Ibolya Csecs
Clinical FellowAbout
Research
Publications
2026
Coronary microvascular dysfunction in systemic sclerosis: insights from PET-derived myocardial flow reserve
Williams K, Emokpae M, Koyi B, Csecs I, Gunes I, Frohlich B, Sinusas A, Hinchcliff M, Feher A. Coronary microvascular dysfunction in systemic sclerosis: insights from PET-derived myocardial flow reserve. Rheumatology 2026, 65: keag215. PMID: 42024682, DOI: 10.1093/rheumatology/keag215.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionMyocardial perfusion imagingPET myocardial perfusion imagingSystemic sclerosis patientsSystemic sclerosisMyocardial blood flowNon-invasive markerMicrovascular dysfunctionPET-derived MBFMarker of vascular involvementFlow reserveResting myocardial blood flowStress myocardial blood flowCalcium channel blockersYale-New Haven HospitalAssociated with vasodilationAutoimmune rheumatologic diseasesMyocardial flow reserveMMF useImmunomodulatory therapyVascular involvementChannel blockersNew Haven HospitalCardiovascular comorbiditiesProspective validationAssociation of Rheumatoid Arthritis with Major Adverse Cardiovascular Events Despite Normal Myocardial Perfusion Imaging
Frohlich B, Pires J, Kyrakoulis I, Wright C, Csecs I, Ahmed A, Jones X, Jacobs M, Hinchcliff M, Miller E, Feher A. Association of Rheumatoid Arthritis with Major Adverse Cardiovascular Events Despite Normal Myocardial Perfusion Imaging. American Journal Of Preventive Cardiology 2026, 101624. DOI: 10.1016/j.ajpc.2026.101624.Peer-Reviewed Original ResearchMyocardial perfusion imagingCoronary artery calcificationNormal myocardial perfusion imagingPerfusion imagingRheumatoid arthritisStress myocardial perfusion imagingPET myocardial perfusion imagingMedian Follow-UpReversible perfusion defectsDetect coronary artery calcificationHeart failure hospitalizationAssociated with higher riskMultivariate Cox regressionAdverse cardiovascular eventsNon-RA patientsAggressive preventive strategiesAssociation of rheumatoid arthritisLate revascularizationFailure hospitalizationCardiovascular-specific mortalityPerfusion defectsRA subgroupsCardiovascular comorbiditiesCardiovascular eventsAutoimmune diseasesCoronary calcifications and myocardial flow reserve in heart transplant patients: a longitudinal study
Wright C, Kiage J, Kyriakoulis I, Csecs I, Ahmed A, Tong G, Zeng Y, Liu Y, Bellumkonda L, Kokkinidis D, Sinusas A, Miller E, Feher A. Coronary calcifications and myocardial flow reserve in heart transplant patients: a longitudinal study. European Heart Journal 2026, ehag163. PMID: 41780909, DOI: 10.1093/eurheartj/ehag163.Peer-Reviewed Original Research
2025
A Comparative Analysis of CZT SPECT/CT to Conventional SPECT and PET: Implications for Risk Stratification
Ahmed A, Csecs I, Wright C, Kyriakoulis I, Kokkinidis D, Miller E, Feher A. A Comparative Analysis of CZT SPECT/CT to Conventional SPECT and PET: Implications for Risk Stratification. Journal Of Nuclear Cardiology 2025, 102583. PMID: 41325821, DOI: 10.1016/j.nuclcard.2025.102583.Peer-Reviewed Original ResearchIndividualized care or standardized protocol: should all patients with systemic sclerosis receive cardiac MRI?
Csecs I, Feher A. Individualized care or standardized protocol: should all patients with systemic sclerosis receive cardiac MRI? Rheumatology 2025, 65: keaf531. PMID: 41105207, PMCID: PMC12862381, DOI: 10.1093/rheumatology/keaf531.Commentaries, Editorials and LettersBlunted hemodynamic response to pharmacological stress is predictive of mortality in liver transplant candidates
Csecs I, Sharma A, Khungar V, Sinusas A, Possick S, Miller E, Feher A. Blunted hemodynamic response to pharmacological stress is predictive of mortality in liver transplant candidates. Journal Of Nuclear Cardiology 2025, 52: 102454. PMID: 40769316, DOI: 10.1016/j.nuclcard.2025.102454.Peer-Reviewed Original ResearchLiver transplant candidatesMELD scoreAssociated with mortalityRetrospective studyCardiovascular comorbiditiesLiver diseaseMedian follow-up periodTransplant candidatesResponse to pharmacological stressSingle-photon Emission Computed TomographyRegadenoson stress testingEnd-stage liver diseaseIncremental prognostic valueNuclear stress testingRetrospective cohort analysisFollow-up periodChronic liver diseaseBody mass indexCoronary artery diseaseHemodynamic responseStress testEmission Computed TomographyDiastolic blood pressurePredictive of mortalityPositron emission tomographyQuantification of Hand Blood Flow by 82Rubidium Positron Emission Tomography
Feher A, Gunes I, Csecs I, Peters D, Sinusas A, Miller E, Hinchcliff M. Quantification of Hand Blood Flow by 82Rubidium Positron Emission Tomography. The Journal Of Rheumatology 2025, 52: jrheum.2025-0415. PMID: 40592556, PMCID: PMC12225603, DOI: 10.3899/jrheum.2025-0415.Commentaries, Editorials and LettersTemporal changes in PET myocardial flow reserve: Implications for cardiovascular outcomes
Nikolakopoulos I, Csecs I, Liu Y, Sinusas A, Miller E, Feher A. Temporal changes in PET myocardial flow reserve: Implications for cardiovascular outcomes. Journal Of Nuclear Cardiology 2025, 48: 102194. PMID: 40139484, DOI: 10.1016/j.nuclcard.2025.102194.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsMyocardial perfusion imagingEvaluation of coronary artery diseasePositron emission tomographyClinical risk factorsMyocardial flow reserveCoronary artery diseasePositron emission tomography myocardial perfusion imagingRates of major-adverse cardiovascular eventsCardiovascular outcomesArtery diseaseFlow reserveMedian follow-up timeRisk factorsLong-term major adverse cardiovascular eventsHistory of heart transplantationC-statisticMedian interval timeKaplan-Meier methodFollow-up timeAdverse cardiovascular eventsChest painTransplant vasculopathyMyocardial blood flowHeart transplantationA series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure
Nazarenko N, Maliha M, Parker M, Borkowski P, Csecs I, Tauras J, Shin J, Pullman J, Sims D, Rochlani Y. A series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure. Annals Of Medicine And Surgery 2025, 87: 1334-1340. PMID: 40213182, PMCID: PMC11981468, DOI: 10.1097/ms9.0000000000002997.Peer-Reviewed Original ResearchSystemic lupus erythematosusHCQ useHeart failureCardiac abnormalitiesCardiac magnetic resonance imagingDose-dependent complicationsRheumatoid arthritisCases of SLE patientsDiscontinuation of hydroxychloroquineResolution of symptomsLong-term therapyEarly detectionShortness of breathA-V blockHCQ therapyMagnetic resonance imagingPrompt discontinuationEndomyocardial biopsyPulmonary hypertensionEjection fractionHF therapyCardiac symptomsImprove patient outcomesSLE patientsSjogren's syndromeBeyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series
Nazarenko N, Maliha M, Cerna L, Abittan N, Borkowski P, Csecs I, Garcia M. Beyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series. Annals Of Medicine And Surgery 2025, 87: 56-61. PMID: 40109641, PMCID: PMC11918691, DOI: 10.1097/ms9.0000000000002855.Peer-Reviewed Original ResearchLeft ventricleDextrocardia patientsICD placementSeverely reduced ejection fractionHigh risk of sudden cardiac deathRight-sided pleural effusionRisk of sudden cardiac deathAbnormal myocardial developmentYears of follow-upNon-compacted myocardiumTreated with amiodaroneSubsegmental pulmonary embolismTreated with enoxaparinLong-term outcomesSudden cardiac deathSystolic dysfunctionEvent-freeWorsening dyspneaEjection fractionPulmonary embolismAtrial dilatationPleural effusionConduction abnormalitiesMedical therapyCase series