Jie Li
Financial Analyst 2, YSM FinanceCards
About
Research
Publications
Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study
Tian X, Liu X, Bai F, Li M, Qiu Y, Jiao Q, Li J, Zhang X. Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study. Brain And Behavior 2024, 14: e3578. PMID: 38844426, PMCID: PMC11156525, DOI: 10.1002/brb3.3578.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleFEDN MDD patientsMDD patientsSuicide attemptsSex differencesDepressive disorderFirst-episodeFactors associated with suicide attemptsRisk of suicide attemptNegative Syndrome ScaleMajor depressive disorderHamilton Depression Scale scoresHamilton Anxiety Scale scoresThyroid peroxidase antibodySubclinical hypothyroidismIncreased suicide attemptsInvestigate sex differencesSignificant sex differencesSyndrome ScalePositive subscaleIncreased riskAnxiety ScaleFEDNSex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study
Luo G, Wang S, Gou L, Li C, Yao C, Jing Y, Xuekelaiti Z, Li J, Zhang X. Sex differences and risk factors of self-reported suicide attempts in middle-aged Chinese Han patients with first-episode drug-naïve anxious depression: a large-scale cross-sectional study. Journal Of Neural Transmission 2024, 1-12. PMID: 38743092, DOI: 10.1007/s00702-024-02779-x.Peer-Reviewed Original ResearchFirst-episode drug-naiveSelf-reported suicide attemptsAnxious depressionSuicide attemptsSex differencesHamilton Anxiety Rating Scale scoresAnxiety Rating Scale scoresClinical characteristics of suicide attemptersCharacteristics of suicide attemptersMajor depressive disorderNon-suicide attemptersSelf-reported suicidalityAD patientsRating Scale scoresInvestigate sex differencesMale AD patientsDepressive disorderDrug-naiveClinical psychiatristsSevere anxietySex-specific risk factorsMiddle-aged patientsDepressionThyroid peroxidase antibodyScale scoreTargeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia
Yan H, Li G, Zhang X, Zhang C, Li M, Qiu Y, Sun W, Dong Y, Li S, Li J. Targeted metabolomics-based understanding of the sleep disturbances in drug-naïve patients with schizophrenia. BMC Psychiatry 2024, 24: 355. PMID: 38741058, PMCID: PMC11089724, DOI: 10.1186/s12888-024-05805-0.Peer-Reviewed Original ResearchConceptsPositive and Negative Symptom ScaleDrug-naive patientsLiquid chromatography-mass spectrometryDrug-naive schizophreniaAssociated with sleep disturbancesOrthogonal partial least squares discriminant analysisSleep disturbancePittsburgh Sleep Quality IndexPartial least-squares discriminant analysisMetabolomics-based approachNegative Symptom ScaleChromatography-mass spectrometryCharacteristic metabolitesSchizophreniaSymptom ScaleMethodsPlasma samplesPotential biological mechanismsSleep Quality IndexClinical symptomsGlycerophospholipid metabolismPartial correlation analysisHealthy controlsMetabolomic analysisPatientsBackgroundSleep disturbanceThe influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity
Luo G, Jing Y, Yang J, Wang S, Xuekelaiti Z, Yao C, Gao Y, Chen H, Sun D, Li J, Zhang X. The influence of gender-specific factors influencing severe anxiety in psychotic major depression: role of thyroid hormones and depression severity. Journal Of Neural Transmission 2024, 131: 833-845. PMID: 38693463, DOI: 10.1007/s00702-024-02781-3.Peer-Reviewed Original ResearchHamilton Depression Rating ScalePositive and Negative Syndrome ScaleHamilton Depression Rating Scale scoresClinical Global Impressions-SeverityHamilton Anxiety Rating ScaleDepression severitySevere anxietyMDD patientsMajor depressionPMD patientsNon-psychotic MDD patientsRating ScaleThyroid-stimulating hormoneNegative Syndrome ScalePsychotic major depressionDepression Rating ScaleThyroid-stimulating hormone levelsAnxiety Rating ScaleIncreased depression severityAssociated with anxietyNo significant gender differencesSyndrome ScalePrevalence of severe anxietyPsychotic symptomsDepressive disorderThe association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review
Zhang Y, Yue W, Li J. The association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review. BMC Psychiatry 2024, 24: 274. PMID: 38609904, PMCID: PMC11010372, DOI: 10.1186/s12888-024-05717-z.Peer-Reviewed Original ResearchConceptsFKBP5 gene polymorphismsAntidepressant treatmentGene polymorphismsResponse to antidepressant treatmentAntidepressant drug treatmentGenetic susceptibilityAffective disordersAssociated with adverse reactionsDepressionTreatment strategiesAdverse reactionsFKBP5Drug treatmentTreatment sensitivityMethodsElectronic databasesGenetic disordersRs1360780Epigenetic changesReplication studySystematic reviewModerate qualityStudy characteristicsTreatmentData extractionDisordersAssociation between peripheral plasma cytokine levels and suicidal ideation in first-episode, drug-naïve major depressive disorder
Tian X, Dong Y, Yuan J, Gao Y, Zhang C, Li M, Li J. Association between peripheral plasma cytokine levels and suicidal ideation in first-episode, drug-naïve major depressive disorder. Psychoneuroendocrinology 2024, 165: 107042. PMID: 38613945, DOI: 10.1016/j.psyneuen.2024.107042.Peer-Reviewed Original ResearchBeck Scale for Suicide Ideation-Chinese VersionChildhood Trauma QuestionnaireSuicidal ideationMDD patientsDepressive disorderFirst-episode drug-naive MDD patientsHamilton Depression Rating Scale-17Drug-naive MDD patientsIL-2 levelsMajor depressive disorderIL-2Plasma levelsIL-10HAMD-17First-episodeChildhood traumaTrauma QuestionnaireIL-8IL-6Plasma IL-2 levelsSuicide riskPlasma levels of cytokinesHAMA-14Stratified analysisIdeationGhrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis
Zhang C, Dong Y, Li S, Li M, Gao Y, Liu Y, Liu X, Zhou C, Li J. Ghrelin and depressive symptoms in patients with first‐episode drug‐naïve major depressive disorder: The mediating role of hypothalamic‐pituitary‐adrenal axis. Asia-Pacific Psychiatry 2024, 16: e12552. PMID: 38348641, DOI: 10.1111/appy.12552.Peer-Reviewed Original ResearchConceptsFirst-episode drug-naive MDD patientsMajor depressive disorderHAMD total scoreDrug-naive MDD patientsMDD patientsDepressive symptomsCorticotropin-releasing-hormoneTotal scoreDepressive disorderPathogenesis of major depressive disorderMeasures of depressive symptomsHealthy controlsHypothalamic-pituitary-adrenal axisHamilton Depression ScaleBody mass indexAdrenocorticotropic hormoneHAMD-17Plasma levels of ghrelinGhrelin levelsMediation analysisHAMDPartial correlation analysisDepression ScaleCortisol levelsLevels of ghrelinThe relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study
Luo G, Bai F, Qu X, Jing Y, Wang S, Xuekelaiti Z, Yao C, Li M, Li J. The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study. Journal Of Neural Transmission 2024, 131: 385-391. PMID: 38277043, DOI: 10.1007/s00702-024-02748-4.Peer-Reviewed Original ResearchSerum prolactin levelsSchizophrenia patientsCognitive functionProlactin levelsCognitive deficitsHealthy controlsPatients serum prolactin levelsConsensus Cognitive BatterySignificant cognitive deficitsSevere cognitive deficitsCognitive batteryTreatment researchPsychiatric symptomsSchizophreniaCognitionMCCBDeficitsCross-sectional studyProlactinClinical symptomsClinical dataClinical severitySymptomsPatientsSymptomatologyEmerging Roles of Cullin-RING Ubiquitin Ligases in Cardiac Development
Zambrano-Carrasco J, Zou J, Wang W, Sun X, Li J, Su H. Emerging Roles of Cullin-RING Ubiquitin Ligases in Cardiac Development. Cells 2024, 13: 235. PMID: 38334627, PMCID: PMC10854628, DOI: 10.3390/cells13030235.Peer-Reviewed Original ResearchConceptsUbiquitin ligaseFamily of ubiquitin ligasesCullin-RING ubiquitin ligasesE3 ubiquitin ligaseRegulation of heart developmentPost-translational mechanismsHeart developmentRegulation of cardiac morphogenesisCongenital heart diseaseCardiac developmental processesSpatiotemporally regulated processCullin-RINGDevelopment of innovative therapiesEpigenetic regulationIntracellular proteinsLigaseMolecular mechanismsDevelopmental processesHeart failureInnovative therapiesCardiac developmentCardiac morphogenesisPostnatal stagesHeart diseaseOrchestrated processPlasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder
Liu Y, Zhang B, Zhou Y, Li M, Gao Y, Qin W, Xie Y, Liu W, Jing Y, Li J. Plasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder. Psychiatry Research 2024, 333: 115742. PMID: 38232568, DOI: 10.1016/j.psychres.2024.115742.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMajor depressive disorder patientsAmplitude of low-frequency fluctuationDepressive disorderSuicidal ideationWhole-brain functional connectivity analysisMDD pathophysiologyDrug-naive MDD patientsResting-state fMRI scansAmplitude of low-frequency fluctuation valuesFunctional brain abnormalitiesAnterior cingulate gyrusSuperior frontal gyrusFunctional connectivity analysisOxidative stress markersAbnormal brain functionLow-frequency fluctuationsPlasma oxidative stress markersMDD patientsFrontal gyrusFMRI scanningFirst-episodeCingulate gyrusBrain regionsConnectivity analysis