Yasmin Zakiniaeiz, PhD
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About
Research
Publications
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes. Nicotine & Tobacco Research 2022, 25: 1047-1051. PMID: 36107715, PMCID: PMC10077933, DOI: 10.1093/ntr/ntac215.Peer-Reviewed Original ResearchConceptsCognitive functionVerbal learningPrefrontal cortexCognitive deficitsWorse verbal learningBrain-behavior relationshipsD2R availabilityDorsolateral prefrontal cortexCognitive performanceComputerized testsTask performanceCogState batteryInhibitory controlNeurocognitive testsReceptor availabilityMesocortical dopaminePositron emission tomographyDopamine D2/3 receptor availabilityMemoryCognitionD2/3 receptor availabilityDopamine releaseSmoking variablesSubject samplesDeficitsSystemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers
Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.Peer-Reviewed Original ResearchConceptsEffects of LPSDopamine elevationTobacco smokersHealthy controlsSystemic inflammationDopamine systemImmune-brain interactionReward-related brain regionsAdministration of placeboAdministration of LPSSmoking statusRepeated-measures ANOVAPathophysiology of addictionDrug dosingPlaceboIndependent cohortSmokersDrug reinforcementEffect size determinationImmune systemRandomized orderBrain regionsLPSMethylphenidatePBO conditionNicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response
Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyDopamine releasePlacebo patchDorsal striatumTobacco smokingReplacement therapyFirst-line pharmacological treatmentVentral striatumMajor public health burdenPositron emission tomography scanEmission tomography scanPublic health burdenNicotine dependence levelNicotine metabolism rateNicotinic acetylcholine receptorsCounter-balanced orderTobacco smokersCigarette smokingSmoking cessationDopamine terminalsPharmacological treatmentDependent smokersFast metabolizersSlow metabolizersNicotine actsDesigning Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction
Zakiniaeiz Y, Cosgrove KP. Designing Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction. Biological Psychiatry 2020, 88: 741-743. PMID: 33092691, DOI: 10.1016/j.biopsych.2020.08.011.Peer-Reviewed Original ResearchBalance of the Sexes: Addressing Sex Differences in Preclinical Research.
Zakiniaeiz Y, Cosgrove KP, Potenza MN, Mazure CM. Balance of the Sexes: Addressing Sex Differences in Preclinical Research. The Yale Journal Of Biology And Medicine 2016, 89: 255-9. PMID: 27354851, PMCID: PMC4918870.Peer-Reviewed Original ResearchCingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals
Zakiniaeiz Y, Scheinost D, Seo D, Sinha R, Constable RT. Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals. NeuroImage Clinical 2016, 13: 181-187. PMID: 27981033, PMCID: PMC5144743, DOI: 10.1016/j.nicl.2016.10.019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAUD patientsFunctional connectivityCingulate cortexCox proportional hazards regressionChronic relapsing illnessWhole-brain investigationProportional hazards regressionFunctional connectivity differencesAlcohol-dependent patientsVoxel-wise connectivityNeutral cuesAlcohol-dependent individualsHealthy control participantsFunctional magnetic resonanceRelapse measuresHazards regressionSubsequent relapseDependent patientsInpatient treatmentAlcohol relapseFuture relapsePatientsAlcohol dependenceConnectivity differencesAltered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents
Zakiniaeiz Y, Yip SW, Balodis IM, Lacadie CM, Scheinost D, Constable RT, Mayes LC, Sinha R, Potenza MN. Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents. Drug And Alcohol Dependence 2017, 180: 129-136. PMID: 28888152, PMCID: PMC5808433, DOI: 10.1016/j.drugalcdep.2017.07.030.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureNeutral-relaxing conditionsPCE adolescentsParietal connectivityConnectivity analysisSensory areasAdolescent brain functionFunctional magnetic resonance imagingCue interaction effectsIntrinsic connectivity analysesMedial prefrontal areasSeed-based connectivity analysisSubstance Use InitiationAltered functional connectivityAppetitive cuesObesity vulnerabilityPCE statusNeural responsesCorticolimbic connectivityPrefrontal areasFunctional connectivityCraving scoresUtero drug exposureGroup differencesLess connectivityDoes Telescoping Exist in Male and Female Gamblers? Does It Matter?
Zakiniaeiz Y, Cosgrove KP, Mazure CM, Potenza MN. Does Telescoping Exist in Male and Female Gamblers? Does It Matter? Frontiers In Psychology 2017, 8: 1510. PMID: 28928697, PMCID: PMC5591942, DOI: 10.3389/fpsyg.2017.01510.Peer-Reviewed Original ResearchToward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex
Liu H, Zakiniaeiz Y, Cosgrove KP, Morris ED. Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex. Brain Imaging And Behavior 2017, 13: 314-322. PMID: 29071465, PMCID: PMC5918462, DOI: 10.1007/s11682-017-9779-7.Peer-Reviewed Original ResearchConceptsDA releaseDA receptorsDA changesCortical DA releaseMesocorticolimbic dopamine circuitRecent PET studiesPositron emission tomography (PET) radiotracerMesocortical DA pathwaysMesocortical systemCigarette smokingDA pathwayDA transmissionMesolimbic pathwayDopamine transmissionMesocortical DAWhole brainDopamine circuitsNovel high affinityTomography radiotracerPET studiesPET dataStriatumPET imagingEffects of stressCortexMechanisms and Clinical Features of Co-Occurring Opioid and Nicotine Use
Lichenstein SD, Zakiniaeiz Y, Yip SW, Garrison KA. Mechanisms and Clinical Features of Co-Occurring Opioid and Nicotine Use. Current Addiction Reports 2019, 6: 114-125. PMID: 32864292, PMCID: PMC7451029, DOI: 10.1007/s40429-019-00245-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNicotine useClinical featuresCholinergic systemUse disordersOpioid use disorderPurpose of ReviewToSubstance use disordersSex/gender considerationsRecent FindingsOpioidPathophysiological mechanismsSmoking cessationRisk factorsTreatment outcomesDrug rewardOpioidsFurther studiesHigh rateTreatmentDisordersHighlight areasPainReviewToEtiologyPharmacologicalCessation
Academic Achievements and Community Involvement
Links & Media
News
- January 19, 2024
Society of Biological Psychiatry Honors Zakiniaeiz With Travel Fellowship Award
- September 08, 2023
Preparing for the Future of Clinical Care and Research Through Medical School Education
- September 13, 2022
Inaugural Yale Conference on Alcohol Research and Education (YCARE) Convenes Diverse Audience for an Interdisciplinary Day of Learning
- July 19, 2022
Yale Researchers Receive ACNP 2022 Travel Award