Yang Zhou, PhD, MPH
Associate Research ScientistCards
About
Research
Publications
2026
Small-molecule modulation of β-arrestins
Kahsai A, Pakharukova N, Kwon H, Shah K, del Real C, Shreiber B, Liang-Lin J, Shim P, Lee M, Ngo V, Schwalb A, Pham U, Chundi A, Jiang H, Flores-Espinoza E, Liu S, Nibley P, Bassford D, Hahn H, Kunzle C, Thomas B, Kim J, Zhou Y, Wang J, Zhang X, Smith J, Rein L, Thomsen A, Shenoy S, Rajagopal S, Shi L, Ahn S, Rockman H, Masoudi A, Lefkowitz R. Small-molecule modulation of β-arrestins. Nature 2026, 656: 770-779. PMID: 42343124, PMCID: PMC13489962, DOI: 10.1038/s41586-026-10683-5.Peer-Reviewed Original ResearchBispecific targeting of CHI3L1 and PD-1 as a therapeutic strategy for pulmonary fibrosis
Jeong H, Sadanaga T, Lee J, Kamle S, Ma B, Zhou Y, Shin S, Elias J, Lee C. Bispecific targeting of CHI3L1 and PD-1 as a therapeutic strategy for pulmonary fibrosis. JCI Insight 2026, 11: e201609. PMID: 42048160, PMCID: PMC13460889, DOI: 10.1172/jci.insight.201609.Peer-Reviewed Original ResearchStructure-guided discovery of non-catechol dopamine D1 receptor ligands with biased agonism and antagonism
Zhou Y, Wetsel W, Kahsai A, Olson S, Barak L. Structure-guided discovery of non-catechol dopamine D1 receptor ligands with biased agonism and antagonism. Journal Of Biological Chemistry 2026, 302: 113076. PMID: 42055336, PMCID: PMC13218150, DOI: 10.1016/j.jbc.2026.113076.Peer-Reviewed Original ResearchRare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor
Balfe E, Torbey A, Stepniewski T, Zhou Y, Kohlenbach L, Sency J, Inoue A, Slosky L, Selent J, Barak L, Gross J. Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor. Molecular Pharmacology 2026, 108: 100119. PMID: 41980512, DOI: 10.1016/j.molpha.2026.100119.Peer-Reviewed Original Research
2025
Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection
Yang A, Ramos-Rodriguez L, Sorkhdini P, Yang D, Norbrun C, Majid S, Lee S, Zhang Y, Holtzman M, Boyd D, Zhou Y. Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection. ELife 2025, 14: rp104359. PMID: 41439508, PMCID: PMC12736948, DOI: 10.7554/elife.104359.Peer-Reviewed Original ResearchPhospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection
Yang A, Ramos-Rodriguez L, Sorkhdini P, Yang D, Norbrun C, Majid S, Lee S, Zhang Y, Holtzman M, Boyd D, Zhou Y. Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection. ELife 2025, 14 DOI: 10.7554/elife.104359.3.Peer-Reviewed Original ResearchEvolving incidence patterns for locally advanced operable breast cancer by receptor status: SEER 2010–2021
Thomas A, Rhoads A, Mayer E, O’Reilly S, Harbeck N, Curigliano G, Zhou Y, Adam V, Chan N, Conway K, Ignatiadis M, Kalinsky K, DeMichele A, Romitti P. Evolving incidence patterns for locally advanced operable breast cancer by receptor status: SEER 2010–2021. Npj Breast Cancer 2025, 11: 127. PMID: 41233330, PMCID: PMC12615583, DOI: 10.1038/s41523-025-00835-7.Peer-Reviewed Original ResearchVirtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators
Zhou Y, Wetsel W, Olson S, Barak L. Virtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators. Journal Of Chemical Information And Modeling 2025, 65: 9713-9722. PMID: 40934869, PMCID: PMC12478865, DOI: 10.1021/acs.jcim.5c00972.Peer-Reviewed Original ResearchWhen Autophagy Fails: ATG7 Variants and Their Impact on Radiation Lung Injury
Yang A, Zhou Y. When Autophagy Fails: ATG7 Variants and Their Impact on Radiation Lung Injury. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 163-165. PMID: 39903843, PMCID: PMC12334875, DOI: 10.1165/rcmb.2025-0006ed.Commentaries, Editorials and LettersArrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain
Guo R, Chen O, Zhou Y, Bang S, Chandra S, Li Y, Chen G, Xie R, He W, Xu J, Zhou R, Song S, Person K, Moore M, Alwin A, Spasojevic I, Jackson M, Olson S, Caron M, Slosky L, Wetsel W, Barak L, Ji R. Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell 2025, 188: 4332-4349.e21. PMID: 40393456, PMCID: PMC12335375, DOI: 10.1016/j.cell.2025.04.038.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
IRB ID1603017333RoleSub InvestigatorPrimary Completion Date06/16/2036Recruiting Participants
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