Eric Isaac Elliott, MD, PhD

Dr. Eric Isaac Elliott obtained his MD and PhD in Molecular and Cellular Biology from the University of Iowa Carver College of Medicine in 2018. His research was conducted in the laboratory of Dr. Fayyaz Sutterwala and Dr. Suzanne Cassel on Nucleotide-Binding Leucine Rich Repeat-Containing Receptors (NLR) that form inflammasomes; central to his thesis work was the regulation of NLRP3 inflammasome activation by mitochondria and the novel role for the mitochondrial phospholipid cardiolipin in NLRP3 and caspase-1 recruitment. His research interests remain focused on innate immune mechanisms for sensing pathogens and cell stress, and how activation or dysregulation of these systems relate to infectious disease susceptibility and auto-immune/inflammatory disease processes.

Select Publications:

Elliott EI, Miller AN, Banoth B, Iyer SS, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS, Cassel SL. Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming. J Immunol. 2018 May 1;200(9):3047-3052.

Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016 Oct 25;7:13180.

Elliott EI, Sutterwala FS. Monocytes Take Their Own Path to IL-1β. Immunity. 2016 Apr 19;44(4):713-5.

Elliott EI, Sutterwala FS. Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev. 2015 May;265(1):35-52.

Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013 Aug 22;39(2):311-323.