Jiasheng Zhang, MD
Senior Research Scientist (Cardiovascular Medicine)DownloadHi-Res Photo
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Cardiovascular Medicine
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Cardiovascular Medicine
300 George Street, 770E
New Haven, CT 06511
United States
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Titles
Senior Research Scientist (Cardiovascular Medicine)
Biography
Dr. Zhang received his education, major in clinical medicine in Bengbu medical college. After five years of residency training, he became an attending physician in 1998. After three years of microsurgery training, he received MS degree at Fudan University in 2001. His research interest focuses on disease models and novel molecular imaging biomarkers.
Last Updated on July 24, 2025.
Appointments
Cardiovascular Medicine
Senior Research ScientistPrimary
Other Departments & Organizations
Education & Training
- MS
- Fudan University, microsurgery (2001)
- MD
- Bengbu Medical College (1993)
Research
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Overview
- In vivo disease models and physiological measurement test
- Molecular imaging
- Surgical instrument and equipment
ORCID
0000-0002-4637-5655
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jiasheng Zhang's published research.
Publications Timeline
A big-picture view of Jiasheng Zhang's research output by year.
Mehran M Sadeghi, MD
Martin Schwartz, PhD
Michael Simons, MD, FACC, FAHA
Gunjan Kukreja, PhD, MSc
Mean Ghim, PhD
Lawrence Young, MD
59Publications
2,684Citations
Publications
2026
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress
Douglas T, Nie P, Zhang J, Abdallah K, Wu Z, McReynolds M, Iwai K, Peng J, Gilbert W, Young L, Crews C. The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress. Nature Cell Biology 2026, 28: 930-945. PMID: 42062483, PMCID: PMC13179138, DOI: 10.1038/s41556-026-01936-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHOIL-1Cellular stressRibosome-associated quality controlE3 ligase HOIL-1Cell fate decisionsCellular glucose levelsMutation associated with dilated cardiomyopathyRibosome ubiquitinationGlucose starvationSignaling hubFate decisionsSignaling networksRibotoxic stressCell fateNutrient stressTranslational stressRibosomeATF4 activationDiverse signalsCell deathCystine-glutamate antiporter xCTMolecular circuitsSensitive cellsMetabolic perturbationsCoordinated responsePO-CES-05 ROLE OF SYNDECAN-2 MEDIATED VASCULAR PERMEABILITY IN THE PATHOGENESIS OF POST-MI ARRHYTHMIAS
Velasco J, Corti F, Cacheux M, Granger J, Zhang J, Zhuang Z, Perrotta P, Simons M, Akar F. PO-CES-05 ROLE OF SYNDECAN-2 MEDIATED VASCULAR PERMEABILITY IN THE PATHOGENESIS OF POST-MI ARRHYTHMIAS. Heart Rhythm 2026, 23: s867. DOI: 10.1016/j.hrthm.2026.03.1519.Peer-Reviewed Original ResearchPO-04-218 ROLE OF SYNDECAN-2 MEDIATED VASCULAR PERMEABILITY IN THE PATHOGENESIS OF POST-MI ARRHYTHMIAS
Velasco J, Corti F, Cacheux M, Granger J, Zhang J, Zhuang Z, Perrotta P, Simons M, Akar F. PO-04-218 ROLE OF SYNDECAN-2 MEDIATED VASCULAR PERMEABILITY IN THE PATHOGENESIS OF POST-MI ARRHYTHMIAS. Heart Rhythm 2026, 23: s725. DOI: 10.1016/j.hrthm.2026.03.1216.Peer-Reviewed Original ResearchMolecular Imaging of Collagen Turnover in Myocardial Infarction
Neishabouri A, Ghim M, Varli O, Ahmad A, Kukreja G, Zhang Z, Li J, Toczek J, Salarian M, Gona K, Hedayatyanfard K, Zhang J, Alshaeba D, Akar F, Liu C, Huang H, Yu S, Sadeghi M. Molecular Imaging of Collagen Turnover in Myocardial Infarction. Journal Of Nuclear Medicine 2026, 67: jnumed.125.271721. PMID: 41887734, PMCID: PMC13224913, DOI: 10.2967/jnumed.125.271721.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTracer uptakeMyocardial infarctionInfarct zoneCardiac fibrosisLeft anterior descending arteryContrast-enhanced CTManagement of cardiomyopathyCollagen turnoverCardiac tissueBiomarkers of collagen turnoverPersonalized managementNoninvasive detectionMyocardial perfusion imagingEx vivo autoradiographyAnterior descending arteryMolecular imagingHuman cardiac tissueControl tracerCardiac uptakeSPECT/CT imagingAntifibrotic treatmentSham surgeryFibrotic changesDescending arteryPerfusion imaging
2025
Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ahmad A, Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPulmonary fibrosisTracer uptakeLung uptakeMurine model of pulmonary fibrosisModel of pulmonary fibrosisMice 3 wkEffect of antifibrotic therapyCollagen turnoverInterstitial lung diseaseClinical diagnostic methodsSPECT/CT imagingHybrid tracersLung histologyAntifibrotic therapyControl miceDisease activityMurine modelLung diseaseMice 8Tissue fibrosisPatient managementLiver uptakeSPECT/CTFibrosisSPECT images
2024
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts
Goedeke L, Ma Y, Gaspar R, Nasiri A, Lee J, Zhang D, Galsgaard K, Hu X, Zhang J, Guerrera N, Li X, LaMoia T, Hubbard B, Haedersdal S, Wu X, Stack J, Dufour S, Butrico G, Kahn M, Perry R, Cline G, Young L, Shulman G. SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. Journal Of Clinical Investigation 2024, 134: e176708. PMID: 39680452, PMCID: PMC11645152, DOI: 10.1172/jci176708.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSodium-glucose cotransporter type 2Heart failureKetone oxidationGas chromatography-mass spectrometryFatty acid oxidationLeft ventricular ejection fractionReduced myocardial oxidative stressVentricular ejection fractionKetone supplementationWeeks of treatmentMyocardial oxidative stressDecreased pyruvate oxidationInduce heart failurePlasma glucose levelsIn vivo effectsSGLT2i treatmentEjection fractionAssociated with improvementsAwake ratsSGLT2 inhibitionCardioprotective benefitsLiquid chromatography-tandem mass spectrometryPlasma ketonesRates of ketonizationChromatography-tandem mass spectrometryA KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling
Deng H, Zhang J, Wang Y, Joshi D, Pi X, De Val S, Schwartz M. A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling. Nature Cardiovascular Research 2024, 3: 785-798. PMID: 39196179, PMCID: PMC12306366, DOI: 10.1038/s44161-024-00496-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFluid shear stressVascular remodelingOutward remodelingBone morphogenetic proteinShear stressMouse models of type 1Ischemic diseasesModels of type 1BMP-binding endothelial regulatorBlood flow recoveryType 2 diabetesPhysiological fluid shear stressPotential therapeutic approachBlocking antibodiesMouse modelSmad1/5 activationArterial remodelingTherapeutic approachesType 1Akt activationBlood flowEndothelial regulationSmad1/5Flow recoveryMorphogenetic proteinsDynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice
Boutagy N, Gamez-Mendez A, Fowler J, Zhang H, Chaube B, Esplugues E, Kuo A, Lee S, Horikami D, Zhang J, Citrin K, Singh A, Coon B, Lee M, Suarez Y, Fernandez-Hernando C, Sessa W. Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice. Journal Of Clinical Investigation 2024, 134: e170453. PMID: 38175710, PMCID: PMC10866653, DOI: 10.1172/jci170453.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imagingHigh-resolution visualization of pial surface vessels by flattened whole mount staining
Xu Y, Zhang J, Lee H, Zhang G, Bai Y, Simons M. High-resolution visualization of pial surface vessels by flattened whole mount staining. IScience 2023, 26: 106467. PMID: 37020957, PMCID: PMC10067958, DOI: 10.1016/j.isci.2023.106467.Peer-Reviewed Original ResearchCitationsConceptsBlood vesselsCerebral vasculatureWhole cerebral cortexCerebral blood vesselsParticular blood vesselCentral nervous system researchCLARITY technologyCerebral cortexStroke settingsCerebral vesselsWhole-mount techniqueDisease settingsEndothelial proliferationNervous system researchPostnatal developmentTherapeutic developmentWhole-mount stainingVasculatureVesselsMount stainingMount techniqueConfocal imagingNormal developmentHigh-resolution visualizationImaging
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Cardiovascular Medicine
300 George Street, 770E
New Haven, CT 06511
United States
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300 George Street
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Ste 770E
New Haven, CT 06511