Chin Siang Ong, MBBS, PhD
Cards
About
Research
Publications
2023
Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review
Bhandarkar S, Tsutsumi A, Schneider E, Ong C, Paredes L, Brackett A, Ahuja V. Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review. Surgical Infections 2023, 25: 7-18. PMID: 38150507, DOI: 10.1089/sur.2023.201.Peer-Reviewed Original ResearchArtificial intelligence toolsNew artificial intelligence toolsArtificial neural networkSupport vector machineMachine learning-based toolLearning-based toolIntelligence toolsMachine learningUse casesNeural networkVector machineRandom forestAverage accuracyNovel solutionMachineEmergent applicationsAlgorithmOptimal modelQueriesHigh operator dependencyArt reviewAccuracyToolNetworkOperator dependencyImpact of Intraoperative Blood Products, Fluid Administration, and Persistent Hypothermia on Bleeding Leading to Reexploration After Cardiac Surgery
Shou B, Zhou A, Ong C, Alejo D, DiNatale J, Larson E, Lawton J, Schena S. Impact of Intraoperative Blood Products, Fluid Administration, and Persistent Hypothermia on Bleeding Leading to Reexploration After Cardiac Surgery. Journal Of Thoracic And Cardiovascular Surgery 2023 PMID: 37839660, DOI: 10.1016/j.jtcvs.2023.10.011.Peer-Reviewed Original ResearchIntraoperative blood product transfusionIntensive care unit arrivalCore body temperatureBlood product transfusionCardiac surgeryPerioperative bleedingProduct transfusionCrystalloid administrationFluid administrationUnit arrivalRisk factorsAdult cardiac surgery patientsGreater postoperative morbidityIntraoperative blood productsSevere postoperative bleedingCardiac surgery patientsBlood product administrationIntravenous fluid administrationLower core body temperatureSuch risk factorsElectronic medical recordsPersistent hypothermiaPostoperative bleedingPostoperative morbidityIntraoperative fluidEffect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery
Asher S, Ong C, Malapero R, Heydarpour M, Malzberg G, Shahram J, Nguyen T, Shook D, Shernan S, Shekar P, Kaneko T, Citro R, Muehlschlegel J, Body S. Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery. Frontiers In Cardiovascular Medicine 2023, 10: 1202174. PMID: 37840960, PMCID: PMC10570832, DOI: 10.3389/fcvm.2023.1202174.Peer-Reviewed Original ResearchAortic valve replacement surgeryCoronary artery bypass graftMitral valve repairSecondary mitral regurgitationModerate mitral regurgitationAortic valve replacementCoronary artery bypassArtery bypass graftValve replacement surgeryMitral regurgitationValve repairArtery bypassValve replacementBypass graftReplacement surgeryCoronary artery bypass graft populationSevere secondary mitral regurgitationCoronary Artery Bypass GraftingCoronary artery bypass surgeryArtery Bypass GraftingArtery bypass surgeryLong-term mortalityMitral valve surgeryMitral valve operationsLong-term survivalHistorical Accounts of Congenital Heart Surgery
Mavroudis C, Ong C, Vricella L, Cameron D. Historical Accounts of Congenital Heart Surgery. World Journal For Pediatric And Congenital Heart Surgery 2023, 14: 626-641. PMID: 37737603, DOI: 10.1177/21501351231186415.Peer-Reviewed Original ResearchRecruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmiasThe impact of a statewide payment reform on transcatheter aortic valve replacement (TAVR) utilization and readmissions
Yesantharao P, Etchill E, Zhou A, Ong C, Metkus T, Canner J, Alejo D, Aliu O, Czarny M, Hasan R, Resar J, Schena S. The impact of a statewide payment reform on transcatheter aortic valve replacement (TAVR) utilization and readmissions. Catheterization And Cardiovascular Interventions 2023, 101: 1193-1202. PMID: 37102376, DOI: 10.1002/ccd.30670.Peer-Reviewed Original ResearchPatient‐matched fetal simulator for fetoscopic myelomeningocele closure
Miller J, Chang R, Ong C, Miller G, Garcia J, Groves M, Rosner M, Baschat A. Patient‐matched fetal simulator for fetoscopic myelomeningocele closure. Ultrasound In Obstetrics And Gynecology 2023, 61: 270-272. PMID: 36178849, DOI: 10.1002/uog.26081.Peer-Reviewed Original Research
2022
Editorial: Artificial intelligence in human physiology
Ong C, Burattini L, Schena S. Editorial: Artificial intelligence in human physiology. Frontiers In Physiology 2022, 13: 1075819. PMID: 36467701, PMCID: PMC9716197, DOI: 10.3389/fphys.2022.1075819.Peer-Reviewed Original ResearchArterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry
Shou B, Ong C, Premraj L, Brown P, Tonna J, Dalton H, Kim B, Keller S, Whitman G, Cho S. Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry. The Journal Of Heart And Lung Transplantation 2022, 42: 503-511. PMID: 36435686, PMCID: PMC10050131, DOI: 10.1016/j.healun.2022.10.019.Peer-Reviewed Original ResearchConceptsAcute brain injuryExtracorporeal Life Support Organization registrySevere hyperoxiaIschemic strokeIntracranial hemorrhageECPR patientsArterial oxygenBrain injuryLarge international multicenter cohortMultivariable logistic regression analysisExtracorporeal cardiopulmonary resuscitation patientsInternational multicenter cohortSignificant risk factorsBlood gas dataBlood gas parametersCardiopulmonary resuscitation patientsLogistic regression analysisCarbon dioxide tensionHospital mortalityMild hypercarbiaMulticenter cohortReperfusion injuryMultivariable analysisResuscitation patientsRisk factorsCausal determinants of postoperative length of stay in cardiac surgery using causal graphical learning
Lee JJR, Srinivasan R, Ong CS, Alejo D, Schena S, Shpitser I, Sussman M, Whitman GJR, Malinsky D. Causal determinants of postoperative length of stay in cardiac surgery using causal graphical learning. Journal Of Thoracic And Cardiovascular Surgery 2022, 166: e446-e462. PMID: 36154975, PMCID: PMC9968823, DOI: 10.1016/j.jtcvs.2022.08.012.Peer-Reviewed Original ResearchConceptsAortic valve replacement surgeryPostoperative lengthCoronary artery bypassValve replacement surgeryElectronic health record dataHealth record dataArtery bypassReplacement surgeryRetrospective electronic health record dataMean postoperative lengthCardiac surgery patientsRecord dataClinical knowledgeIndirect causesPreoperative dialysisPostoperative complicationsSurgery patientsCardiac surgeryPatient managementStayClinical protocolsPatientsSurgeryOperating roomStatistical association