Zaira Ianniello, PhD
Associate Research Scientist in Therapeutic RadiologyAbout
Research
Publications
2025
Harnessing exDNA for precision exatecan delivery in cancer: a novel antibody-drug conjugate approach
Ianniello Z, Lu H, Quijano E, Colón-Ríos D, Rackear M, Bommireddy V, Ludwig D, Shen Z, Glazer P. Harnessing exDNA for precision exatecan delivery in cancer: a novel antibody-drug conjugate approach. Molecular Cancer 2025, 24: 253. PMID: 41077566, PMCID: PMC12516839, DOI: 10.1186/s12943-025-02462-z.Peer-Reviewed Original ResearchSystemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer
Quijano E, Saucedo D, Ianniello Z, Pinto-Medici N, Rackear M, Chen H, Lola-Pereira L, Liu Y, Hegan D, Shan X, Tseng R, Yugawa D, Chowdhury S, Khang M, Singh J, Abdullah R, Azhir P, Kashima S, Woods W, Gosstola N, Turner B, Squinto S, Ludwig D, Bindra R, Robert M, Braun D, Pinera P, Saltzman W, Escobar-Hoyos L, Glazer P. Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer. Science Translational Medicine 2025, 17: eadk1868-eadk1868. PMID: 40668891, PMCID: PMC12375925, DOI: 10.1126/scitranslmed.adk1868.Peer-Reviewed Original Research
2024
Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition
Rackear M, Quijano E, Ianniello Z, Colón-Ríos D, Krysztofiak A, Abdullah R, Liu Y, Rogers F, Ludwig D, Dwivedi R, Bleichert F, Glazer P. Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition. Oncotarget 2024, 15: 699-713. PMID: 39352803, PMCID: PMC11444335, DOI: 10.18632/oncotarget.28651.Peer-Reviewed Original Research
2023
circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype‐definition in small cell lung cancer
Tolomeo D, Traversa D, Venuto S, Ebbesen K, Rodríguez J, Tamma G, Ranieri M, Simonetti G, Ghetti M, Paganelli M, Visci G, Liso A, Kok K, Muscarella L, Fabrizio F, Frassanito M, Lamanuzzi A, Saltarella I, Solimando A, Fatica A, Ianniello Z, Marsano R, Palazzo A, Azzariti A, Longo V, Tommasi S, Galetta D, Catino A, Zito A, Mazza T, Napoli A, Martinelli G, Kjems J, Kristensen L, Vacca A, Storlazzi C. circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype‐definition in small cell lung cancer. Genes Chromosomes And Cancer 2023, 62: 377-391. PMID: 36562080, DOI: 10.1002/gcc.23121.Peer-Reviewed Original Research
2022
MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer
Turco C, Esposito G, Iaiza A, Goeman F, Benedetti A, Gallo E, Daralioti T, Perracchio L, Sacconi A, Pasanisi P, Muti P, Pulito C, Strano S, Ianniello Z, Fatica A, Forcato M, Fazi F, Blandino G, Fontemaggi G. MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer. Communications Biology 2022, 5: 598. PMID: 35710947, PMCID: PMC9203778, DOI: 10.1038/s42003-022-03539-x.Peer-Reviewed Original Research
2021
New insight into the catalytic -dependent and -independent roles of METTL3 in sustaining aberrant translation in chronic myeloid leukemia
Ianniello Z, Sorci M, Ceci Ginistrelli L, Iaiza A, Marchioni M, Tito C, Capuano E, Masciarelli S, Ottone T, Attrotto C, Rizzo M, Franceschini L, de Pretis S, Voso M, Pelizzola M, Fazi F, Fatica A. New insight into the catalytic -dependent and -independent roles of METTL3 in sustaining aberrant translation in chronic myeloid leukemia. Cell Death & Disease 2021, 12: 870. PMID: 34561421, PMCID: PMC8463696, DOI: 10.1038/s41419-021-04169-7.Peer-Reviewed Original ResearchAdenosineCatalysisCell Line, TumorCell NucleusCell ProliferationCell SurvivalDrug Resistance, NeoplasmGene Knockdown TechniquesHumansImatinib MesylateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMethyltransferasesModels, BiologicalProtein BiosynthesisProto-Oncogene Proteins c-mycRNA-Binding ProteinsRNA, MessengerUp-RegulationMETTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors
Iaiza A, Tito C, Ianniello Z, Ganci F, Laquintana V, Gallo E, Sacconi A, Masciarelli S, De Angelis L, Aversa S, Diso D, Anile M, Petrozza V, Facciolo F, Melis E, Pescarmona E, Venuta F, Marino M, Blandino G, Fontemaggi G, Fatica A, Fazi F. METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors. Clinical Epigenetics 2021, 13: 173. PMID: 34530916, PMCID: PMC8447796, DOI: 10.1186/s13148-021-01159-6.Peer-Reviewed Original ResearchTranslational control of polyamine metabolism by CNBP is required for Drosophila locomotor function
Coni S, Falconio F, Marzullo M, Munafò M, Zuliani B, Mosti F, Fatica A, Ianniello Z, Bordone R, Macone A, Agostinelli E, Perna A, Matkovic T, Sigrist S, Silvestri G, Canettieri G, Ciapponi L. Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function. ELife 2021, 10: e69269. PMID: 34517941, PMCID: PMC8439652, DOI: 10.7554/elife.69269.Peer-Reviewed Original ResearchADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism
Tassinari V, Cesarini V, Tomaselli S, Ianniello Z, Silvestris D, Ginistrelli L, Martini M, De Angelis B, De Luca G, Vitiani L, Fatica A, Locatelli F, Gallo A. ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism. Genome Biology 2021, 22: 51. PMID: 33509238, PMCID: PMC7842030, DOI: 10.1186/s13059-021-02271-9.Peer-Reviewed Original Research
2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation
Coni S, Serrao S, Yurtsever Z, Di Magno L, Bordone R, Bertani C, Licursi V, Ianniello Z, Infante P, Moretti M, Petroni M, Guerrieri F, Fatica A, Macone A, De Smaele E, Di Marcotullio L, Giannini G, Maroder M, Agostinelli E, Canettieri G. Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation. Cell Death & Disease 2020, 11: 1045. PMID: 33303756, PMCID: PMC7729396, DOI: 10.1038/s41419-020-03174-6.Peer-Reviewed Original ResearchAdenomatous Polyposis ColiAmino Acid MotifsAmino Acid SequenceAnimalsCell Line, TumorCell ProliferationColorectal NeoplasmsDown-RegulationEukaryotic Translation Initiation Factor 5AGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLysineMice, NudeOpen Reading FramesOxidoreductases Acting on CH-NH Group DonorsPeptide Initiation FactorsPeptidesPolyaminesProtein BiosynthesisProto-Oncogene Proteins c-mycRNA-Binding Proteins
Academic Achievements & Community Involvement
News
News
- July 16, 2025
Yale Researchers Develop Novel Antibody-RNA Therapy for Resistant Cancers
- May 01, 2025
New Research Presented from Yale Cancer Center at #AACR25
- April 21, 2025
Yale Cancer Center Research Breakthroughs Unveiled at AACR Annual Meeting
- April 12, 2024
Yale Cancer Center Faculty and Trainees Present at AACR Annual Meeting