Stephanie O'Malley, PhD
Elizabeth Mears and House Jameson Professor of PsychiatryDownloadHi-Res Photo
Cards
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
About
Titles
Elizabeth Mears and House Jameson Professor of Psychiatry
Deputy Chair, Clinical Research
Appointments
Psychiatry
ProfessorPrimary
Other Departments & Organizations
- ADVANCE Study
- Call it a Night
- Cancer Prevention and Control
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Center for the Translational Neuroscience of Alcohol
- Connecticut Mental Health Center
- Division of Addictions
- Division of Substance Abuse
- Division of Women's Behavioral Health Research
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Psychology Section
- Psychotherapy Development Center
- Smoking Cessation and Alcohol Treatment Research Clinic
- Stress & Addiction Clinical Research Program
- Substance Abuse Research
- Tobacco Research in Youth (TRY)
- Yale Cancer Center
- Yale Medicine
- Yale Tobacco Center of Regulatory Science
- Yale Ventures
Education & Training
- PhD
- Vanderbilt University (1983)
- BS
- Vanderbilt University (1976)
Research
Overview
Yale Tobacco Center for Regulatory Science
Clinical trials of varenicline for the treatment of alcohol dependence among smokers and of naltrexone for young adult heavy drinkers
Laboratory studies to evaluate medications for substance use disorders
Validation of biomarkers for monitoring drinking in clinical trials
Secondary analyses to identify moderators and predictors of response to treatments for alcohol dependence using tree based and trajectory analyses
Training of clinician and transdisciplinary scientists
Medical Research Interests
Alcoholism; Psychiatry; Psychiatry and Psychology; Risk Reduction Behavior; Smoking; Substance-Related Disorders
ORCID
0000-0002-1976-2369
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie O'Malley's published research.
Research Interests
Research topics Stephanie O'Malley is interested in exploring.
Suchitra Krishnan-Sarin, PhD
Krysten Bold, PhD
Meghan Morean, PhD
Lisa Fucito, PhD
Ralitza Gueorguieva, PhD
Angela Haeny, PhD
Publications
2025
Examining E-Cigarette Flavor Use and Preference by Menthol Cigarette Status and Quit Duration Among US Adults Using E-Cigarettes in a Smoking Cessation Attempt
Joseph M, Morean M, Wu R, Krishnan-Sarin S, O’Malley S, Bold K. Examining E-Cigarette Flavor Use and Preference by Menthol Cigarette Status and Quit Duration Among US Adults Using E-Cigarettes in a Smoking Cessation Attempt. Nicotine & Tobacco Research 2025, ntaf059. PMID: 40056399, DOI: 10.1093/ntr/ntaf059.Peer-Reviewed Original ResearchAltmetricConceptsSmoking menthol cigarettesSmoking cessation attemptsE-cigarettesE-cigarette flavorsMenthol cigarettesNon-menthol cigarettesQuit smokingCessation attemptsCross-sectional survey dataReduce cigarette useE-cigarette flavor preferenceDuration of abstinenceDuration of smoking abstinenceUS adultsCigarette typesQuit durationSmoking mentholSmoking abstinenceSurvey dataCigarette useGeneralized linear modelSmokingCigaretteNon-mentholAdultsT49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping
Baldassarri S, McKinney E, Mysirlidis S, Sharma M, Blohowiak R, Joseph P, Eid T, Nadim H, Hanna E, Karaoghlanian N, Adeniji A, Shihadeh A, Eissenberg T, Krishnan-Sarin S, O'Malley S, El-Hellani A, Talih S. T49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping. Drug And Alcohol Dependence 2025, 267: 111817. DOI: 10.1016/j.drugalcdep.2024.111817.Peer-Reviewed Original ResearchEvading Menthol Bans through Chemistry: The tobacco industry illustrates why we need to overhaul the way we regulate chemicals.
Zimmerman J, Erythropel H, Muellers T, Petrovic P, O'Malley S, Krishnan-Sarin S, Jabba S, Jordt S, Anastas P. Evading Menthol Bans through Chemistry: The tobacco industry illustrates why we need to overhaul the way we regulate chemicals. Scientific American 2025, 332: 71. PMID: 39688992, DOI: 10.1038/scientificamerican012025-7utzdfyksaqx7txbhvuhtg.Peer-Reviewed Original ResearchConcepts
2024
Natural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults
Griffith F, Ash G, Augustine M, Latimer L, Verne N, Redeker N, O’Malley S, DeMartini K, Fucito L. Natural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults. Npj Digital Medicine 2024, 7: 342. PMID: 39613828, PMCID: PMC11606959, DOI: 10.1038/s41746-024-01321-3.Peer-Reviewed Original ResearchCitationsConceptsYoung adultsLanguage processingEvaluating young adultsControl participantsHeavy drinkingSleep factorsImprove sleepNatural language processingPersonalized feedbackParticipation motivationParticipantsSleepAdultsMixed-methods evaluationControl interventionsInterventionConvergent mixed methodsMotivationIncreased awarenessAlcoholUnderstanding Use of E-cigarettes for Smoking Cessation Among a Sample of U.S. Adults
Sharma A, Morean M, Krishnan-Sarin S, O’Malley S, Bold K. Understanding Use of E-cigarettes for Smoking Cessation Among a Sample of U.S. Adults. Nicotine & Tobacco Research 2024, ntae251. PMID: 39475073, DOI: 10.1093/ntr/ntae251.Peer-Reviewed Original ResearchAltmetricConceptsQuit smokingNicotine replacement treatmentSmoking cessation aidE-cigarettesSmoking cessationCessation aidsSmoking cigarettesCessation attemptsSample of US adultsMajority of participantsSmoking cessation attemptsE-cigarette useComponents of e-cigarettesTime of surveyCessation supportUS adultsRegular cigarette smokingSmoking abstinenceRelapse rateNicotine patchSmokingReplacement treatmentNicotine-freeCigarette smokingOnline surveyA Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treatWords matter: descriptors for nicotine that comes from tobacco and descriptors for synthetic nicotine that is created in a laboratory differentially impact understanding of nicotine source and risk perceptions
Morean M, O'Malley S, Krishnan-Sarin S. Words matter: descriptors for nicotine that comes from tobacco and descriptors for synthetic nicotine that is created in a laboratory differentially impact understanding of nicotine source and risk perceptions. Tobacco Control 2024, tc-2024-058649. PMID: 39168594, DOI: 10.1136/tc-2024-058649.Peer-Reviewed Original ResearchThe Scientific Basis for the Regulation of Flavors in Tobacco Products
Bold K, Kong G, O'Malley S. The Scientific Basis for the Regulation of Flavors in Tobacco Products. Annual Review Of Clinical Psychology 2024, 20: 381-406. PMID: 38346292, PMCID: PMC11446566, DOI: 10.1146/annurev-clinpsy-080921-075624.Peer-Reviewed Original ResearchCitationsConceptsTobacco policiesTobacco productsTobacco useReduce tobacco-related health disparitiesTobacco-related health disparitiesFlavored tobacco productsMenthol tobacco productsHealth disparitiesFood and Drug AdministrationEvidence-based policyClinical research methodsMenthol cigarettesClinical sciencePublic healthTobaccoPopulation levelScientific evidencePublication dateRegulation of flavorClinical researchUS Food and Drug AdministrationProtect public healthAnnual ReviewExpected final online publication dateTobacco marketplaceEVALUATING THE FEASIBILITY AND PRELIMINARY EFFICACY OF A REAL-TIME SMOKING INTERVENTION USING WEARABLE TECHNOLOGY
Bold K, O'Malley S, Horvath M, Fucito L. EVALUATING THE FEASIBILITY AND PRELIMINARY EFFICACY OF A REAL-TIME SMOKING INTERVENTION USING WEARABLE TECHNOLOGY. Drug And Alcohol Dependence 2024, 260: 110062. DOI: 10.1016/j.drugalcdep.2023.110062.Peer-Reviewed Original ResearchConceptsSmartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial
Horvath M, Pittman B, O’Malley S, Grutman A, Khan N, Gueorguieva R, Brewer J, Garrison K. Smartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial. Annals Of Medicine 2024, 56: 2352803. PMID: 38823419, PMCID: PMC11146247, DOI: 10.1080/07853890.2024.2352803.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBrief mindfulness interventionsMindfulness exercisesTreatment startersMindfulness interventionSmoking interventionsOnline mindfulness trainingWhite non-HispanicMindfulness trainingTreatment fidelityFeasibility measuresHelpfulness ratingsNon-HispanicDaily smokersPredicting smokingReduce smokingExerciseSmokingCigarette smokingInterventionLow completenessAdherenceParticipantsSmartbandAcceptanceMindfulness
Clinical Trials
Current Trials
Brief training for 18-26 year olds: Regulation of alcohol craving
HIC ID2000029394RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18 years - 26 yearsVarenicline for treatment of e-cigarette dependence
HIC ID2000032740RoleSub InvestigatorPrimary Completion Date09/30/2023Recruiting ParticipantsGenderBothAge18+ yearsThe interaction of flavor with nicotine form in adult smokers
HIC ID2000025687RoleSub InvestigatorPrimary Completion Date05/31/2022Recruiting ParticipantsGenderBothAge21+ years
Academic Achievements & Community Involvement
Activities
activity Alcoholism:Clinical and Experimental Research
2011 - PresentProfessional OrganizationsMemberDetailsSenior Advisory Boardactivity American College of Neuropsychopharmacology/American Society of Clinical Psychopharmacology
2008 - PresentProfessional OrganizationsMemberDetailsWorking group on alcohol medication trial designactivity Psychiatry Investigation
2004 - PresentProfessional OrganizationsMemberDetailsEditorial Boardactivity JAMA Psychiatry
2015 - PresentProfessional OrganizationsMemberDetailsEditorial Boardactivity NIDA
2015 - PresentCommitteesMemberDetailsData Safety Monitoring Board, Clinical Trials Network
Honors
honor Thwarp Award
11/01/2018National AwardFirst Tennessee Bank, Trustee under Will of James H. ThwarpDetailsUnited Stateshonor Distinguished Researcher Award
06/15/2018National AwardResearch Society on AlcoholismDetailsUnited Stateshonor Sidney J. Blatt Award
06/01/2015Yale School of Medicine AwardPsychology Section, Department of PsychiatryDetailsUnited Stateshonor Elected Member
04/01/2014Regional AwardConnecticut Academy of Science and Engineering (CASE)DetailsUnited Stateshonor Presidential Citation for Leadership and Research in the Field of Addictions
04/01/2014National AwardAmerican Psychological AssociationDetailsUnited States
News & Links
News
- December 03, 2024Source: Nature Digital Medicine
Natural Language Processing in Mixed-Methods Evaluation of a Digital Sleep-Alcohol Intervention For Young Adults
- September 26, 2024
Yale Study: Digital Cognitive Behavioral Therapy Program Found More Effective Than Clinician-Delivered Therapy at Reducing Alcohol Use in a Clinical Trial
- June 03, 2024Source: Scientific American
How Tobacco Companies Use Chemistry To Get Around Menthol Bans
- September 27, 2023
$20M Federal Grant Renewed for Yale Tobacco Center of Regulatory Science
Get In Touch
Contacts
Mailing Address
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States