Paul Heerdt, PhD, MD
Professor of AnesthesiologyCards
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
Appointments
Additional Titles
Director of Applied Hemodynamics, Anesthesiology
Contact Info
About
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Titles
Professor of Anesthesiology
Director of Applied Hemodynamics, Anesthesiology
Biography
Paul M. Heerdt is a Professor of Anesthesiology at Yale University School of Medicine. Dr. Heerdt earned his MD from the University of Tennessee in 1982 followed by a PhD in cardiovascular pharmacology in 1985. He completed his residency in anesthesiology at Massachusetts General Hospital in Boston and then a fellowship in cardiothoracic anesthesia at Washington University in St. Louis, MO.
Following clinical training, Dr. Heerdt remained on the faculty at Washington University for several years before moving to Cornell University in 1992. At Cornell, he was a faculty member in the departments of Anesthesiology and Pharmacology and also maintained an appointment at Memorial Sloan Kettering Center. In 2016 Dr. Heerdt moved to Yale where he has been conducting clinical and basic science research with a particular emphasis on developing collaborative opportunities for residents, fellows, and junior faculty. He serves on several committees within the Yale School of Medicine and lectures in the medical student pharmacology curriculum. Outside of Yale, Dr. Heerdt is active in the Society of Cardiovascular Anesthesiologists and a member of the editorial board for the Journal of Pharmacology and Experimental Therapeutics.
Appointments
Education & Training
- Resident
- Massachusetts General Hospital (1988)
- Fellow
- Washington University (1988)
- PhD
- University of Tennessee, Pharmacology (1985)
- Intern
- Blodgett Memorial Medical Center (1985)
- MD
- University of Tennessee College of Medicine (1982)
- BS
- Memphis State University (1978)
Board Certifications
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 1990
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0002-9765-9885
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP, MD
Phillip Joseph, MD
Edward Manning, MD, PhD
George Tellides, MD, PhD
Naftali Kaminski, MD
Lissa Sugeng, MD, MPH
Cardiovascular Diseases
Publications
2026
Echocardiographic Correlates of Pressure-Volume-Derived Indices: Advancing Intraoperative Assessment of Right Ventricular Function
Kiarad V, Ahmed U, Heerdt P, Mahmood F, Moaddab M, Liu D, Senthilnathan V, Kai M, Chu L, Khabbaz K. Echocardiographic Correlates of Pressure-Volume-Derived Indices: Advancing Intraoperative Assessment of Right Ventricular Function. JTCVS Open 2026, 101712. DOI: 10.1016/j.xjon.2026.101712.Peer-Reviewed Original ResearchConceptsRV-PA couplingImpaired RV-PA couplingRV-PACardiac surgeryEchocardiographic measurementsEchocardiographic measures of right ventricular (RV) functionRight ventricular (RV) functionAssessment of right ventricular functionMeasures of right ventricular (RV) functionIntraoperative assessmentAdult cardiac surgery patientsPulmonary artery catheter monitoringRight ventricular functionCardiac surgery patientsIntraoperative three-dimensionalSTS risk scoreImpaired couplingProspective observational studySingle-beat methodMultivariate logistic regressionRV volumesTransesophageal echocardiographyVentricular functionEchocardiographic variablesPressure-volume analysis3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Kundu P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Hunter K, Singh I. 3D echo derived right ventricular principal surface strain in pulmonary arterial hypertension. AJP Heart And Circulatory Physiology 2026, 330: h729-h736. PMID: 41616802, DOI: 10.1152/ajpheart.00923.2025.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPulmonary arterial hypertension patientsPulmonary arterial hypertensionRV systolic functionRight heart catheterizationSystolic functionEchocardiographic representationArterial hypertensionControl patientsOptimal cutoffRight heartNew York Heart Association functional classRight ventricular (RV) functionTricuspid annular plane systolic excursionAnnular plane systolic excursionFunctional classLongitudinal systolic functionThirty-day outcomesSystolic excursionPAH patientsRV functionHeart catheterizationPrognostic valueThirty-dayHemodynamic criteriaRobust markersProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsProximal pulmonary arteriesPulmonary arterySmooth muscle cellsPerivascular macrophagesMouse modelMuscle cellsRight ventricle functionMedial smooth muscle cellsPulmonary arterial stiffeningRight ventricleVentricle functionAssociated with senescenceECM turnoverLung functionArterial stiffeningArteryAdventitial fibroblastsMolecular targetsAge-relatedGeroscience hypothesisLungAgeIntercellular signalingMiceMacrophagesRelationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic
Buber I, Heerdt P, Singh I, Phillip J, Sevgican C, Lamy J, Xiang J, Peters D. Relationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic. The International Journal Of Cardiovascular Imaging 2026, 1-9. PMID: 41484521, DOI: 10.1007/s10554-025-03589-2.Peer-Reviewed Original ResearchConceptsRight heart catheterizationPulmonary artery stiffnessPulse wave velocityRelative area changeCardiac magnetic resonancePulmonary hypertensionPost-capillaryRight heart catheterization measurementsDisease severityRight ventricular pressureBiomarkers associated with disease severityMixed venous saturationArterial stiffness markersPH subgroupsHeart catheterizationPH subtypesPulmonary arteryRetrospective studyNoninvasive markerProspective studyImpaired hemodynamicsVenous saturationHemodynamic parametersClinical utilityArterial stiffness
2025
Correction: Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
McEvoy M, Heerdt P, Morton V, Bartz R, Miller T. Correction: Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period. Perioperative Medicine 2025, 14: 134. PMID: 41316494, PMCID: PMC12664171, DOI: 10.1186/s13741-025-00608-7.Peer-Reviewed Original ResearchInteractions of Patent Ductus Arteriosus and Ventilation on Preterm Pulmonary Vascular Disease
Myers C, Heerdt P, Carlo W, Ambalavanan N, Gentle S. Interactions of Patent Ductus Arteriosus and Ventilation on Preterm Pulmonary Vascular Disease. Pediatric Pulmonology 2025, 60: e71382. PMID: 41221960, PMCID: PMC12606688, DOI: 10.1002/ppul.71382.Peer-Reviewed Original ResearchAltmetricDifferential biventricular responses to VA-ECMO flow ramping after cardiac arrest: establishment of a preclinical ECPR model with PV loop monitoring
Owyang C, Teran F, Landau A, Suh C, Satalin J, Lopez D, Searles B, Nejatollahi M, Kulthinee S, King A, Finkelstein R, Berlin D, Martin-Flores M, Heerdt P, Araos J. Differential biventricular responses to VA-ECMO flow ramping after cardiac arrest: establishment of a preclinical ECPR model with PV loop monitoring. Resuscitation Plus 2025, 26: 101153. PMID: 41341995, PMCID: PMC12670879, DOI: 10.1016/j.resplu.2025.101153.Peer-Reviewed Original ResearchConceptsMethod for generating right ventricular pressure-volume loops in routine practice
Kremer N, Glocker F, Schaefer S, Janetzko P, Yogeswaran A, Rako Z, Thal B, Hopf H, Seeger W, Ghofrani H, Heerdt P, Tello K. Method for generating right ventricular pressure-volume loops in routine practice. The Journal Of Heart And Lung Transplantation 2025, 45: 273-281. PMID: 40947078, DOI: 10.1016/j.healun.2025.09.002.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRoutine right heart catheterizationEnd-diastolic volumeConductance catheterizationEjection fractionFeasibility cohortStroke workRight ventricular pressure-volume loopsRight ventricular (RV) functionClinical cohortStroke volumeRight heart catheterizationBland-Altman analysisPreclinical cohortPV loopsEnd-systolic elastanceRV volumesHeart catheterizationPulmonary hypertensionVentricular pressure-volume loopsPressure-volume loopsRoutine clinical workflowCatheterizationGold standardClinical implementationArterial elastance“Right Ventricular Function and Echocardiographic Pressure-volume Loops”: There Is More to the Story
Heerdt P, Kariya T. “Right Ventricular Function and Echocardiographic Pressure-volume Loops”: There Is More to the Story. Journal Of Cardiothoracic And Vascular Anesthesia 2025, 39: 3642-3646. PMID: 41027797, DOI: 10.1053/j.jvca.2025.08.057.Peer-Reviewed Original ResearchEarly detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies?
Cho S, Jang S, Heerdt P, Thorn S, Sinusas A. Early detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies? Expert Review Of Respiratory Medicine 2025, 19: 899-901. PMID: 40462542, PMCID: PMC12354204, DOI: 10.1080/17476348.2025.2515993.Peer-Reviewed Original Research
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