Wei Zheng
Associate Research ScientistAbout
Research
Publications
2026
Co-exposure to phthalates and their alternatives in early pregnancy and the subsequent risk of pregnancy complications: A nested case-control study
Xiong Z, Huang Y, Xu Z, Mahai G, Wu C, Xu M, Zheng T, Liu H, Xia W, Xu S, Chen T, Li Y. Co-exposure to phthalates and their alternatives in early pregnancy and the subsequent risk of pregnancy complications: A nested case-control study. Ecotoxicology And Environmental Safety 2026, 320: 120392. PMID: 42314420, DOI: 10.1016/j.ecoenv.2026.120392.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusPremature rupture of membranesRisk of pregnancy complicationsAssociated with elevated ORsNested Case-Control StudyPregnancy complicationsAssociated with higher riskEarly pregnancyCase-control studyConditional logistic regressionAssociated with elevated oddsPlacental abnormalitiesPremature rupturePreterm birthIntrauterine distressFetal sexHigher risk of pregnancy complicationsOR of GDMQuantile g-computation modelsOdds of gestational diabetes mellitusPhthalate exposureRupture of membranesUrinary phthalate metabolitesPrenatal phthalate exposureLogistic regressionDesign, Synthesis, and Structure–Activity Optimization of Marine-Inspired Macrolactones as Nanomolar Anticancer Agents
Qian S, Qiu H, Sanchez P, Head S, Hartke R, Liu J, Zheng W, Jin Z. Design, Synthesis, and Structure–Activity Optimization of Marine-Inspired Macrolactones as Nanomolar Anticancer Agents. ACS Medicinal Chemistry Letters 2026, 17: 1416-1420. PMID: 42305198, PMCID: PMC13266650, DOI: 10.1021/acsmedchemlett.6c00222.Peer-Reviewed Original ResearchCorrection to: Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance
Zhou W, Sun W, Yung M, Dai S, Cai Y, Chen C, Meng Y, Lee J, Braisted J, Xu Y, Southall N, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung A, Ngan H, Liu S, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan D, Zheng W, Zhu W. Correction to: Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance. Oncogene 2026, 45: 2072-2073. PMID: 42115410, DOI: 10.1038/s41388-026-03820-x.Peer-Reviewed Original ResearchAfrican ancestry and risk variants associated with triple-negative breast cancer susceptibility in African American women
Jia G, Liu L, Ping J, Fiorica P, Guo X, Tao R, Li B, Gu J, John E, Olopade O, Press M, Brewster A, Olshan A, Zirpoli G, Butler E, Huang M, Huo D, Palmer J, Haiman C, Ambrosone C, Troester M, Long J, Yao S, Zheng W. African ancestry and risk variants associated with triple-negative breast cancer susceptibility in African American women. Genome Medicine 2026 PMID: 42098873, DOI: 10.1186/s13073-026-01665-3.Peer-Reviewed Original ResearchAfrican American womenTriple-negative breast cancerCase-control analysisAmerican womenTriple-negative breast cancer casesTriple-negative breast cancer riskER-positive casesAfrican ancestryBreast cancer geneticsRisk variantsBreast cancer susceptibilityAllelic odds ratioAssociation analysisBreast cancerRisk allele frequenciesProportion of African ancestryBody mass indexAssociated with triple-negative breast cancerAssociated with TNBC riskEstrogen receptor (ER)-positive casesER-positive breast cancerAssociation of African ancestryEuropean American womenStatistically significant associationGenetic factorsDietary Patterns and the Risk of Liver Cancer and Chronic Liver Disease Mortality
Khil J, Zhao L, Zhang X, Chen Y, Jung S, Pichardo M, Lopez-Pentecost M, Rohan T, Saquib N, Sun Y, Tabung F, Zheng T, Wactawski-Wende J, Manson J, Neuhouser M, Keum N, Zhang X. Dietary Patterns and the Risk of Liver Cancer and Chronic Liver Disease Mortality. Journal Of Nutrition 2026, 156: 101557. PMID: 42061715, DOI: 10.1016/j.tjnut.2026.101557.Peer-Reviewed Original ResearchChronic liver disease mortalityChronic liver disease deathsLiver cancer riskChronic liver diseaseDietary patternsCancer riskInverse associationWomen's Health Initiative Observational StudyHazard ratioAdherence to healthy dietary patternsOverall eating behaviorsRisk of liver cancerConfidence intervalsLiver disease mortalityNational Death IndexPostmenopausal womenFood-frequency questionnaireLiver cancer incidenceHealthy dietary patternSignificant inverse associationLiver cancerCox proportional hazards regressionReview of medical recordsLiver cancer casesLiver diseaseLead (Pb) exposure results in cell type specific changes in the mouse retina and optic nerve
Khandokar L, Liu L, Zheng W, Kerstein P. Lead (Pb) exposure results in cell type specific changes in the mouse retina and optic nerve. NeuroToxicology 2026, 114: 103461. PMID: 42034125, DOI: 10.1016/j.neuro.2026.103461.Peer-Reviewed Original ResearchRetinal ganglion cellsOligodendrocyte precursor cellsOptic nerveDensity of retinal ganglion cellsAdult miceNervous systemVisual deficitsDaily oral gavageTissue immunohistochemical analysisCell type-specific markersMyelin structureType-specific markersC57BL/6 adult miceOptic nerve samplesPb acetateDensity of oligodendrocytesCell type-specific changesCell densityNervous system functionPb exposureRetinal vasculatureOral gavageImmunohistochemical analysisMolecular mechanismsLow dosesChoroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles
Liu L, Shannahan J, Zheng W. Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles. Fluids And Barriers Of The CNS 2026, 23: 50. PMID: 41917944, PMCID: PMC13045046, DOI: 10.1186/s12987-026-00793-7.Peer-Reviewed Original ResearchSubventricular zone adult neurogenesisSecretion of small extracellular vesiclesChoroid plexusAdult neurogenesisSubventricular zoneNeural stem/progenitor cellsOlfactory bulbCerebrospinal fluidSmall extracellular vesiclesAdjacent subventricular zoneAdult neurogenic regionsCP epithelial cellsExtracellular vesiclesOlfactory performanceCo-culture assayIn vivo transplantationBehavioral importanceOB neurogenesisNormal olfactionStem/progenitor cellsNewborn neuronsEpithelial cellsNeurogenic regionsBrain ventriclesNeurogenesisA reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case–control analysis
Chang X, Mariapun S, Li M, Wang L, Ho P, Khng A, Muir K, Lophatananon A, Aronson K, Murphy R, Kwong A, Au C, Kim S, Park S, Stram D, Wu A, Teo S, Yip C, Tai N, Investigators M, John E, Kurian A, Iwasaki M, Yamaji T, Choi J, Kang D, Shu X, Zheng W, Hartman M, Tan E, Tan V, Lim G, Bolla M, Dunning A, Dennis J, Wang Q, Naven M, Easton D, Consortium S, Dorajoo R, Ho W, Li J. A reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case–control analysis. Human Molecular Genetics 2026, 35: ddag015. PMID: 41871294, PMCID: PMC13017919, DOI: 10.1093/hmg/ddag015.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosis Regulatory ProteinsAsian PeopleBreast NeoplasmsCase-Control StudiesEstrogen Receptor alphaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideReceptor, Fibroblast Growth Factor, Type 2Receptors, ProgesteroneTrans-ActivatorsConceptsGenome-wide association studiesReference panelBreast Cancer Association ConsortiumAssociation studiesBreast cancer riskImputation reference panelAsian populationsCase-control analysisCancer riskVariant discoveryCandidate lociImputation panelAssociation signalsCase-controlRare allelesVariant detectionGenetic variantsRare variantsBreast cancerEuropean populationsCancer datasetsBreastBreast cancer datasetVariantsSG10Deep Learning-Guided Discovery of Dual Inhibitors of SARS-CoV-2 Entry and 3CL Protease
Gao P, Pavlinov I, Xu M, Chen C, Vasquez D, Zhang Q, Ye Y, Martinez-Sobrido L, Zheng W, Shen M. Deep Learning-Guided Discovery of Dual Inhibitors of SARS-CoV-2 Entry and 3CL Protease. Molecules 2026, 31: 1043. PMID: 41900142, DOI: 10.3390/molecules31061043.Peer-Reviewed Original ResearchConceptsMolecular docking studiesMolecular dynamics simulationsSARS-CoV-2 inhibitorsChemically diverse scaffoldsDual-target inhibitionIn-house collectionEvolution of severe acute respiratory syndrome coronavirus 2Protease active siteDiverse scaffoldsDocking studiesBinding modeSARS-CoV-2 entryNovel hitsDynamics simulationsActive siteInhibitors of SARS-CoV-2 entryHost interactionsModerate potencyGraph convolutional networkSARS-CoV-2Sulfate interactionAntiviral strategiesViral mechanismsConvolutional networkProteaseCirculating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study
Zheng Y, Yang J, Gupta D, Herrington D, Yu B, Nguyen N, Pinto R, Tzoulaki I, Cai H, Cai Q, Lipworth L, Shu X, Zheng W, Yu D. Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study. PLOS Medicine 2026, 23: e1004750. PMID: 41843497, PMCID: PMC12994840, DOI: 10.1371/journal.pmed.1004750.Peer-Reviewed Original ResearchConceptsIncident coronary heart diseaseBody mass indexCoronary heart diseaseFollow-up timeOdds ratioMulti-Ethnic StudyShanghai Women's Health StudyHeart diseaseShanghai Men's Health StudyMetabolic disease historyHealth StudyAssociated with incident coronary heart diseaseMicrobial metabolitesWomen's Health StudySouthern Community Cohort StudyPlasma metabolite profilesCoronary heart disease developmentMen's Health StudyRisk of coronary heart diseaseConditional logistic regressionHuman cardiometabolic healthMulti-Ethnic Study of AtherosclerosisCommunity Cohort StudyGut microbial metabolismCoronary heart disease diagnosis
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