Michael Chen, MD
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Cardiovascular Medicine
Primary
Contact Info
Cardiovascular Medicine
789 Howard Avenue, PO Box 208017
New Haven, CT 06520-8017
United States
About
Titles
Assistant Professor of Medicine (Cardiovascular Medicine)
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
- Cardiovascular Medicine
- Heart Failure Program
- Heart Transplant and Left Ventricular Assist Device Program
- Internal Medicine
- Yale Medicine
Education & Training
- MD
- University of Michigan (2007)
- BA
- Harvard University, Biochemistry
- Residency
- New York University Medical Center
- Fellowship
- Mount Sinai Hospital
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Michael Chen's published research.
Publications Timeline
A big-picture view of Michael Chen's research output by year.
Pramod Bonde, MD, FACS
Tariq Ahmad, MD, MPH
Jeffrey Testani, MD, MTR
Lavanya Bellumkonda, MD
Forrester Lee, MD
F. Perry Wilson, MD, MSCE
12Publications
287Citations
Publications
2020
Blood Conservation Strategy at Time of Left Ventricular Assist Device Placement Improves Survival
Stawiarski K, Agboola O, Park J, Mangi A, Geirsson A, Lee F, Jacoby D, Bellumkonda L, Ahmad T, Chou J, Testani J, Chen M, McCloskey G, Bonde P. Blood Conservation Strategy at Time of Left Ventricular Assist Device Placement Improves Survival. The Journal Of Heart And Lung Transplantation 2020, 39: s151. DOI: 10.1016/j.healun.2020.01.1086.Peer-Reviewed Original ResearchConceptsVentricular assist device placementBlood conservationLeft ventricular assist device placementBCS groupDevice placementAnti-platelet useLarger ventricular sizeLiberal transfusion strategyStandardized transfusion protocolTime of LVADLength of hospitalBlood conservation strategiesUnits of PRBCsLiberal groupCirculatory support devicesDevice use ratesExcessive transfusionICU stayTransfusion protocolCommon complicationHeart failureLVAD patientsTransfusion strategyTransfusion triggerSingle centerThe Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative Period
Stawiarski K, Agboola O, Park J, Mangi A, Geirsson A, Bellumkonda L, Lee F, Chen M, Jacoby D, Chou J, Ahmad T, Testani J, McCloskey G, Bonde P. The Effects of Less Invasive Extra-Pericardial Placement of Left Ventricular Assist Devices on Right Ventricular Failure in the Early Postoperative Period. The Journal Of Heart And Lung Transplantation 2020, 39: s151-s152. DOI: 10.1016/j.healun.2020.01.1087.Peer-Reviewed Original ResearchCitationsConceptsRight ventricular failureVentricular failureMedian sternotomyLeft ventricular assist deviceBlood product useChest tube outputGiant cell myocarditisPoor surgical candidatesPulmonary vascular resistanceSingle-center experienceEarly postoperative periodStandard median sternotomyVentricular assist deviceMann-Whitney testIABP useINTERMACS profileMS implantationRVAD placementRVAD useLess transfusionRV dilationSurgical candidatesVascular resistanceAdverse eventsLVAD patients
2019
Improving Outcomes in INTERMACS 1 Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support
Mori M, McCloskey G, Geirsson A, Mangi AA, Yun JJ, Jacoby D, Ahmad T, Bellumkonda L, Lee F, Chen ME, Bonde P. Improving Outcomes in INTERMACS 1 Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support. ASAIO Journal 2019, Publish Ahead of Print: &na;. PMID: 30664019, DOI: 10.1097/mat.0000000000000908.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCategory 1 patientsECMO supportDurable LVADECMO groupDurable left ventricular assist device implantationVenous-arterial extracorporeal membrane oxygenationLeft ventricular assist device implantationVentricular assist device implantationCox proportional hazards analysisExtracorporeal membrane oxygenation supportECMO-supported patientsPost-LVAD survivalVenous-arterial ECMOOutcomes of patientsAssist device implantationEnd-organ functionMembrane oxygenation supportProportional hazards analysisExtracorporeal membrane oxygenationRisk of deathINTERMACS scaleInteragency RegistryOxygenation supportECMO patientsUnadjusted survivalLVAD Survival May Be Predicted by Preoperative Lymphopenia
Stawiarski K, Agboola O, Jacoby D, Bellumkonda L, Sugeng L, Ahmad T, Chen M, McCloskey G, Geirsson A, Anwar M, Bonde P. LVAD Survival May Be Predicted by Preoperative Lymphopenia. The Journal Of Heart And Lung Transplantation 2019, 38: s63-s64. DOI: 10.1016/j.healun.2019.01.142.Peer-Reviewed Original ResearchConceptsAbsolute lymphocyte countCause mortalityLVAD patientsImmune modulator therapyImpact of lymphopeniaImportant prognostic indicatorCells/μL.Kaplan-Meir plotsLog-rank statisticsPhysiologic stress responseLVAD survivalPreoperative lymphopeniaSplanchnic congestionCox modellingLymphocyte countLymphocyte levelsLymphopenic patientsUnadjusted survivalWorse survivalHeart failurePrognostic roleSerum sodiumSingle centerPatient groupLVAD therapyChloride Homeostasis in End Stage Heart Failure and LVAD Recipients
Stawiarski K, Agboola O, Jacoby D, Bellumkonda L, Ahmad T, Sugeng L, Chen M, McCloskey G, Geirsson A, Anwar M, Bonde P. Chloride Homeostasis in End Stage Heart Failure and LVAD Recipients. The Journal Of Heart And Lung Transplantation 2019, 38: s382-s383. DOI: 10.1016/j.healun.2019.01.974.Peer-Reviewed Original ResearchConceptsSerum chloride levelsChloride homeostasisLVAD patientsHeart failureLVAD therapyEnd-stage heart failureCardio-renal axisChronic heart failureStage heart failureChloride levelsLong-term survivalKaplan-Meir plotsLog-rank statisticsL riseCause mortalityLVAD recipientsWorse survivalSingle centerNeurohormonal responsesPrognostic implicationsPrognostic valueLVAD implantsRetrospective analysisGroup ACox model
2018
(787) Gender and Diastolic Dysfunction May be the Driver of Failure of Myocardial Recovery Following LVAD Implantation
Stawiarski K, Zogg C, Park J, Jacoby D, Bellumkonda L, Chen M, Ahmad T, Testani J, McCloskey G, Sugeng L, Bonde P. (787) Gender and Diastolic Dysfunction May be the Driver of Failure of Myocardial Recovery Following LVAD Implantation. The Journal Of Heart And Lung Transplantation 2018, 37: s311. DOI: 10.1016/j.healun.2018.01.790.Peer-Reviewed Original ResearchPREVALENCE AND PREDICTORS OF DECISION REGRET IN LEFT VENTRICULAR ASSIST DEVICE PATIENTS
Sciria C, Jacoby D, Bonde P, Lee F, Ahmad T, Testani J, Chen M. PREVALENCE AND PREDICTORS OF DECISION REGRET IN LEFT VENTRICULAR ASSIST DEVICE PATIENTS. Journal Of The American College Of Cardiology 2018, 71: a971. DOI: 10.1016/s0735-1097(18)31512-2.Peer-Reviewed Original Research
2017
Inflammation and cardio‐renal interactions in heart failure: a potential role for interleukin‐6
Hanberg JS, Rao VS, Ahmad T, Chunara Z, Mahoney D, Jackson K, Jacoby D, Chen M, Wilson FP, Tang WHW, Kakkar R, Testani JM. Inflammation and cardio‐renal interactions in heart failure: a potential role for interleukin‐6. European Journal Of Heart Failure 2017, 20: 933-934. PMID: 29024287, PMCID: PMC5895540, DOI: 10.1002/ejhf.963.Peer-Reviewed Original ResearchCitationsAltmetricPlasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support
Wang T, O’Brien E, Rogers JG, Jacoby DL, Chen ME, Testani JM, Bowles DE, Milano CA, Felker GM, Patel CB, Bonde PN, Ahmad T. Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support. ASAIO Journal 2017, 63: 536-541. PMID: 28319523, PMCID: PMC5585122, DOI: 10.1097/mat.0000000000000564.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLVAD supportHeart failureMechanically Assisted Circulatory Support level 1Continuous-flow LVAD implantationLong-term LVAD supportMiR-155Ventricular assist device therapyMicroRNA-155Ventricular assist device supportPost-LVAD placementAdverse clinical outcomesAssist device supportPlasma expression levelsSupport level 1Real-time polymerase chain reactionQuantitative real-time polymerase chain reactionRelative quantification valuesContinuous blood flowWilcoxon signed-rank testMultiple biologic processesLVAD physiologyMeasurement of miRNAsInteragency RegistryLVAD implantationHF pathogenesisCompensatory Distal Reabsorption Drives Diuretic Resistance in Human Heart Failure
Rao VS, Planavsky N, Hanberg JS, Ahmad T, Brisco-Bacik MA, Wilson FP, Jacoby D, Chen M, Tang WHW, Cherney DZI, Ellison DH, Testani JM. Compensatory Distal Reabsorption Drives Diuretic Resistance in Human Heart Failure. Journal Of The American Society Of Nephrology 2017, 28: 3414-3424. PMID: 28739647, PMCID: PMC5661276, DOI: 10.1681/asn.2016111178.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDiuretic resistanceHeart failureLoop diureticsSodium reabsorptionHigh-dose loop diureticsDistal tubular sodium reabsorptionSodium exitLoop diuretic administrationTubular sodium reabsorptionHuman heart failureFurosemide equivalentsDistal reabsorptionConsecutive patientsFractional excretionSodium handlingDiuretic administrationProximal tubularControl cohortCare centerTreatment strategiesAnimal modelsDiureticsNet sodiumFENaTubular location
Clinical Care
Overview
Michael Chen, MD, is a cardiovascular medicine specialist focusing on heart failure. He utilizes therapies, including cardiac contractility modulation and cardiac resynchronization therapy, designed to enhance the quality of life for heart failure patients and augment the heart's functionality.
Dr. Chen's research interests include improving heart function using devices such as left ventricular assist devices (LVADs), as well as developing less invasive methods for their placement and understanding their impact on other heart components. Additionally, he investigates heart failure management using treatments like hypertonic saline and drug therapies such as tofacitinib.
Dr. Chen is an assistant professor of medicine at Yale University School of Medicine.
Clinical Specialties
Heart Failure; Cardiovascular Medicine
Fact Sheets
Ventricular Assist Device (VAD)
Learn More on Yale MedicineCongestive Heart Failure (CHF)
Learn More on Yale MedicineHeart Failure Surgery
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Cardiovascular Medicine
789 Howard Avenue, PO Box 208017
New Haven, CT 06520-8017
United States
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