Jiasheng Zhang, MD
Senior Research Scientist (Cardiovascular Medicine)DownloadHi-Res Photo
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Cardiovascular Medicine
Primary
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Cardiovascular Medicine
300 George Street, 770E
New Haven, CT 06511
United States
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Titles
Senior Research Scientist (Cardiovascular Medicine)
Biography
Dr. Zhang received his education, major in clinical medicine in Bengbu medical college. After five years of residency training, he became an attending physician in 1998. After three years of microsurgery training, he received MS degree at Fudan University in 2001. His research interest focuses on disease models and novel molecular imaging biomarkers.
Last Updated on July 24, 2025.
Appointments
Cardiovascular Medicine
Senior Research ScientistPrimary
Other Departments & Organizations
Education & Training
- MS
- Fudan University, microsurgery (2001)
- MD
- Bengbu Medical College (1993)
Research
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Overview
- In vivo disease models and physiological measurement test
- Molecular imaging
- Surgical instrument and equipment
ORCID
0000-0002-4637-5655
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jiasheng Zhang's published research.
Publications Timeline
A big-picture view of Jiasheng Zhang's research output by year.
Mehran M Sadeghi, MD
Martin Schwartz, PhD
Gunjan Kukreja, PhD, MSc
Mean Ghim, PhD
Michael Simons, MD, FACC, FAHA
Lawrence Young, MD
59Publications
2,748Citations
Publications
2026
Metabolic control of smooth muscle cell phenotype switching in atherosclerosis
Zhang R, Bae H, Zhang J, Li Y, Chen P, Shen Y, Tellides G, Snyder N, Jang C, Schwartz M, Arany Z, Simons M. Metabolic control of smooth muscle cell phenotype switching in atherosclerosis. Science Advances 2026, 12: eaef6065. PMID: 42647644, PMCID: PMC13510649, DOI: 10.1126/sciadv.aef6065.Peer-Reviewed Original ResearchAltmetricA signal sequence multi-leucine motif regulates VEGF receptor signaling
Ghim M, Wei L, Jung J, The E, Kukreja G, Neishabouri A, Golbazi A, Hedayatyanfard K, Nie L, Zhang Z, Wang L, Zhang J, Sadeghi M. A signal sequence multi-leucine motif regulates VEGF receptor signaling. Journal Of Biological Chemistry 2026, 302: 113406. PMID: 42567520, PMCID: PMC13570295, DOI: 10.1016/j.jbc.2026.113406.Peer-Reviewed Original ResearchThe atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress
Douglas T, Nie P, Zhang J, Abdallah K, Wu Z, McReynolds M, Iwai K, Peng J, Gilbert W, Young L, Crews C. The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress. Nature Cell Biology 2026, 28: 930-945. PMID: 42062483, PMCID: PMC13179138, DOI: 10.1038/s41556-026-01936-6.Peer-Reviewed Original ResearchCitationsAltmetricMolecular Imaging of Collagen Turnover in Myocardial Infarction
Neishabouri A, Ghim M, Varli O, Kukreja G, Zhang Z, Li J, Toczek J, Salarian M, Gona K, Hedayatyanfard K, Zhang J, Alshaeba D, Akar F, Liu C, Huang H, Yu S, Sadeghi M. Molecular Imaging of Collagen Turnover in Myocardial Infarction. Journal Of Nuclear Medicine 2026, 67: jnumed.125.271721. PMID: 41887734, PMCID: PMC13224913, DOI: 10.2967/jnumed.125.271721.Peer-Reviewed Original ResearchAltmetric
2025
Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original ResearchCitationsAltmetric
2024
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts
Goedeke L, Ma Y, Gaspar R, Nasiri A, Lee J, Zhang D, Galsgaard K, Hu X, Zhang J, Guerrera N, Li X, LaMoia T, Hubbard B, Haedersdal S, Wu X, Stack J, Dufour S, Butrico G, Kahn M, Perry R, Cline G, Young L, Shulman G. SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. Journal Of Clinical Investigation 2024, 134: e176708. PMID: 39680452, PMCID: PMC11645152, DOI: 10.1172/jci176708.Peer-Reviewed Original ResearchCitationsAltmetricA KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling
Zhang J, Wang Y, Joshi D, Pi X, De Val S, Schwartz M. A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling. Nature Cardiovascular Research 2024, 3: 785-798. PMID: 39196179, PMCID: PMC12306366, DOI: 10.1038/s44161-024-00496-y.Peer-Reviewed Original ResearchCitationsAltmetricDynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice
Gamez-Mendez A, Fowler J, Zhang H, Esplugues E, Kuo A, Zhang J, Citrin K, Singh A, Lee M, Suarez Y, Fernandez-Hernando C, Sessa W. Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice. Journal Of Clinical Investigation 2024, 134: e170453. PMID: 38175710, PMCID: PMC10866653, DOI: 10.1172/jci170453.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchCitationsAltmetricHigh-resolution visualization of pial surface vessels by flattened whole mount staining
Xu Y, Zhang J, Zhang G, Bai Y, Simons M. High-resolution visualization of pial surface vessels by flattened whole mount staining. IScience 2023, 26: 106467. PMID: 37020957, PMCID: PMC10067958, DOI: 10.1016/j.isci.2023.106467.Peer-Reviewed Original ResearchCitations
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Cardiovascular Medicine
300 George Street, 770E
New Haven, CT 06511
United States
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300 George Street
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Ste 770E
New Haven, CT 06511