Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsVivian Rotman
Assistant Professor AdjunctAbout
Research
Publications
2026
THU-255 Dynamic changes in liver stiffness during anti-copper therapy in wilson disease: a longitudinal cohort study
Chindamo M, Agoglia L, Guaraná T, Rotman V, Madureira M, Cardoso A, Perez R. THU-255 Dynamic changes in liver stiffness during anti-copper therapy in wilson disease: a longitudinal cohort study. Journal Of Hepatology 2026, 84: s830-s831. DOI: 10.1016/s0168-8278(26)02247-6.Peer-Reviewed Original ResearchSAT-394 Frequency of PFIC-associated genetic variants across different adult cholestatic phenotypes
Rotman V, Evangelista A, Pereira A, Franz C, Agoglia L, Perez R, Chindamo M. SAT-394 Frequency of PFIC-associated genetic variants across different adult cholestatic phenotypes. Journal Of Hepatology 2026, 84: s340-s341. DOI: 10.1016/s0168-8278(26)01069-x.Peer-Reviewed Original ResearchTHU-022 Trends in hospitalizations and in-hospital mortality due to primary biliary cholangitis in Brazil (2015–2024): a decade of real-world evidence from the public unified health system
Cançado G, Couto C, Faria L, Moraes B, Bittencourt P, Villela-Nogueira C, Rotman V, Terrabuio D, Cançado E, Ferraz M. THU-022 Trends in hospitalizations and in-hospital mortality due to primary biliary cholangitis in Brazil (2015–2024): a decade of real-world evidence from the public unified health system. Journal Of Hepatology 2026, 84: s768. DOI: 10.1016/s0168-8278(26)02094-5.Peer-Reviewed Original ResearchTHU-254 Genotypic spectrum and clinical presentation ofWilson disease in a Brazilian cohort
Chindamo M, Schwartz I, Quintana G, Sgobbi P, Guaraná T, Rotman V, Franz C, Agoglia L, Perez R. THU-254 Genotypic spectrum and clinical presentation ofWilson disease in a Brazilian cohort. Journal Of Hepatology 2026, 84: s830. DOI: 10.1016/s0168-8278(26)02246-4.Peer-Reviewed Original Research
2025
High frequency of ABCB4 and ABCB11 gene variants in adult patients with idiopathic chronic or recurrent cholestasis
Bittencourt P, Rotman V, Codes L, de Andrade A, de Araújo Gama R, Celestino L, Paraná R, Ferraz M, de Athayde Costa L, Thompson R, Porta G. High frequency of ABCB4 and ABCB11 gene variants in adult patients with idiopathic chronic or recurrent cholestasis. Hepatology Communications 2025, 10: e0851. PMCID: PMC12708102, DOI: 10.1097/hc9.0000000000000851.Peer-Reviewed Original ResearchClinical and Prognostic Factors Associated With Inflammatory Bowel Disease in a Highly Admixed Population With Primary Sclerosing Cholangitis
Nardelli M, Cançado G, Barros L, Dotta D, Faria L, Rotman V, Villela-Nogueira C, Ferraz M, Rocco R, Felga G, de Souza Martins A, Codes L, Mendes L, da Silva M, Hyppolito E, Gomide G, Signorelli I, de Oliveira M, Ivantes C, Chiara M, de Almeida e Borges V, Terrabuio D, Cançado E, Bittencourt P, Couto C. Clinical and Prognostic Factors Associated With Inflammatory Bowel Disease in a Highly Admixed Population With Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2025, 60: 549-554. PMID: 40985598, DOI: 10.1097/mcg.0000000000002253.Peer-Reviewed Original ResearchPrimary sclerosing cholangitisInflammatory bowel disease diagnosisInflammatory bowel diseaseTransplant-free survivalAdvanced liver diseaseLiver transplantationLiver diseasePSC patientsSclerosing cholangitisAntinuclear antibodiesCombined outcomeAssociation of inflammatory bowel diseaseCombined outcome of deathAnti-smooth muscle antibodiesConcomitant inflammatory bowel diseasePrevalence of inflammatory bowel diseasePSC diagnosisBowel diseaseCohort of Brazilian patientsStudy Group databaseOutcome of deathCohort mortalityMuscle antibodiesAutoimmune hepatitisBrazilian patients
2024
Recurrence of Primary Sclerosing Cholangitis and De Novo Cholangiocarcinoma After Liver Transplantation: Results From the Brazilian Cholestasis Consortium
Bittencourt P, Nardelli M, Barros L, Cançado G, Cançado E, Terrabuio D, Villela‐Nogueira C, Ferraz M, Codes L, Rotman V, Rocco R, Felga G, Dotta D, de Souza Martins A, Mendes L, da Silva M, Hyppolito E, Gomide G, Signorelli I, de Oliveira M, Ivantes C, Chindamo M, de Almeida e Borges V, Faria L, Couto C. Recurrence of Primary Sclerosing Cholangitis and De Novo Cholangiocarcinoma After Liver Transplantation: Results From the Brazilian Cholestasis Consortium. Clinical Transplantation 2024, 38: e70002. PMID: 39436152, DOI: 10.1111/ctr.70002.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisRecurrent primary sclerosing cholangitisLiver transplantationRecurrent PSCSclerosing cholangitisFollow-upRecurrence of primary sclerosing cholangitisRisk of disease recurrenceHigher risk of graft lossRisk of graft lossHigh riskMonths of follow-upDe novo inflammatory bowel diseaseStudy Group databaseAssociated with longer timeInflammatory bowel diseaseLT patientsDisease recurrenceGraft lossAllograft rejectionFemale patientsMELD scoreLaboratory variablesPosttransplant survivalCholangiocarcinomaAlkaline phosphatase and liver fibrosis at diagnosis are associated with deep response to ursodeoxycholic acid in primary biliary cholangitis
Cançado G, Fucuta P, Gomes N, Couto C, Cançado E, Terrabuio D, Villela-Nogueira C, Braga M, Nardelli M, Faria L, Oliveira E, Rotman V, Oliveira M, Cunha S, Silva M, Mendes L, Ivantes C, Codes L, de Almeida E Borges V, Pace F, Pessôa M, Signorelli I, Coral G, Bittencourt P, Ferraz M. Alkaline phosphatase and liver fibrosis at diagnosis are associated with deep response to ursodeoxycholic acid in primary biliary cholangitis. Clinics And Research In Hepatology And Gastroenterology 2024, 48: 102453. PMID: 39174006, DOI: 10.1016/j.clinre.2024.102453.Peer-Reviewed Original ResearchConceptsPrimary biliary cholangitisUrsodeoxycholic acidDeep responsesBiliary cholangitisLiver fibrosisNormalization of alkaline phosphataseProgressive autoimmune liver diseaseResponse to UDCA therapyYear of UDCA treatmentResponse to ursodeoxycholic acidBaseline alkaline phosphatase levelsAlkaline phosphataseAutoimmune liver diseaseStudy Group cohortAlkaline phosphatase levelsResponse scoresBaseline ALPToronto criteriaUDCA therapyUDCA treatmentPrognostic factorsPrognostic markerPhosphatase levelsLiver diseaseIncomplete responseMultiparametric magnetic resonance imaging of the liver and spleen in Gaucher disease
Parente D, de Melo Malta F, de Souza Cravo R, Luiz R, Rotman V, Perez R, Rodrigues R. Multiparametric magnetic resonance imaging of the liver and spleen in Gaucher disease. Abdominal Radiology 2024, 49: 3069-3077. PMID: 38642092, DOI: 10.1007/s00261-024-04293-w.Peer-Reviewed Original ResearchConceptsGD-DS3Spleen volumeGaucher diseaseSplenic volumeConclusionThe prevalenceIron overloadMR elastographySpleen stiffnessMultiparametric magnetic resonance imagingBiomarkers of disease severityLiver MR elastographyType 1 Gaucher diseaseLiver fat fractionLiver iron overloadPrevalence of hepatosplenomegalySeverity scoring systemMagnetic resonance imagingMultiparametric MRILaboratory variablesEffects of treatmentLiver stiffnessTreated patientsLiver fibrosisSeverity scoreMann-WhitneyA new and simple score to predict adequate and deep response to ursodeoxycholic acid in patients with primary biliary cholangitis: the ALP-A score
Cançado G, de Faria Gomes N, Couto C, Cançado E, Terrabuio D, Villela-Nogueira C, Braga M, Nardelli M, Faria L, Oliveira E, Rotman V, Oliveira M, da Cunha S, de Campos Mazo D, Mendes L, Ivantes C, Codes L, de Almeida e Borges V, de Lima Pace F, Pessôa M, Signorelli I, Coral G, Bittencourt P, Fucuta P, de Carvalho Filho R, Ferraz M. A new and simple score to predict adequate and deep response to ursodeoxycholic acid in patients with primary biliary cholangitis: the ALP-A score. European Journal Of Gastroenterology & Hepatology 2024, 36: 628-635. PMID: 38555601, DOI: 10.1097/meg.0000000000002744.Peer-Reviewed Original ResearchConceptsPrimary biliary cholangitisResponse to UDCAPrimary biliary cholangitis patientsUrsodeoxycholic acidBiliary cholangitisDerivation cohortResponse to ursodeoxycholic acidCohort of PBC patientsPredictive valueRisk of adverse outcomesNegative predictive valueUrsodeoxycholic acid treatmentUDCA responseProportion of patientsPositive predictive valueYear of treatmentALP-ARoutine clinical useAlternative therapeutic approachArea under the ROC curveLogistic regression analysisDeep respondersPBC patientsStandard treatmentNon-responders