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Mei-Ling Yang, PhD

Assistant Professor Adjunct
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Assistant Professor Adjunct

Biography

Dr. Mei-Ling Yang is Associate Research Scientist for Rheumatology, Allergy & Immunology at Yale University School of Medicine. She obtained her PhD degree in Biochemistry and Molecular Biology at National Taiwan University at 2002 and then joined the laboratory of Dr. Mark Mamula for her postdoctoral training. She studied the role of protein modifications in lupus autoimmunity under Arthritis Foundation Postdoctoral Fellowship. Dr. Yang became part of the faculty in 2008 and current research focus is to understand how inflammation and posttranslational modifications evoke autoimmune responses in type 1 diabetes and systemic lupus erythematosus.

Last Updated on May 20, 2025.

Appointments

Other Departments & Organizations

Education & Training

PhD
National Taiwan Univ (2002)
BS
National Taiwan Univ (1993)

Research

Overview

Post-translational protein modification influences immunologic responses ranging from intracellular signaling to protein processing and presentation and creates neo-epitopes from self-proteins to break immune tolerance that leads to autoimmune diseases. Systemic erythematosus lupus (SLE) and type 1 diabetes (T1D) are the complex autoimmune diseases involving multiple genetic and environmental factors. My research is to investigate the role of posttranslational protein modifications including isoaspartyl modification, methylation, carbonylation and citrullination on genetic association analysis and biological functions of T cells in the pathogenesis of SLE and T1D. My work provides new insight into the diagnosis of autoimmune diseases where the specific auto-antigen is unknown and provides targets in autoimmune pathways to discover novel therapeutic concepts and biomarkers for inflammatory conditions.

Medical Research Interests

Autoimmune Diseases; Diabetes Mellitus, Type 1; Lupus Erythematosus, Systemic

Research at a Glance

Yale Co-Authors

Frequent collaborators of Mei-Ling Yang's published research.

Publications

2023

2022

2021

2018

2017

2016

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