Xiangyu Ge
Postdoctoral AssociateDownloadHi-Res Photo
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Titles
Postdoctoral Associate
Graduate Student, Pathology
Biography
Xiangyu(Gigi) Ge graduated from Nanjing University, China in 2019 majoring in biosciences. She received the 2019 China Scholarship Council (CSC) Scholarship and was selected to join Yale Biological & Biomedical Sciences (BBS) Program. Out of great curiosity in cancer biology, she then decided to join Dr. Mandar Muzumdar's lab and will work on revealing the underlying mechanisms of required resistance to targeted therapies for KRAS in pancreatic cancer.
Last Updated on November 14, 2023.
Appointments
Education & Training
- BS
- Nanjing University, Biosciences (2019)
Research
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Publications
2021
Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy
Zuo S, Sun L, Wang Y, Chen B, Wang J, Ge X, Lu Y, Yang N, Shen P. Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy. Cell Death & Disease 2021, 12: 208. PMID: 33627636, PMCID: PMC7904926, DOI: 10.1038/s41419-021-03499-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsBenzoatesCell LineageCoculture TechniquesGene Expression Regulation, LeukemicHumansHydrazinesJanus KinasesK562 CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, NudeMitogen-Activated Protein KinasesPyrazolesReceptors, ThrombopoietinSignal TransductionSTAT Transcription FactorsThrombopoiesisUmbilical CordXenograft Model Antitumor AssaysConceptsChronic myeloid leukemiaTyrosine kinase inhibitorsProgression of CMLCML cellsUC-MSCsDifferentiation therapyCurrent tyrosine kinase inhibitorsTherapeutic potentialMesenchymal stem cell treatmentAcute promyelocytic leukemia (APL) treatmentImmature white blood cellsSevere adverse effectsWhite blood cellsTrans retinoic acidStem cell treatmentStem/progenitor cellsComplete remissionTreatment regimenTumor burdenCML patientsCure rateMAPK signaling pathwaysPeripheral bloodHematopoietic stem/progenitor cellsMyeloid leukemia
2019
Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization
Yang N, Tang Q, Qin W, Li Z, Wang D, Zhang W, Cao X, Lu Y, Ge X, Sun H, Shen P. Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization. EBioMedicine 2019, 45: 473-486. PMID: 31285187, PMCID: PMC6642413, DOI: 10.1016/j.ebiom.2019.06.053.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMacrophage polarizationAdipose inflammationObese miceMetabolic disordersObesity-related metabolic disordersHFD mouse modelObesity-related inflammationPro-inflammatory phenotypeHigh-fat dietPromising therapeutic strategyChemical small moleculesFatty acid oxidationChronic inflammationMagnetic cell sortingFat dietM1 polarizationM2 polarizationMetabolic dysfunctionMouse modelTherapeutic strategiesInflammationCDDO-MeCompound oleanolic acidInflammation treatmentHistological analysis