Marek Chawarski, PhD
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Appointments
Psychiatry
Fully Joint
Emergency Medicine
Fully Joint
Titles
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Psychiatry
CMHC/SAC, 34 Park Street
New Haven, CT 06519
United States
Appointments
Psychiatry
Fully Joint
Emergency Medicine
Fully Joint
Titles
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Psychiatry
CMHC/SAC, 34 Park Street
New Haven, CT 06519
United States
Appointments
Psychiatry
Fully Joint
Emergency Medicine
Fully Joint
Titles
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Psychiatry
CMHC/SAC, 34 Park Street
New Haven, CT 06519
United States
About
Titles
Professor of Psychiatry and Emergency Medicine
Affiliated Faculty, Yale Institute for Global HealthAppointments
Psychiatry
ProfessorFully JointEmergency Medicine
ProfessorFully Joint
Other Departments & Organizations
Education & Training
- PhD
- Yale University (1995)
- MPhil
- Yale University, Psychology (1993)
- MS
- Yale University, Psychology/Cognitive (1992)
- MA
- Jagiellonian University, Psychology/Clinical, Cognitive (1987)
Research
Overview
Medical Subject Headings (MeSH)
Amphetamine-Related Disorders; China; Indonesia; Iran; Malaysia; Opioid-Related Disorders; Psychiatry; Risk-Taking; Russia; Substance Abuse Detection; Taiwan
ORCID
0000-0001-6254-3092
Research at a Glance
Yale Co-Authors
Frequent collaborators of Marek Chawarski's published research.
Publications Timeline
A big-picture view of Marek Chawarski's research output by year.
Research Interests
Research topics Marek Chawarski is interested in exploring.
Patrick G. O'Connor, MD, MPH, MACP
Gail D'Onofrio, MD, MS
David Fiellin, MD
Kathryn Hawk, MD, MHS
Declan Barry, PhD
Edouard Coupet II, MD, MS
109Publications
4,205Citations
Opioid-Related Disorders
Malaysia
China
Risk-Taking
Substance Abuse Detection
Amphetamine-Related Disorders
Publications
2024
Phytochemical analysis of water and ethanol liquid extracts prepared using freshly harvested leaves of Mitragyna speciosa (Korth.)
Karunakaran T, Vicknasingam B, Chawarski M. Phytochemical analysis of water and ethanol liquid extracts prepared using freshly harvested leaves of Mitragyna speciosa (Korth.). Natural Product Research 2024, ahead-of-print: 1-8. PMID: 38842220, DOI: 10.1080/14786419.2024.2362428.Peer-Reviewed Original ResearchConceptsFreshly harvested leavesPhytochemical compositionO-coumaric acidDried leaf materialLiquid extractionSpectrum of phytochemicalsKratom leavesBioactive phenolicsChlorogenic acidPhytochemical analysisWater extractLeaf materialLeavesLCMS/MS analysisAnalysis of waterMass spectraFreshlyExtractionLeaves of Mitragyna speciosaSpectrometric methodOxidized derivativesRutinQuercitrinAcidPhytochemicalsResearch and publication gaps on kratom and kratom products: a scoping review of current literature
Vicknasingam B, Karunakaran T, Chawarski M. Research and publication gaps on kratom and kratom products: a scoping review of current literature. Current Opinion In Psychiatry 2024, 37: 282-291. PMID: 38818826, DOI: 10.1097/yco.0000000000000950.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHealth system databasePublic health impactPublic health consequencesPrevalence ratesNational surveyHealth impactsPublic healthPublication gapSystem databaseCase series reportControlled clinical studiesClinical case reportEpidemiological factorsEpidemiological surveillanceCase reportScopus databasesSeries reportClinical studiesKratom productsSurveyHuman laboratoryResearch articlesKratomHealthAnalytical study
2023
Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats
Hassan Z, Singh D, Suhaimi F, Chear N, Harun N, See C, Kaur G, Mat N, Bakar S, Yusof N, Kasinather V, Chawarski M, Murugaiyah V, Ramanathan S. Evaluation of toxicity profile of kratom (Mitragyna speciosa Korth) decoction in rats. Regulatory Toxicology And Pharmacology 2023, 143: 105466. PMID: 37536550, DOI: 10.1016/j.yrtph.2023.105466.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDays of treatmentToxicity profileFemale Sprague-Dawley ratsOpioid replacement therapyLow platelet countEnd of treatmentSprague-Dawley ratsEvidence of toxicityOccurrence of mortalityPlatelet countDawley ratsHematology profileBody weightMitragyna speciosa KorthBrain tissueHistopathology analysisHistological investigationHerbal drug preparationsDecoctionUric acidDrug preparationTherapeutic propertiesKidneyMortalityRatsPerspectives on and experiences of emergency department–initiated buprenorphine among clinical pharmacists: A multi-site qualitative study
Justen M, Edelman E, Chawarski M, Coupet E, Cowan E, Lyons M, Owens P, Martel S, Richardson L, Rothman R, Whiteside L, O'Connor P, Zahn E, D'Onofrio G, Fiellin D, Hawk K. Perspectives on and experiences of emergency department–initiated buprenorphine among clinical pharmacists: A multi-site qualitative study. Journal Of Substance Use And Addiction Treatment 2023, 155: 209058. PMID: 37149149, DOI: 10.1016/j.josat.2023.209058.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsOpioid use disorderClinical pharmacistsED careEmergency department-initiated buprenorphineEffective OUD treatmentEffectiveness-implementation studyHealth Services frameworkFocus groups/interviewsMulti-site qualitative studyFuture implementation effortsOUD treatmentUrban EDGroups/interviewsEmergency departmentPromoting ActionUnique pharmacologyED staffBuprenorphinePharmacist participantsUse disordersED contextPharmacistsPractice changePharmacy resourcesSuccessful program implementationPerspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine Programs
Sue K, Chawarski M, Curry L, McNeil R, Coupet E, Schwartz R, Wilder C, Tsui J, Hawk K, D’Onofrio G, O’Connor P, Fiellin D, Edelman E. Perspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine Programs. JAMA Network Open 2023, 6: e2312718. PMID: 37163263, PMCID: PMC10173026, DOI: 10.1001/jamanetworkopen.2023.12718.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCommunity-based cliniciansOpioid use disorderEmergency departmentOUD treatmentMedication treatmentSubstance use disorders trainingUrban academic emergency departmentEffectiveness-implementation studyAcademic emergency departmentDisorder treatment settingsPerspectives of cliniciansCommunity-based treatmentCommunity-based treatment programsStaff perspectivesImplementation science frameworkBuprenorphine programTreatment cliniciansPeer navigatorsReferral sitesPromoting ActionMAIN OUTCOMEED staffBuprenorphineFocus groupsUse disordersImplementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder
D’Onofrio G, Edelman E, Hawk K, Chawarski M, Pantalon M, Owens P, Martel S, Rothman R, Saheed M, Schwartz R, Cowan E, Richardson L, Salsitz E, Lyons M, Freiermuth C, Wilder C, Whiteside L, Tsui J, Klein J, Coupet E, O’Connor P, Matthews A, Murphy S, Huntley K, Fiellin D. Implementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder. JAMA Network Open 2023, 6: e235439. PMID: 37017967, PMCID: PMC10077107, DOI: 10.1001/jamanetworkopen.2023.5439.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOpioid use disorderRate of patientsOUD treatmentImplementation facilitationED visitsObservational cohortED cliniciansX-waiverUse disordersEmergency Department-Initiated BuprenorphineUntreated opioid use disorderEvaluation periodHybrid type 3Provision of buprenorphineBaseline periodGrand roundsRates of EDPrimary outcomeWhite patientsAcademic EDBlack patientsED patientsEmergency departmentCommunity cliniciansMAIN OUTCOMEKratom withdrawal: Discussions and conclusions of a scientific expert forum
Henningfield J, Chawarski M, Garcia-Romeu A, Grundmann O, Harun N, Hassan Z, McCurdy C, McMahon L, Sharma A, Shoaib M, Singh D, Smith K, Swogger M, Vicknasingam B, Walsh Z, Wang D, Huestis M. Kratom withdrawal: Discussions and conclusions of a scientific expert forum. Drug And Alcohol Dependence Reports 2023, 7: 100142. PMID: 37397437, PMCID: PMC10311168, DOI: 10.1016/j.dadr.2023.100142.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model
Mat N, Bakar S, Murugaiyah V, Chawarski M, Hassan Z. Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model. Behavioural Brain Research 2022, 439: 114251. PMID: 36503042, DOI: 10.1016/j.bbr.2022.114251.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-inflammatory propertiesAnalgesic effectTRPV1 expressionAcute pain animal modelsEffective doseFemale Sprague-Dawley ratsPain animal modelsPain-like behaviorsNon-opioid receptorsOpioid receptor activationNumber of writhesSprague-Dawley ratsInflammatory painPain pathwaysTRPV1 receptorsDawley ratsWrithing behaviorED95 valuesRat brainAnimal modelsReceptor activationReceptor pathwayRatsBehavior scoresMain indole alkaloidsMissed Opportunities for HIV and Hepatitis C Screening Among Emergency Department Patients With Untreated Opioid Use Disorder
Lyons MS, Chawarski MC, Rothman R, Whiteside L, Cowan E, Richardson LD, Hawk K, Tsui JI, Schwartz RP, O’Connor P, D’Onofrio G, Fiellin DA, Edelman EJ. Missed Opportunities for HIV and Hepatitis C Screening Among Emergency Department Patients With Untreated Opioid Use Disorder. Journal Of Addiction Medicine 2022, 17: 210-214. PMID: 36170184, PMCID: PMC10023471, DOI: 10.1097/adm.0000000000001074.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUntreated opioid use disorderOpioid use disorderRecent injection drug useEmergency department HIVInjection drug useHCV screeningED patientsUse disordersEnrollment periodDrug useHepatitis C screeningStructured screening programmeUnknown HCV statusUnknown HIV statusHigh-risk cohortMedical care providersHCV statusC screeningHepatitis CED visitsAcademic EDHIV statusEmergency departmentCohort 2Cohort 1Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use Disorder
Hawk K, McCormack R, Edelman EJ, Coupet E, Toledo N, Gauthier P, Rotrosen J, Chawarski M, Martel S, Owens P, Pantalon MV, O’Connor P, Whiteside LK, Cowan E, Richardson LD, Lyons MS, Rothman R, Marsch L, Fiellin DA, D’Onofrio G. Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use Disorder. JAMA Network Open 2022, 5: e2144955. PMID: 35076700, PMCID: PMC8790663, DOI: 10.1001/jamanetworkopen.2021.44955.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUntreated opioid use disorderOpioid use disorderEmergency departmentED visitsOUD treatmentUse disordersPublic safety-net hospitalRural critical access hospitalsEmergency department careSafety-net hospitalUrban academic centerLife-saving treatmentCritical access hospitalsImplementation science frameworkPatient factorsTreatment initiationED careUS patientsStaff trainingDemand treatmentPatient readinessNet hospitalPatient's perspectivePromoting ActionImproved care
Academic Achievements and Community Involvement
activity Substance abuse treatment
ResearchDetails11/01/2010 - 10/31/2017Wuhan, Hubei, ChinaAbstract/SynopsisA study entitled "Behavioral Drug and HIV Risk Reduction Counseling with MMT in China" will provide critical data regarding the efficacy for reducing drug-and sex-related HIV transmission risk behaviors, as well as improving MMT outcomes and patient functioning of two transportable counseling models, behavioral drug and HIV risk reduction counseling (BDRC) and educational counseling (EC) as compared with the current standard of care model in MMT in China.
activity Heroin Dependence
ResearchDetails01/01/2008 - 10/31/2017Tehran, Tehran Province, Iran; Muar, Johor, MalaysiaAbstract/SynopsisProfessor Schottenfeld has established research projects in Malaysia and Iran which are aimed at evaluating treatments for heroin or other opiate dependence and are comparing the efficacy of maintenance treatment with buprenorphine or naltrexone.
activity Substance abuse treatment
ResearchDetails01/01/2010 - 06/30/2017Saint Petersburg, St.-Petersburg, RussiaAbstract/SynopsisA study entitled "Naltrexone and Behavioral Drug and HIV Risk Reduction Counseling in Russia" will examine the effects of combining behavioral therapy with naltrexone pharmacotherapy for the treatment of opiate dependence and reduction of HIV risks in opiate dependent individuals in St. Petersburg, Russia.
activity Prevention of HIV Infection among Opiate Dependent Injectors - Phase III Randomized Controlled Trial to Evaluate the Efficacy of buprenorphine/naloxone drug treatment in p
ResearchDetails01/01/2008 - 09/30/2015Beijing, Beijing, China; Chiang Mai, จ.ร้อยเอ็ด, Thailand; Nanning, Guangxi, China +1 moreAbstract/SynopsisThe purpose of the study is to determine the efficacy of a drug treatment intervention (buprenorphine/naloxone) in the prevention of HIV transmission among opiate dependent injectors by reducing drug use and associated risk behaviors. URL: http://www.hptn.org/research_studies/hptn058.asp
honor Honorary Guest Professorship
International AwardCentral South University, Changsha, ChinaDetails09/01/2015China
Links & Media
News
- June 06, 2024Source: Natural Product Research
Phytochemical Analysis of Water and Ethanol Liquid Extracts Prepared Using Freshly Harvested Leaves of Mitragyna Speciosa (Korth.)
- December 13, 2022
Department of Emergency Medicine Congratulates Four Faculty on Recent Promotions
- January 30, 2022Source: Connecticut Health I-Team
Calls To Rethink The War On Opioids
- December 19, 2019Source: Health Affairs
For Hospitals, A Blueprint For Fighting The Opioid Epidemic
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Psychiatry
CMHC/SAC, 34 Park Street
New Haven, CT 06519
United States