Ramakrishnan Kannan, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax
Curt J, Martín P, Foronda D, Hudry B, Kannan R, Shetty S, Merabet S, Saurin A, Graba Y, Herrero E. Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax. PLOS Genetics 2025, 21: e1011355. PMID: 39804927, PMCID: PMC11759358, DOI: 10.1371/journal.pgen.1011355.Peer-Reviewed Original Research
2022
Novel insights into the genetic profile of hereditary spastic paraplegia in India
Narendiran S, Debnath M, Shivaram S, Kannan R, Sharma S, Christopher R, Seshagiri D, Jain S, Purushottam M, Mangalore S, Bharath R, Bindu P, Sinha S, Taly A, Nagappa M. Novel insights into the genetic profile of hereditary spastic paraplegia in India. Journal Of Neurogenetics 2022, 36: 21-31. PMID: 35499206, DOI: 10.1080/01677063.2022.2064463.Peer-Reviewed Original ResearchConceptsHereditary spastic paraplegiaNovel variantsClinical exome sequencingGenetic profileSpectrum of genetic variationSpastic paraplegia syndromeGenetically heterogeneous disorderHereditary spastic paraplegia phenotypeThin corpus callosumSpastic paraplegiaSpastic paraplegia phenotypeCerebellar atrophyRadiological abnormalitiesClinical featuresModifiable disordersDiffuse atrophyBrain MRIPeriventricular hyperintensitiesExome sequencingCerebral atrophyLength-dependent degenerationHeterogeneous disorderPatientsMetabolic disordersCorpus callosum
2021
Genetics of hereditary spastic paraplegia from India
Nagappa M, Narendiran S, Debnath M, Shivaram S, Kannan R, Sharma S, Christopher R, Seshagiri D, Jain S, Purushottam M, Sandhya M, Bharath R, Bindu P, Sinha S, Taly A. Genetics of hereditary spastic paraplegia from India. Journal Of The Neurological Sciences 2021, 429: 118283. DOI: 10.1016/j.jns.2021.118283.Peer-Reviewed Original Research
2020
Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase
Clarke A, McQueen P, Fang H, Kannan R, Wang V, McCreedy E, Buckley T, Johannessen E, Wincovitch S, Giniger E. Dynamic morphogenesis of a pioneer axon in Drosophila and its regulation by Abl tyrosine kinase. Molecular Biology Of The Cell 2020, 31: 452-465. PMID: 31967935, PMCID: PMC7185889, DOI: 10.1091/mbc.e19-10-0563.Peer-Reviewed Original ResearchConceptsGrowth conesRegulation of actin organizationAbelson (Abl) tyrosine kinaseTyrosine kinaseDistribution of actinGrowth cone motilityGrowth cone velocityAbl tyrosine kinaseGrowth cone structureAxonal guidance signalingDiscrete morphsMode of growthActin organizationProtrusion modesFilopodial dynamicsCytoplasmic signalsAxonal growthDynamic morphogenesisGenetic manipulationStochastic fluctuationsLive imagingGuidance signalsAxon extensionABLKinaseAbl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin
Clarke A, McQueen P, Fang H, Kannan R, Wang V, McCreedy E, Wincovitch S, Giniger E. Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin. Molecular Biology Of The Cell 2020, 31: 466-477. PMID: 31967946, PMCID: PMC7185895, DOI: 10.1091/mbc.e19-10-0564.Peer-Reviewed Original ResearchConceptsGrowth conesAbelson (Abl) tyrosine kinaseGrowth cone morphogenesisGrowth cone motilityActin organizationAbl signalingCytoplasmic signalsAxonal growthActinSignaling moleculesStochastic fluctuationsTyrosine kinaseLive imagingGuidance signalsDistal axonsMotilityPioneer axonsIntrinsic fluctuationsABLDrosophilaTSM1GrowthCytoskeletonSignalMorphogenesis
2019
Identification and functional characterization of two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome without electrolyte imbalance
Nadella R, Chellappa A, Subramaniam A, More R, Shetty S, Prakash S, Ratna N, Vandana V, Purushottam M, Saini J, Viswanath B, Bindu P, Nagappa M, Mehta B, Jain S, Kannan R. Identification and functional characterization of two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome without electrolyte imbalance. Human Genomics 2019, 13: 53. PMID: 31640787, PMCID: PMC6805350, DOI: 10.1186/s40246-019-0236-0.Peer-Reviewed Original ResearchConceptsLoss-of-function effectPI4KBCytoplasmic domainHomozygous variantLymphoblastoid cellsSeSAME syndromeVariant prioritization pipelineAutosomal-recessiveWhole-exome sequencingElectrolyte imbalancePrioritization pipelineWhole-cell patch-clamp electrophysiologySubcellular localizationInwardly rectifying potassium channel Kir4.1Functional characterizationPotassium channel Kir4.1Patch-clamp electrophysiologyEndogenous K+ currentsPhosphatidylinositol bisphosphateMulti-system disorderSignaling mechanismsMutationsComorbid phenotypesKir4.1 dysfunctionK+ currentChronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells
Datta KK, Patil S, Patel K, Babu N, Raja R, Nanjappa V, Mangalaparthi KK, Dhaka B, Rajagopalan P, Deolankar SC, Kannan R, Kumar P, Prasad TSK, Mathur PP, Kumari A, Manoharan M, Coral K, Murugan S, Sidransky D, Gupta R, Gupta R, Khanna-Gupta A, Chatterjee A, Gowda H. Chronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells. Cells 2019, 8: 949. PMID: 31438645, PMCID: PMC6770059, DOI: 10.3390/cells8090949.Peer-Reviewed Original ResearchConceptsEsophageal epithelial cellsQuantitative proteomic analysisQuantitative proteomic profilingEpithelial cellsCancer stem cell-like phenotypeElectron transport chainEsophageal squamous cell carcinomaStem cell-like phenotypeTricarboxylic acid cycleMolecular alterationsMitochondrial proteinsTobacco exposurePhosphorylation phenotypeProteomic analysisCell-like phenotypeStem cell-like propertiesMetabolic reprogrammingProteomic profilingCancer stem cell-like propertiesOXPHOS phenotypeStem cell markersChronic exposureTransport chainCell-like propertiesMolecular markersDerivation of iPSC lines from two patients with familial Alzheimer's disease from India.
Najar AH, Sneha KM, Ashok A, Babu S, Subramaniam AG, Kannan R, Viswanath B, Purushottam M, Varghese M, Parvez S, Panicker MM, Mukherjee O, Jain S. Derivation of iPSC lines from two patients with familial Alzheimer's disease from India. Stem Cell Research 2019, 34: 101370. PMID: 30605839, DOI: 10.1016/j.scr.2018.101370.Peer-Reviewed Original Research
2018
GSK-3b 50 T/C polymorphism in bipolar disorder and its relationship with clinical phenotypes and treatment response
Sathur Raghuraman B, Paul P, Nadella R, Kapur V, Purushottam M, Jain S, Kannan R, Del Zompo M, Viswanath B. GSK-3b 50 T/C polymorphism in bipolar disorder and its relationship with clinical phenotypes and treatment response. Journal Of Affective Disorders 2018, 241: 433-435. PMID: 30145514, DOI: 10.1016/j.jad.2018.08.079.Peer-Reviewed Original ResearchDoes retinoic acid reverse cell cycle dysregulation in Alzheimer’s disease lymphocytes?
Ashok A, Naaz S, Kota L, Sen S, Purushottam M, Faruq M, Kumari R, Yadav V, Kannan R, Jain S, Panicker M, Viswanath B. Does retinoic acid reverse cell cycle dysregulation in Alzheimer’s disease lymphocytes? Asian Journal Of Psychiatry 2018, 39: 174-177. PMID: 30139662, DOI: 10.1016/j.ajp.2018.08.010.Peer-Reviewed Original ResearchConceptsAberrant re-entryCell cycle analysisCell cycle dysregulationCell cycleRetinoic acidAberrant re-entry of neuronesAlzheimer's diseaseAD lymphocytesG2/M phaseE2F transcription factorsExpression of cell cycle genesCycle analysisG2/M phase of cell cycleGlobal gene expression analysisCell cycle genesPhase of cell cycleGene expression analysisResponse to RA treatmentCycle genesTranscription factorsRNA sequencingCellular phenotypesExpression analysisEarly eventTherapeutic potential