Vijay Menon
Associate Research ScientistCards
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Research
Publications
2025
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif T, Qiu J, Khademian H, Lohithakshan A, Menon A, Menon V, Slavinsky M, Batignes M, Lin M, Sebra R, Beaumont K, Benson D, Tzavaras N, Ménager M, Ghaffari S. Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells. Cell Stem Cell 2025, 32: 1904-1922.e7. PMID: 41289991, DOI: 10.1016/j.stem.2025.10.012.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsAging hematopoietic stem cellsCyclic GMP-AMP synthase-stimulatorHematopoietic stem cell agingStem cellsIn vivo repopulating capacityYouthful stateLysosomal processingMyeloid malignanciesRepopulating capacityClonal hematopoiesisLysosomal dysfunctionHematopoietic functionImmune declineEpigenetic homeostasisSelf-RenewalSingle-cell transcriptomicsInterferon genesDysfunctionLysosomal integrityLysosomal inhibitionVacuolar ATPaseAgeCellsMalignancyDNA repair helicases: from mechanistic understanding to therapeutic implications
Menon V, Gueble S. DNA repair helicases: from mechanistic understanding to therapeutic implications. NAR Cancer 2025, 7: zcaf034. PMID: 41064806, PMCID: PMC12501782, DOI: 10.1093/narcan/zcaf034.Peer-Reviewed Original ResearchConceptsHelicase functionDNA helicaseMaintenance of genome integrityHuman DNA helicaseNormal cell physiologyResolution of DNA damageSynthetic lethal interactionsATP-dependent enzymesDNA damage responseDNA repair processesProtein playersGenome integrityHelicase mutationsDNA double helixRothmund-Thomson syndromeCell physiologyLethal interactionsHelicaseGenomic instabilityDamage responseCellular DNABloom syndromeHuman disordersDNAFanconi anemia
2024
Mitochondrial regulation of erythropoiesis in homeostasis and disease
Menon V, Slavinsky M, Hermine O, Ghaffari S. Mitochondrial regulation of erythropoiesis in homeostasis and disease. British Journal Of Haematology 2024, 205: 429-439. PMID: 38946206, PMCID: PMC11619715, DOI: 10.1111/bjh.19600.Peer-Reviewed Original ResearchClearance of mitochondriaComplex maturation processCell maturation processMitochondrial DNAMitochondrial participationChromatin condensationMitochondrial regulationMaturation processRetention of mitochondriaErythroid cell maturationNuclear expulsionMitochondriaErythroblast enucleationRed blood cell productionMature red blood cellsErythroid maturationRegulation of erythropoiesisCell maturationErythroid cellsHomeostasisCellsDisease conditionsRed blood cellsChromatinOrganelles
2023
Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation
Menon V, Katner S, Lee D, Peterson E, Koblinski J, Farrell N. Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation. Journal Of Inorganic Biochemistry 2023, 252: 112475. PMID: 38199050, DOI: 10.1016/j.jinorgbio.2023.112475.Peer-Reviewed Original ResearchElevated CDKN1a (p21) mediates β-thalassemia erythroid apoptosis but its loss does not improve β-thalassemic erythropoiesis
Liang R, Lin M, Menon V, Qiu J, Menon A, Breda L, Arif T, Rivella S, Ghaffari S. Elevated CDKN1a (p21) mediates β-thalassemia erythroid apoptosis but its loss does not improve β-thalassemic erythropoiesis. Blood Advances 2023, 7: 6873-6885. PMID: 37672319, PMCID: PMC10685172, DOI: 10.1182/bloodadvances.2022007655.Peer-Reviewed Original ResearchConceptsErythroid cell maturationErythroid cell survivalCell cycle inhibitor Cdkn1aFoxO3 target genesErythroid apoptosisFoxO3 transcription factorElevated reactive oxygen speciesΒ-globin geneCell maturationEmbryonic lethalityTranscription factorsTarget genesErythroid maturationReactive oxygen speciesMolecular networksMolecular mechanismsThalassemic erythropoiesisCell survivalProgenitor compartmentErythroid compartmentFOXO3Extramedullary erythropoiesisΒ-thalassemiaApoptosisHemoglobin productionNext-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”
Menon V, Brash D. Next-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”. Mutation Research/Reviews In Mutation Research 2023, 792: 108471. PMID: 37716438, PMCID: PMC10843083, DOI: 10.1016/j.mrrev.2023.108471.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Protocol to identify and analyze mouse and human quiescent hematopoietic stem cells using flow cytometry combined with confocal imaging
Qiu J, Menon V, Tzavaras N, Liang R, Ghaffari S. Protocol to identify and analyze mouse and human quiescent hematopoietic stem cells using flow cytometry combined with confocal imaging. STAR Protocols 2022, 3: 101828. PMID: 36595934, PMCID: PMC9676629, DOI: 10.1016/j.xpro.2022.101828.Peer-Reviewed Original Research
2021
Erythroid enucleation: a gateway into a “bloody” world
Menon V, Ghaffari S. Erythroid enucleation: a gateway into a “bloody” world. Experimental Hematology 2021, 95: 13-22. PMID: 33440185, PMCID: PMC8147720, DOI: 10.1016/j.exphem.2021.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBirdsCalciumCell NucleusChromatinColony-Forming Units AssayComputational BiologyCytokinesCytoskeletal ProteinsDNA-Binding ProteinsErythroblastsErythrocytesErythropoiesisIntercellular Signaling Peptides and ProteinsMammalsMiceMicroRNAsProto-Oncogene ProteinsReceptors, Thyroid HormoneRepressor ProteinsReticulocytesrho GTP-Binding ProteinsTranscription FactorsTransport VesiclesYolk SacConceptsTerminal erythroid maturationFormation of reticulocytesEnucleation processHematopoietic stem cellsTranscription factorsCytoskeletal proteinsErythroid maturationFascinating processOrthochromatic erythroblastsTerminal maturationRate-limiting stepStem cellsIntricate processMaturationRed blood cellsCellsRBC productionMicroRNAsProteinProduction ex vivoErythroblastsEx vivoMechanismDaily productionProduction
2020
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
Liang R, Arif T, Kalmykova S, Kasianov A, Lin M, Menon V, Qiu J, Bernitz JM, Moore K, Lin F, Benson DL, Tzavaras N, Mahajan M, Papatsenko D, Ghaffari S. Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency. Cell Stem Cell 2020, 26: 359-376.e7. PMID: 32109377, PMCID: PMC8075247, DOI: 10.1016/j.stem.2020.01.013.Peer-Reviewed Original Research
2019
Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation
Wilson A, Menon V, Khan Z, Alam A, Litovchick L, Yakovlev V. Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation. Redox Biology 2019, 24: 101169. PMID: 30889466, PMCID: PMC6423503, DOI: 10.1016/j.redox.2019.101169.Peer-Reviewed Original ResearchConceptsPARP inhibitorsBRCA1/2 mutationsSingle agentTumor microenvironmentAdditional therapeutic benefitBRCA1 expressionNew drug combinationsDNA-damaging therapiesNon-toxic concentrationsTumor-targeting approachesCancer patientsOvarian cancerBreast cancerDrug combinationsTherapeutic benefitClinical developmentTumorsRadiation treatmentCancerOxidative stressSubsequent inhibitionSynthetic lethality approachSensitizationHigh potencyDNA damage
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