Hester Doyle, PhD
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Rheumatology
Primary
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Research Scientist (Rheumatology, Allergy & Immunology )
Appointments
Rheumatology
Research ScientistPrimary
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Education & Training
- PhD
- University of Oklahoma (1998)
- MSc
- University of Oklahoma (1995)
- BS
- Baldwin Wallace University (1992)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Hester Doyle's published research.
Publications Timeline
A big-picture view of Hester Doyle's research output by year.
Mark Mamula, PhD
11Publications
897Citations
Publications
2017
Oxidative Modifications in Tissue Pathology and Autoimmune Disease
Yang ML, Doyle H, Clarke SG, Herold K, Mamula M. Oxidative Modifications in Tissue Pathology and Autoimmune Disease. Antioxidants & Redox Signaling 2017, 29: 1415-1431. PMID: 29088923, PMCID: PMC6166690, DOI: 10.1089/ars.2017.7382.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPost-translational protein modificationReactive oxygen speciesProtein modificationGene expressionAberrant gene expressionInitiation of apoptosisChromosome inactivationOxidative stressDNA methylationCellular pathwaysGenetic elementsLevels of tissueMicroenvironmental influencesProtein expressionOxygen speciesOxidative modificationTissue pathogenesisPathwayExpressionTherapeutic manipulationPotential therapeutic manipulationEnvironmental influencesCellsIntracellular autoantigensSilencing
2014
Targeting multiple ErbB family members by EGFR peptide immunization. (VAC12P.1016)
Doyle H, Koski R, Bonafé N, Bruck R, Tagliatela S, Gee R, Mamula M. Targeting multiple ErbB family members by EGFR peptide immunization. (VAC12P.1016). The Journal Of Immunology 2014, 192: 206.5-206.5. DOI: 10.4049/jimmunol.192.supp.206.5.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorMonoclonal antibody treatmentAntibody treatmentAnti-EGFR monoclonal antibodiesMonoclonal antibodiesPeptide-based vaccinationAnti-tumor antibodiesMultiple EGFR family membersNatural anti-tumor antibodiesMembrane-proximal epitopeErbB family membersFamily membersGrowth factor receptorStandard chemotherapyTumor vaccinesEGFR family membersCurrent treatmentDrug infusionTumor antigensGreater tumorSerum inhibitsSide effectsTumor killingSingle agentSolid tumors
2006
Intracellular protein modification associated with altered T cell functions in autoimmunity
Yang M, Doyle H, Gee R, Lowenson J, Clarke S, Lawson B, Aswad D, Mamula M. Intracellular protein modification associated with altered T cell functions in autoimmunity. The Journal Of Immunology 2006, 177: 8878-8878. DOI: 10.4049/jimmunol.177.12.8878.Peer-Reviewed Original ResearchIncrease in intracellular protein modification associated with altered lymphocyte functions in autoimmunity
Yang M, Doyle H, Gee R, Aswad D, Mamula M. Increase in intracellular protein modification associated with altered lymphocyte functions in autoimmunity. The FASEB Journal 2006, 20: a964-a964. DOI: 10.1096/fasebj.20.5.a964-a.Peer-Reviewed Original ResearchConceptsT cellsT-cell proliferative defectsLupus-like autoimmunityT cell hyperproliferationAutoimmune miceImmune toleranceAutoimmune responseLupus CD4Peripheral circulationLymphocyte functionAntigen stimulationT lymphocytesThymic selectionB cellsBone marrowCell hyperproliferationHyperproliferative responseAutoimmunityLymphocytesMiceProliferative defectPhysiologic pHNon-enzymatic modificationIsoaspartyl proteinsVivo
2003
Memory CD4+ T cells do not induce graft-versus-host disease
Anderson BE, McNiff J, Yan J, Doyle H, Mamula M, Shlomchik MJ, Shlomchik WD. Memory CD4+ T cells do not induce graft-versus-host disease. Journal Of Clinical Investigation 2003, 112: 101-108. PMID: 12840064, PMCID: PMC162285, DOI: 10.1172/jci17601.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDonor T cellsMemory CD4 cellsMemory T cellsT cellsHost diseaseCD4 cellsMemory T cell depletionPost-transplant immune reconstitutionAllogeneic stem cell transplantationT cell-mediated immunityT-cell depletionCell-mediated immunityRegulatory T cellsStem cell transplantationStem cell graftsGVHD prophylaxisHistologic GVHDLess GVHDMurine resultsImmune reconstitutionLeukemia effectMemory CD4Naive CD4Cell depletionCell transplantation
2001
Post-translational protein modifications in antigen recognition and autoimmunity
Doyle H, Mamula M. Post-translational protein modifications in antigen recognition and autoimmunity. Trends In Immunology 2001, 22: 443-449. PMID: 11473834, DOI: 10.1016/s1471-4906(01)01976-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsStructural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme*
Young A, Carter W, Doyle H, Mamula M, Aswad D. Structural Integrity of Histone H2B in Vivo Requires the Activity of Protein l-IsoaspartateO-Methyltransferase, a Putative Protein Repair Enzyme*. Journal Of Biological Chemistry 2001, 276: 37161-37165. PMID: 11479322, DOI: 10.1074/jbc.m106682200.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHistone H2BIsoaspartate (D-aspartate) O-methyltransferaseNormal gene regulationProtein repair enzymePIMT knockout miceActivity of proteinsRat PC12 cellsGene regulationProtein functionHistone H2B.Core histonesNuclear proteinsSubcellular fractionationProtein agingRepair enzymesH2BO-methyltransferaseAdenosine dialdehydeMethyltransferase inhibitorProtein LHistonesAsp-XaaPC12 cellsIsoAspStoichiometric levelsLupus autoantigens: Their origins, forms, and presentation
Doyle H, Yan J, Liang B, Mamula M. Lupus autoantigens: Their origins, forms, and presentation. Immunologic Research 2001, 24: 131-147. PMID: 11594452, DOI: 10.1385/ir:24:2:131.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSystemic lupus erythematosusMaintenance of autoimmunityT cell compartmentCentral lymphoid organsT cell developmentAutoimmune processLupus erythematosusAntigenic sinAutoreactive cellsAutoimmune diseasesLymphoid organsPresenting cellsB lymphocytesImmune systemAutoimmunityCell compartmentNumber of mechanismsCell developmentInductionErythematosusCellsLupusForeign proteinsLymphocytesCostimulation
2000
Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice
Buchanan K, Doyle H. Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice. Infection And Immunity 2000, 68: 456-462. PMID: 10639404, PMCID: PMC97163, DOI: 10.1128/iai.68.2.456-462.2000.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCentral nervous systemCell-mediated immunityImmune miceT cellsT lymphocytesNervous systemRole of CMIC. neoformansCryptococcus neoformansProtective mechanismT cell numbersSpinal cord homogenateCMI responsesCNS infectionsCryptococcal meningitisLeukocyte accumulationAIDS patientsFatal outcomeImmunized miceVivo depletionCord homogenateIFN-gammaMurine modelHost resistanceCytometric analysis
1999
Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response.
Doyle H, Murphy J. Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. The Journal Of Immunology 1999, 162: 4824-33. PMID: 10202026, DOI: 10.4049/jimmunol.162.8.4824.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntibodies, FungalAntigens, FungalCell MovementChemokine CCL1Chemokine CCL3Chemokine CCL4Chemokines, CCCryptococcosisCryptococcus neoformansCytokinesFemaleGelatin Sponge, AbsorbableHypersensitivity, DelayedImmunity, CellularKineticsLeukocytesMacrophage Inflammatory ProteinsMiceMice, Inbred CBANeutrophilsReceptors, CCR8Recombinant ProteinsConceptsDelayed-type hypersensitivityMIP-1alphaC chemokinesAnticryptococcal cell-mediated immune responseCell-mediated immune responsesCell-mediated immune reactionsMacrophage inflammatory protein-1alphaMonocyte chemotactic protein-1DTH reaction sitesNumber of neutrophilsActivated T lymphocytesGelatin sponge modelCMI responsesNaive miceDTH reactionInfected miceCMI reactionsT cellsT lymphocytesImmune responseImmune reactionsCellular infiltrationLymphocytesChemokinesNeutrophils
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