation and Disparities in Blood Pressure Monitoring in Patients with Intracerebral Hemorrhage (P4-4.018). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000216140.Peer-Reviewed Original ResearchMulti-trait Polygenic Profiling and Dementia- and Disability-free Survival: Results from the Health and Retirement Study (P5-13.001)
Tawaldemedhen Y, Clocchiatti-Tuozzo S, Rivier C, Huo S, Gill T, Falcone G. Multi-trait Polygenic Profiling and Dementia- and Disability-free Survival: Results from the Health and Retirement Study (P5-13.001). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000216565.Peer-Reviewed Original ResearchProteogenomic Integration Reveals Paralemmin-1 as a Mediator of Increased Intracerebral Hemorrhage Risk in APOE ɛ4 Carriers (S10.008)
Huo S, Clocchiatti-Tuozzo S, Rangaraju S, Murthy S, Payabvash S, Rivier C, Falcone G. Proteogenomic Integration Reveals Paralemmin-1 as a Mediator of Increased Intracerebral Hemorrhage Risk in APOE ɛ4 Carriers (S10.008). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000217189.Peer-Reviewed Original ResearchConceptsFunctional Outcomes After Intensive Blood Pressure Reduction in Deep and Lobar Intracerebral Hemorrhage
Clocchiatti-Tuozzo S, Qureshi A, Rivier C, Huo S, Matouk C, Payabvash S, Murthy S, Sheth K, Rabinstein A, Falcone G, Hawkes M. Functional Outcomes After Intensive Blood Pressure Reduction in Deep and Lobar Intracerebral Hemorrhage. Neurology 2026, 106: e214860. PMID: 41962119, DOI: 10.1212/wnl.0000000000214860.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLobar intracerebral hemorrhageIntensive BP reductionIntensive Blood Pressure ReductionATACH-2Intracerebral hemorrhage locationBP reductionBlood pressure reductionIntracerebral hemorrhageDeep intracerebral hemorrhagePoor functional outcomeRandomized clinical trialsFunctional outcomesBlood pressureRisk of poor functional outcomeModified Rankin Scale scoreAcute intracerebral hemorrhageMeta-analysisPressure reductionIntensive blood pressureRankin Scale scoreAcute cerebral hemorrhageClinically distinct subtypesIndividual patient dataHematoma locationExposure of interest
Academic Achievements & Community Involvement
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Activities
activity American Heart Association
08/24/2022 - PresentProfessional OrganizationsMemberactivity American Academy of Neurology
2022 - PresentProfessional OrganizationsMemberactivity American Geriatrics Society
11/30/2022 - PresentProfessional OrganizationsMemberactivity Gerontological Society of America
06/15/2023 - PresentProfessional OrganizationsMemberactivity Stroke, American Heart Association
2023 - PresentJournal ServiceReviewer
Honors
honor Futures in Neurologic Research Scholarship
04/13/2024National AwardAmerican Academy of Neurology (AAN)DetailsUnited Stateshonor Junior Investigator Travel Grant, International Stroke Conference
02/07/2024National AwardAmerican Heart AssociationDetailsUnited Stateshonor Butler-Williams Scholars Program
08/23/2023National AwardNational Institute on Aging (NIA), National Institutes of Health (NIH).DetailsUnited Stateshonor HEADS-UP: Health Equity and Actionable Disparities in Stroke Travel Award
02/08/2023National AwardAmerican Heart AssociationDetailsUnited Stateshonor Bernard J. Tyson Career Development Award and Underrepresented Racial and Ethnic Groups Travel Grant
02/08/2023National AwardAmerican Heart AssociationDetailsUnited States
News & Links
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News
- June 15, 2026
Traditional and Primary Care Residency Programs Recognize Outstanding Educators
- August 21, 2025
Study Ties Genetics and Common Anticoagulant to Risk of Intracranial Hemorrhage
- June 13, 2024Source: MedPage Today
APOE Genotypes and Dementia
- May 07, 2024
Santiago Clocchiatti-Tuozzo, MD, Wins 2024 Futures in Neurologic Research Scholarship
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