Gregor Gryglewski, MD, PhD
Cards
About
Research
Publications
2023
Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo
Spies M, Murgaš M, Vraka C, Philippe C, Gryglewski G, Nics L, Balber T, Baldinger-Melich P, Hartmann A, Rujescu D, Hacker M, Winkler-Pjrek E, Winkler D, Lanzenberger R. Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo. Translational Psychiatry 2023, 13: 208. PMID: 37322010, PMCID: PMC10272199, DOI: 10.1038/s41398-023-02506-2.Peer-Reviewed Original ResearchConceptsMAO-A levelsMAO-A VTSerotonin turnoverCerebral serotonin systemPositron emission tomography studyGenetic variantsEmission tomography studiesTryptophan hydroxylase 2 geneCerebral MAODepressed cohortBrain MAOMonoamine oxidase ASerotonin systemRelated clinical phenomenaRs1386494Distribution volumeTPH2 polymorphismsTomography studyClinical phenomenaMonoamine oxidaseSerotonin transporter occupancy with citalopram challenge in single positron emission tomography [11C]DASB scans
De León M, Murgaš M, Silberbauer L, Hacker M, Gryglewski G, Hahn A, Lanzenberger R. Serotonin transporter occupancy with citalopram challenge in single positron emission tomography [11C]DASB scans. Neuroscience Applied 2023, 2: 103358. DOI: 10.1016/j.nsa.2023.103358.Peer-Reviewed Original Research
2022
Meta-analysis of molecular imaging of translocator protein in major depression
Eggerstorfer B, Kim JH, Cumming P, Lanzenberger R, Gryglewski G. Meta-analysis of molecular imaging of translocator protein in major depression. Frontiers In Molecular Neuroscience 2022, 15: 981442. PMID: 36226319, PMCID: PMC9549359, DOI: 10.3389/fnmol.2022.981442.Peer-Reviewed Original ResearchBody mass indexMajor depressive disorderMDD patientsMolecular imaging studiesTranslocator proteinImaging studiesTSPO availabilityPositron emission tomography studyMarkers of neuroinflammationSerotonin transporter availabilityEmission tomography studiesSystematic literature searchTime of scanningEffect sizeMolecular neuroimaging studiesMass indexDepressive disorderHealthy controlsMajor depressionTransporter availabilityHealthy subjectsTreatment statusDepression severityTemporal cortexBrain regionsABCB1 variants and sex affect serotonin transporter occupancy in the brain
Silberbauer LR, Rischka L, Vraka C, Hartmann AM, Godbersen GM, Philippe C, Pacher D, Nics L, Klöbl M, Unterholzner J, Stimpfl T, Wadsak W, Hahn A, Hacker M, Rujescu D, Kasper S, Lanzenberger R, Gryglewski G. ABCB1 variants and sex affect serotonin transporter occupancy in the brain. Molecular Psychiatry 2022, 27: 4502-4509. PMID: 36071112, PMCID: PMC7613909, DOI: 10.1038/s41380-022-01733-1.Peer-Reviewed Original ResearchConceptsMinor allele carriersTransporter occupancyAllele carriersABCB1 single nucleotide polymorphismsBasic clinical variablesCitalopram plasma concentrationsYears of ageMajor allele homozygotesCross-over designPET/MRISERT occupancyClinical variablesTreatment promisesClinical algorithmMajor depressionPlasma concentrationsPrecision pharmacotherapyABCB1 variantsHealthy volunteersABCB1 geneAllele homozygotesSame dosageDrug-target engagementTarget engagementSingle nucleotide polymorphismsBiodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1
Rischka L, Murgaš M, Pichler V, Vraka C, Rausch I, Winkler D, Nics L, Rasul S, Silberbauer LR, Reed MB, Godbersen GM, Unterholzner J, Handschuh P, Gryglewski G, Mindt T, Mitterhauser M, Hahn A, Ametamey SM, Wadsak W, Lanzenberger R, Hacker M. Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1. EJNMMI Research 2022, 12: 53. PMID: 36018389, PMCID: PMC9418393, DOI: 10.1186/s13550-022-00925-8.Peer-Reviewed Original ResearchExtrasynaptic NMDA receptorsStandardized uptake valueNMDA receptorsUrinary bladderEffective dose coefficientsPET radioligandNeuropsychiatric disordersTreatment monitoringSynaptic NMDA receptorsTime-integrated activity coefficientsCentral nervous systemUrinary bladder contentsDrug developmentDose coefficientsAdverse eventsExcitotoxic processTRIAL REGISTRATIONBladder contentsHealthy subjectsSynaptic transmissionSide effectsBone marrowNervous systemUptake valueEffective doseRegional gene expression patterns are associated with task‐specific brain activation during reward and emotion processing measured with functional MRI
Komorowski A, Murgaš M, Vidal R, Singh A, Gryglewski G, Kasper S, Wiltfang J, Lanzenberger R, Goya‐Maldonado R. Regional gene expression patterns are associated with task‐specific brain activation during reward and emotion processing measured with functional MRI. Human Brain Mapping 2022, 43: 5266-5280. PMID: 35796185, PMCID: PMC9812247, DOI: 10.1002/hbm.26001.Peer-Reviewed Original ResearchCorrelation of receptor density and mRNA expression patterns in the human cerebral cortex
Murgaš M, Michenthaler P, Reed MB, Gryglewski G, Lanzenberger R. Correlation of receptor density and mRNA expression patterns in the human cerebral cortex. NeuroImage 2022, 256: 119214. PMID: 35452805, DOI: 10.1016/j.neuroimage.2022.119214.Peer-Reviewed Original ResearchConceptsMRNA expression patternsExpression patternsPost-translational processesGene expression patternsRNA sequencing dataComprehensive proteomic studyMolecular targetsMulti-receptor systemsMessenger ribonucleic acid transcriptsRibonucleic acid transcriptsTranscriptome dataProteomic informationProteomic dataProteomic studiesMost proteinsSequencing dataVivo linkMicroarray dataAllen Human Brain AtlasMRNA expressionProtein densitySubunits α3ProteinHuman Brain AtlasHigh-resolution topologySimultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual
Vraka C, Murgaš M, Rischka L, Geist BK, Lanzenberger R, Gryglewski G, Zenz T, Wadsak W, Mitterhauser M, Hacker M, Philippe C, Pichler V. Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual. Scientific Reports 2022, 12: 3283. PMID: 35228586, PMCID: PMC8885643, DOI: 10.1038/s41598-022-06906-0.Peer-Reviewed Original ResearchEscitalopram administration, relearning, and neuroplastic effects: A diffusion tensor imaging study in healthy individuals
Vanicek T, Reed MB, Unterholzner J, Klöbl M, Godbersen GM, Handschuh PA, Spurny-Dworak B, Ritter V, Gryglewski G, Kraus C, Winkler D, Lanzenberger R, Seiger R. Escitalopram administration, relearning, and neuroplastic effects: A diffusion tensor imaging study in healthy individuals. Journal Of Affective Disorders 2022, 301: 426-432. PMID: 35016914, DOI: 10.1016/j.jad.2021.12.135.Peer-Reviewed Original ResearchSerotonergic modulation of effective connectivity in an associative relearning network during task and rest
Reed MB, Klöbl M, Godbersen GM, Handschuh PA, Ritter V, Spurny-Dworak B, Unterholzner J, Kraus C, Gryglewski G, Winkler D, Seiger R, Vanicek T, Hahn A, Lanzenberger R. Serotonergic modulation of effective connectivity in an associative relearning network during task and rest. NeuroImage 2022, 249: 118887. PMID: 34999203, DOI: 10.1016/j.neuroimage.2022.118887.Peer-Reviewed Original ResearchConceptsRight angular gyrusAnterior cingulate cortexEffective connectivityRight insulaCognitive flexibilityAngular gyrusCingulate cortexAssociative learning taskAssociative learningLearning taskTask connectivityLearning phaseInsulaGray matter volume changesSelective serotonin reuptake inhibitor escitalopramDouble-blind designNeuroplastic changesGyrusTaskParticipantsSSRI intakeCortexEffective connectionSerotonergic modulationConnectivity