Catherine Mezzacappa, MD, MPH
she/her/hers
Clinical FellowAbout
Research
Publications
2024
Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data
Torgersen J, Mezochow A, Newcomb C, Carbonari D, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Re V. Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data. JAMA Internal Medicine 2024, 184: 943-952. PMID: 38913369, PMCID: PMC11197444, DOI: 10.1001/jamainternmed.2024.1836.Peer-Reviewed Original ResearchIncidence rateUS Department of Veterans AffairsMedication initiationDepartment of Veterans AffairsInitiation of medicationVeterans AffairsMain OutcomesPotential of medicationsOutpatient settingDischarge diagnosisCohort studyDay of admissionCase reportReal World DataReport countsMedicationMedical cohortSevere acute liver injuryUS DepartmentFollow-upAcute liver injuryHospitalCohortHepatotoxic medicationsIncidenceIntegrated Telemedicine to Treat HCV Through Opioid Treatment Programs
Mezzacappa C. Integrated Telemedicine to Treat HCV Through Opioid Treatment Programs. Gastroenterology 2024 PMID: 39025413, DOI: 10.1053/j.gastro.2024.07.010.Peer-Reviewed Original ResearchScreening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure
Mezzacappa C, Kim N, Vutien P, Kaplan D, Ioannou G, Taddei T. Screening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure. JAMA Network Open 2024, 7: e2420963. PMID: 38985470, PMCID: PMC11238019, DOI: 10.1001/jamanetworkopen.2024.20963.Peer-Reviewed Original ResearchConceptsHepatitis C virus cureHepatitis C virusAssociated with improved overall survivalHepatocellular carcinoma diagnosisEarly-stage hepatocellular carcinomaImproved overall survivalOverall survivalHepatocellular carcinomaFollow-upHCC screeningCurative treatmentCumulative incidence of hepatocellular carcinomaDirect-acting antiviral (DAA) therapyCohort studyVeterans Affairs health care systemIncidence of hepatocellular carcinomaRisk of hepatocellular carcinomaCohort study of personsHepatitis C virus cirrhosisDiagnosis of hepatocellular carcinomaLikelihood of curative treatmentYears of follow-upHealth care systemHepatocellular carcinoma screeningHCV-related cirrhosisReview of the cost-effectiveness of surveillance for hereditary pancreatic cancer
Wang L, Levinson R, Mezzacappa C, Katona B. Review of the cost-effectiveness of surveillance for hereditary pancreatic cancer. Familial Cancer 2024, 23: 351-360. PMID: 38795221, PMCID: PMC11255025, DOI: 10.1007/s10689-024-00392-1.Peer-Reviewed Original ResearchHigh-risk individualsHereditary pancreatic cancerSusceptibility to pancreatic cancerPancreatic cancer riskFamily history of PCSurveillance strategiesPancreatic cancerCost-effectiveness of surveillanceHistory of PCCost-effectiveness studiesCost-effectiveCancer riskCost-effectiveness analysisPancreatic surveillanceHigh-risk groupOptimal surveillance strategyFamily historyNew-onset diabetesRisk individualsSporadic PCHealth benefitsPotential health benefitsPC diagnosisSub-groupsSurveillanceManagement of HBV reactivation: Challenges and opportunities
Mezzacappa C, Lim J. Management of HBV reactivation: Challenges and opportunities. Clinical Liver Disease 2024, 23: e0143. PMID: 38720793, PMCID: PMC11078521, DOI: 10.1097/cld.0000000000000143.Peer-Reviewed Original ResearchTu1420 THE ASSOCIATION OF HEPATITIS C VIRUS ON THE RISK OF PANCREATIC CANCER
Levinson R, Larki N, Tate J, Skanderson M, Mezzacappa C, Park L, Hauser R, Brandt C, Schuster K, Ketwaroo G, Yang Y, Justice A, Wang L. Tu1420 THE ASSOCIATION OF HEPATITIS C VIRUS ON THE RISK OF PANCREATIC CANCER. Gastroenterology 2024, 166: s-1333. DOI: 10.1016/s0016-5085(24)03510-8.Peer-Reviewed Original ResearchCo-occurring MASLD and Diabetes Is Associated With Increased Incidence of Cardiovascular Events and Mortality
Mezzacappa C. Co-occurring MASLD and Diabetes Is Associated With Increased Incidence of Cardiovascular Events and Mortality. Gastroenterology 2024, 167: 812-813. PMID: 38670284, DOI: 10.1053/j.gastro.2024.04.021.Peer-Reviewed Original ResearchDetection of hepatocellular carcinoma methylation markers in salivary DNA
Mezzacappa C, Wang Z, Lu L, Risch H, Taddei T, Yu H. Detection of hepatocellular carcinoma methylation markers in salivary DNA. Bioscience Reports 2024, 44: bsr20232063. PMID: 38457142, PMCID: PMC10958141, DOI: 10.1042/bsr20232063.Peer-Reviewed Original ResearchHepatocellular carcinoma screeningCase patientsHepatocellular carcinomaControl subjectsDiagnosis of hepatocellular carcinomaAssociated with hepatocellular carcinomaScreening testSalivary DNASaliva-based testCpG sitesStudy of risk factorsSalivary DNA methylationDNA methylationViral hepatitisCirculating DNAAlterations to DNA methylationRisk factorsMethylation markersPatientsRegulation of cell cycle progressionBlood samplesCell cycle progressionAffected individualsAlternative to blood samplingMultiple comparisonsDevelopment and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration
Mezzacappa C, Larki N, Skanderson M, Park L, Brandt C, Hauser R, Justice A, Yang Y, Wang L. Development and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration. Digestive Diseases And Sciences 2024, 69: 1507-1513. PMID: 38453743, DOI: 10.1007/s10620-024-08324-w.Peer-Reviewed Original ResearchElectronic health recordsVeterans Health AdministrationHealth AdministrationElectronic health records data elementsElectronic health record dataDiagnosis of exocrine pancreatic cancerNational Cancer RegistryCancer RegistryHealth recordsExocrine pancreatic cancerOncology settingOutpatient encountersInpatient encountersData elementsExpert adjudicationPancreatic ductal adenocarcinomaEpidemiological studiesRandom sampleInterquartile rangeIdentification of patientsRange of patientsPancreatic cancerVeteransLate diagnosisExcellent PPV
2023
Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study.
Mezzacappa C, Rossi R, Jaffe A, Taddei T, Strazzabosco M. Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study. Cancer Epidemiology Biomarkers & Prevention 2023, 33: 270-278. PMID: 38059831, PMCID: PMC10872555, DOI: 10.1158/1055-9965.epi-23-0902.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- September 10, 2024
Liver Cancer Screening Post-Hep C Cure Improves Survival
- September 19, 2023
Liver Center Retreat Highlights Breadth of Liver Research at Yale
- August 01, 2023
Fellow Focus in Four: Catherine Mezzacappa, MD, MPH, Digestive Diseases
- May 12, 2020
Good Times Never Seemed So Good