Leonardo Pipek
Hospital ResidentCards
About
Research
Publications
2026
Efficacy and safety of adjuvant tirofiban versus intravenous thrombolysis alone in acute ischemic stroke: an updated meta-analysis of randomized controlled trials
Leite M, Ribeiro Gonçalves O, de Almeida Monteiro G, Marinheiro G, Mutarelli A, Pereira da Silva A, Andrade Fernandes J, Pensenstadler K, Singh J, Lee W, Pipek L, Mota Telles J. Efficacy and safety of adjuvant tirofiban versus intravenous thrombolysis alone in acute ischemic stroke: an updated meta-analysis of randomized controlled trials. Journal Of Thrombosis And Thrombolysis 2026, 1-12. PMID: 42315720, DOI: 10.1007/s11239-026-03335-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsResponse to: “INTERACT3 in Intensive Blood Pressure Meta‑Analysis: A Methodological Reappraisal”
Reginato P, Neves H, Pipek L. Response to: “INTERACT3 in Intensive Blood Pressure Meta‑Analysis: A Methodological Reappraisal”. Neurocritical Care 2026, 1-3. PMID: 42303960, DOI: 10.1007/s12028-026-02557-5.Commentaries, Editorials and LettersThe authors reply:
Pipek L, Pascual G, Nascimento R, Silva G, Castro L. The authors reply:. Critical Care Medicine 2026, 54: 681-682. PMID: 41773931, DOI: 10.1097/ccm.0000000000007035.Commentaries, Editorials and Letters
2025
Response to “When Precision Meets Bias: Questioning the Validity of Pooled Estimates in Intensive Blood Pressure Lowering for Intracerebral Hemorrhage Meta-analyses”
Reginato P, Mantovani G, da Silva Castro V, Pascual G, Saldanha L, Neves H, Pipek L. Response to “When Precision Meets Bias: Questioning the Validity of Pooled Estimates in Intensive Blood Pressure Lowering for Intracerebral Hemorrhage Meta-analyses”. Neurocritical Care 2025, 44: 738-740. PMID: 41398514, DOI: 10.1007/s12028-025-02419-6.Commentaries, Editorials and LettersAssociation between vitamin D deficiency and subarachnoid hemorrhage: a systematic review
da Silva V, Manicardi R, Brito J, de Sena Barbosa M, Pipek L, Telles J, Welling L, Baldoncini M, Campero A, Chavda V, De Oliveira Dourado J, Chaurasia B, Rabelo N. Association between vitamin D deficiency and subarachnoid hemorrhage: a systematic review. Annals Of Medicine And Surgery 2025, 87: 6443-6450. PMID: 41181431, PMCID: PMC12578030, DOI: 10.1097/ms9.0000000000002798.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNutritional Emergencies
Kamel A, Shah P, Pipek L, Shah A, Kandiah P. Nutritional Emergencies. Current Surgery Reports 2025, 13: 30. DOI: 10.1007/s40137-025-00465-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAcetylcholinesterase Inhibitors for Delirium Prevention: A Systematic Review and Meta-Analysis
Pipek L, Pascual G, Nascimento R, Silva G, Castro L. Acetylcholinesterase Inhibitors for Delirium Prevention: A Systematic Review and Meta-Analysis. Critical Care Medicine 2025, 53: e2054-e2061. PMID: 40758382, DOI: 10.1097/ccm.0000000000006786.Peer-Reviewed Original ResearchIntensive Blood Pressure Lowering for Intracerebral Hemorrhage: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials
Reginato P, Mantovani G, Furtado da Silva Castro V, Salema Pascual G, Felício Saldanha L, Ferreira Neves H, Pipek L. Intensive Blood Pressure Lowering for Intracerebral Hemorrhage: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials. Neurocritical Care 2025, 43: 864-875. PMID: 40739079, DOI: 10.1007/s12028-025-02325-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCould rituximab revolutionize multiple sclerosis treatment in Brazil? The missed opportunity for fewer relapses and lower costs
Silva G, Pipek L, de Oliveira M, Apóstolos-Pereira S, Adoni T, Lino A, Callegaro D, Castro L. Could rituximab revolutionize multiple sclerosis treatment in Brazil? The missed opportunity for fewer relapses and lower costs. The Lancet Regional Health - Americas 2025, 49: 101171. PMID: 40688562, PMCID: PMC12271893, DOI: 10.1016/j.lana.2025.101171.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAntithrombotic therapy for secondary stroke prevention in patients with cancer: a systematic review and network meta-analysis
Pipek L, Nascimento R, Coronel S, Baker M, Basto F, Silva G. Antithrombotic therapy for secondary stroke prevention in patients with cancer: a systematic review and network meta-analysis. European Journal Of Clinical Pharmacology 2025, 81: 1001-1015. PMID: 40332574, DOI: 10.1007/s00228-025-03847-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements