Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsJoseph Paul Eder, MD
Professor AdjunctAbout
Copy Link
Titles
Professor Adjunct
Biography
I was the principal clinical investigator of the Harvard UO1 Phase I program in 1995, uniting the clinical efforts at the DFCI, BWH, MGH and BIDMC. In 1998, I became the Clinical Director of the Experimental Therapeutics Program for the Dana-Farber/Harvard Cancer Center. As Clinical Director, I assumed overall responsibility for the trials performed at the DF/HCC. In 2004 I assumed the responsibilities as the Clinical Director of the DFCI General Cancer Research Center at the Dana-Farber/ Brigham and Women’s Hospital. These clinical and basic research activities have involved collaboration with clinical and basic scientists at Harvard and elsewhere, the Cancer Therapy Evaluation Program of the National Cancer Institute, presentations at national and international meetings, and correspondence with a number of leaders in the field of cancer drug development.
At AstraZeneca PLC, I was the Medical Science Director for AstraZeneca’s Boston site, responsible for the medical and clinical aspects of development of agents from chemical lead identification through clinical proof of concept in phase II. I was responsible for the design and interpretation of the entire clinical development plan for five agents. This position had global responsibilities with clinical trials in the US, Canada, European Union, Japan and Korea. I was a member of the Strategic Planning & Business Development as an ad hoc member and was the global Disease Area Clinical Expert for Hematology.
Appointments
Medical Oncology and Hematology
Professor AdjunctPrimary
Other Departments & Organizations
- Early Phase Clinical Trial Program
- Internal Medicine
- Medical Oncology and Hematology
- Pancreatic Diseases Program
- Yale Cancer Center
Education & Training
- Fellow
- Dana-Farber Cancer Institute (1985)
- Fellowship
- Beth Israel Hospital (1985)
- Fellowship
- Georgetown University Hospital (1982)
- Residency
- Georgetown University Hospital (1981)
- MD
- Georgetown University School of Medicine (1978)
Research
Copy Link
Overview
Dr. Eder 's particular areas of past and present involvement have been in early clinical trials for cancer/Phase I trials and include high dose chemotherapy, the modulation/ reversal of drug resistance, growth factors, vaccines, immune-oncology, signal transduction pathway inhibitors, cell cycle inhibitors, and molecularly targeted therapies/Precision Medicine.
Early drug development, Immuno-oncology
Medical Research Interests
ORCID
0000-0002-7805-0986
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Patricia LoRusso, DO
Barbara Burtness, MD
Zenta Walther, MD, PhD
Daniel P. Petrylak, MD
Joseph Kim, MD
Michael Cecchini, MD
Precision Medicine
Publications
2025
Polymerase Ѳ inhibitors combinations with approved and investigational agents in patient-derived tumor multi-cell type (mct) spheroids
Teicher B, Dexheimer T, Chen L, Silvers T, Jones E, Coussens N, Eder J, Doroshow J. Polymerase Ѳ inhibitors combinations with approved and investigational agents in patient-derived tumor multi-cell type (mct) spheroids. Experimental And Molecular Pathology 2025, 143: 104978. PMID: 40580893, PMCID: PMC12290468, DOI: 10.1016/j.yexmp.2025.104978.Peer-Reviewed Original ResearchCitations
2024
Financial Toxicity Among Patients With Advanced Solid Tumors Participating in Early-Phase Clinical Trials
Blanter J, Van Hyfte G, Ahmad M, Xu S, Hapanowicz O, Fazilov G, Lu A, Lucas N, Wu K, Shelton G, DeMerchant M, Lachowicz M, Kier M, Werner M, Eder J, Galsky M, Marron T, Smith C, LoRusso P, Hofstatter E, Doroshow D. Financial Toxicity Among Patients With Advanced Solid Tumors Participating in Early-Phase Clinical Trials. JCO Oncology Practice 2024, 21: 862-875. PMID: 39661920, PMCID: PMC12508792, DOI: 10.1200/op.24.00293.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEarly-phase clinical trialsSolid tumorsClinical trialsAssociated with higher FTFinancial toxicityBarriers to clinical trial enrollmentAdvanced solid malignanciesAdvanced solid tumorsInverse association with ageBaseline to 2 monthsYale Cancer CenterCOST scoreClinical trial enrollmentProspective survey studySolid malignanciesNo significant differenceBaseline FTTime of consentNovel therapiesPrimary outcomeCancer CenterSurvey 1Trial enrollmentPatientsEarly-phaseCEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials
Segal N, Melero I, Moreno V, Steeghs N, Marabelle A, Rohrberg K, Rodriguez-Ruiz M, Eder J, Eng C, Manji G, Waterkamp D, Leutgeb B, Bouseida S, Flinn N, Das Thakur M, Elze M, Koeppen H, Jamois C, Martin-Facklam M, Lieu C, Calvo E, Paz-Ares L, Tabernero J, Argilés G. CEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials. Nature Communications 2024, 15: 4091. PMID: 38750034, PMCID: PMC11096172, DOI: 10.1038/s41467-024-48479-8.Peer-Reviewed Original ResearchCitationsAltmetricCirculating Tumor DNA Dynamics Fail to Predict Efficacy of Poly(ADP-ribose) Polymerase/VEGFR Inhibition in Patients With Heavily Pretreated Advanced Solid Tumors
Hu Y, Narayan A, Xu Y, Wolfe J, Vu D, Trinh T, Kantak C, Ivy S, Eder J, Deng Y, LoRusso P, Kim J, Patel A. Circulating Tumor DNA Dynamics Fail to Predict Efficacy of Poly(ADP-ribose) Polymerase/VEGFR Inhibition in Patients With Heavily Pretreated Advanced Solid Tumors. JCO Precision Oncology 2024, 8: e2300289. PMID: 38412387, PMCID: PMC10914240, DOI: 10.1200/po.23.00289.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCell-free circulating tumor DNANon-small-cell lung cancerSmall-cell lung cancerTriple-negative breast cancerPancreatic ductal adenocarcinomaAdvanced solid tumorsVariant allele fractionRadiographic responseOverall survivalCombination therapySolid tumorsCtDNA levelsLung cancerPretreated advanced solid tumorsDays of combination therapyMetastatic pancreatic ductal adenocarcinomaResponse to anticancer therapyAssociated with disease progressionProgression-free survivalPlasma samplesLead-InPoly(ADP-riboseInferior OSTumor DNASurvival outcomes
2023
Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All “BRCAness” Is Created Equal
Doroshow D, Wei W, Mehrotra M, Sia D, Eder J, Bindra R, Houldsworth J, LoRusso P, Walther Z. Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All “BRCAness” Is Created Equal. Cancer Investigation 2023, 41: 646-655. PMID: 37505929, DOI: 10.1080/07357907.2023.2242957.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsClinical benefit rateIntrahepatic cholangiocarcinomaPlatinum sensitivityUnresectable intrahepatic cholangiocarcinomaObjective response rateMulticenter retrospective studyHomologous recombination repairDefective homologous recombination (HR) repairPrimary endpointPlatinum chemotherapyRetrospective studyPreclinical dataBenefit rateWildtype tumorsResponse rateMT tumorsWT diseasePatientsGene defectsCholangiocarcinomaTumorsNCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) Plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Cecchini M, Walther Z, Wei W, Hafez N, Pilat M, Boerner S, Durecki D, Eder J, Schalper K, Chen A, LoRusso P. NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) Plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors. Cancer Research Communications 2023, 3: 1113-1117. PMID: 37377610, PMCID: PMC10292219, DOI: 10.1158/2767-9764.crc-22-0485.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDose-limiting toxicityHomologous recombination deficiencyPARP inhibitorsStable diseaseWeekly irinotecanObjective responseDay 1Day 3Solid tumorsPhase I dose-escalation studyTwice daily days 1I dose-escalation studyPhase I clinical trialDaily days 1Dose level 1Doses of veliparibGrade 3 neutropeniaMultiple-dose schedulesProgression-free survivalAdvanced solid tumorsDose-escalation studyEvaluable patientsNonoverlapping toxicitiesDose scheduleSystemic treatmentDeveloping a definition of immune exclusion in cancer: results of a modified Delphi workshop
Clifton G, Rothenberg M, Ascierto P, Begley G, Cecchini M, Eder J, Ghiringhelli F, Italiano A, Kochetkova M, Li R, Mechta-Grigoriou F, Pai S, Provenzano P, Puré E, Ribas A, Schalper K, Fridman W. Developing a definition of immune exclusion in cancer: results of a modified Delphi workshop. Journal For ImmunoTherapy Of Cancer 2023, 11: e006773. PMID: 37290925, PMCID: PMC10254706, DOI: 10.1136/jitc-2023-006773.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsImmune exclusionTumor microenvironmentCheckpoint inhibitorsImmune checkpoint inhibitorsMinority of patientsT cell infiltrationPoor clinical outcomeImmune regulatory pathwaysEffective treatment approachDevelopment of treatmentsVariety of cancersLack of responseCheckpoint therapyImmune profileClinical outcomesClinical benefitPatient outcomesCancer expertsCancer histologyT cellsConsensus definitionTreatment approachesCancer typesRound questionnaireDelphi process
2022
Principles of Dose, Schedule, and Combination Therapy
Eder J, Hafez N. Principles of Dose, Schedule, and Combination Therapy. 2022, 1-13. DOI: 10.1002/9781119000822.hfcm055.pub3.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaCombination chemotherapyMonoclonal antibodiesChemotherapeutic agentsHigh single-agent activityContemporary cancer therapyContinuous oral administrationSingle-agent activityBone marrow transplantationClinical toxicity profileCytotoxic chemotherapeutic agentsDose-response effectTyrosine kinase inhibitorsOutcome of therapyRapid plasma clearanceClinical trial designCombination of agentsDeoxyribonucleic acid damaging agentsNormal tissue recoveryPolymerase inhibitor rucaparibRole of doseMost chemotherapeutic agentsPrecise pathologic diagnosisTumor cell sensitivityHematopoietic growth factors10 Oral CBX-12-101: A first-in-human study of CBX-12, an alphalex peptide drug conjugate (PDC) in patients with advanced or metastatic solid tumors
Meric-Bernstam F, Eder J, Vandross A, Gara M, Gayle S, Pearson P, DeCillis A, Tolcher A. 10 Oral CBX-12-101: A first-in-human study of CBX-12, an alphalex peptide drug conjugate (PDC) in patients with advanced or metastatic solid tumors. European Journal Of Cancer 2022, 174: s7-s8. DOI: 10.1016/s0959-8049(22)00823-1.Peer-Reviewed Original ResearchCitationsFinancial toxicity in patients with advanced solid malignancies participating in early-phase clinical trials.
Blanter J, Werner M, Kier M, Hapanowicz O, Itani M, Ahmad M, DeMerchant M, Eder J, Galsky M, Hammad A, King P, Lachowicz M, Lucas N, Marron T, Shelton G, Wu K, Xu S, LoRusso P, Hofstatter E, Doroshow D. Financial toxicity in patients with advanced solid malignancies participating in early-phase clinical trials. Journal Of Clinical Oncology 2022, 40: 267-267. DOI: 10.1200/jco.2022.40.28_suppl.267.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Copy Link
Honors
honor Who’s Who Madison
UnknownDetailsUnited States
Get In Touch
Copy Link