Sandra Wolin, MD, PhD
Professor Emeritus of Cell BiologyCards
About
Research
Publications
2026
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
Nam H, Deme J, Sim S, Boccitto M, Lea S, Wolin S. Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens. Cell 2026, 189: 1135-1152.e23. PMID: 41610850, PMCID: PMC12866964, DOI: 10.1016/j.cell.2025.12.030.Peer-Reviewed Original Research
2025
DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs
Williams S, Sim S, Guiblet W, George J, Jones J, Wolin S. DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2526318122. PMID: 41401009, PMCID: PMC12745716, DOI: 10.1073/pnas.2526318122.Peer-Reviewed Original ResearchRNA sensing at the crossroads of autoimmunity and autoinflammation
Williams S, Sim S, Wolin S. RNA sensing at the crossroads of autoimmunity and autoinflammation. RNA 2025, 31: rna.080304.124. PMID: 39779213, PMCID: PMC11874990, DOI: 10.1261/rna.080304.124.Peer-Reviewed Original Research
2023
CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology
Ortega J, Sasselli I, Boccitto M, Fleming A, Fortuna T, Li Y, Sato K, Clemons T, Mckenna E, Nguyen T, Anderson E, Asin J, Ichida J, Pandey U, Wolin S, Stupp S, Kiskinis E. CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology. Science Advances 2023, 9: eadf7997. PMID: 37948524, PMCID: PMC10637751, DOI: 10.1126/sciadv.adf7997.Peer-Reviewed Original Research
2018
Bacterial Y RNAs: Gates, Tethers, and tRNA Mimics
Sim S, Wolin S. Bacterial Y RNAs: Gates, Tethers, and tRNA Mimics. 2018, 369-381. DOI: 10.1128/9781683670247.ch21.Chapters
2013
An RNA Degradation Machine Sculpted by Ro Autoantigen and Noncoding RNA
Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, Wolin SL. An RNA Degradation Machine Sculpted by Ro Autoantigen and Noncoding RNA. Cell 2013, 153: 166-177. PMID: 23540697, PMCID: PMC3646564, DOI: 10.1016/j.cell.2013.02.037.Peer-Reviewed Original Research
2012
An MBoC Favorite: The historic covers selected by Joseph Gall that graced MBoC from 1992 to 1996
Wolin S. An MBoC Favorite: The historic covers selected by Joseph Gall that graced MBoC from 1992 to 1996. Molecular Biology Of The Cell 2012, 23: 1797-1797. PMCID: PMC3350544, DOI: 10.1091/mbc.e12-02-0141.Peer-Reviewed Original Research
2011
An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors
Kucera NJ, Hodsdon ME, Wolin SL. An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 1308-1313. PMID: 21212361, PMCID: PMC3029687, DOI: 10.1073/pnas.1017085108.Peer-Reviewed Original ResearchAmino Acid SequenceAnticodonChymotrypsinElectrophoretic Mobility Shift AssayImmunoblottingModels, MolecularMolecular Sequence DataMutationNucleic Acid ConformationProtein BindingProtein Structure, TertiaryRNA PrecursorsRNA-Binding ProteinsRNA, FungalRNA, RibosomalRNA, Small NuclearRNA, TransferRNA, UntranslatedSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidTrypsin
2006
Molecular Chaperones and Quality Control in Noncoding RNA Biogenesis
WOLIN S, WURTMANN E. Molecular Chaperones and Quality Control in Noncoding RNA Biogenesis. Cold Spring Harbor Symposia On Quantitative Biology 2006, 71: 505-511. PMID: 17381333, DOI: 10.1101/sqb.2006.71.051.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2001
Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization.
Long K, Cedervall T, Walch-Solimena C, Noe D, Huddleston M, Annan R, Wolin S. Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization. RNA 2001, 7: 1589-602. PMID: 11720288, PMCID: PMC1370201.Peer-Reviewed Original ResearchAmino Acid SequenceAutoantigensBinding SitesCell NucleolusCell NucleusFungal ProteinsMolecular Sequence DataPeptide MappingPhosphorylationProtein IsoformsRibonucleoproteinsRibonucleoproteins, Small NuclearRNARNA StabilityRNA-Binding ProteinsRNA, FungalRNA, TransferSaccharomyces cerevisiaeSaccharomyces cerevisiae Proteins