Mancy Tong, PhD
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Biography
Dr. Mancy Tong obtained her Ph.D. in Obstetrics and Gynecology from The University of Auckland, New Zealand in 2017. She trained as a postdoctoral associate in reproductive immunology at Yale School of Medicine and in 2020, she was awarded an NIH K99/R00 Pathways to Independence Award from NICHD and joined the faculty in the Department of Obstetrics, Gynecology and Reproductive Sciences at the Yale School of Medicine.
Dr. Tong has published in leading journals in Reproductive Sciences and her current R01-funded research program focuses on determining the impact of viral infection and inflammation on endometrial differentiation and their downstream effects on placental development and pregnancy outcomes. Dr. Tong is a strong advocate for mentorship and she serves as Chair for the Career Development Committee in the Society for Reproductive Investigation. She is also an active member of the International Federation of Placenta Associations, and serves on the editorial board for Human Reproduction Update and Trophoblast Research.
Last Updated on September 22, 2025.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Assistant ProfessorPrimary
Other Departments & Organizations
- Human and Translational Immunology Program
- Janeway Society
- Obstetrics, Gynecology & Reproductive Sciences
- Program in Translational Biomedicine (PTB)
- Reproductive Sciences
Education & Training
- Associate research scientist
- Yale School of Medicine (2022)
- Postdoctoral Associate
- Yale University (2020)
- PhD
- The University of Auckland, Obstetrics and Gynaecology (2017)
- BS (Hon)
- The University of Auckland, Biomedical Sciences (2012)
Research
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Overview
Medical Research Interests
Abortion, Habitual; Abortion, Spontaneous; Decidua; Endometrium; Extracellular Vesicles; Fetal Growth Retardation; Hypertension, Pregnancy-Induced; Inflammation; Neutrophils; Placenta; Pregnancy; Pregnancy Complications; Toll-Like Receptors
ORCID
0000-0002-7378-8033
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mancy Tong's published research.
Publications Timeline
A big-picture view of Mancy Tong's research output by year.
Research Interests
Research topics Mancy Tong is interested in exploring.
Vikki M Abrahams, PhD
Seth Guller, PhD
Alyssa Ann Grimshaw, MBA, MLIS, MPH
Shannon Whirledge, PhD, MSc
27Publications
546Citations
Pregnancy
Placenta
Endometrium
Extracellular Vesicles
Inflammation
Pregnancy Complications
Publications
2024
TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
Georges H, Cassin C, Tong M, Abrahams V. TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS. Immunology 2024, 172: 577-587. PMID: 38631842, PMCID: PMC11223956, DOI: 10.1111/imm.13794.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMiR-146a-3pPreterm birthFetal membranesToll-like receptorsExpression of miR-146a-3pLipopolysaccharide exposureMouse model of pregnancyIL-8Response to bacterial LPSAssociated with chorioamnionitisFetal membrane inflammationHuman FM explantsMouse fetal membranesInduced preterm birthBacterial lipopolysaccharideMaternal-fetal interfaceDanger signalsWild-type miceIn Vivo Mouse ModelModel of pregnancyInterleukin (IL)-8Pro-inflammatory roleResponse to bacterial lipopolysaccharideAssociated with elevated levelsResponse to LPS
2023
Impact of preimplantation exposure to viral double-stranded RNA on decidualization, placental development and pregnancy outcome
Tong M. Impact of preimplantation exposure to viral double-stranded RNA on decidualization, placental development and pregnancy outcome. Placenta 2023, 140: e21. DOI: 10.1016/j.placenta.2023.07.083.Peer-Reviewed Original ResearchDecidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα
Tong M, Scott J, Whirledge S, Abrahams V. Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα. Journal Of Reproductive Immunology 2023, 159: 103988. PMID: 37451159, PMCID: PMC10530124, DOI: 10.1016/j.jri.2023.103988.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEndometrial stromal cellsInflammatory responseStromal cellsHuman endometrial stromal cellsToll-like receptor signalingSex hormone levelsMenstrual cycle stageToll-like receptorsImmune response changesViral double-stranded RNAHuman EnSCsEndometrial responseProinflammatory cytokinesSuccessful pregnancyMenstrual cycleHuman endometriumHormone levelsMajor cell typesImmune responseNFκB p65Viral infectionDecidualizationBacterial lipopolysaccharideReceptor signalingBacterial componentsEndometrial responses to bacterial and viral infection: a scoping review.
Lindsay C, Potter J, Grimshaw A, Abrahams V, Tong M. Endometrial responses to bacterial and viral infection: a scoping review. Human Reproduction Update 2023, 29: 675-693. PMID: 37290428, PMCID: PMC10477945, DOI: 10.1093/humupd/dmad013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEndometrial responseViral infectionUterus/endometriumFull-text studiesInnate immune sensingInnate immune responseFree-text termsEmbase/MedlineIntrauterine infectionObstetric complicationsEndometrial productionCochrane LibraryFuture studiesImplantation failureNeisseria gonorrheaImmune cellsMost infectionsImmune responseUterine functionChlamydia trachomatisAnimal modelsImmune sensingEndometriumZika virusMajority of studies
2020
Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS
Potter JA, Tong M, Aldo P, Kwon JY, Pitruzzello M, Mor G, Abrahams VM. Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS. Journal Of Reproductive Immunology 2020, 140: 103126. PMID: 32289593, PMCID: PMC7299810, DOI: 10.1016/j.jri.2020.103126.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsType I IFNsMaternal-fetal interfaceI IFNsAbility of LPSMouse fetal membranesI interferonFetal membranesViral infectionMHV-68IRF-7LPS treatmentBacterial LPSType I IFN productionLow-dose LPSPrior viral infectionΓ-herpes virusMHV-68 infectionPregnant C57BL/6 miceI IFN productionType I interferonHuman fetal membranesDose LPSInnate immune strategiesC57BL/6 miceIFN productionImmunology of the Placenta
Tong M, Abrahams VM. Immunology of the Placenta. Obstetrics And Gynecology Clinics Of North America 2020, 47: 49-63. PMID: 32008671, DOI: 10.1016/j.ogc.2019.10.006.ChaptersCitationsAltmetricMeSH Keywords and ConceptsConceptsMaternal immune regulationMajor immune cellsMaternal-fetal interfaceInnate immune propertiesObstetric complicationsPregnancy complicationsPreterm birthPregnancy lossImmune cellsImmune regulationImmune propertiesHuman placentaPlacentaComplicationsPreeclampsiaPregnancyInfectionKey mechanismImmunology
2019
Neutrophil Activation and Extracellular Trap Formation at the Fetal Membranes: Relevance for Preterm Birth
Tong M. Neutrophil Activation and Extracellular Trap Formation at the Fetal Membranes: Relevance for Preterm Birth. Placenta 2019, 83: e6-e7. DOI: 10.1016/j.placenta.2019.06.024.Peer-Reviewed Original ResearchLipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps.
Tong M, Potter JA, Mor G, Abrahams VM. Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps. The Journal Of Immunology 2019, 203: 500-510. PMID: 31167775, PMCID: PMC6616008, DOI: 10.4049/jimmunol.1900262.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNeutrophil extracellular trapsNeutrophil recruitmentFetal membranesReactive oxygen species productionPreterm birthExtracellular trapsOxygen species productionCytokine/chemokine secretionChemokine/cytokine productionMajor risk factorSpecies productionBacterial LPS stimulationNeutrophil infiltrationProinflammatory factorsFetal interfaceChemokine secretionNeonatal mortalityCytokine productionNeutrophil activationRisk factorsTissue injuryNeutrophil viabilityLPS stimulationEx vivoNET formation
2018
Immunological effects of placental extracellular vesicles
Tong M, Abrahams VM, Chamley LW. Immunological effects of placental extracellular vesicles. Immunology And Cell Biology 2018, 96: 714-722. PMID: 29604098, DOI: 10.1111/imcb.12049.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia
Tong M, Johansson C, Xiao F, Stone PR, James JL, Chen Q, Cree LM, Chamley LW. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia. Scientific Reports 2017, 7: 16556. PMID: 29185455, PMCID: PMC5707355, DOI: 10.1038/s41598-017-16448-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRisk of preeclampsiaAntiphospholipid antibodiesTLR-9Placental vesiclesEndothelial cellsFirst trimester human placental explantsMaternal endothelial cell dysfunctionToll-like receptor 9Danger-associated molecular patternsHuman placental explantsPathogenesis of preeclampsiaEndothelial cell dysfunctionEndothelial cell activationPlacental extracellular vesiclesLevels of mtDNAPlacental factorsPlacental explantsReceptor 9Cell dysfunctionNano-vesiclesPreeclampsiaPharmaceutical interventionsCell activationAmount of mtDNAMolecular patterns
Academic Achievements & Community Involvement
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Honors
honor Paul Titus Fellowship
09/01/2025Yale School of Medicine Awardhonor Longo/Power New Investigator Award in Maternal-fetal and Perinatal Biology
02/12/2025International AwardLoma Linda Universityhonor Rudolph J. Anderson Endowed Postdoctoral Fellowship
10/01/2024Yale School of Medicine AwardOffice of Physician and Physician Scientist Developmenthonor Pfizer President’s Presenter’s Award
03/11/2020International AwardSociety of Reproductive InvestigationDetailsCanadahonor Elsevier Trophoblast Research New Investigator Award
09/23/2018International AwardInternational Federation of Placenta AssociationDetailsJapan
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