Yun Chen
she/her/hers
Postdoctoral AssociateAbout
Research
Publications
2026
Helicobacter pylori infection and metabolic dysfunction-associated steatotic liver disease: a prospective study and meta-analysis.
Zhao L, Chen Y, Zhang X, Mezzacappa C, Ma X, Banini B, Lee J, Liu C, Zhang X, Hsing A, Nguyen M, Hyun C, Camargo M, McGlynn K, Hou L, Taddei T, Zhang X. Helicobacter pylori infection and metabolic dysfunction-associated steatotic liver disease: a prospective study and meta-analysis. Cancer Epidemiology Biomarkers & Prevention 2026 PMID: 42233960, DOI: 10.1158/1055-9965.epi-26-0038.Peer-Reviewed Original ResearchH. pylori seropositivityHazard ratioConfidence intervalsCagA seropositivityCross-sectional studyCardiometabolic factorsH. pyloriPrevention strategiesProspective cohortHealth concernMedian Follow-UpMeta-analysisAsian populationsUKBParticipantsHigh riskCox modelH. pylori infectionGlobal health concernFollow-upProspective studyRiskRisk stratificationLiver diseaseSteatotic liver diseaseSu2107 HELICOBACTER PYLORI INFECTION AND MASLD: A PROSPECTIVE STUDY AND META-ANALYSIS
Zhao L, Chen Y, Zhang X, Mezzacappa C, Ma X, Banini B, Lee J, Liu C, Zhang X, Hsing A, Nguyen M, Hyun C, Camargo M, McGlynn K, Hou L, Taddei T, Zhang X. Su2107 HELICOBACTER PYLORI INFECTION AND MASLD: A PROSPECTIVE STUDY AND META-ANALYSIS. Gastroenterology 2026, 170: s-1557. DOI: 10.1016/s0016-5085(26)03805-9.Peer-Reviewed Original ResearchSu2107 HELICOBACTER PYLORI INFECTION AND MASLD: A PROSPECTIVE STUDY AND META-ANALYSIS
Zhao L, Chen Y, Zhang X, Mezzacappa C, Ma X, Banini B, Lee J, Liu C, Zhang X, Hsing A, Nguyen M, Hyun C, Camargo M, McGlynn K, Hou L, Taddei T, Zhang X. Su2107 HELICOBACTER PYLORI INFECTION AND MASLD: A PROSPECTIVE STUDY AND META-ANALYSIS. Gastrointestinal Endoscopy 2026, 103: s-1557. DOI: 10.1016/s0016-5107(26)03736-3.Peer-Reviewed Original ResearchDietary Patterns and the Risk of Liver Cancer and Chronic Liver Disease Mortality
Khil J, Zhao L, Zhang X, Chen Y, Jung S, Pichardo M, Lopez-Pentecost M, Rohan T, Saquib N, Sun Y, Tabung F, Zheng T, Wactawski-Wende J, Manson J, Neuhouser M, Keum N, Zhang X. Dietary Patterns and the Risk of Liver Cancer and Chronic Liver Disease Mortality. Journal Of Nutrition 2026, 156: 101557. PMID: 42061715, DOI: 10.1016/j.tjnut.2026.101557.Peer-Reviewed Original ResearchChronic liver disease mortalityChronic liver disease deathsLiver cancer riskChronic liver diseaseDietary patternsCancer riskInverse associationWomen's Health Initiative Observational StudyHazard ratioAdherence to healthy dietary patternsOverall eating behaviorsRisk of liver cancerConfidence intervalsLiver disease mortalityNational Death IndexPostmenopausal womenFood-frequency questionnaireLiver cancer incidenceHealthy dietary patternSignificant inverse associationLiver cancerCox proportional hazards regressionReview of medical recordsLiver cancer casesLiver diseaseBlood Pressure Trajectories in Young Adulthood and Midlife Steatotic Liver Disease
Chen Y, Zhao L, Zheng Y, Carr J, Gao T, Terry J, Qu Y, Ning H, Zhang X, Wilkins J, Bae S, Carnethon M, Allen N, Jacobs D, Lloyd-Jones D, Hou L, Zhang X. Blood Pressure Trajectories in Young Adulthood and Midlife Steatotic Liver Disease. Hypertension 2026, 83: e26319. PMID: 41867060, DOI: 10.1161/hypertensionaha.125.26319.Peer-Reviewed Original ResearchBP trajectoriesYoung adulthoodSystolic BP trajectoriesBlood pressureBlood pressure trajectoriesHigh riskSteatotic liver diseaseHigh blood pressureCARDIA studyElevated-stableHypertensive trajectoryWhite adultsLong-term BP changesPressure trajectoriesModerate-stableAnalytic sampleIdentification of individualsModerate-increasingMid-adulthoodLiver diseaseAbdominal computed tomography scanProspective cohortAccurate identification of individualsDiastolic BP groupPositive associationFactors associated with social inclusion of parents of children with autism spectrum disorder: a multicenter cross-sectional study in China
Ji B, Zhang B, Chen S, Chen Y, Wei W, Zhao L, Li J, Ni Z, Jiang X. Factors associated with social inclusion of parents of children with autism spectrum disorder: a multicenter cross-sectional study in China. Child And Adolescent Psychiatry And Mental Health 2026, 20: 61. PMID: 41832554, PMCID: PMC13101307, DOI: 10.1186/s13034-026-01065-w.Peer-Reviewed Original ResearchSocial inclusionParents of childrenAutism spectrum disorderBackgroundSocial inclusionAssociated with social inclusionFather inclusionInclusion of parentsSelf-esteemHigher educationSocial supportInclusion ScaleGender differencesInteraction effect testingSocial Inclusion ScaleMulticenter cross-sectional studySpectrum disorderSubgroup analysisCross-sectional studyPotential gender differencesGender subgroup analysisSelf-report psychometric scaleCaregiving capacityHealthcare providersRehabilitation centerExternal barriersSex and age differences in the association between obesity and long-term changes with the risk of incident type 2 diabetes mellitus: the Rural Deqing Cohort Study
Wu B, Chen Y, Xu H, Chen Y, Dong X, Fu C. Sex and age differences in the association between obesity and long-term changes with the risk of incident type 2 diabetes mellitus: the Rural Deqing Cohort Study. HepatoBiliary Surgery And Nutrition 2026, 15: 7-7. PMID: 41676777, PMCID: PMC12887344, DOI: 10.21037/hbsn-24-417.Peer-Reviewed Original ResearchRisk of incident T2DMBody mass indexIncident T2DMRisk of T2DMObesity indicesWaist circumferenceRural adultsCohort studyHigher risk of incident T2DMSD incrementType 2 diabetes mellitusAssociation of obesity indicesWaist-to-height ratioIncident type 2 diabetes mellitusElectronic health record systemsRisk of incident type 2 diabetes mellitusLimitations of body mass indexPopulation-based cohort studyAbdominal obesity indicesRural Chinese adultsRisk of type 2 diabetes mellitusConfidence intervalsCases of incident T2DMHealth record systemsWeight changeAssociation of change in healthy lifestyle in early adulthood with steatotic liver disease risk in midlife
Chen Y, Zhao L, Mezzacappa C, Steffen L, Carr J, Gao T, Terry J, Qu Y, Bae S, Taddei T, Justice A, Jacobs D, Lloyd-Jones D, Hou L, Zhang X. Association of change in healthy lifestyle in early adulthood with steatotic liver disease risk in midlife. Clinical Gastroenterology And Hepatology 2026 PMID: 41620192, PMCID: PMC13097063, DOI: 10.1016/j.cgh.2026.01.019.Peer-Reviewed Original ResearchHealthy lifestyle scoreHealthy lifestyleUnhealthy lifestyleLifestyle scoreHealthy behaviorsAbsolute riskBenefits of healthy behavioursRelative riskCoronary Artery Risk DevelopmentMultivariate adjusted relative riskHealthy lifestyle changesAdjusted relative risksEarly adulthoodYoung adultsLiver disease riskSteatotic liver diseasePhysical activityGenetic predispositionNon-contrast abdominal computed tomographyDietary qualityRisk DevelopmentLifestyle changesAlcohol intakeGenetic riskAbdominal computed tomographySocial determinants disadvantage score and liver health in the All of Us Research Program
Zhang X, Zhao L, Zhang K, Vlahov D, Chen Y, Hsing A, Nguyen M, McGlynn K, Taddei T, Hou L, Zhang X. Social determinants disadvantage score and liver health in the All of Us Research Program. European Journal Of Epidemiology 2026, 41: 207-216. PMID: 41579292, PMCID: PMC12975775, DOI: 10.1007/s10654-025-01358-y.Peer-Reviewed Original ResearchConceptsSocial determinants of healthUs Research ProgramOdds ratioSocial determinantsSocial determinants of health domainsDisadvantage scoreDeterminants of healthConfidence intervalsElectronic health recordsCross-sectional analysisHigh riskLogistic regression modelsSDOH domainsHealthcare accessHealth outcomesHealth recordsTargeted interventionsSocial disadvantageCommunity contextHealthLongitudinal studyRegression modelsQuintileLiver conditionsAssociation
2025
The impact of genetic and environmental risk factors on adverse liver outcomes
Zhang X, Zhao L, Campbell P, Chen Y, Fang A, Liu Z, Li X, Yang W, Fan J, Petrick J, McGlynn K, Lai M, Zhang X. The impact of genetic and environmental risk factors on adverse liver outcomes. International Journal Of Cancer 2025, 158: 2317-2328. PMID: 41345374, DOI: 10.1002/ijc.70259.Peer-Reviewed Original ResearchPolygenic risk scoresPopulation attributable riskPolygenic risk score tertileEnvironmental risk scoreRisk scoreUK Biobank participantsLevel of genetic predispositionRisk factorsEnvironmental risk factorsCancer RegistryBiobank participantsAttributable riskIncident outcomesLiver cancerGenetic riskHospital recordsTertileLiver cirrhosisGenetic predispositionFollow-upRiskLiver diseaseParticipantsLiver outcomesAdverse liver outcomes
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