Haris Mirza, MBBS, PhD
Assistant Professor of PathologyCards
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Featured Publications
Immune Control of Oncogene Selection in the Colon.
Mirza H, Tschiatschek* B, Maqsood* M, Li X, Oh MH, Sefik E, Zhang F, Lau SF, Hashim S, Juric V, Tran F, Agrawal K, Blackburn N, Roulis M, Olaloye O, Konnikova L, Haase G, Kluger Y, Simons B, Corominas-Murtra B, Flavell R. Immune Control of Oncogene Selection in the Colon. 2026 DOI: 10.21203/rs.3.rs-8673399/v1.Peer-Reviewed Original Research
2025
Editorial: Advancements in translational models: bridging basic infection research and clinical applications.
Schmidtchen A, Nadeem A, Mirza H, Wallblom K, Raina DB, Shannon O, Petrlova J, Puthia M. Editorial: Advancements in translational models: bridging basic infection research and clinical applications. Front Med (Lausanne) 2025, 12: 1730195. PMID: 41341817, DOI: 10.3389/fmed.2025.1730195.Peer-Reviewed Original ResearchHumanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow
Sefik E, Philbrick W, Zhang F, Agrawal K, Van Lee B, Sam J, Karatepe K, Zheng Y, Liang K, Peng S, Mirza H, Rangavajhula A, Simon P, Arun N, Babu P, Eynon E, Chiorazzi M, Shan L, Halene S, Luo H, Rongvaux A, Kluger Y, Flavell R. Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2426546122. PMID: 40956886, PMCID: PMC12478129, DOI: 10.1073/pnas.2426546122.Peer-Reviewed Original ResearchConceptsBone marrowHuman CD47Human granulocyte-macrophage progenitorsHuman immune developmentMature human monocytesHuman neutrophilsHumanized mouse modelNeutrophil extracellular trap formationHuman hematopoietic stemGranulocyte-macrophage progenitorsHuman M-CSFHuman immune responseGenetically modified miceResponse to inflammationExtracellular trap formationHuman bone marrowCD47 promoterHuman immune systemPhysiological levelsNK cellsHumanized miceDendritic cellsHematopoietic stemMyeloid lineageHuman hematopoiesisIntegrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma
Nassar A, Kim C, Adeyelu T, Bou Farhat E, Abushukair H, Rakaee M, Matteson K, Lau S, Takabe Y, Ocejo A, Ardeshir-Larijani F, Leal T, Ramalingam S, Alam S, Gray J, Hicks J, Kaldas D, Baena J, Berjaga M, Nana F, Grohe C, Leuders H, Citarella F, Cortellini A, Mingo E, Pancirer D, Das M, Ellis-Caleo T, Cheung J, Lin J, Watson A, Camidge D, Sridhar A, Parikh K, Crowley F, Marron T, Aggarwal V, Ahmed M, Sankar K, Kawtharany H, Zhang J, Owen D, Li M, Nagasaka M, Pinato D, Awosika N, Alhamad K, Puri S, Zaman U, Gupta D, Lau C, Khan H, Liauw J, Velazquez A, Brown T, Moliner L, Mosteiro M, Rocha P, Evans M, Vanderwalde A, Elliott A, Nieva J, Lopes G, Ma P, Borghaei H, Lee M, Young L, Aljumaily R, Mirza H, Kwiatkowski D, Herbst R, Flavell R, Naqash A, Chiang A. Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma. Nature Communications 2025, 16: 7717. PMID: 40830141, PMCID: PMC12365225, DOI: 10.1038/s41467-025-63091-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCarcinoma, Large CellCarcinoma, NeuroendocrineCarcinoma, Non-Small-Cell LungFemaleGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsKelch-Like ECH-Associated Protein 1Lung NeoplasmsLymphocytes, Tumor-InfiltratingMaleMembrane ProteinsMiddle AgedMutationTrypsin Inhibitor, Kazal PancreaticConceptsLarge cell neuroendocrine carcinomaPulmonary large cell neuroendocrine carcinomaCell neuroendocrine carcinomaNeuroendocrine carcinomaClinical characterizationFGL-1DLL3-targeting therapiesTumor-infiltrating lymphocytesAggressive lung tumorsImmunogenomic profilingSCLC-likeOverall survivalLAG-3SPINK1 expressionLung tumorsTreatment regimensAdverse eventsLung cancerIndependent cohortCancer-likeSerial samplesMolecular heterogeneitySPINK1CarcinomaTranscriptional profiles
2023
1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. 1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma. 2023, a1133-a1133. DOI: 10.1136/jitc-2023-sitc2023.1025.Peer-Reviewed Original ResearchHumanized mouse liver reveals endothelial control of essential hepatic metabolic functions
Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner D, Mehal W, AlcHepNet, Kluger Y, Flavell R. Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell 2023, 186: 3793-3809.e26. PMID: 37562401, PMCID: PMC10544749, DOI: 10.1016/j.cell.2023.07.017.Peer-Reviewed Original ResearchConceptsMetabolic functionsSpecies-specific interactionsKey metabolic functionsCell-autonomous mechanismsNon-alcoholic fatty liver diseaseMajor metabolic hubNon-parenchymal cellsMetabolic hubHuman hepatocytesMicroenvironmental regulationHuman diseasesHuman-specific aspectsHuman pathologiesHomeostatic processesSpecies mismatchCholesterol uptakeFatty liver diseaseParacrine mannerHuman immuneBile acid conjugationSinusoidal endothelial cellsHepatic metabolic functionMouse liverEndothelial cellsCellsIL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304319120. PMID: 37459511, PMCID: PMC10372654, DOI: 10.1073/pnas.2304319120.Peer-Reviewed Original ResearchConceptsIL-7R expressionT cellsIL-7RAntitumor memorySuperior antitumor efficacyCell-based therapiesTumor-specific T cellsAntigen-specific T cellsAntitumor efficacyPowerful antitumor immune responseMarkers of exhaustionTumor-specific CD8Antitumor immune responseIndependent prognostic factorAntitumor immune memoryMemory T cellsMajor risk factorSuperior antitumor activityFunctional CD8Memory CD8Prognostic factorsSurgical resectionAdvanced melanomaLymph nodesNaive mice
2022
Editorial: Methods and applications in inflammation pharmacology
Schmidtchen A, Mirza H, van der Plas M, Nadeem A, Puthia M. Editorial: Methods and applications in inflammation pharmacology. Frontiers In Pharmacology 2022, 13: 1108263. PMID: 36578538, PMCID: PMC9792174, DOI: 10.3389/fphar.2022.1108263.Commentaries, Editorials and LettersAn update on ductal plate malformations and fibropolycystic diseases of the liver
Mirza H, Besse W, Somlo S, Weinreb J, Kenney B, Jain D. An update on ductal plate malformations and fibropolycystic diseases of the liver. Human Pathology 2022, 132: 102-113. PMID: 35777701, DOI: 10.1016/j.humpath.2022.06.022.Peer-Reviewed Original ResearchConceptsDuctal plate malformationLiver diseaseAdult polycystic liver diseaseAutosomal dominant polycystic kidneyFibropolycystic liver diseaseIsolated liver involvementCongenital hepatic fibrosisPolycystic liver diseaseVon Meyenburg complexesGenetic underpinningsMultiple clinical phenotypesFibropolycystic diseasePortal hypertensionCaroli's diseaseLiver involvementLiver cystsMeyenburg complexesHepatic fibrosisFibrocystic lesionsHepatocellular malignanciesCyst enlargementAbnormal organ developmentPolycystic kidneysAnimal modelsHepatocellular malignancyInflammasome activation in infected macrophages drives COVID-19 pathology
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature 2022, 606: 585-593. PMID: 35483404, PMCID: PMC9288243, DOI: 10.1038/s41586-022-04802-1.Peer-Reviewed Original ResearchConceptsInflammasome activationLung inflammationInflammatory responseInfected macrophagesSARS-CoV-2 infectionHuman macrophagesChronic lung pathologyPersistent lung inflammationSevere COVID-19Immune inflammatory responseInflammatory cytokine productionHumanized mouse modelNLRP3 inflammasome pathwayCOVID-19 pathologyCOVID-19SARS-CoV-2Productive viral cycleHyperinflammatory stateChronic stageIL-18Cytokine productionInflammatory cytokinesLung pathologyInflammasome pathwayInterleukin-1
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