Paul Heerdt, PhD, MD
Professor of AnesthesiologyCards
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
About
Titles
Professor of Anesthesiology
Director of Applied Hemodynamics, Anesthesiology
Biography
Paul M. Heerdt is a Professor of Anesthesiology at Yale University School of Medicine. Dr. Heerdt earned his MD from the University of Tennessee in 1982 followed by a PhD in cardiovascular pharmacology in 1985. He completed his residency in anesthesiology at Massachusetts General Hospital in Boston and then a fellowship in cardiothoracic anesthesia at Washington University in St. Louis, MO.
Following clinical training, Dr. Heerdt remained on the faculty at Washington University for several years before moving to Cornell University in 1992. At Cornell, he was a faculty member in the departments of Anesthesiology and Pharmacology and also maintained an appointment at Memorial Sloan Kettering Center. In 2016 Dr. Heerdt moved to Yale where he has been conducting clinical and basic science research with a particular emphasis on developing collaborative opportunities for residents, fellows, and junior faculty. He serves on several committees within the Yale School of Medicine and lectures in the medical student pharmacology curriculum. Outside of Yale, Dr. Heerdt is active in the Society of Cardiovascular Anesthesiologists and a member of the editorial board for the Journal of Pharmacology and Experimental Therapeutics.
Appointments
Education & Training
- Resident
- Massachusetts General Hospital (1988)
- Fellow
- Washington University (1988)
- PhD
- University of Tennessee, Pharmacology (1985)
- Intern
- Blodgett Memorial Medical Center (1985)
- MD
- University of Tennessee College of Medicine (1982)
- BS
- Memphis State University (1978)
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1990
Research
Overview
Medical Research Interests
Public Health Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
Phillip Joseph, MD
Edward Manning, MD, PhD
George Tellides, MD, PhD
Naftali Kaminski, MD
Uma Reddy, MD, MPH
Cardiovascular Diseases
Publications
2024
Exercise Limitation in Pulmonary Hypertension - Physiological Insights into the Six-Minute Walk Test.
Kremer N, Schaefer S, Yogeswaran A, Rako Z, Ghofrani H, Seeger W, Kojonazarov B, Heerdt P, Tedford R, Tello K. Exercise Limitation in Pulmonary Hypertension - Physiological Insights into the Six-Minute Walk Test. American Journal Of Respiratory And Critical Care Medicine 2024 PMID: 39404674, DOI: 10.1164/rccm.202407-1397rl.Peer-Reviewed Original ResearchThe metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchAltmetricConceptsPeak VO<sub>2</sub>Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairmentNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original ResearchTime domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs
Keast T, Glass A, McCall P, Heerdt P, Shelley B. Time domain analysis of wave reflection in the pulmonary circulation after lung resection in pigs. British Journal Of Anaesthesia 2024, 132: 1009. DOI: 10.1016/j.bja.2024.01.027.Peer-Reviewed Original ResearchThree-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.Peer-Reviewed Original ResearchRight Ventriculoarterial Coupling During Positive End-expiratory Pressure Titration Based on a Pressure-based Single Beat Method: A Proof-of-Concept Study
Araos J, Owyang C, Martin-Flores M, Teran F, Kim J, Retamal Montes J, Notarianni A, Heerdt P. Right Ventriculoarterial Coupling During Positive End-expiratory Pressure Titration Based on a Pressure-based Single Beat Method: A Proof-of-Concept Study. 2024, a3477-a3477. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3477.Peer-Reviewed Original ResearchEssential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
McEvoy M, Heerdt P, Morton V, Bartz R, Miller T. Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative Medicine 2024, 13: 27. PMID: 38594738, PMCID: PMC11003027, DOI: 10.1186/s13741-024-00378-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRight heart physiologyPerioperative Quality InitiativePerioperative periodRight heartRight ventricular (RV) dysfunctionHeart physiologyRight-sided heart functionRight heart anatomyRight heart diseasePrevent subsequent morbidityRV dysfunctionPerioperative morbidityChronic health issuesHeart functionHeart diseasePerioperative careHeart anatomyPerioperative cliniciansMorbidityPatientsHealth issuesDysfunctionQuality InitiativePulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchAltmetricConceptsPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressure
2023
Optimization of lung ventilation and perfusion in anesthetized horses using a ventilation mode with flow-limited expiration.
Araos J, Driessen B, Brandly J, Gorenberg E, Heerdt P, Bruhn A, Martin-Flores M, Adler A, Hopster K. Optimization of lung ventilation and perfusion in anesthetized horses using a ventilation mode with flow-limited expiration. American Journal Of Veterinary Research 2023, 85: 1-8. PMID: 38113642, DOI: 10.2460/ajvr.23.09.0200.Peer-Reviewed Original ResearchCitationsAltmetricDifferential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalities
News
News
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
- September 16, 2021
Discoveries & Impact (September 2021)
- September 29, 2020
Yale Department of Anesthesiology 5th Annual Celebration of Research 2020