Huihui Yu, PhD
she/her/hers
Statistician 3Cards
About
Research
Publications
2025
Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID
Gottlieb M, Chen J, Yu H, Santangelo M, Spatz E, Gentile N, Geyer R, Malicki C, Gatling K, O’Laughlin K, Stephens K, Elmore J, Wisk L, L’Hommedieu M, Rodriguez R, Montoy J, Wang R, Rising K, Kean E, Dyal J, Hill M, Venkatesh A, Weinstein R, Koo K, Derden A, Ahmed Z, Gomez C, Guzman D, Hassaballa M, Kaadan A, Kinsman J, Lin Z, Li S, Mannan I, Yang Z, Liu M, Ulrich A, Dorney J, Pierce S, Puente X, Salah W, Nichol G, Anderson J, Schiffgens M, Morse D, Adams K, Stober T, Maat Z, Willis M, Zhang Z, Chang G, Lyon V, Klabbers R, Ruiz L, Malone K, Park J, Chang A, Renzi N, Watts P, Kelly M, Schaeffer K, Grau D, Cheng D, Shutty C, Charlton A, Shughart L, Shughart H, Amadio G, Miao J, Hannikainen P, Chandler C, Eguchi M, Diaz Roldan K, Moreno R, Kemball R, Chan V, Lara Chavez C, Wong A, Arreguin M, Huebinger R, Kane A, Nikonowicz P, Sapp S, Idris A, McDonald S, Gallegos D, Martin K, Saydah S, Plumb I, Hall A, Briggs-Hagen M. Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID. JAMA Network Open 2025, 8: e2526310. PMID: 40794410, PMCID: PMC12344534, DOI: 10.1001/jamanetworkopen.2025.26310.Peer-Reviewed Original ResearchConceptsProspective cohort studyWork impairmentFinancial toxicityFollow-up electronic surveyProspective cohort study of adultsCohort study of adultsChronic Illness TherapyLongitudinal cohort studyActivity Impairment QuestionnaireStudy of adultsQuality of lifeLong COVIDFinancial outcomesIllness TherapyHealth statusImpairment QuestionnaireMain OutcomesElectronic surveySelf-ReportCohort studyAdult participantsOddsHealthWork productivityAssistance programsEffects of long COVID on healthcare utilization
Gottlieb M, Spatz E, Yu H, Mannan I, Santangelo M, Malicki C, Gentile N, Geyer R, Charlton A, Dyal J, Elmore J, Gatling K, Hill M, Montoy J, O’Laughlin K, Rising K, Saydah S, Stephens K, Wang R, Wisk L, Venkatesh A, Weinstein R, Group F. Effects of long COVID on healthcare utilization. PLOS ONE 2025, 20: e0327218. PMID: 40700379, PMCID: PMC12286388, DOI: 10.1371/journal.pone.0327218.Peer-Reviewed Original ResearchConceptsHealthcare utilizationElectronic health record dataLong COVIDHealth record dataHealthcare resource planningQuality of lifeEffects of long COVIDHealthcare usageVisit lengthED visitsVisit categoryTelehealth visitsVisit typeOffice visitsSecondary analysisRecord dataAdult participantsInclusion criteriaSecondary outcomesPrimary outcomeConfirmed with testsHealthcareNon-LC groupVisitsVisit numberThe Effect of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection on Long-Term Symptoms in the Innovative Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE)
Openshaw J, Chen J, Rodriguez R, Gottlieb M, McCullough K, Santangelo M, Hill M, Gatling K, Idris A, McDonald S, Wisk L, Dyal J, Wang R, Rising K, Kean E, O’Laughlin K, Stephens K, Malicki C, Lin Z, Spatz E, Yu H, Weinstein R, Elmore J. The Effect of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection on Long-Term Symptoms in the Innovative Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE). Clinical Infectious Diseases 2025, ciaf225. PMID: 40576557, DOI: 10.1093/cid/ciaf225.Peer-Reviewed Original ResearchLong-term symptomsSymptoms 3Positive SARS-CoV-2 testSARS-CoV-2 testingAcute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2SARS-CoV-2Severe fatigueLonger-term clinical outcomesSyndrome coronavirus 2Effects of severe acute respiratory syndrome coronavirus 2Single infectionSARS-CoV-2 infectionCoronavirus 2Time of initial infectionDelta periodOddsRegistryClinical outcomesSevere acute respiratory syndrome coronavirus 2Clinical consequencesRepeated infectionsSymptomsReinfectionIndividualsAssociation of SARS-CoV-2 With Health-related Quality of Life 1 Year After Illness Using Latent Transition Analysis
Wisk L, Gottlieb M, Chen P, Yu H, O’Laughlin K, Stephens K, Nichol G, Montoy J, Rodriguez R, Santangelo M, Gatling K, Spatz E, Venkatesh A, Rising K, Hill M, Huebinger R, Idris A, Willis M, Kean E, McDonald S, Elmore J, Weinstein R. Association of SARS-CoV-2 With Health-related Quality of Life 1 Year After Illness Using Latent Transition Analysis. Open Forum Infectious Diseases 2025, 12: ofaf278. PMID: 40496983, PMCID: PMC12150399, DOI: 10.1093/ofid/ofaf278.Peer-Reviewed Original ResearchCOVID-19-like illnessPoor physicalOptimal HRQoLHealth-related quality of life 1 yearHealth-related quality-of-lifeLatent transition analysisHealth-related qualityPatient-reported HRQoLQuality of life 1 yearFollow-up assessmentQuality-of-lifeLongitudinal registry studySuboptimal HRQoLInverse probability weightingMental HRQOLPhysical HRQoLOverall HRQoL.PROMIS-29HRQoL scoresSARS-CoV-2 testingHRQoL changesHRQoL classesHRQoLWell-being classesTested SARS-CoV-2Differences in Long COVID severity by duration of illness, symptom evolution, and vaccination: a longitudinal cohort study from the INSPIRE group
Gottlieb M, Yu H, Chen J, Spatz E, Gentile N, Geyer R, Santangelo M, Malicki C, Gatling K, Saydah S, O'Laughlin K, Stephens K, Elmore J, Wisk L, L'Hommedieu M, Rodriguez R, Montoy J, Wang R, Rising K, Kean E, Dyal J, Hill M, Venkatesh A, Weinstein R. Differences in Long COVID severity by duration of illness, symptom evolution, and vaccination: a longitudinal cohort study from the INSPIRE group. The Lancet Regional Health - Americas 2025, 44: 101026. PMID: 40040820, PMCID: PMC11875141, DOI: 10.1016/j.lana.2025.101026.Peer-Reviewed Original ResearchPatient-Reported Outcomes Measurement Information SystemMental health outcomesMental healthHealth outcomesAssociated with better outcomesOutcomes Measurement Information SystemModerate-to-high stressLong COVIDMeasurement Information SystemCenters for Disease Control and PreventionModerate-to-severe fatigueDisease Control and PreventionLongitudinal cohort studyControl and PreventionStudy of participantsBetter outcomesVaccination statusCohort studyCOVID cohortDuration of long-COVIDWorse dyspneaHealthDuration of illnessHigher likelihoodInspiration group
2024
Race, Ethnicity, and Gender Differences in Patient Reported Well-Being and Cognitive Functioning Within 3 Months of Symptomatic Illness During COVID-19 Pandemic
Hill M, Huebinger R, Ebna Mannan I, Yu H, Wisk L, O’Laughlin K, Gentile N, Stephens K, Gottlieb M, Weinstein R, Koo K, Santangelo M, Saydah S, Spatz E, Lin Z, Schaeffer K, Kean E, Montoy J, Rodriguez R, Idris A, McDonald S, Elmore J, Venkatesh A. Race, Ethnicity, and Gender Differences in Patient Reported Well-Being and Cognitive Functioning Within 3 Months of Symptomatic Illness During COVID-19 Pandemic. Journal Of Racial And Ethnic Health Disparities 2024, 12: 3192-3209. PMID: 39172356, PMCID: PMC11891493, DOI: 10.1007/s40615-024-02124-8.Peer-Reviewed Original ResearchPROMIS T-scoresPain interferenceBlack participantsWell-beingHealth-related quality of lifeNon-Hispanic white participantsCognitive functionMeasures of healthHealth-related qualityMethodsThis prospective cohort studyFollow-up surveyProspective cohort studyT-scoreQuality of lifeCOVID-19-related health outcomesLower well-beingPROMIS-29Physical functionHealth outcomesBaseline to 3Social participationWhite participantsCohort studyCOVID-19Sleep disturbanceThe association between prolonged SARS-CoV-2 symptoms and work outcomes
Venkatesh A, Yu H, Malicki C, Gottlieb M, Elmore J, Hill M, Idris A, Montoy J, O’Laughlin K, Rising K, Stephens K, Spatz E, Weinstein R, Group F. The association between prolonged SARS-CoV-2 symptoms and work outcomes. PLOS ONE 2024, 19: e0300947. PMID: 39074096, PMCID: PMC11285965, DOI: 10.1371/journal.pone.0300947.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 symptomsReturn to workAssociated with increased oddsAnalyzed self-reported dataNational cohort studySelf-reported dataLong COVIDCOVID-19 pandemicLost work timePublic health emergencyWork absenteeismMissed workdaysElectronic surveyEmployment statusSARS-CoV-2 infectionWell-being impactsOdds ratioWork lossCohort studyNumerous healthImpact of long COVIDCOVID-19Risk factorsThree-monthsHealth emergencyMeasuring Equity in Readmission as a Distinct Assessment of Hospital Performance
Nash K, Weerahandi H, Yu H, Venkatesh A, Holaday L, Herrin J, Lin Z, Horwitz L, Ross J, Bernheim S. Measuring Equity in Readmission as a Distinct Assessment of Hospital Performance. JAMA 2024, 331: 111-123. PMID: 38193960, PMCID: PMC10777266, DOI: 10.1001/jama.2023.24874.Peer-Reviewed Original ResearchConceptsBlack patientsPatient populationHospital characteristicsHospital-wide readmission measureDual-eligible patientsHospital patient populationCross-sectional studyMeasures of hospitalHealth care qualityPatient demographicsReadmission ratesClinical outcomesPatient raceEligible hospitalsReadmissionMAIN OUTCOMEReadmission measuresMedicare dataUS hospitalsHospitalCare qualityPatientsMedicaid ServicesOutcomesLower percentage
2022
Three-Month Symptom Profiles Among Symptomatic Adults With Positive and Negative Severe Acute Respiratory Syndrome Coronavirus 2 Tests: A Prospective Cohort Study From the INSPIRE Group
Spatz E, Gottlieb M, Wisk L, Anderson J, Chang A, Gentile N, Hill M, Huebinger R, Idris A, Kinsman J, Koo K, Li S, McDonald S, Plumb I, Rodriguez R, Saydah S, Slovis B, Stephens K, Unger E, Wang R, Yu H, Hota B, Elmore J, Weinstein R, Venkatesh A. Three-Month Symptom Profiles Among Symptomatic Adults With Positive and Negative Severe Acute Respiratory Syndrome Coronavirus 2 Tests: A Prospective Cohort Study From the INSPIRE Group. Clinical Infectious Diseases 2022, 76: 1559-1566. PMID: 36573005, PMCID: PMC11361781, DOI: 10.1093/cid/ciac966.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 symptomsSARS-CoV-2 infectionPost-infectious syndromesProspective cohort studyCohort studyCOVID groupAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2 test resultsSyndrome coronavirus 2 infectionEar/nose/throatSevere acute respiratory syndrome coronavirus 2 testsCoronavirus 2 infectionLong-term symptomsNose/throatLong COVIDSymptomatic adultsMean ageActive symptomsSymptom profilesDrug AdministrationSociodemographic characteristicsSymptomsInfectionMonthsAssociation of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness
Wisk L, Gottlieb M, Spatz E, Yu H, Wang R, Slovis B, Saydah S, Plumb I, O’Laughlin K, Montoy J, McDonald S, Lin Z, Lin J, Koo K, Idris A, Huebinger R, Hill M, Gentile N, Chang A, Anderson J, Hota B, Venkatesh A, Weinstein R, Elmore J, Nichol G, Santangelo M, Ulrich A, Li S, Kinsman J, Krumholz H, Dorney J, Stephens K, Black K, Morse D, Morse S, Fernandes A, Sharma A, Stober T, Geyer R, Lyon V, Adams K, Willis M, Ruiz L, Park J, Malone K, Shughart H, Schaeffer K, Shughart L, Arab A, Grau D, Patel A, Watts P, Kelly M, Hunt A, Hannikainen P, Chalfin M, Cheng D, Miao J, Shutty C, Chavez S, Kane A, Marella P, Gallegos G, Martin K, L'Hommedieu M, Chandler C, Diaz Roldan K, Villegas N, Moreno R, Eguchi M, Rodriguez R, Kemball R, Chan V, Chavez C, Wong A, Hall A, Briggs-Hagen M. Association of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness. JAMA Network Open 2022, 5: e2244486. PMID: 36454572, PMCID: PMC9716377, DOI: 10.1001/jamanetworkopen.2022.44486.Peer-Reviewed Original ResearchConceptsCOVID-19 positive groupCOVID-19-negative groupSARS-CoV-2 infectionCOVID-19 testCOVID-19 resultsSymptomatic illnessSymptomatic SARS-CoV-2 infectionNegative COVID-19 resultsSARS-CoV-2 statusSARS-CoV-2 test positivityPositive COVID-19 testSARS-CoV-2 testNegative COVID-19 testLongitudinal registry studyOutcomes Measurement Information SystemPatient-reported outcomesHealth care usePositive COVID-19 resultMultivariable regression analysisMeasurement Information SystemCOVID-19 testingNegative test resultsCohort studyRegistry studyPROMIS scores
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