Scott Halperin, MD, MHS
Hospital ResidentAbout
Research
Publications
2026
Clinical and Nonclinical Determinants of Simultaneous vs Staged Bilateral Total Knee Arthroplasty
Maloy G, Day W, Halperin S, Islam W, Grauer J, Molloy I. Clinical and Nonclinical Determinants of Simultaneous vs Staged Bilateral Total Knee Arthroplasty. Arthroplasty Today 2026, 39: 102025. PMID: 42100109, PMCID: PMC13145251, DOI: 10.1016/j.artd.2026.102025.Peer-Reviewed Original ResearchStaged bilateral TKABilateral TKASimultaneous bilateral TKABilateral total knee arthroplastyTotal knee arthroplastyStaged bilateral total knee arthroplastyNonclinical factorsMultivariate logistic regressionKnee arthroplastyElixhauser Comorbidity IndexNonclinical determinantsAdult patientsStaging procedureSurgical decisionSurgical selectionPatient characteristicsComorbidity indexStaged fashionPatientsSimultaneous procedureTKA patientsLogistic regressionOddsArthroplastySurgeryNational trends in lumbar facet cyst surgical management: Rising fusion utilization without improved five-year outcomes over decompression alone
Sanchez J, Smith-Voudouris J, Zehner K, Seddio A, Halperin S, Jabbouri S, Ansah-Twum J, Gala R, Grauer J. National trends in lumbar facet cyst surgical management: Rising fusion utilization without improved five-year outcomes over decompression alone. The Spine Journal 2026 PMID: 41985680, DOI: 10.1016/j.spinee.2026.04.021.Peer-Reviewed Original ResearchLumbar facet cystsElixhauser Comorbidity IndexFacet cystsHigher Elixhauser comorbidity indexMatched CohortLumbar facet synovial cystsReoperation-free survivalYearly incidence rateSame-day diagnosisLog-rank testMultivariate logistic regressionKaplan-Meier curvesFive-year outcomesWilcoxon rank sum testTobacco useLumbar radiculopathyRank sum testIncidence rateMultilevel fusionReoperation rateSurgical managementLogistic regressionOrthopaedic surgeonsPatient selectionAdult patientsIntraoperative Vancomycin Does Not Change Periprosthetic Joint Infection Risk in Patients Undergoing Total Joint Arthroplasty
Jiang W, Sanchez J, Halperin S, Molloy I, Grauer J, Rubin L. Intraoperative Vancomycin Does Not Change Periprosthetic Joint Infection Risk in Patients Undergoing Total Joint Arthroplasty. The Journal Of Arthroplasty 2026 PMID: 41544893, DOI: 10.1016/j.arth.2026.01.043.Peer-Reviewed Original ResearchRevision-free survivalPeriprosthetic joint infectionIntraoperative vancomycinSurgical site infectionSite infectionMatched patientsMethicillin-resistant Staphylococcus aureusOdds of superficial surgical site infectionsSuperficial surgical site infectionLog-rank testKaplan-Meier analysisBody mass indexMultivariate logistic regressionAssociated with lower oddsCefazolin prophylaxisProphylactic antibioticsElixhauser Comorbidity IndexAntibiotic prescriptionsAdult patientsAdverse eventsJoint infectionMass indexMedical complicationsType II diabetesComorbidity index
2025
Erratum to ‘Perioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: risk factors associated with this “never event”’ by Anthony E. Seddio et al’ [The Spine Journal 25/5 (2025) 911-920]
Seddio A, Jabbouri S, Gouzoulis M, Vasudevan R, Halperin S, Varthi A, Rubio D, Grauer J. Erratum to ‘Perioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: risk factors associated with this “never event”’ by Anthony E. Seddio et al’ [The Spine Journal 25/5 (2025) 911-920]. The Spine Journal 2025, 26: 643. PMID: 41453812, DOI: 10.1016/j.spinee.2025.11.005.Commentaries, Editorials and LettersEndoscopic lumbar decompression in patients with obesity does not correlate with inferior outcomes
Sanchez J, Smith-Voudouris J, Zehner K, Halperin S, Jabbouri S, Seddio A, R. Rubio D, Grauer J. Endoscopic lumbar decompression in patients with obesity does not correlate with inferior outcomes. European Spine Journal 2025, 1-8. PMID: 41407997, DOI: 10.1007/s00586-025-09682-3.Peer-Reviewed Original ResearchEndoscopic lumbar decompressionNon-obese patientsLumbar decompressionObese patientsReoperation-free survivalObstructive sleep apneaHealthcare utilizationAssociated with obesityWilcoxon rank sum testMultivariate logistic regressionNational administrative databaseRank sum testPatient-reported outcomesType 2 diabetesLonger-term complicationsSleep apneaLumbar proceduresSpine surgerySurgical indicationsElixhauser Comorbidity IndexInferior outcomesPerioperative riskNinety-dayFollow-upComorbidity indexFollowing posterior spinal fusion for adolescent idiopathic scoliosis, patients with asthma are at increased odds of pulmonary adverse events
Kim L, Smith-Voudouris J, Halperin S, Tuason D, Grauer J. Following posterior spinal fusion for adolescent idiopathic scoliosis, patients with asthma are at increased odds of pulmonary adverse events. North American Spine Society Journal (NASSJ) 2025, 25: 100833. PMID: 41551025, PMCID: PMC12809486, DOI: 10.1016/j.xnsj.2025.100833.Peer-Reviewed Original ResearchPosterior spinal fusionAdolescent idiopathic scoliosisPostoperative adverse eventsAdverse eventsRespiratory failureAsthma severityIdiopathic scoliosisAdolescent patientsSpinal fusionAdverse outcomesOdds of respiratory failurePulmonary adverse eventsPatients meeting study criteriaLog-rank testKaplan-Meier analysisPostoperative adverse outcomesMultivariate logistic regressionNon-asthma patientsAssociated with higher oddsSecondary multivariate analysisPostoperative pneumoniaYounger patientsKaplan-MeierLevels of asthma severityPostoperative managementPatients With Cystic Fibrosis Undergoing Posterior Lumbar Fusion Are at an Increased Odds of Perioperative Complications
Halperin S, Dhodapkar M, Gouzoulis M, Varthi A, Rubio D, Grauer J. Patients With Cystic Fibrosis Undergoing Posterior Lumbar Fusion Are at an Increased Odds of Perioperative Complications. JAAOS Global Research And Reviews 2025, 9: e24.00304. PMID: 40749196, PMCID: PMC12309916, DOI: 10.5435/jaaosglobal-d-24-00304.Peer-Reviewed Original ResearchConceptsPosterior lumbar fusionCystic fibrosisPostoperative outcomesLumbar fusionRevision rateOdds of perioperative complicationsAcute kidney injuryPerioperative risk assessmentMultivariate logistic regressionLumbar surgeryPerioperative outcomesPerioperative complicationsSpine surgeryRespiratory failureElixhauser Comorbidity IndexPleural effusionVenous thromboembolismKidney injuryAdverse eventsNinety-dayComorbidity indexEmergency department visitsMatched ControlsPatientsSurgical preparationPredictors of Physical, Chiropractic, and Acupuncture Therapy Utilization in the Three Months Following Newly Diagnosed Low Back Pain.
Seddio A, Dhodapkar M, Halperin S, Jabbouri S, Gouzoulis M, Joo P, Grauer J. Predictors of Physical, Chiropractic, and Acupuncture Therapy Utilization in the Three Months Following Newly Diagnosed Low Back Pain. Clinical Spine Surgery A Spine Publication 2025 PMID: 40521727, DOI: 10.1097/bsd.0000000000001859.Peer-Reviewed Original ResearchLow back painChiropractic therapyAcupuncture therapyBack painDays of low back painNonclinical factorsLow back pain patientsPredictors of CT utilizationTherapy utilizationMultivariate logistic regressionMusculoskeletal problemsPhysical therapyElixhauser Comorbidity IndexIndependent predictorsLogistic regressionCT utilizationUtilization patternsAcupunctureLevel IIIMale sexExclusion criteriaComorbidity indexTherapy typeNational levelPainPostoperative complications in patients with sickle cell disease undergoing single-level anterior cervical discectomy and fusion
Maloy G, Doshi R, Day W, Dhodapkar M, Halperin S, Jayaram R, Jain B, Grauer J, Varthi A. Postoperative complications in patients with sickle cell disease undergoing single-level anterior cervical discectomy and fusion. North American Spine Society Journal (NASSJ) 2025, 22: 100617. PMID: 40548100, PMCID: PMC12182323, DOI: 10.1016/j.xnsj.2025.100617.Peer-Reviewed Original ResearchSickle cell disease patientsSickle cell diseaseSingle-level ACDFAnterior cervical discectomyAdverse eventsCervical discectomyPostoperative complicationsPostoperative outcomesElixhauser Comorbidity IndexCell diseaseSingle-level anterior cervical discectomyEmergency departmentUrinary tract infectionMultiple postoperative complicationsOdds of adverse eventsSerious adverse eventsAcute kidney injuryPostoperative adverse eventsDeep vein thrombosisMinor adverse eventsIndividual adverse eventsDegenerative disc diseaseMultivariate logistic regressionStudent's t-testHigh-risk populationOutcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study
Dhodapkar M, Halperin S, Day W, Saifi C, Rubio D, Koumpouras F, Grauer J, Varthi A. Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study. North American Spine Society Journal (NASSJ) 2025, 22: 100604. PMID: 40487382, PMCID: PMC12141882, DOI: 10.1016/j.xnsj.2025.100604.Peer-Reviewed Original ResearchPosterior lumbar fusionSystemic lupus erythematosusDiscoid lupus erythematosusSingle-level posterior lumbar fusionPostoperative adverse eventsMinor adverse eventsAdverse eventsIncreased oddsLupus erythematosusLumbar fusionDiagnosis of discoid lupus erythematosusCohort of systemic lupus erythematosusLevel posterior lumbar fusionsMultivariate analysisDiagnosis of systemic lupus erythematosusDiscoid lupus erythematosus patientsUrinary tract infectionPerioperative adverse outcomesSurgical site infectionAcute kidney injuryDeep vein thrombosisNational database studyHistory of infectionSampled adult patientsMultivariate logistic regression