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Lester Rodriguez Santos, BSc (Hon)

he/him/his
PhD Candidate , Interdepartmental Neuroscience Program
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About

Titles

PhD Candidate , Interdepartmental Neuroscience Program

Biography

Lester earned a B.S. in Cellular and Molecular Biology from the University of Puerto Rico, Río Piedras Campus in San Juan, Puerto Rico. As an undergraduate, he conducted research using pre-clinical rodent models to investigate the role of endocannabinoids in regulating anxiety-like behaviors.

Following graduation, he joined the Neuroimaging Research Branch at the National Institute on Drug Abuse as a postbaccalaureate fellow under the mentorship of Dr. Elliot Stein. His work focused on examining alterations in functional connectivity during acute nicotine abstinence in smokers.

At Yale, Lester is co-mentored by Dr. Sarah W Yip and Dr. Kelly Cosgrove. His research focuses on examining how acute stimulant drug administration affects brain function and behavior, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET).

In addition to his research, Lester is committed to scientific outreach and education. He currently serves as Director of OpenLabs at Yale, a student-led initiative that hosts science outreach events on campus each semester. He also serves as Outreach Co-Chair for the Wu Tsai Institute’s Student, Postbac, and Postdoc Collective (SPPC), where he developed an annual Neuroscience and Cognition Bootcamp for local high school students. These efforts led to his receiving the 2025 Public Service Award from the Graduate School of Arts and Sciences for Disciplinary Outreach.

Last Updated on April 25, 2026.

Education & Training

BSc (Hon)
University of Puerto Rio - Rio Piedras Campus, Cellular and Molecular Biology (2020)

Research

Overview

  1. Explore the effects of acute stimulant drug administration on functional connectivity in healthy adults with resting-state fMRI.
  2. Link stimulant-induced alterations of functional connectivity to dopamine release through PET imaging.
  3. Identify biomarkers of stimulant misuse vulnerability.

Medical Research Interests

Affect; Amphetamine; Central Nervous System Stimulants; Connectome; Dopamine; Euphoria; Magnetic Resonance Imaging; Receptors, Dopamine

Public Health Interests

Substance Use, Addiction

Research at a Glance

Yale Co-Authors

Frequent collaborators of Lester Rodriguez Santos's published research.

Academic Achievements & Community Involvement

Activities

  • activity

    Open Labs at Yale

Honors

  • honor

    Graduate Research Fellowship Program (GRFP)

  • honor

    Graduate Fellow

Get In Touch

Contacts

Locations

  • Cosgrove Lab - Yale Translational Brain Imaging Program

    Lab

    Temple Medical Center

    40 Temple Street

    New Haven, CT 06510

  • Yale Imaging & Psychopharmacology (YIP) Lab

    Lab

    1 Church Street

    New Haven, CT 06510