Lais Osmani, MD, MHS
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Biography
Lais grew up in Newton, MA. He graduated from Boston University in 2010. After college, he worked on the COMBREX (Computational Bridges to Experiments) project which sought to accelerate microbial genome annotation through collaboration between computational and experimental biologists. He then attended the University of Illinois College of Medicine and graduated in 2015. He completed a Pathology residency at Johns Hopkins Hospital, during which time he was involved in identifying the antigen specificity of the monoclonal immunoglobulin in patients with Schnitzler syndrome. He most recently completed a second residency in Internal Medicine at Dartmouth-Hitchcock Medical Center. During this time, he investigated the role of neutrophils in lupus nephritis. He is interested in leveraging omics data to study the pathogenesis and heterogeneity of autoimmune diseases and to identify potential therapeutic targets.
Last Updated on January 14, 2023.
Appointments
Rheumatology
InstructorPrimary
Other Departments & Organizations
- All Institutions
- Internal Medicine
- Rheumatology
- Rheumatology, Allergy, & Immunology
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Fellowship
- Yale University (2024)
- MHS
- Yale School of Medicine (2024)
- Resident
- Dartmouth-Hitchcock Medical Center (2021)
- Residency
- Johns Hopkins Hospital (2018)
- MD
- University of Illinois College of Medicine (2015)
- MD
- The University Of Illinois College of Medicine
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Lais Osmani's published research.
Publications Timeline
A big-picture view of Lais Osmani's research output by year.
Insoo Kang, MD
Richard Bucala, MD, PhD
Jennefer Par-Young
Min Shin, PhD
Gabriela Sanchez-Zuno
Gary Soffer, MD, FAAP
19Publications
929Citations
Publications
2026
Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus.
Osmani L, Shin M, Lee SJ, Cai H, Seong WJ, Kim H, Yoo J, Kim M, Bracamonte W, Felix M, Ahn JG, Park HJ, Shin JJ, Unlu S, Par-Young J, Doherty E, Chen J, Dong MX, Koumpouras F, Gomez JL, Kaminski N, Bucala R, You S, Kang I. Identification of Lupus Immune Complex-Driven Pathogenic Pro-inflammatory Monocytes and Macrophages in Systemic Lupus Erythematosus. BioRxiv 2026 PMID: 41648138, DOI: 10.64898/2026.01.21.700902.Peer-Reviewed Original ResearchPathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis
Doherty E, Osmani L, Bilsborrow J, Par-Young J, Choi S, Tilstam P, Shin M, Piecychna M, Cai H, Leng L, Kim W, Kang I, Bucala R. Pathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2509156123. PMID: 41505516, PMCID: PMC12799170, DOI: 10.1073/pnas.2509156123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMacrophage migration inhibitory factorT cell-dependent modelCollagen-induced arthritisT cellsImpact of gene deletionPathogenic roleMIF's roleCollagen-induced arthritis developmentEffector memory phenotypeRheumatoid arthritisMacrophage migration inhibitory factor inhibitionExperimental models of arthritisModel of collagen-induced arthritisT cell subpopulationsArthritogenic T cellsT cell activationExperimental modelHigh-expression alleleT lineage cellsAutoimmune inflammatory diseaseJoint synoviumMigration inhibitory factorModels of arthritisExpressed alleleMemory phenotype
2025
Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1
Tran T, Sánchez-Zuno G, Osmani L, Caulfield J, Valdez C, Piecychna M, Leng L, Armstrong M, Donnelly S, Bifulco C, Clister T, Kulkarni R, Zhang L, Sznol M, Jilaveanu L, Kluger H, Kang I, Bucala R. Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1. JCI Insight 2025, 10: e191539. PMID: 41122966, PMCID: PMC12581657, DOI: 10.1172/jci.insight.191539.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-PD-1Macrophage migration inhibitory factorAnti-MIFMigration inhibitory factorTumor growthTherapeutic efficacyAnti-programmed cell death 1Intratumoral immune cell populationsAssociated with advanced diseaseHigh-expression MIF allelesCell death 1Inhibitory factorTh1 cytokine levelsInhibition of macrophage migration inhibitory factorDual inhibitionMurine tumor modelsColorectal cancer modelImmune cell populationsTumor-bearing animalsClinical trial developmentMultiple cancer typesAntitumor responseDeath-1PD-1Tumor burdenInvestigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus
Lee S, Shin M, Lee Y, Osmani L, Seong W, Cai H, Par-Young J, Ahn J, Park H, Kim M, Unlu S, Kim H, Han M, Dong X, You S, Lee E, Kang I. Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus. EBioMedicine 2025, 119: 105898. PMID: 40857939, PMCID: PMC12398881, DOI: 10.1016/j.ebiom.2025.105898.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCD8+ T cellsCD8+ T cell subsetsT cell subsetsT cellsPeripheral bloodNeutrophil extracellular trapsEffector memoryGene signatureLupus pathogenesisImaging Mass CytometryEffector memory CD8+ T cellsCD8+ T cell accumulationCD8+ T cell infiltrationKidney tissueMemory CD8+ T cellsType I IFN gene signatureCD8+ T cellsEM CD8+ T cellsAnalysis of immune cellsCytotoxic molecule expressionT cell infiltrationT cell accumulationAssociated with treatment outcomeKidney tissues of patientsT cell heterogeneityTo Be Similar, or Not to Be Similar, That Is the Question: A Story of CD8+ T Cells in Psoriatic Arthritis
Osmani L, Kang I. To Be Similar, or Not to Be Similar, That Is the Question: A Story of CD8+ T Cells in Psoriatic Arthritis. Arthritis & Rheumatology 2025, 78: 4-6. PMID: 40524513, DOI: 10.1002/art.43284.Peer-Reviewed Original ResearchAltmetricTumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV
Desai S, Salahuddin S, Yusuf R, Ranjan K, Gu J, Osmani L, Lin Y, Mehta S, Talmon R, Kang I, Kluger Y, Zhao H, Schalper K, Emu B. Tumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV. Journal Of Clinical Investigation 2025, 135: e177310. PMID: 40459946, PMCID: PMC12259253, DOI: 10.1172/jci177310.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNon-small cell lung cancerTumor microenvironmentImmune cellsLung cancerCohort of non-small cell lung cancerExpression of PD-1Impairs anti-tumor responsesTumor-infiltrating CD8+Tumor-specific immune responsesCD4+ T cellsHIV-associated tumorsInfiltrating CD8+Expression of immunoregulatory moleculesAnti-tumor responsesTumor-associated macrophagesCell lung cancerImmune cell functionNSCLC cell linesPD-1Tumor killingBlocker therapyCD8+LAG-3Immune landscapeImmunoregulatory phenotypeAssociation of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchAltmetricConceptsInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCD4+ T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4+ T cellsCD4+ T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokines
2024
Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma
Valdez C, Sánchez-Zuno G, Osmani L, Ibrahim W, Galan A, Bacchiocchi A, Halaban R, Kulkarni R, Kang I, Bucala R, Tran T. Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma. Oncotarget 2024, 15: 507-520. PMID: 39028303, PMCID: PMC11259151, DOI: 10.18632/oncotarget.28615.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAgedAged, 80 and overAntigens, Differentiation, B-LymphocyteBiomarkers, TumorFemaleHistocompatibility Antigens Class IIHumansImmune Checkpoint InhibitorsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMelanomaMiddle AgedMutationPrognosisRetrospective StudiesSkin NeoplasmsConceptsMacrophage migration inhibitory factorImmune checkpoint inhibitionD-dopachrome tautomeraseExpression of macrophage migration inhibitory factorDrivers of tumor progressionInflammatory cell markersPatient tumor samplesPatient survival outcomesMigration inhibitory factorStatistically significant differenceCheckpoint inhibitionImmune therapyPrognostic valueSurvival outcomesResistant melanomaGene expressionImproved survivalRetrospective studyInflammatory markersTumor progressionCell markersTumor samplesClinical evidenceMelanomaBulk RNA sequencing
2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal persons
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Overview
Lais Osmani, MD, is a rheumatologist who specializes in the diagnosis and treatment of autoimmune diseases. He focuses on conditions such as lupus nephritis and other disorders affecting the immune system.
As an instructor at Yale School of Medicine, Dr. Osmani conducts research on the pathogenesis and heterogeneity of autoimmune diseases. He is particularly interested in using biological data to identify potential therapeutic targets, which could lead to more effective treatments.
Dr. Osmani received his medical training from the University of Illinois College of Medicine. He completed a residency in anatomical and clinical pathology at Johns Hopkins Hospital, followed by a residency in internal medicine at Dartmouth-Hitchcock Medical Center and a fellowship in rheumatology at Yale School of Medicine.
Clinical Specialties
Rheumatology
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News
- January 08, 2026
New Yale Study Reveals Mechanism Behind Persistent Autoimmune Joint Destruction
- September 11, 2025
Finding Patterns in Genetic Uncertainty: Clues for Inborn Errors of Immunity
- October 16, 2024
Welcome New Staff, Faculty, Postdocs & Postgrads (October 2024)
- September 16, 2024
Introducing the New Yale Rheumatology, Allergy and Immunology Faculty
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