Iris Isufi, MD
Associate Professor of Medicine (Hematology)DownloadHi-Res Photo
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Additional Titles
Co-Director Adult CAR T-Cell Therapy Program, Hematology
Co-Leader, Cellular Therapy Clinical Research Team, Yale Cancer Center
Co-Chair, Cellular Therapy (CT)-SAFE Committee, Yale Cancer Center
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About
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Titles
Associate Professor of Medicine (Hematology)
Co-Director Adult CAR T-Cell Therapy Program, Hematology; Co-Leader, Cellular Therapy Clinical Research Team, Yale Cancer Center; Co-Chair, Cellular Therapy (CT)-SAFE Committee, Yale Cancer Center
Appointments
Medical Oncology and Hematology
Associate Professor on TermPrimary
Other Departments & Organizations
- Developmental Therapeutics
- Hematology
- Internal Medicine
- Leukemia & Lymphoma Program
- Medical Oncology and Hematology
- Office for CE in Medicine
- Yale Cancer Center
- Yale Ventures
- YCC Collaborative Excellence
Education & Training
- Fellowship
- Yale University School of Medicine (2011)
- Residency
- Albert Einstein College of Medicine/Montefiore Medical Center (2007)
- MD
- State University of New York at Stony Brook (2004)
- BA
- The College of Saint Rose, Albany, NY, 2000, Biology (2000)
Research
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Overview
Dr. Isufi's clinical work has been in the area of hematologic malignancies and autologous and allogeneic stem cell transplantation for these conditions. As part of the lymphoid malignancy and transplant teams, she developed a strong clinical interest in aggressive lymphomas. She has focused her efforts in treating patients with aggressive lymphomas as part of clinical trials and consolidating their response to treatment with either autologous or allogeneic transplant based on specifics of their disease. She has a research interest in early drug development in lymphoma, and has served as local PI for a variety of industry- and cooperative-group-sponsored lymphoma trials, including phase 1 trials.
Medical Research Interests
Bone Marrow Transplantation; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Graft vs Host Disease; Lymphoma; Transplantation Conditioning
Research at a Glance
Yale Co-Authors
Frequent collaborators of Iris Isufi's published research.
Publications Timeline
A big-picture view of Iris Isufi's research output by year.
Research Interests
Research topics Iris Isufi is interested in exploring.
Francine Foss, MD
Stuart Seropian, MD
Lohith Gowda, MD, MRCP
Scott Huntington, MD, MPH, MSc
Shalin Kothari, MD
Noffar Bar, MD
47Publications
511Citations
Graft vs Host Disease
Transplantation Conditioning
Lymphoma
Publications
2025
Weekly dosing schedule of brentuximab vedotin is well tolerated in mycosis fungoides/Sézary syndrome
Lee M, Schiffer M, Isufi I, Huntington S, Xu M, Sethi T, Kothari S, Girardi M, Foss F. Weekly dosing schedule of brentuximab vedotin is well tolerated in mycosis fungoides/Sézary syndrome. British Journal Of Haematology 2025 PMID: 40968584, DOI: 10.1111/bjh.70147.Peer-Reviewed Original ResearchAltmetricCT-305: Optimizing Post-Chimeric Antigen Receptor (CAR) T-Cell Monitoring: Evidence Across Lisocabtagene Maraleucel (liso-cel) Pivotal Clinical Trials and Real-World Experience
Kamdar M, Shadman M, Ahmed S, Abramson J, Perales M, Ahmed N, Mirza A, Isufi I, Frigault M, Crombie J, Miklos D, Vasconcelos A, Crotta A, Bernasconi D, Roy D, Bleickardt E, Pasquini M, Hunter B, Lunning M. CT-305: Optimizing Post-Chimeric Antigen Receptor (CAR) T-Cell Monitoring: Evidence Across Lisocabtagene Maraleucel (liso-cel) Pivotal Clinical Trials and Real-World Experience. Clinical Lymphoma Myeloma & Leukemia 2025, 25: s1010-s1011. DOI: 10.1016/s2152-2650(25)02770-3.Peer-Reviewed Original ResearchCitationsConceptsImmune effector cell-associated neurotoxicity syndromeCytokine release syndromeCenter for International Blood and Marrow Transplant ResearchStandard-of-careClinical trialsB-cell non-Hodgkin lymphomaCAR-T cell therapyStandard-of-care settingsT-cell therapyNon-Hodgkin's lymphomaMarrow Transplant ResearchLiso-celLisocabtagene maraleucelPivotal trialsAntigen receptorNeurotoxicity syndromeB cellsInfusionPatientsTransplantation researchInformed consentRegistry dataLBCLLow gradeWeeksPOSTER: CT-305 Optimizing Post-Chimeric Antigen Receptor (CAR) T-Cell Monitoring: Evidence Across Lisocabtagene Maraleucel (liso-cel) Pivotal Clinical Trials and Real-World Experience
Kamdar M, Shadman M, Ahmed S, Abramson J, Perales M, Ahmed N, Mirza A, Isufi I, Frigault M, Crombie J, Miklos D, Vasconcelos A, Crotta A, Bernasconi D, Roy D, Bleickardt E, Pasquini M, Hunter B, Lunning M. POSTER: CT-305 Optimizing Post-Chimeric Antigen Receptor (CAR) T-Cell Monitoring: Evidence Across Lisocabtagene Maraleucel (liso-cel) Pivotal Clinical Trials and Real-World Experience. Clinical Lymphoma Myeloma & Leukemia 2025, 25: s318. DOI: 10.1016/s2152-2650(25)01398-9.Peer-Reviewed Original ResearchA multicenter phase 1/2 trial of lenalidomide and dose-adjusted EPOCH-R in MYC-associated DLBCL
Cahill K, Godfrey J, Nabhan C, Kline J, Riedell P, Cohen K, Narula S, Karrison T, Robertson J, Karmali R, Venugopal P, Kim S, Rapoport A, Lee S, Law J, Fishkin P, Isufi I, Velasco M, Kaminer L, Smith S. A multicenter phase 1/2 trial of lenalidomide and dose-adjusted EPOCH-R in MYC-associated DLBCL. Blood Advances 2025 PMID: 40720747, DOI: 10.1182/bloodadvances.2025017092.Peer-Reviewed Original ResearchCitationsConceptsDiffuse large B-cell lymphomaDA-EPOCH-RProgression-free survivalDose-adjusted EPOCH-REPOCH-RResponse rateEfficacy criteriaRandomized trialsMulticenter phase 1/2 studyLarge B-cell lymphomaBenefit of lenalidomidePhase 1/2 studyTrial of lenalidomideMedian Follow-UpB-cell lymphomaMyc-driven lymphomasFifty-five patientsDeregulation of MYCR-CHOPBCL2 rearrangementNeutropenic feverOverall survivalPrimary malignancyStage III/IVInferior outcomes458 | OPTIMIZING POST–CHIMERIC ANTIGEN RECEPTOR T CELL MONITORING: EVIDENCE ACROSS LISOCABTAGENE MARALEUCEL PIVOTAL CLINICAL TRIALS AND REAL‐WORLD EXPERIENCE
Kamdar M, Shadman M, Ahmed S, Abramson J, Perales M, Ahmed N, Mirza A, Isufi I, Frigault M, Crombie J, Miklos D, Vasconcelos A, Crotta A, Bernasconi D, Roy D, Bleickardt E, Pasquini M, Hunter B, Lunning M. 458 | OPTIMIZING POST–CHIMERIC ANTIGEN RECEPTOR T CELL MONITORING: EVIDENCE ACROSS LISOCABTAGENE MARALEUCEL PIVOTAL CLINICAL TRIALS AND REAL‐WORLD EXPERIENCE. Hematological Oncology 2025, 43 DOI: 10.1002/hon.70094_458.Peer-Reviewed Original ResearchConceptsOptimizing post–chimeric antigen receptor (CAR) T cell monitoring: Evidence across lisocabtagene maraleucel (liso-cel) pivotal clinical trials and real-world experience.
Kamdar M, Shadman M, Ahmed S, Abramson J, Perales M, Ahmed N, Mirza S, Isufi I, Frigault M, Crombie J, Miklos D, Vasconcelos A, Crotta A, Bernasconi D, Roy D, Bleickardt E, Pasquini M, Hunter B, Lunning M. Optimizing post–chimeric antigen receptor (CAR) T cell monitoring: Evidence across lisocabtagene maraleucel (liso-cel) pivotal clinical trials and real-world experience. Journal Of Clinical Oncology 2025, 43: 7026-7026. DOI: 10.1200/jco.2025.43.16_suppl.7026.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStandard of careLiso-celPivotal clinical trialsMedian durationClinical trialsR/R LBCLCenter for International Blood and Marrow Transplant Research (CIBMTR) registryCAR-T cell therapyB-cell NHLT-cell therapyT-cell monitoringLisocabtagene maraleucelCause of deathAntigen receptorB cellsCIBMTRInfusionLBCLRegistryLow gradeTrialsR/RMedianDurationDaysNivolumab plus ifosfamide, carboplatin, and etoposide are a highly effective first salvage regimen in high‐risk relapsed/refractory Hodgkin lymphoma
Mei M, Palmer J, Lee H, Isufi I, Chen R, Tsai N, Armenian S, Godfrey J, Song J, Baird J, Thiruvengadam S, Samara Y, Flores J, Peters L, Rosen S, Kwak L, Forman S, Herrera A. Nivolumab plus ifosfamide, carboplatin, and etoposide are a highly effective first salvage regimen in high‐risk relapsed/refractory Hodgkin lymphoma. HemaSphere 2025, 9: e70126. PMID: 40313510, PMCID: PMC12042211, DOI: 10.1002/hem3.70126.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAutologous stem cell transplantationProgression-free survivalOverall survivalRr-cHLSalvage regimenHodgkin lymphomaAnti-PD-1 antibodyEffective salvage regimenRelapsed/Refractory Hodgkin LymphomaImmune-related toxicitiesPatients discontinued treatmentHigh-risk diseaseStem cell transplantationLugano classificationRefractory cHLExtranodal diseasePost-ASCTB symptomsFrontline therapyResponding patientsBrentuximab vedotinCR rateB. PatientsCell transplantationPrimary endpointImpact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant
VanOudenhove J, Liu Y, Nelakanti R, Kim D, Busarello E, Ovalle N, Qi Z, Mamillapalli P, Siddon A, Bai Z, Axtmayer A, Corso C, Kothari S, Foss F, Isufi I, Tebaldi T, Gowda L, Fan R, Seropian S, Halene S. Impact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant. PLOS ONE 2025, 20: e0320744. PMID: 40294012, PMCID: PMC12036906, DOI: 10.1371/journal.pone.0320744.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHematopoietic stem cell transplantationMemory T cellsStem cell transplantationCell transplantationT cellsSARS-CoV-2Hematopoietic stem cell transplant recipientsAntigen-specific T-cell activationSARS-CoV-2 mRNA vaccinesSARS-CoV-2 vaccine responsesSevere diseaseAnti-spike IgGT cell activationAdaptive immune responsesRobust antibody responsesPost-vaccination responseSARS-CoV-2 infectionMRNA vaccine seriesSingle-cell RNAMyeloablative chemotherapyCellular responsesImmune profileVaccine responseCOVID-19 infectionMRNA vaccinesOutcomes after Allogeneic Transplantation with Reduced Intensity Conditioning and Post Transplant Cyclophosphamide GvHD Prophylaxis in T-Cell Lymphomas: A Single Institution Experience
Taborda C, Isufi I, Bar N, Sethi T, Gowda L, Perreault S, Roberts K, Seropian S, Foss F. Outcomes after Allogeneic Transplantation with Reduced Intensity Conditioning and Post Transplant Cyclophosphamide GvHD Prophylaxis in T-Cell Lymphomas: A Single Institution Experience. Transplantation And Cellular Therapy 2025, 31: s393-s394. DOI: 10.1016/j.jtct.2025.01.606.Peer-Reviewed Original ResearchConceptsAcute graft-versus-host diseaseReduced-intensity conditioningGraft-versus-lymphomaNon-relapse mortalityPosttransplant cyclophosphamideT-cell lymphomaAllo-SCTOverall survivalGVHD prophylaxisT cellsAssociated with improved overall survivalTacrolimus-based GVHD prophylaxisAllogeneic stem cell transplantationGraft-versus-host diseaseAggressive T-cell lymphomaT-cell lymphoma patientsHaplo-identical transplantationReduced intensity conditioningImproved overall survivalRelapse-free survivalMedian Follow-UpSingle-center experienceReduce treatment toxicityStem cell transplantationSingle institution experienceEffectiveness and Safety Outcomes of Standard of Care (SOC) Lisocabtagene Maraleucel (liso-cel) in Patients (Pts) with Relapsed or Refractory (R/R) Transformed Large B-Cell Lymphoma (tLBCL): Results from the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry
Isufi I, Crombie J, Frigault M, Andreadis C, Lin Y, Mirza A, Kim S, Bernasconi D, Toron F, Krimmel T, Roy D, Pasquini M, Ahmed S. Effectiveness and Safety Outcomes of Standard of Care (SOC) Lisocabtagene Maraleucel (liso-cel) in Patients (Pts) with Relapsed or Refractory (R/R) Transformed Large B-Cell Lymphoma (tLBCL): Results from the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry. Transplantation And Cellular Therapy 2025, 31: s215. DOI: 10.1016/j.jtct.2025.01.329.Peer-Reviewed Original ResearchCitationsConceptsImmune effector cell-associated neurotoxicity syndromeCytokine release syndromeDuration of responseLiso-celNonrelapse mortalityCR rateCenter for International Blood and Marrow Transplant Research (CIBMTR) registryMedian duration of responseCAR-T cell productsLarge B-cell lymphomaB-cell lymphomaClinically significant infectionsB-cell malignanciesT cell productionConsistent with clinical studiesCD19-directedExtranodal involvementLisocabtagene maraleucelNRM ratesProlonged cytopeniasR/R LBCLIndolent lymphomaData cutoffElevated LDHRadiation therapy
Clinical Trials
Current Trials
Phase 2 Study of Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory CD30 Positive T-cell Lymphoma
HIC ID2000029793RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsPhase 1b/2, Open-Label Study to Evaluate Safety and Tolerability of Epcoritamab in Combination With Anti-Neoplastic Agents in Subjects With Non-Hodgkin Lymphoma
HIC ID2000032539RolePrincipal InvestigatorPrimary Completion Date05/19/2029Recruiting ParticipantsA Randomized, Phase IIB, Multicenter, Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in Patients With Relapse or Refractory Peripheral T-cell Lymphoma (PTCL)
HIC ID2000030190RoleSub InvestigatorPrimary Completion Date06/02/2026Recruiting ParticipantsNovel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma
HIC ID2000028918RoleSub InvestigatorPrimary Completion Date01/30/2026Recruiting ParticipantsA Multi-center Single Arm Phase II Study to Evaluate the Safety and Efficacy of Genetically Engineered Autologous Cells Expressing Anti-CD20 and Anti-CD19 Specific Chimeric Antigen Receptor in Subjects With Relapsed and/or Refractory Diffuse Large B Cell Lymphoma
HIC ID2000028478RolePrincipal InvestigatorPrimary Completion Date07/30/2023Recruiting Participants
Academic Achievements & Community Involvement
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Honors
honor ASCO/AACR Methods in Clinical Cancer Research Workshop Fellow, Vail, CO
08/01/2008National AwardAACRDetailsUnited Stateshonor Outstanding House Officer in Internal Medicine Award
10/01/2007Other AwardAlbert Einstein College of Medicine/Montefiore Medical CenterDetailsUnited Stateshonor The Kijeon Yoo Award for Determination in Pursuit of a Medical Education
10/01/2004Other AwardStony Brook University School of MedicineDetailsUnited Stateshonor Medical School Merit-Based Scholarship
10/01/2004Other AwardStony Brook University School of MedicineDetailsUnited States
News & Links
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News
- March 31, 2025
Yale’s Post ASH Review: Highlights from the 2024 American Society of Hematology Annual Meeting
- November 26, 2024
Yale Cancer Center to Highlight Breakthroughs in Blood Cancers and Disorders at World’s Largest Hematology Meeting
- July 30, 2024
Smilow Cancer Hospital Cellular Therapies Program
- November 08, 2023
Smilow Shares with Primary Care: Lymphadenopathy and Diagnosis
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