Namrata Krishnan, MBBS
Associate Professor of Medicine (Nephrology)Cards
About
Research
Publications
2025
Biology of drug-induced acute nephrotoxicity: focus on the tubulointerstitium
Krishnan N, Perazella M. Biology of drug-induced acute nephrotoxicity: focus on the tubulointerstitium. Nephrology Dialysis Transplantation 2025, gfaf266. PMID: 41395877, DOI: 10.1093/ndt/gfaf266.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseKidney injuryMechanism of injuryTubulointerstitial injuryDrug exposureHigh indexHigh index of clinical suspicionDegree of drug exposureDrug-related toxic effectsCase of acute tubulointerstitial nephritisIndex of clinical suspicionSusceptibility to renal injuryRisk factorsMonitoring of kidney functionResponse to drug exposureAcute tubulointerstitial nephritisAcute tubular injuryAcute tubulointerstitial injuryChronic kidney injuryDrug-induced nephrotoxicityIndependent of doseClinical suspicionTubulointerstitial nephritisClinical characteristicsManagement of Acute Tubulointerstitial Nephritis
Krishnan N, Caravaca-Fontán F, Praga M. Management of Acute Tubulointerstitial Nephritis. Advances In Kidney Disease And Health 2025, 32: 373-381. PMID: 40947153, DOI: 10.1053/j.akdh.2025.03.002.Peer-Reviewed Original ResearchConceptsAcute tubulointerstitial nephritisAcute kidney injuryKidney injuryHigh indexEtiology of acute kidney injuryHigh index of suspicionDrug-induced hypersensitivitySystemic autoimmune conditionsIndex of suspicionImmune cell infiltrationPrompt treatment initiationIrreversible interstitial fibrosisAcute kidney diseaseRandomized Controlled TrialsImmunosuppressive therapyRenal prognosisUrinary findingsImmune-mediatedKidney biopsyDiagnostic challengeTreatment initiationTubulointerstitial nephritisTubular injuryAutoimmune conditionsCell infiltrationThrombotic Risks in Primary Membranous Nephropathy
Jobson C, Krishnan N. Thrombotic Risks in Primary Membranous Nephropathy. Kidney360 2025, 6: 886-888. PMCID: PMC12233839, DOI: 10.34067/kid.0000000807.Peer-Reviewed Original Research
2024
Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2022
Assessment of a hemodialysis E-curriculum in postgraduate nephrology education: A pilot mixed methods study.
Krishnan N, Brannan E, Hafler J, Brennan-Wydra E, Encandela J. Assessment of a hemodialysis E-curriculum in postgraduate nephrology education: A pilot mixed methods study. Clinical Nephrology 2022, 98: 247-255. PMID: 36149024, DOI: 10.5414/cn110778.Peer-Reviewed Original ResearchConceptsE-curriculumCurriculum completionSelf-motivated learnersAsynchronous e-learningKey competency areasSequential mixed-methods designOnline educational moduleMixed methods designMulti-institutional pilot studySelf-assessment sectionCurriculum assessmentLearning environmentCollaborative learningKinesthetic learnersLearners’ attitudesE-learningNephrology educationU.S. training programsE-moduleLearners' knowledgeActive learningLevel of knowledgeEducational moduleAnimated videoCompetency areasShould Corticosteroids Be Used to Treat Biopsy-Proven Drug-Induced Acute Interstitial Nephritis?: PRO
Donati A, Krishnan N. Should Corticosteroids Be Used to Treat Biopsy-Proven Drug-Induced Acute Interstitial Nephritis?: PRO. Kidney360 2022, 3: 1306-1309. PMID: 36176666, PMCID: PMC9416830, DOI: 10.34067/kid.0006642021.Peer-Reviewed Original ResearchUpdate on Renal Sympathetic Denervation for the Treatment of Hypertension
Rao A, Krishnan N. Update on Renal Sympathetic Denervation for the Treatment of Hypertension. Current Cardiology Reports 2022, 24: 1261-1271. PMID: 35895182, DOI: 10.1007/s11886-022-01753-x.Peer-Reviewed Original ResearchConceptsRenal sympathetic denervationTreatment of hypertensionRenal sympathetic nervesPathophysiology of hypertensionSympathetic denervationSympathetic nervesBlood pressureSafety of RSDRenal sympathetic nerve fibersAmbulatory blood pressure measurementsAntihypertensive drug useSham-controlled trialAdvanced kidney diseaseSympathetic nerve fibersLong-term efficacyPurpose of ReviewHypertensionBlood pressure measurementsExcellent safety profileModest treatment effectsLong-term safetyAntihypertensive medicationsAldosterone antagonistsCause mortalityNeurogenic controlResistant hypertension
2021
Pathogenesis and Treatment of Refractory Oedema in Nephrotic Syndrome
Jethwani P, Krishnan N. Pathogenesis and Treatment of Refractory Oedema in Nephrotic Syndrome. EMJ Urology 2021, 9: 107-117. DOI: 10.33590/emjurol/21-00041.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEffective arterial blood volumeNephrotic syndromeArterial blood volumeSodium retentionEdema formationLoop diureticsRefractory edemaClinical trialsBlood volumeSodium-potassium adenosine triphosphatase activityCombination diuretic therapySalt-poor albuminSecondary sodium retentionMainstay of therapySubset of patientsLarge clinical trialsSignificant patient morbidityVasopressin receptor antagonistsEpithelial sodium channel activationLimited available evidenceDiuretic resistanceDiuretic therapySodium channel activationTreatment algorithmInflammation contributesPost-Kidney Transplant Care and Health Outcomes of US Veterans
Krishnan N, Crowley ST. Post-Kidney Transplant Care and Health Outcomes of US Veterans. Clinical Journal Of The American Society Of Nephrology 2021, 16: 337-339. PMID: 33602754, PMCID: PMC8011009, DOI: 10.2215/cjn.00580121.Peer-Reviewed Original ResearchA hemodialysis curriculum for nephrology fellows using a blended learning approach: best of both worlds?
Krishnan N. A hemodialysis curriculum for nephrology fellows using a blended learning approach: best of both worlds? Journal Of Nephrology 2021, 34: 1697-1700. PMID: 33476037, PMCID: PMC7818058, DOI: 10.1007/s40620-020-00945-4.Peer-Reviewed Original ResearchConceptsBlended learning approachMedical educationLearning approachTraditional pedagogical methodsPost-test surveyBlended learningFlipped classroomBlended curriculumLearner engagementPedagogical methodsEffective learningCognitive learningCurriculumLearningKnowledge acquisitionOnline toolWeb-based toolFeedback featuresFellow trainingEducationMedicine house staffClinical workloadNephrology fellowsInstructive approachCOVID era