John MacMicking is a Howard Hughes Medical Institute (HHMI) Investigator. He trained in synthetic organic chemistry at the Australian National University (B.Sc, 1st Class Honors) where he conducted thesis work in the Department of Immunology & Cell Biology formerly headed by 1996 Nobel Laureate, Peter Doherty, at the John Curtin School of Medical Research.
He then came to the U.S. to pursue Ph.D studies with Carl Nathan in the Immunology program at Cornell University-Sloan-Kettering Institute in New York City before being selected as an HHMI Life Science Research Foundation Fellow at The Rockefeller University to conduct studies with John McKinney.
His doctoral dissertation described the first knockout of an innate immune gene in mammals - inducible nitric oxide synthase (iNOS) - genetically engineered between 1992-1995. It served as an early paradigm for cell-autonomous immunity to bacterial, viral and protozoan infections. At Rockefeller University he computationally identified, physically mapped and began functionally characterizing a complete IFN-inducible GTPase superfamily in humans and mice as a new defense network operating against all pathogen classes. For these discoveries he was named a Edward Mallinckrodt Jr Foundation Fellow (2004), Searle Scholar (2005), Cancer Research Institute Investigator (2006), Burroughs-Wellcome Fund Investigator (2008), CCFA Senior Research Awardee (2010), AAF Scholar (2014), and Kenneth Rainin Foundation Innovator (2014). In 2022, he received the Alumni Award of Distinction (Medical Sciences) from Cornell University.
Dr. MacMicking was promoted to Associate Professor in 2010 and tenured in 2014. He was chosen as an HHMI Investigator in 2015 before moving to the Yale Systems Biology Institute in 2017.
|Alumni Award of Distinction||Cornell University||2022|
|Investigator||Howard Hughes Medical Institute (HHMI)||2015|
|Innovator Award||Kenneth Rainin Foundation||2014|
|Scholar Award||American Asthma Foundation (AAF)||2014|
|Senior Investigator Award||Crohn’s and Colitis Foundation of America (CCFA)||2010|
|Investigator in the Pathogenesis of Infectious Disease Award||Burroughs Wellcome Fund (BWF)||2008|
|Investigator Award||Cancer Research Institute (CRI)||2006|
|Searle Scholar Award||Searle-Chicago Community Trust||2005|
|Edward Mallinckrodt, Jr. Foundation Fellow||Yale University||2004|
|Howard Hughes Medical Institute Life Science Research Foundation (LSRF) Fellow||The Rockefeller University||1998|
|Charles H. Revson Fellow in Biomedical Research||The Rockefeller University||1997|
|Distinguished Student Commencement Speaker Award||Cornell University, New York, NY||1997|
|Advisory Council, Searle Scholars Program||Scientific board member||2022 - Present|
|Journal of Experimental Medicine||Editorial Advisory Board||2022 - Present|
|Cellular Microbiology||Editorial Advisory Board||2017 - 2021|
|American Society of Microbiology (Immunology division)||Chair and Chair-Elect, Immunology Division||2014 - 2016|
|NIAID, NIH||Standing member, Immunity and Host Defense (IHD) Study Section||2013 - 2015|
|Proceedings National Academy of Sciences USA||Guest Editor||2013 - Present|