Leonardo Pipek, MD

Hospital Resident

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Contact Info

leonardo.pipek@yale.edu

About

Titles

Hospital Resident

Biography

Leonardo was born and raised in São Paulo, Brazil. He earned his medical degree from the University of São Paulo School of Medicine (FMUSP) and went on to complete his neurology residency at Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP) before coming to Yale. He has always had a deep passion for research and has contributed to projects across many areas of neurology, with a more recent focus on stroke, multiple sclerosis, and neurocritical care. During his prior residency, he led several quality improvement projects that had a lasting impact on patient care. Outside of medicine, he loves sports of all kinds, especially tennis.

Medical School: University of São Paulo School of Medicine (FMUSP)

Neurology Residency: Hospital das Clínicas, University of São Paulo (HCFMUSP)

Last Updated on October 12, 2026.

Departments & Organizations

Internal Medicine

Education & Training

Neurology Residency: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP) (2026)

MD: Faculdade de Medicina da Universidade de São Paulo (FMUSP) (2022)

Research

Research at a Glance

Publications Timeline

A big-picture view of Leonardo Pipek, MD's research output by year.

58Publications

639Citations

Publications

2026

Efficacy and safety of adjuvant tirofiban versus intravenous thrombolysis alone in acute ischemic stroke: an updated meta-analysis of randomized controlled trials
Leite M, Ribeiro Gonçalves O, de Almeida Monteiro G, Marinheiro G, Mutarelli A, Pereira da Silva A, Andrade Fernandes J, Pensenstadler K, Singh J, Lee W, Pipek L, Mota Telles J. Efficacy and safety of adjuvant tirofiban versus intravenous thrombolysis alone in acute ischemic stroke: an updated meta-analysis of randomized controlled trials. Journal Of Thrombosis And Thrombolysis 2026, 1-12. PMID: 42315720, DOI: 10.1007/s11239-026-03335-y.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Response to: “INTERACT3 in Intensive Blood Pressure Meta‑Analysis: A Methodological Reappraisal”
Reginato P, Neves H, Pipek L. Response to: “INTERACT3 in Intensive Blood Pressure Meta‑Analysis: A Methodological Reappraisal”. Neurocritical Care 2026, 1-3. PMID: 42303960, DOI: 10.1007/s12028-026-02557-5.
Commentaries, Editorials and Letters
The authors reply:
Pipek L, Pascual G, Nascimento R, Silva G, Castro L. The authors reply:. Critical Care Medicine 2026, 54: 681-682. PMID: 41773931, DOI: 10.1097/ccm.0000000000007035.
Commentaries, Editorials and Letters

2025

Response to “When Precision Meets Bias: Questioning the Validity of Pooled Estimates in Intensive Blood Pressure Lowering for Intracerebral Hemorrhage Meta-analyses”
Reginato P, Mantovani G, da Silva Castro V, Pascual G, Saldanha L, Neves H, Pipek L. Response to “When Precision Meets Bias: Questioning the Validity of Pooled Estimates in Intensive Blood Pressure Lowering for Intracerebral Hemorrhage Meta-analyses”. Neurocritical Care 2025, 44: 738-740. PMID: 41398514, DOI: 10.1007/s12028-025-02419-6.
Commentaries, Editorials and Letters
Association between vitamin D deficiency and subarachnoid hemorrhage: a systematic review
da Silva V, Manicardi R, Brito J, de Sena Barbosa M, Pipek L, Telles J, Welling L, Baldoncini M, Campero A, Chavda V, De Oliveira Dourado J, Chaurasia B, Rabelo N. Association between vitamin D deficiency and subarachnoid hemorrhage: a systematic review. Annals Of Medicine And Surgery 2025, 87: 6443-6450. PMID: 41181431, PMCID: PMC12578030, DOI: 10.1097/ms9.0000000000002798.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Nutritional Emergencies
Kamel A, Shah P, Pipek L, Shah A, Kandiah P. Nutritional Emergencies. Current Surgery Reports 2025, 13: 30. DOI: 10.1007/s40137-025-00465-9.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Acetylcholinesterase Inhibitors for Delirium Prevention: A Systematic Review and Meta-Analysis
Pipek L, Pascual G, Nascimento R, Silva G, Castro L. Acetylcholinesterase Inhibitors for Delirium Prevention: A Systematic Review and Meta-Analysis. Critical Care Medicine 2025, 53: e2054-e2061. PMID: 40758382, DOI: 10.1097/ccm.0000000000006786.
Peer-Reviewed Original Research
MeSH Keywords
Intensive Blood Pressure Lowering for Intracerebral Hemorrhage: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials
Reginato P, Mantovani G, Furtado da Silva Castro V, Salema Pascual G, Felício Saldanha L, Ferreira Neves H, Pipek L. Intensive Blood Pressure Lowering for Intracerebral Hemorrhage: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials. Neurocritical Care 2025, 43: 864-875. PMID: 40739079, DOI: 10.1007/s12028-025-02325-x.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Could rituximab revolutionize multiple sclerosis treatment in Brazil? The missed opportunity for fewer relapses and lower costs
Silva G, Pipek L, de Oliveira M, Apóstolos-Pereira S, Adoni T, Lino A, Callegaro D, Castro L. Could rituximab revolutionize multiple sclerosis treatment in Brazil? The missed opportunity for fewer relapses and lower costs. The Lancet Regional Health - Americas 2025, 49: 101171. PMID: 40688562, PMCID: PMC12271893, DOI: 10.1016/j.lana.2025.101171.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Antithrombotic therapy for secondary stroke prevention in patients with cancer: a systematic review and network meta-analysis
Pipek L, Nascimento R, Coronel S, Baker M, Basto F, Silva G. Antithrombotic therapy for secondary stroke prevention in patients with cancer: a systematic review and network meta-analysis. European Journal Of Clinical Pharmacology 2025, 81: 1001-1015. PMID: 40332574, DOI: 10.1007/s00228-025-03847-1.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords

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ORCID
0000-0001-5268-4668

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Contacts

Email

leonardo.pipek@yale.edu