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Francis Lee

Wayne O. Southwick Professor of Orthopaedics and Rehabilitation; Professor, Biomedical Engineering; Professor, Graduate School of Arts and Sciences; with Tenure in Traditional Track; Professor in Department of Pathology, Secondary Appointment; Biological and Biomedical Science Program, YSM Postgraduate School; Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation

Contact Information

Francis Lee, MD, PhD, FAAOS, MBA

Patient Care Locations

Mailing Address

  • Orthopaedics & Rehabilitation

    47 College Street Second Floor

    New Haven, CT 06520

    United States



  • Affiliation: Professor with Tenure, Unmodified Title; Wayne O. Southwick Professor; Orthopedic Surgeon and Scientist, Department of Orthopedic Surgery, School of Medicine, Yale University (2016-Present); Professor in Pathology, Secondary Appointment, Yale University (2017-Present); Professor in Biomedical Engineering, Secondary Appointment (2019-Present); Professor, Graduate School of Art and Science, Yale University (2019-Present); Professor with Tenure and Robert Carroll & Jane Chace Carroll Professor, Columbia University, New York (2012-2016); Orthopaedic Attending & Chief of Orthopaedic Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York (1999-2016)
  • Clinical Practice Locations: Greenwich Hospital, Stamford Office, and Yale New Haven Hospital System
  • Clinical Expertise: Sarcomas, Complex Musculoskeletal Reconstruction in Adults and Children; Musculoskeletal Bone and Soft Tissue Tumors (Benign Tumors and Cancers) & Complex Limb Reconstruction in Adults and Children; Pathological Fractures, Minimally Invasive Surgery for Metastatic Cancers to Bone (Breast, Prostate, Thyroid and Others); Failed Knee & Hip Implants; Osteomyelitis; Pediatric Orthopedics; Osteoid Osteoma, Enchodroma, Osteochondroma, Metabolic and Genetic Bone Diseases, Spine Tumors
  • Research Interest: NIH R01-funded research programs in metastatic cancer-induced bone loss, fracture healing, regenerative orthopedics, and bone infection. Our lab is located in Tompkin 5 Orthopedic Research Laboratories.
  • Administration: Vice Chair of Academic, Scientific, and Research Affairs (2016-2018; Interim; 2020-Present); Yale School of Medicine Admissions Committee; Yale University Saybrook College Advisor
  • Education: American Board of Orthopaedic Surgery Written Question Task Force, Orthopaedic Research Society Mentorship Committee, New York Orthopaedic Pathology Review Course
  • External Activities: NIH Skeletal Biology, Structure, and Regeneration (SBSR) Study Section Chair (2018-2020); Musculoskeletal Tumor Society Research Committee Chair (2017-2020); American Academy of Orthopaedic Surgeons Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2019-2020); OREF Research Grant Chair & OREF Board of Directors (2020-2023)
  • Current Research Programs & Grants:

- NIH/NIAMS R01 AR 073607 (2019-2024; PI: Francis Y. Lee, M.D.): PTH to rescue impaired fracture healing.

- NIH/NIAMS R01 (2015-2022; PI: Francis Y. Lee, M.D.): Infection and bone destruction; Eradication of bone destruction

- NIH/NCI R01 (2015-2022; PI: Francis Y. Lee, M.D.): Interactions between metastatic cancers and bone; Bone loss

- NIH/NIAMS R01 (2009-2019; PI: Francis Y. Lee, M.D.): Inflammation and bone loss; Osteoclastogenesis

- NIH/NIBIB R01 (Completed; 2007-2018; PI: Francis Y. Lee, M.D.): Biomaterials interface biology

- Musculoskeletal Transplantation Foundation (2013-2018): Enhanced Allograft Incorporation with Growth Factors

- NIAMS Mentored K08 Award (2017-2022; Mentor for PI Dr. David Koveacevic): Shoulder Inflammation

- Department of Defense (Completed; 2010-2015; PI: Francis Y. Lee, M.D.): 3D printed scaffolds for bone and cartilage defects

  • External Scholarly Activities: Musculoskeletal Tumor Society Executive Committee member and Research Committee Chair (2017-2020); National Institute of Health Skeletal Biology, Structure and Regeneration(SBSR) Study Section Permanent Member (2015-2020) and Study Section Chair (2018-2020); Musculoskeletal Tumor Society (MSTS) Research Committee Chair (2018-2020); AAOS Tumor Program Committee (2016-2019); AAOS Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2018-2020); Orthopaedic Research Society/International Society for Fracture Repair (ISFR) Board Member (2019-2021); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Chair (2020-Present); American Bone and Joint Surgery Member (2020-Present); AAOS Kappa Delta Award & OREF Clinical Research Award Selection Task Force Co-Chair
  • Interactions with Undergraduate Students, YSM Medical Students, M.D.-Thesis Medical Students, M.D.-Ph.D. Candidate, Graduate Students, and Post-doctoral Fellows: Please send inquiries to for research and clinical opportunities. Summer Research Fellow and One-Year YSM-sponsored Fellowships are provided.
  • Mentoring and Supporting Junior Faculty, Fellows, and Residents: Assisting Career Development Awards or Grants. Academic Promotion Guidance; Primary Mentorship for NIAMS K08 Career Development Award for an Orthopaedic Surgeon at Yale Orthopaedics & Rehabilitation (2017-2022); Mentorship for OREF Residents & Faculty Award
  • Yale University (2016 - Present): Yale University Saybrook College Fellow; Medical School Admissions Committee; Biological and Biomedical Science Program; Faculty, Yale university Art and Science Graduate School
  • Columbia University, New York, and New York Presbyterian Hospital (1999 - 2016): Professor of Orthopaedic Surgery with Tenure (2012-2016), Robert Carroll and Jane Chace Carroll Professor (2014-2016), Associate Professor with Tenure (2009-2012), Associate Professor (2005-2009), Assistant Professor (1999-2005); Orthopedic Surgeon, New York Presbyterian Hospital, New York; Columbia University Senate Budget Review Committee (2011-2015)

Education & Training

  • MBA
    Yale School of Management, Honorary MBA (2019)
  • Honorary Executive MBA
    Yale School of Management (2018)
  • Non Degree Program
    Hospital for Sick Chidren, Pediatric Orthopaedics Fellowship (1999)
  • Clinical Orthopedic Fellowship
    Hospital for Sick Children, University of Toronto (1999)
  • Non Degree Program
    Massachusetts General Hospital & Boston Children’s Hospital, Orthopaedic Oncology Fellowship (1998)
  • Clinical Orthopedic Fellowship
    Harvard Medical School (Mass General Hospital & Boston Children's Hospital) (1998)
  • Non Degree Program
    Rutgers Medical School, Orthopaedic Surgery Residency (1997)
  • Orthopaedic Residency
    Rutgers New Jersey Medical School (1997)
  • Non Degree Program
    Mount Sinai Hospital, Bone Research Fellowship (1996)
  • Orthopedic Research Fellowship
    Mount Sinai School of Medicine (1996)
  • PhD
    Seoul National University College of Medicine, Orthopedic Basic Science (1992)
  • Orthopaedic Residency
    Seoul National University Hospital (1992)
  • Non Degree Program
    Seoul National University Hospital, Orthopaedic Surgery Residency (1992)
  • MD
    Seoul National University College of Medicine, Doctor of Medicine (1986)
  • Premed & Doctor of Medicine
    Seoul National University College of Medicine (1986)
  • Undergraduate Student
    University of Maryland at U.S. 8th Army, Seoul, Korea (1982)


  • 2022 08 31 Grand Round
    Detroit, United States 2022
    Henry Ford Hospital Department of Orthopaedic Surgery Grand Round
  • 2022 WIRES SGCR
    Singapore, Singapore 2022
    Workshop Faculty and Paper Presentation at the Interventional Skeletal Oncology Meeting
  • 3D Medical Printing Society, Catholic Medical Center, Samsung Medical Center, Bundang Seoul National University Hospital
    Seoul, South Korea 2022
    Keynote Talk & Grand Round 3D Printing; AORIF
  • 2022 Annual Meeting of American Academy of Orthopaedic Surgeons
    Chicago, United States 2022
    Talk 1: "Rocket Fuel for the Young Academic Orthopaedic Surgeon - The National Institutes of Health K Award" Talk 2. 2. MRSA infection impairs long bone fracture healing by sustained inflammation and cytokine dysfunction. Talk 3. 3. Fracture Microenvironment Characterization in the Setting of Local Breast Cancer Metastases and Rescue of Fracture Healing Through Inhibition of ERK1/2 Signaling Talk 4. 4. A prospective cohort study on pain and ambulatory functional outcomes of AORIF (Ablation-Osteoplasty-Reinforcement-Internal Fixation) for peri-articular lesions in weight bearing bone. Talk 5. 5. Stabilization of Osteolytic Lesions in Pelvis, Femoral Head, and Femoral Neck with Ablation-Osteoplasty-Reinforcement-Internal Fixation.
  • 2022 Orthopaedic Research Society Meeting Research Presentations & Grant Writing Workshop Faculty
    Tampa, United States 2022
    1. Synovial Lactate And Inflammation Accumulated In A Murine Model Of Septic Arthritis Caused By Methicillin-resistant Staphylococcus Aureus (mrsa) Infection. 2. Excessive Transforming Growth Factor-β Expressions In The Fracture
  • 2021 EMSOS Meeting Presentations
    Virtual Meeting, EMSOS, Graz, Austria 2021
    Talk 1: Functional Ambulation and Pain Outcomes of Same-Day Percutaneous Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF) Reconstruction of Massive Periacetabular Osteolytic Defects and Pathological Fractures; Talk 2: Surgical Anatomy, Techniques and Biomechanical Analysis of Aorif Percutaneous Stabilization of Periacetabular Osteolytic Lesions and Biomechanical Analysis; Talk 3: Aggressive Osteolytic Breast Cancer Inflammatory Tumor Microenvironment in the Skeletal Compartment
  • 2021 ORS Clinician Scholar Career Development Program
    Chicago, United States 2021
    Faculty & Mentor
  • 2021 American Academy of Orthopaedic Surgeons
    San Diego, United States 2021
    Paper Presentations
  • Kelly Visiting Professorship, Mayo Clinic
    Rochester, United States 2020
    Grand Round and Research Seminar, Mayo Orthopaedics, Nov 30, 2020
  • OREF Key Note Speaker at HSS
    Keynote Speech 2020
    OREF North East Regional Resident Research Symposium
  • Visiting Professor
    Providence, United States 2019
  • International Society of Limb Salvage
    Athens, Greece 2019
    Introductory Lecture-17. Metastasis Session. Ambulatory Minimally invasive percutaneous Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF) for osteolytic skeletal metastasis.
  • Visiting Professor at Baylor School of Medicine, M.D. Anderson., and University of Texas
    Houston, United States 2019
    Grand Round Speaker, Baylor College of Medicine/M.D. Anderson Cancer Center/U Texas Houston, May, 2019
  • Speaker, Faculty, Moderator
    Las Vegas, United States 2019
    American Academy of Orthopaedic Surgeons Tumor Session Moderator; Presentation of 2 Papers; Metastatic Cancer Symposium Moderator, Organizer, Speaker
  • Key Note Speaker
    Farmington, United States 2019
    U Conn Musculoskeletal Institute Research Day
  • Visiting Professor, University of California San Francisco
    San Francisco, United States 2018
    Grand Round
  • AAOS/OREF/ORS Clinician Scholar Program
    Rosemont, United States 2017
    AAOS/OREF/ORS Clinician Scholar Program
  • Lecture
    Seoul, South Korea 2017
    Musculoskeletal Infection
  • Musculoskeletal Tumor Society
    Denver, United States 2017
    Precision Medicine Prediction Of Skeletal Metastasis: Big Clinical And Gene Profiling Data Analysis
  • Musculoskeletal Tumor Society
    Denver, United States 2017
  • Metastatic Breast Cancer Cells Destroy Bone by Inhibiting Ossification and Promoting Osteolytic Cytokine Production: A New Mechanism
    Kanazawa, Japan 2017
  • Intracellular Staphylococcus Aureus Are Resistant to Antibiotics
    San Diego, United States 2017
  • Mechanical Integrity of Unseeded, BMP-2 And Canine BMSC Seeded HA-PCL Scaffolds Compared to Allografts in Critical Size Defects in a Canine Model
    San Diego, United States 2017
  • Osteosarcoma Compartment Stiffness Affects Growth Rate
    San Diego, United States 2017
  • Trametinib Protects Bone from MRSA Induced Bone Erosion
    San Diego, United States 2017
  • Aggressive osteolytic breast cancer cells destroy bone by stealing calcium and making osteolytic cytokines: new mechanism and therapeutic target
    San Diego, United States 2017
  • Local PTH treatment enhances intercalary allograft incorporation
    San Diego, United States 2017
  • The Hidden Enemy: MRSA-Osteoblast Interaction and Its Consequences in Tissue Destruction and Recurrence
    Orlando, United States 2016
  • Erk Mediates Aggressive Growth And Bone Destruction In Osteolytic Metastatic Breast Cancers To Bone
    Orlando, United States 2016

Honors & Recognition

AwardAwarding OrganizationDate
Best Paper Award, 3rd PlaceMusculoskeletal Tumor Society2021
Best Poster Award, 2nd Place; Osteolytic Metastatic CancersMusculoskeletal Tumor Society2016
Kappa Delta Ann Doner Vaughn Award (2016)American Academy of Orthopedic Surgeons2016
Best Paper Award, Second PlaceEuropean Musculoskeletal Tumor Society2014
J. Neff AwadMusculoskeletal Transplantation Foundation2014
Career Development AwardOrthopedic Research and Education Foundation2006
AAOS/OREF/ORS Clinician Scientist Traveling Fellowship AwardAAOS2005
AOA Resident Traveling Fellowship AwardAmerican Orthopedic Association1996
Young Investigator AwardInternal Society for Fracture Repair1996

Professional Service

Association of Bone and Joint SurgeonsMember2020 - Present
Orthopaedic Research and Education FoundationOREF Grant Committee Vice Chair (2018-2019); Chair (2019-Present); OREF Executive Board Committee2019 - Present
National Institute of Health Skeletal Biology, Structure, and Reconstruction (SBSR) Study SectionNIH SBSR Study Section Permanent Member 2015-2018; Study Section Chair 2018-20202017 - 2019
Musculoskeletal Tumor SocietyResearch Committee2015 - 2020
Department of Defense Orthopaedic Trauma PRMRP Study Section Chair2014
American Academy of Orthopedic SurgeonsAAOS Tumor Program Committee2013 - 2019
American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education FoundationClinician Scholar Development Program Chair2012 - 2014
American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education FoundationNew Investigator Mentoring Workshop Chair2011 - 2015
American Board of Orthopedic SurgeryOrthopedic Surgery Board Written Question Writing2008 - 2019
NIH, NCI, 2013 NIAMS P50 and P30 Study Section Panel; NIH CSR MTE, SBDD, Skeletal Biology Structure Regeneration (Standing Member 2015-2019), SEP Panel Members; 2017 NIAMS Musculoskeletal Center P50 CORT Review Panel; 2017 NIAMS Musculoskeletal Clinical Research Center P30 Review PanelNIH Study Section Panel Members (2007 - Present) ; NIH SBSR Study Section Chair 2018-20202007 - 2022
American Academy of Orthopedic SurgeonsResearch Development Committee2006 - 2012

Departments & Organizations