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2026
Robust inference and correlates from genetic associations with personality
Schwaba T, Clapp Sullivan M, Akingbuwa W, Ilves K, Tanksley P, Williams C, Dragostinov Y, Mallard T, Tubbs J, Liao W, Ackerman L, Fealy J, Hemani G, de la Fuente J, Smith G, Gupta P, Stein M, Gelernter J, Levey D, Võsa U, Ausmees L, Realo A, Vaht M, Allik J, Esko T, Mõttus R, Vainik U, Jonsdottir G, Thorleifsson G, Gunnarsson Á, Bjornsdottir G, Thorgeirsson T, Stefansson H, Stefansson K, Cheesman R, Qin Q, Corfield E, Ask H, Torvik F, Ystrom E, Tesli M, Boomsma D, de Geus E, Hottenga J, Melo D, Snieder H, Hartman C, Xia C, Campbell A, Luciano M, Deary I, Hill W, Jang S, Vrieze S, Abecasis G, Lupton M, Mitchell B, Viher P, Colodro-Conde L, Martin N, Medland S, Derks E, Wormington B, Kaprio J, Silventoinen K, Palviainen T, Musial A, Rimfeld K, Plomin R, Malanchini M, Dick D, Aliev F, Wesseldijk L, Ullén F, Mosing M, Kranzler H, Nunez Y, Beck S, Polimanti R, Edwards T, Giannelis A, Willoughby E, Lee J, McGue M, Terracciano A, Marongiu M, Fiorillo E, Cucca F, Sutin A, van der Most P, Oldehinkel A, Kretschmer T, Shabalin A, Docherty A, Krueger R, Freilich C, Mishra B, Lehtimäki T, Raitakari O, Kähönen M, Saarinen A, Dobewall H, Keltikangas-Järvinen L, Berger K, Herrera-Rivero M, Streit F, Awasthi S, Witt S, Tuhkanen J, Räikkönen K, Eriksson J, Lahti J, Davies G, Redmond P, Taylor A, Corley J, Russ T, Ciullo M, Nutile T, Ding J, Qian Y, Tanaka T, Ferrucci L, Zillich L, Sirignano L, Harden K, Genç E, Gajewski P, Getzmann S, Fraenz C, Schneider Peñate J, Lis S, Hall A, Schmahl C, Herpertz S, Abdellaoui A, Nivard M, Tucker-Drob E. Robust inference and correlates from genetic associations with personality. Nature 2026, 1-11. PMID: 42686911, PMCID: PMC13589609, DOI: 10.1038/s41586-026-10992-9.Peer-Reviewed Original ResearchDirect and indirect associations linking COVID-19 severity to internalizing disorders and symptoms among participants in New Haven, CT
Davtian D, Qiu D, Nunez Y, Krystal J, Pietrzak R, Gelernter J, Polimanti R. Direct and indirect associations linking COVID-19 severity to internalizing disorders and symptoms among participants in New Haven, CT. Journal Of Affective Disorders 2026, 412: 122082. PMID: 42259487, PMCID: PMC13312232, DOI: 10.1016/j.jad.2026.122082.Peer-Reviewed Original Research
2025
Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants
Wang L, Nuñez Y, Martínez-Magaña J, Rivera-Hernandez M, Mao Z, Brennand K, Montalvo-Ortiz J, Kranzler H, Gelernter J, Zhou H. Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants. Translational Psychiatry 2025, 15: 380. PMID: 41052974, PMCID: PMC12500996, DOI: 10.1038/s41398-025-03578-y.Peer-Reviewed Original ResearchThe genetics of cannabis lifetime use
Bright U, Beck S, Galimberti M, Gupta P, Chen Y, Dao C, Nunez Y, Kranzler H, Zhou Y, Zhang Y, Choi K, Levey D, Gelernter J. The genetics of cannabis lifetime use. Neuropsychopharmacology 2025, 51: 554-564. PMID: 41044382, PMCID: PMC12824155, DOI: 10.1038/s41386-025-02255-4.Peer-Reviewed Original ResearchMulti-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Johnson E, Lai D, Balbona J, Miller A, Hatoum A, Deak J, Jennings M, Baranger D, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert S, Adhikari K, Docherty A, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries P, Korhonen T, Morrison C, Nunez Y, Palviainen T, Su M, Villela P, Wetherill L, Willoughby E, Zellers S, Bierut L, Buchwald J, Copeland W, Corley R, Friedman N, Foroud T, Gillespie N, Gizer I, Heath A, Hickie I, Kaprio J, Keller M, Lee J, Lind P, Madden P, Maes H, Martin N, McGue M, Medland S, Nelson E, Pearson J, Porjesz B, Stallings M, Vrieze S, Wilhelmson K, Kranzler H, Walters R, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg H, Gelernter J, Agrawal A. Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. Psychological Medicine 2025, 55: e234. PMID: 40831304, PMCID: PMC12360691, DOI: 10.1017/s0033291725100883.Peer-Reviewed Original ResearchEpigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses
Pietrzak R, Lacobelle A, Overstreet C, Wendt F, Deak J, Friligkou E, Nunez Y, Montalvo-Ortiz J, Levey D, Kranzler H, Gelernter J, Polimanti R. Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. Molecular Psychiatry 2025, 30: 4435-4443. PMID: 40247127, PMCID: PMC12343199, DOI: 10.1038/s41380-025-03031-y.Peer-Reviewed Original ResearchA multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis
Peng P, Hao Y, Zhang X, Ma Y, Liu X, Shen D, Shen W, Zhao B, Li D, Beck S, Nunez Y, Potenza M, Gelernter J, Liu T, Yang B. A multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis. Annals Of General Psychiatry 2025, 24: 12. PMID: 40033412, PMCID: PMC11877697, DOI: 10.1186/s12991-025-00546-0.Peer-Reviewed Original Research
2024
Association patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchIdentifying neurofunctional domains across substance use disorders
Hartwell E, Schwandt M, Nunez Y, Wetherill R, Kember R, Wiers C, Gelernter J, Kranzler H. Identifying neurofunctional domains across substance use disorders. The American Journal Of Drug And Alcohol Abuse 2024, 50: 536-546. PMID: 39018668, DOI: 10.1080/00952990.2024.2368180.Peer-Reviewed Original Research
2023
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
Levey D, Galimberti M, Deak J, Wendt F, Bhattacharya A, Harrington K, Quaden R, Johnson E, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal V, Empke S, Zhou H, Nunez Y, Kranzler H, Edenberg H, Agrawal A, Smoller J, Lencz T, Hougaard D, Børglum A, Demontis D, Gaziano J, Gandal M, Polimanti R, Stein M, Gelernter J. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nature Genetics 2023, 55: 2094-2103. PMID: 37985822, PMCID: PMC10703690, DOI: 10.1038/s41588-023-01563-z.Peer-Reviewed Original Research
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