Pingze Zhang, PhD
Postdoctoral AssociateAbout
Research
Publications
2024
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system
Zhang P, Catterson J, Grönke S, Partridge L. Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature Aging 2024, 4: 491-509. PMID: 38413780, PMCID: PMC11031405, DOI: 10.1038/s43587-024-00578-3.Peer-Reviewed Original ResearchConceptsTarget of rapamycin complex 1S6KActivation of S6KDrosophila fat bodyImmune deficiencyImmune deficiency pathwayExtension of lifespanRapamycin complex 1Syntaxin 13PGRP-LCRapamycin treatmentDiverse speciesEndolysosomal systemLysosomal morphologyS6 kinaseFat bodyInhibition of S6KK signalingNF-kB signalingAge-related inflammationSyntaxinAge-related increaseMouse liverLysosomesRapamycin
2023
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
Morón-Oset J, Fischer L, Jauré N, Zhang P, Jahn A, Supèr T, Pahl A, Isaacs A, Grönke S, Partridge L. Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity. Acta Neuropathologica Communications 2023, 11: 140. PMID: 37644512, PMCID: PMC10463776, DOI: 10.1186/s40478-023-01634-6.Peer-Reviewed Original ResearchConceptsDipeptide repeat proteinsExperimental down-regulationER-to-Golgi traffickingInsulin signalingER-to-Golgi transportProteomic analysisCause of familial amyotrophic lateral sclerosisArginine-rich dipeptide repeat proteinsNon-coding regionsDown-regulated proteinsG4C2 hexanucleotide repeat expansionSurvival of fliesHexanucleotide repeat expansionAmyotrophic lateral sclerosisNeuronal expressionFrontotemporal dementiaGolgi traffickingGolgi transportFamilial amyotrophic lateral sclerosisRepeat proteinsToxicity in vivoFly linesC9orf72 geneModel organismsMild toxicityToxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags
Morón-Oset J, Fischer L, Carcolé M, Giblin A, Zhang P, Isaacs A, Grönke S, Partridge L. Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags. Life Science Alliance 2023, 6: e202201739. PMID: 37308278, PMCID: PMC10262077, DOI: 10.26508/lsa.202201739.Peer-Reviewed Original ResearchConceptsProtein tagsDipeptide repeat (DPR) proteinsGenetic causeFluorescent tagsCause of amyotrophic lateral sclerosisHexanucleotide repeat expansionC9ORF72 geneFLAG tagRepeat expansionGA proteinsDNA damageProteinAmyotrophic lateral sclerosisFrontotemporal dementiaGFPMCherryEffects of taggingTagsLateral sclerosisP62 levelsGA100HexanucleotidePreclinical modelsPreclinical studiesTranscription
2018
Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7
Zhang P, Ding Z, Liu X, Chen Y, Li J, Tao Z, Fei Y, Xue C, Qian J, Wang X, Li Q, Stoeger T, Chen J, Bi Y, Yin R. Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7. Frontiers In Immunology 2018, 9: 366. PMID: 29670609, PMCID: PMC5893744, DOI: 10.3389/fimmu.2018.00366.Peer-Reviewed Original ResearchConceptsVirulent Newcastle disease virusNewcastle disease virusNewcastle diseaseChicken macrophagesDisease virusVirulent strains of Newcastle disease virusStrain of Newcastle disease virusVirulent strainsGenotypes of Newcastle disease virusNewcastle disease virus strainsInhibition of TLR7Toll-like receptorsEarly stages of infectionLentogenic virusesLentogenic strainsVirulence mechanismsDomestic birdsStages of infectionChickenViral infectionAvian macrophagesBlocking Toll-like receptorLate stage of viral infectionLow virulenceNDV replication
2017
Dispersal and Transmission of Avian Paramyxovirus Serotype 4 among Wild Birds and Domestic Poultry
Yin R, Zhang P, Liu X, Chen Y, Tao Z, Ai L, Li J, Yang Y, Li M, Xue C, Qian J, Wang X, Chen J, Li Y, Xiong Y, Zhang J, Stoeger T, Bi Y, Chen J, Ding Z. Dispersal and Transmission of Avian Paramyxovirus Serotype 4 among Wild Birds and Domestic Poultry. Frontiers In Cellular And Infection Microbiology 2017, 7: 212. PMID: 28603697, PMCID: PMC5445105, DOI: 10.3389/fcimb.2017.00212.Peer-Reviewed Original ResearchConceptsAPMV-4 strainsWild bird-origin virusesAPMV-4Wild birdsInterspecies transmissionDomestic poultryFree-living wild birdsSerotype 4Surveillance of wild birdsPhylogenetic analysisSwan gooseBean gooseChicken originHost speciesPoultry pathogensBirdsGenotype IPoultryLive bird marketsSpeciesStrainGeeseIsolatesProvince of ChinaVirus
2016
A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus
Yin R, Liu X, Zhang P, Chen Y, Xie G, Ai L, Xue C, Qian J, Bi Y, Chen J, Sun Y, Stoeger T, Ding Z. A Raf kinase inhibitor demonstrates antiviral activities both in vitro and in vivo against different genotypes of virulent Newcastle disease virus. Antiviral Research 2016, 133: 140-144. PMID: 27498149, DOI: 10.1016/j.antiviral.2016.08.003.Peer-Reviewed Original ResearchConceptsNewcastle disease virusVirulent Newcastle disease virusNewcastle diseaseDisease virusRaf kinase inhibitor proteinLungs of infected chickensInfected chickensNDV infectionRaf kinaseChickenChicken modelKinase inhibitor proteinAntiviral activityCell-based assaysEfficient replicationInhibitor proteinNewcastleRAF kinase inhibitorsEffective concentrationVirus replicationReplicationAntiviral interventionRafVirusLethal infection
2015
High Genetic Diversity of Newcastle Disease Virus in Wild and Domestic Birds in Northeastern China from 2013 to 2015 Reveals Potential Epidemic Trends
Zhang P, Xie G, Liu X, Ai L, Chen Y, Meng X, Bi Y, Chen J, Sun Y, Stoeger T, Ding Z, Yin R. High Genetic Diversity of Newcastle Disease Virus in Wild and Domestic Birds in Northeastern China from 2013 to 2015 Reveals Potential Epidemic Trends. Applied And Environmental Microbiology 2015, 82: 1530-1536. PMID: 26712543, PMCID: PMC4771317, DOI: 10.1128/aem.03402-15.Peer-Reviewed Original ResearchConceptsNewcastle disease virusDomestic birdsNewcastle diseaseHigh genetic diversityDisease virusLive bird marketsIsolates of Newcastle disease virusVirulent Newcastle disease virusViral disease of birdsClass II Newcastle disease virusViral diseasesDisease of birdsNortheastern ChinaGenotype IIClass I virusesBirdsPhylogenetic analysisBird marketsVirus transmissionSubgenotype IBEpidemiological connectionVirusSoutheastern ChinaIsolatesDomesticationExpression of Raf kinase inhibitor protein is downregulated in response to Newcastle disease virus infection to promote viral replication
Yin R, Liu X, Bi Y, Xie G, Zhang P, Meng X, Ai L, Xu R, Sun Y, Stoeger T, Ding Z. Expression of Raf kinase inhibitor protein is downregulated in response to Newcastle disease virus infection to promote viral replication. Journal Of General Virology 2015, 96: 2579-2586. PMID: 26297355, DOI: 10.1099/jgv.0.000228.Peer-Reviewed Original ResearchConceptsRaf kinase inhibitory proteinNewcastle disease virus replicationNewcastle disease virusNewcastle disease virus infectionHost cellsAntiviral defence mechanismsRaf kinase inhibitor proteinExpression of Raf kinase inhibitor proteinPhysiological inhibitorActivation of Raf/MEK/ERKC-Raf kinaseKinase inhibitor proteinRKIP expressionInhibitor proteinInhibitory proteinExperimental upregulationSignaling pathwayNF-kB signalingControl of immune responsesDefence mechanismsVirus replicationDisease virusProteinPoultry industryViral replication