Lais Osmani, MD, BA
InstructorDownloadHi-Res Photo
Cards
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAbout
Copy Link
Titles
Instructor
Biography
Lais grew up in Newton, MA. He graduated from Boston University in 2010. After college, he worked on the COMBREX (Computational Bridges to Experiments) project which sought to accelerate microbial genome annotation through collaboration between computational and experimental biologists. He then attended the University of Illinois College of Medicine and graduated in 2015. He completed a Pathology residency at Johns Hopkins Hospital, during which time he was involved in identifying the antigen specificity of the monoclonal immunoglobulin in patients with Schnitzler syndrome. He most recently completed a second residency in Internal Medicine at Dartmouth-Hitchcock Medical Center. During this time, he investigated the role of neutrophils in lupus nephritis. He is interested in leveraging omics data to study the pathogenesis and heterogeneity of autoimmune diseases and to identify potential therapeutic targets.
Last Updated on January 14, 2023.
Appointments
Rheumatology
InstructorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- Yale University (2024)
- Resident
- Dartmouth-Hitchcock Medical Center (2021)
- Residency
- Johns Hopkins Hospital (2018)
- MD
- University of Illinois College of Medicine (2015)
Research
Copy Link
Research at a Glance
Yale Co-Authors
Frequent collaborators of Lais Osmani's published research.
Publications Timeline
A big-picture view of Lais Osmani's research output by year.
Insoo Kang, MD
Jennefer Par-Young
Min Shin, PhD
Richard Bucala, MD, PhD
Gary Soffer, MD, FAAP
Hong-Jai Park
17Publications
893Citations
Publications
2025
Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1.
Tran TT, Sánchez-Zuno GA, Osmani L, Caulfield J, Valdez CN, Piecychna M, Leng L, Armstrong ME, Donnelly SC, Bifulco CB, Clister T, Kulkarni RP, Zhang L, Sznol M, Jilaveanu L, Kluger HM, Kang I, Bucala R. Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1. JCI Insight 2025, 10 PMID: 41122966, DOI: 10.1172/jci.insight.191539.Peer-Reviewed Original ResearchInvestigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus
Lee S, Shin M, Lee Y, Osmani L, Seong W, Cai H, Par-Young J, Ahn J, Park H, Kim M, Unlu S, Kim H, Han M, Dong X, You S, Lee E, Kang I. Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus. EBioMedicine 2025, 119: 105898. PMID: 40857939, PMCID: PMC12398881, DOI: 10.1016/j.ebiom.2025.105898.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCD8+ T cellsCD8+ T cell subsetsT cell subsetsT cellsPeripheral bloodNeutrophil extracellular trapsEffector memoryGene signatureLupus pathogenesisImaging Mass CytometryEffector memory CD8+ T cellsCD8+ T cell accumulationCD8+ T cell infiltrationKidney tissueMemory CD8+ T cellsType I IFN gene signatureCD8+ T cellsEM CD8+ T cellsAnalysis of immune cellsCytotoxic molecule expressionT cell infiltrationT cell accumulationAssociated with treatment outcomeKidney tissues of patientsT cell heterogeneityTo Be Similar, or Not to Be Similar, That Is the Question: A Story of CD8+ T Cells in Psoriatic Arthritis
Osmani L, Kang I. To Be Similar, or Not to Be Similar, That Is the Question: A Story of CD8+ T Cells in Psoriatic Arthritis. Arthritis & Rheumatology 2025 PMID: 40524513, DOI: 10.1002/art.43284.Peer-Reviewed Original ResearchAltmetricTumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV
Desai S, Salahuddin S, Yusuf R, Ranjan K, Gu J, Osmani L, Lin Y, Mehta S, Talmon R, Kang I, Kluger Y, Zhao H, Schalper K, Emu B. Tumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV. Journal Of Clinical Investigation 2025, 135: e177310. PMID: 40459946, PMCID: PMC12259253, DOI: 10.1172/jci177310.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNon-small cell lung cancerTumor microenvironmentImmune cellsLung cancerCohort of non-small cell lung cancerExpression of PD-1Impairs anti-tumor responsesTumor-infiltrating CD8+Tumor-specific immune responsesCD4+ T cellsHIV-associated tumorsInfiltrating CD8+Expression of immunoregulatory moleculesAnti-tumor responsesTumor-associated macrophagesCell lung cancerImmune cell functionNSCLC cell linesPD-1Tumor killingBlocker therapyCD8+LAG-3Immune landscapeImmunoregulatory phenotypeAssociation of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchAltmetricConceptsInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCD4+ T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4+ T cellsCD4+ T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokines
2024
Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma
Valdez C, Sánchez-Zuno G, Osmani L, Ibrahim W, Galan A, Bacchiocchi A, Halaban R, Kulkarni R, Kang I, Bucala R, Tran T. Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma. Oncotarget 2024, 15: 507-520. PMID: 39028303, PMCID: PMC11259151, DOI: 10.18632/oncotarget.28615.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAgedAged, 80 and overAntigens, Differentiation, B-LymphocyteBiomarkers, TumorFemaleHistocompatibility Antigens Class IIHumansImmune Checkpoint InhibitorsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMelanomaMiddle AgedMutationPrognosisRetrospective StudiesSkin NeoplasmsConceptsMacrophage migration inhibitory factorImmune checkpoint inhibitionD-dopachrome tautomeraseExpression of macrophage migration inhibitory factorDrivers of tumor progressionInflammatory cell markersPatient tumor samplesPatient survival outcomesMigration inhibitory factorStatistically significant differenceCheckpoint inhibitionImmune therapyPrognostic valueSurvival outcomesResistant melanomaGene expressionImproved survivalRetrospective studyInflammatory markersTumor progressionCell markersTumor samplesClinical evidenceMelanomaBulk RNA sequencing
2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal personsInvestigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus
Osmani L, Shin MS, Cai H, Lee SJ, Kim H, Yoo J, You S, Li C, Dong MX, Gomez-Villalobos J, Bucala R, Kang I. Investigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus. Single Cell Analyses conference at Cold Spring Harbor Laboratory. Nov 2023. Cold Spring Harbor, NY.Peer-Reviewed Original Research
2021
204 The role of neutrophils in the clinical severity of lupus nephritis patients with concurrent skin disease
Osmani L, Pettus J, Roy A, Skopelja-Gardner S. 204 The role of neutrophils in the clinical severity of lupus nephritis patients with concurrent skin disease. Lupus Science & Medicine 2021, 8: a5-a5. DOI: 10.1136/lupus-2021-lupus21century.8.Peer-Reviewed Original ResearchConceptsConcurrent skin diseasesHigher neutrophil countLupus nephritisSkin rashLN flareSkin diseasesSkin inflammationHigh neutrophilLN patientsLupus patientsNeutrophil countLupus nephritis biopsiesNeutrophil-lymphocyte ratioWorse kidney functionOnly female patientsRole of neutrophilsAnti-dsDNA IgGActivation of neutrophilsT-testStudent's t-testRenal inflammatoryActive diseaseKidney injuryChart reviewIgA deposition
Clinical Care
Copy Link
Overview
Lais Osmani, MD, is a rheumatologist who specializes in the diagnosis and treatment of autoimmune diseases. He focuses on conditions such as lupus nephritis and other disorders affecting the immune system.
As an instructor at Yale School of Medicine, Dr. Osmani conducts research on the pathogenesis and heterogeneity of autoimmune diseases. He is particularly interested in using biological data to identify potential therapeutic targets, which could lead to more effective treatments.
Dr. Osmani received his medical training from the University of Illinois College of Medicine. He completed a residency in anatomical and clinical pathology at Johns Hopkins Hospital, followed by a residency in internal medicine at Dartmouth-Hitchcock Medical Center and a fellowship in rheumatology at Yale School of Medicine.
Clinical Specialties
Rheumatology
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews & Links
Copy Link
Media
News
- September 11, 2025
Finding Patterns in Genetic Uncertainty: Clues for Inborn Errors of Immunity
- October 16, 2024
Welcome New Staff, Faculty, Postdocs & Postgrads (October 2024)
- September 16, 2024
Introducing the New Yale Rheumatology, Allergy and Immunology Faculty
- April 20, 2023
Fellow Focus in Four: Lais Osmani, MD, Rheumatology
Get In Touch
Copy Link
Contacts
Email
Appointment Number