Sarah E. Beck, MD
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2025
The genetics of cannabis lifetime use
Bright U, Beck S, Galimberti M, Gupta P, Chen Y, Dao C, Nunez Y, Kranzler H, Zhou Y, Zhang Y, Choi K, Levey D, Gelernter J. The genetics of cannabis lifetime use. Neuropsychopharmacology 2025, 51: 554-564. PMID: 41044382, PMCID: PMC12824155, DOI: 10.1038/s41386-025-02255-4.Peer-Reviewed Original ResearchCannabis use disorderGenome-wide association studiesMendelian randomizationGenetic correlation analysisUse disorderGenetic architectureSubstance useGenetic basisLifetime useLocal genetic correlation analysisHealth-related phenotypesPost-GWAS analysisRisk-taking behaviorGenetic correlationsAssociation studiesGenetic populationsUse-related traitsGenetic relationshipsAssociation analysisCannabisGenetic mechanismsIntervention strategiesRisk takingIndependent variantsSexual behaviorW90. MAJOR DEPRESSIVE DISORDER AMPLIFIES THE COMBINED EFFECT OF POLYGENIC RISK AND CHILDHOOD TRAUMA ON RISK OF LIFETIME SUICIDE ATTEMPT
Fischer I, Overstreet C, Beck S, Galimberti M, Zhou H, Pietrzak R, Nunez Y, Kranzler H, Levey D, Gelernter J. W90. MAJOR DEPRESSIVE DISORDER AMPLIFIES THE COMBINED EFFECT OF POLYGENIC RISK AND CHILDHOOD TRAUMA ON RISK OF LIFETIME SUICIDE ATTEMPT. European Neuropsychopharmacology 2025, 99: 254-255. DOI: 10.1016/j.euroneuro.2025.08.447.Peer-Reviewed Original ResearchCumulative childhood traumaSuicide attemptsChildhood traumaSuicidal behaviorPolygenic riskGenetic riskAssociated with suicide attemptsEffects of suicide attemptsInfluence of genetic riskLifetime suicide attemptsEarly-life traumaProbability of suicide attemptsEarly-life adversitySubstance use disordersGWAS Meta-AnalysisEffects of genetic riskEffect of genetic liabilityAssociated with SAMDD statusLifetime MDDDepressive disorderMDD diagnosisLifetime SAPolygenic risk scoresSuicide riskThe genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskA multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis
Peng P, Hao Y, Zhang X, Ma Y, Liu X, Shen D, Shen W, Zhao B, Li D, Beck S, Nunez Y, Potenza M, Gelernter J, Liu T, Yang B. A multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis. Annals Of General Psychiatry 2025, 24: 12. PMID: 40033412, PMCID: PMC11877697, DOI: 10.1186/s12991-025-00546-0.Peer-Reviewed Original ResearchSemi-Structured Assessment for Drug Dependence and AlcoholismDSM-5 diagnostic criteriaGambling disorderDSM-5Antisocial personality disorderMethamphetamine use disorderSubstance use disordersDiagnostic criteriaPersonality disorderBridge symptomsDepressive episodeDrug rehabilitation centersCentral symptomsPsychiatric diagnosisGambling durationUse disorderSelf-harmChildhood experiencesMethamphetamineAlcohol useViolent experiencesDisordersManifest symptomsChinese versionMDE
2024
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology
Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Kranzler H, Stein M, Gelernter J, Levey D. A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. Nature Human Behaviour 2024, 8: 2235-2249. PMID: 39134740, PMCID: PMC11576509, DOI: 10.1038/s41562-024-01951-3.Peer-Reviewed Original ResearchPersonality traitsPsychiatric traitsBidirectional effectsGenetic architectureHuman personality traitsGenetic correlation analysisGene-based association testsGenome-wide significant lociNeuroticismAgreeablenessGenome-wide association studiesGenome-wide association study meta-analysisMental illnessGenome-wide investigationAssociation TestComplex human traitsProteome-wide analysisAnxietyDepressionExtraversionConscientiousnessExpression of genesNovel lociSignificant lociTranscriptome-wide
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