Tang Tang
Associate Research Scientist in PathologyAbout
Research
Publications
2022
Extracellular Vesicles Mediate the Intercellular Exchange of Nanoparticles
Wu X, Tang T, Wei Y, Cummins K, Wood D, Pang H. Extracellular Vesicles Mediate the Intercellular Exchange of Nanoparticles. Advanced Science 2022, 9: 2102441. PMID: 35243822, PMCID: PMC8895114, DOI: 10.1002/advs.202102441.Peer-Reviewed Original ResearchConceptsIntercellular exchangeExtracellular vesiclesComplex tissuesImportance of EVsCell-cell contactTranscellular transport routeDirect cell-cell contactSubcellular transportNP endocytosisExocytosisAccumulative evidenceVesiclesSame receptorCrucial rolePotential mechanismsCellsTransport routesEndocytosisTissueSignificant fractionTransportVitroAssaysVivoReceptors
2021
iRGD‐Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis
Guan J, Guo H, Tang T, Wang Y, Wei Y, Seth P, Li Y, Dehm S, Ruoslahti E, Pang H. iRGD‐Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis. Advanced Functional Materials 2021, 31 PMID: 34211360, PMCID: PMC8240484, DOI: 10.1002/adfm.202100478.Peer-Reviewed Original ResearchAndrogen receptorProstate cancerSubcutaneous xenograftsSolid tumorsAR splice variantsHigh loading efficiencySignificant side effectsProstate cancer treatmentPrimary prostate cancerBone metastasesAR expressionLoading efficiencyEfficient knockdownTumor deliverySide effectsProstate tumorsTherapeutic efficacyTumor growthTreatment studiesTumor tissueAntisense oligonucleotide drugXenograftsAntitumor efficacyCancer treatmentMetastasis
2019
Rapid chelator-free radiolabeling of quantum dots for in vivo imaging
Tang T, Wei Y, Yang Q, Yang Y, Sailor M, Pang H. Rapid chelator-free radiolabeling of quantum dots for in vivo imaging. Nanoscale 2019, 11: 22248-22254. PMID: 31746913, DOI: 10.1039/c9nr08508d.Peer-Reviewed Original ResearchConceptsChelator-free radiolabelingQuantum dotsZinc sulfide quantum dotsSulfide quantum dotsNanoparticle surfaceSurface functionalizationAqueous solutionHigh labeling efficiencyMetal chelationCation exchangeRadiolabeling approachChemical propertiesCellular uptakeMetal chelatorsLabeling efficiencyDotsVivo PET imagingHigh tumor uptakeMurine cancer modelsRadiochemical purityRadiolabelingNanoparticlesFunctionalizationChelatorsChelationCellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine
Wei Y, Tang T, Pang H. Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine. Nature Communications 2019, 10: 3646. PMID: 31409778, PMCID: PMC6692393, DOI: 10.1038/s41467-019-11631-w.Peer-Reviewed Original ResearchConceptsCargo selectivityExtracellular cysteinesCysteine regulationNP entryCellular activitiesMacropinocytosis pathwayCellular uptakeAmino acidsCargoCellular internalizationInternalizationTAT peptideNanomaterial deliveryCellsUptakeVivoEndocytosisIntensive studyCysteinePathwayRegulationActivityPeptidesEntryTumor-specific macrophage targeting through recognition of retinoid X receptor beta
Tang T, Wei Y, Kang J, She Z, Kim D, Sailor M, Ruoslahti E, Pang H. Tumor-specific macrophage targeting through recognition of retinoid X receptor beta. Journal Of Controlled Release 2019, 301: 42-53. PMID: 30871996, PMCID: PMC6500479, DOI: 10.1016/j.jconrel.2019.03.009.Peer-Reviewed Original ResearchConceptsRetinoid X receptor betaTumor macrophagesSystemic administrationReceptor betaNormal macrophage functionCancer therapyTumor-bearing miceTumor-selective bindingCell surface markersNovel cell surface markersMacrophage modulationMacrophage functionSolid tumorsTumor-specific mannerMacrophage typesSurface markersMacrophagesCancer progressionTumorsHealthy organsNuclear receptorsTherapyAdministrationCell surface localizationReceptors
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