Mean Ghim, PhD
Associate Research ScientistCards
About
Research
Publications
2026
Molecular Imaging of Collagen Turnover in Myocardial Infarction
Neishabouri A, Ghim M, Varli O, Ahmad A, Kukreja G, Zhang Z, Li J, Toczek J, Salarian M, Gona K, Hedayatyanfard K, Zhang J, Alshaeba D, Akar F, Liu C, Huang H, Yu S, Sadeghi M. Molecular Imaging of Collagen Turnover in Myocardial Infarction. Journal Of Nuclear Medicine 2026, 67: jnumed.125.271721. PMID: 41887734, PMCID: PMC13224913, DOI: 10.2967/jnumed.125.271721.Peer-Reviewed Original Research
2025
Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ahmad A, Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original Research
2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchDisturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway
Rickman M, Ghim M, Pang K, von Huelsen Rocha A, Drudi E, Sureda-Vives M, Ayoub N, Tajadura-Ortega V, George S, Weinberg P, Warboys C. Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal Of Cell Science 2023, 136: jcs260449. PMID: 36846872, PMCID: PMC10112981, DOI: 10.1242/jcs.260449.Peer-Reviewed Original ResearchHomeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity
Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J, Kukreja G, Zhang J, Lakheram D, Kim S, Humphrey J, Sadeghi M. Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. Circulation Research 2023, 132: 432-448. PMID: 36691905, PMCID: PMC9930896, DOI: 10.1161/circresaha.122.322096.Peer-Reviewed Original ResearchPositron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm
Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.Peer-Reviewed Original Research
2022
Shear-mediated ALK5 expression regulates endothelial activation
Pang K, Ghim M, Sarathchandra P, Warboys C, Yacoub M, Chester A, Weinberg P. Shear-mediated ALK5 expression regulates endothelial activation. Biochemical And Biophysical Research Communications 2022, 642: 90-96. PMID: 36566567, DOI: 10.1016/j.bbrc.2022.12.058.Peer-Reviewed Original ResearchNO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium
Ghim M, Yang S, David K, Eustaquio J, Warboys C, Weinberg P. NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium. International Journal Of Molecular Sciences 2022, 23: 8076. PMID: 35897652, PMCID: PMC9332325, DOI: 10.3390/ijms23158076.Peer-Reviewed Original ResearchDifferential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification
Jung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.Peer-Reviewed Original Research
2021
Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation
Ghim M, Pang K, Burnap S, Baig F, Yin X, Arshad M, Mayr M, Weinberg P. Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation. Atherosclerosis 2021, 333: 56-66. PMID: 34425528, PMCID: PMC8459397, DOI: 10.1016/j.atherosclerosis.2021.08.025.Peer-Reviewed Original Research
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