Sandra Wolin, MD, PhD
Professor Emeritus of Cell BiologyCards
About
Research
Publications
2026
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
Nam H, Deme J, Sim S, Boccitto M, Lea S, Wolin S. Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens. Cell 2026, 189: 1135-1152.e23. PMID: 41610850, PMCID: PMC12866964, DOI: 10.1016/j.cell.2025.12.030.Peer-Reviewed Original ResearchConceptsRNA chaperoneRo60 ribonucleoproteinATP-independent chaperonesC-terminal domainN-terminal domainNon-native structuresCryo-electron microscopyRNA 3Primer extensionChaperone machineLa autoantigenRNA foldingRo60 proteinNcRNAsCryo-electronChaperoneRNANoncoding RNAsMutation profilesMechanistic insightRo60FoldingRibonucleoproteinMisfoldingPrimers
2025
DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs
Williams S, Sim S, Guiblet W, George J, Jones J, Wolin S. DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2526318122. PMID: 41401009, PMCID: PMC12745716, DOI: 10.1073/pnas.2526318122.Peer-Reviewed Original ResearchConceptsCellular RNATransfer RNAExtracellular vesiclesI interferon-stimulated genesHigh-throughput sequencingMessenger RNACulture mediumInnate immune sensorsRNA surveillanceAberrant RNAsRNA componentEV-ncRNAsVesicle packagingDIS3L2Structural intronsNcRNAsHost cellsType I interferon-stimulated genesHuman cellsRNANorthern blottingSphingomyelinase inhibitorExosome biogenesisImmune sensorsNoncoding RNAsRNA sensing at the crossroads of autoimmunity and autoinflammation
Williams S, Sim S, Wolin S. RNA sensing at the crossroads of autoimmunity and autoinflammation. RNA 2025, 31: rna.080304.124. PMID: 39779213, PMCID: PMC11874990, DOI: 10.1261/rna.080304.124.Peer-Reviewed Original ResearchConceptsRNA sensorsInnate immune system's abilityImmune systemAutoinflammatory diseasesHost defense systemRNA homeostasisForeign RNAHost RNAType I interferon-stimulated genesPathogen recognitionInnate immune systemI interferon-stimulated genesRNA sensingImmune-mediated diseasesImmune system's abilityRNAAdaptive immune systemHuman immune systemTumor surveillanceViral counterpartsSenescent cellsGenesHomeostatic processesViral infectionPathogens
2023
CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology
Ortega J, Sasselli I, Boccitto M, Fleming A, Fortuna T, Li Y, Sato K, Clemons T, Mckenna E, Nguyen T, Anderson E, Asin J, Ichida J, Pandey U, Wolin S, Stupp S, Kiskinis E. CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology. Science Advances 2023, 9: eadf7997. PMID: 37948524, PMCID: PMC10637751, DOI: 10.1126/sciadv.adf7997.Peer-Reviewed Original Research
2018
Bacterial Y RNAs: Gates, Tethers, and tRNA Mimics
Sim S, Wolin S. Bacterial Y RNAs: Gates, Tethers, and tRNA Mimics. 2018, 369-381. DOI: 10.1128/9781683670247.ch21.ChaptersY RNAsBacterial Y RNAsRing-shaped proteinSubset of bacteriaCharacterized organismsProtein partnersNoncoding RNAsTRNA mimicAnimal cellsHomology searchHuman RNAHuman cellsRNANucleotidesImportant targetBacteriaSystemic autoimmune rheumatic diseasesAutoimmune rheumatic diseasesSystemic lupus erythematosusCellsRNAsOrganismsSpeciesProteinLupus erythematosus
2015
A retrovirus packages nascent host noncoding RNAs from a novel surveillance pathway
Eckwahl MJ, Sim S, Smith D, Telesnitsky A, Wolin SL. A retrovirus packages nascent host noncoding RNAs from a novel surveillance pathway. Genes & Development 2015, 29: 646-657. PMID: 25792599, PMCID: PMC4378196, DOI: 10.1101/gad.258731.115.Peer-Reviewed Original ResearchConceptsSmall nuclear RNAMoloney leukemia virusSurveillance pathwayU6 small nuclear RNASmall nucleolar RNAsHigh-throughput sequencingHost cell RNAExoribonuclease DIS3L2RNA exosomeLeukemia virusExportin-5Nucleolar RNAsNuclear RNAHost RNASpecific tRNAsCytoplasmic recruitmentMurine leukemia virusCell RNAEndogenous retrovirusesRNAModel retrovirusRNAsVirionsCytoplasmPathway
2014
Bacterial noncoding Y RNAs are widespread and mimic tRNAs
Chen X, Sim S, Wurtmann EJ, Feke A, Wolin SL. Bacterial noncoding Y RNAs are widespread and mimic tRNAs. RNA 2014, 20: 1715-1724. PMID: 25232022, PMCID: PMC4201824, DOI: 10.1261/rna.047241.114.Peer-Reviewed Original ResearchConceptsY RNAsStructured RNA degradationRing-shaped proteinNoncoding Y RNAsBacterial physiologyAnimal cellsNucleotide modificationsDeinococcus radioduransPhage speciesRNA degradationTRNARo60 autoantigenRNAOrthologsNcRNAsSpeciesBacteriaExoribonucleaseRNAsRadioduransProteinRo60EnzymePhysiologyPhosphorylase
2013
An RNA Degradation Machine Sculpted by Ro Autoantigen and Noncoding RNA
Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, Wolin SL. An RNA Degradation Machine Sculpted by Ro Autoantigen and Noncoding RNA. Cell 2013, 153: 166-177. PMID: 23540697, PMCID: PMC3646564, DOI: 10.1016/j.cell.2013.02.037.Peer-Reviewed Original ResearchConceptsRNA degradation machineDegradation machineY RNAsSingle-particle electron microscopyRing-shaped proteinRibosomal RNA maturationExoribonuclease polynucleotide phosphorylaseRo autoantigenNcRNAs actRRNA decayRNA maturationProtein cofactorsNoncoding RNAsSubstrate specificityDeinococcus radioduransStructured RNAsPolynucleotide phosphorylaseBiochemical assaysRNAOrthologsNcRNAPNPaseProteinSalmonella typhimuriumAtomic model
2012
An MBoC Favorite: The historic covers selected by Joseph Gall that graced MBoC from 1992 to 1996
Wolin S. An MBoC Favorite: The historic covers selected by Joseph Gall that graced MBoC from 1992 to 1996. Molecular Biology Of The Cell 2012, 23: 1797-1797. PMCID: PMC3350544, DOI: 10.1091/mbc.e12-02-0141.Peer-Reviewed Original ResearchNuclear noncoding RNA surveillance: is the end in sight?
Wolin SL, Sim S, Chen X. Nuclear noncoding RNA surveillance: is the end in sight? Trends In Genetics 2012, 28: 306-313. PMID: 22475369, PMCID: PMC3378728, DOI: 10.1016/j.tig.2012.03.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRNA surveillance pathwaySurveillance pathwayAberrant RNAsSteady-state transcriptomeYeast counterpartEukaryotic cellsProtein cofactorsMammalian cellsRNA determinantsHuman diseasesSubsequent degradationRNACofactorPathwayKey roleRecent studiesMetazoansExoribonucleasesAccessible endTranscriptomeNcRNAsCellsYeastNucleaseProtein