Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsChristoph Anacker
About
Research
Publications
2024
Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors
Dixon R, Malave L, Thompson R, Wu S, Li Y, Sadik N, Anacker C. Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors. Neuropsychopharmacology 2024, 50: 507-518. PMID: 39396089, PMCID: PMC11736140, DOI: 10.1038/s41386-024-01999-9.Peer-Reviewed Original ResearchEffects of early life adversityEarly life adversityVentral dentate gyrusAcute swim stressCorticotropin-releasing factorStress reactivityParaventricular nucleusSwim stressLife adversityNeuronal activityModel of early life adversityEarly life adversity effectsIn adulthoodIncreased passive copingSex-specific impairmentsFemale miceSerotonin-1ASerotonin systemNeurobiological mechanismsStress vulnerabilityIncreased microglia activationLimited beddingPassive copingAutoreceptorsCorticosterone levelsSex Differences in Early Life Stress Effects on Fear Generalization are Mediated by Serotonergic Regulation of the Ventral Dentate Gyrus
Anacker C, Malave L, Dixon R. Sex Differences in Early Life Stress Effects on Fear Generalization are Mediated by Serotonergic Regulation of the Ventral Dentate Gyrus. Biological Psychiatry 2024, 95: s12-s13. DOI: 10.1016/j.biopsych.2024.02.036.Peer-Reviewed Original Research21. How Genes and Environments Modify Intergenerational Risk for Depression – Using Polygenic Scores to Translate Between Rodents and Humans
van Dijk M, Malave L, Pokhvisneva I, Patel S, Kashyap P, Desai K, Cha J, Gameroff M, Posner J, Weissman M, Talati A, Silveira P, Anacker C. 21. How Genes and Environments Modify Intergenerational Risk for Depression – Using Polygenic Scores to Translate Between Rodents and Humans. Biological Psychiatry 2024, 95: s83. DOI: 10.1016/j.biopsych.2024.02.199.Peer-Reviewed Original ResearchTAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding
Dedic N, Wang L, Hajos-Korcsok E, Hecksher-Sørensen J, Roostalu U, Vickers S, Wu S, Anacker C, Synan C, Jones P, Milanovic S, Hopkins S, Bristow L, Koblan K. TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding. Molecular Metabolism 2024, 80: 101883. PMID: 38237896, PMCID: PMC10839149, DOI: 10.1016/j.molmet.2024.101883.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptor 1Trace amine-associated receptor 1 agonistAntipsychotic drugsEffects of TAAR1 agonistsOlanzapine-induced weight gainDiet-induced obesityReduced body weightFood intakeHigh-fat dietSub-chronic administrationC-Fos protein expressionDiet-induced obese miceImprove glycemic controlRegulators of metabolic controlGlycemic controlGastric emptyingSchizophrenia patientsTAAR1 agonistsHedonic feedingLimbic structuresBody weightMetabolic parametersMouse modelGlucose toleranceWeight gain
2023
Impact of Stress Exposure on Mental and Physical Health across the Life Span: Molecular mechanisms, Neurobiological abnormalities, and Novel Pathways for Intervention
Cattaneo A, Anacker C, Daskalakis N, Riva M. Impact of Stress Exposure on Mental and Physical Health across the Life Span: Molecular mechanisms, Neurobiological abnormalities, and Novel Pathways for Intervention. Psychoneuroendocrinology 2023, 153: 106142. DOI: 10.1016/j.psyneuen.2023.106142.Peer-Reviewed Original ResearchStress exposureEffects of stress exposureImpact of stress exposureSensorimotor gating deficitsChildhood trauma survivorsNegative outcomesPhysical healthEarly life adversityNegative effects of stressExposure to adversityExposure to stressEffects of stressGating deficitsNeurobiological abnormalitiesNeurobiological mechanismsLife stressLife adversityTrauma survivorsSerotonin SignalingAffective behaviorNeurodevelopmental windowBrain functionAt adulthoodPhysical diseaseMouse hippocampus