Marc Pelletier, MD
Division Chief, Cardiac SurgeryCards
About
Research
Publications
2025
Diaphragm Dysfunction from Phrenic Nerve Injures During LVAD or Heart Transplant: Positive Role of Diaphragm Pacing
Boutros C, Elmo M, Carl N, Abu-Omar Y, Arora R, Elgudin Y, Gray K, Pelletier M, Onders R. Diaphragm Dysfunction from Phrenic Nerve Injures During LVAD or Heart Transplant: Positive Role of Diaphragm Pacing. JHLT Open 2025, 100281. DOI: 10.1016/j.jhlto.2025.100281.Peer-Reviewed Original ResearchNon-invasive ventilationLeft ventricular assist deviceDiaphragm pacingHeart transplantationMechanical ventilationNerve injurySingle-center cohort studyPhrenic nerve dysfunctionPhrenic nerve injuryLeft ventricular assist device recipientsPhrenic injuryDiaphragm dysfunctionDifficulty weaningNerve dysfunctionNerve injuresCase seriesDiaphragm functionMV weaningDP useAdverse eventsCohort studyVentricular assist deviceHTxExploratory case seriesTransplantation(432) Enhanced Recovery After Surgery (ERAS): Early Phrenic Nerve/Diaphragm Dysfunction Analysis and Treatment in Lung Transplant Patients
Onders R, Elmo M, Carl N, Elgudin Y, Abu-Omar Y, Gray K, Pelletier M, Arora R, Kilaru S, Schilz R. (432) Enhanced Recovery After Surgery (ERAS): Early Phrenic Nerve/Diaphragm Dysfunction Analysis and Treatment in Lung Transplant Patients. The Journal Of Heart And Lung Transplantation 2025, 44: s217. DOI: 10.1016/j.healun.2025.02.439.Peer-Reviewed Original Research
2024
Transcatheter or surgical aortic valve replacement in pregnant women? A comprehensive review of the current literature.
Kuchibhatla A, Soghrati N, Saleh Y, Rushing G, Halim M, Pelletier M, Baeza C, El-Diasty M. Transcatheter or surgical aortic valve replacement in pregnant women? A comprehensive review of the current literature. Journal Of Invasive Cardiology 2024, 37 PMID: 39453868, DOI: 10.25270/jic/24.00065.Peer-Reviewed Original ResearchRandomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation
Hungate J, Onders R, Diasty M, Abu-Omar Y, Arora R, Baeza C, Elgudin Y, Gray K, Markowitz A, Pelletier M, Ribeiro I, Vega P, Rushing G, Sabik J. Randomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation. JTCVS Open 2024, 22: 76-84. PMID: 39780786, PMCID: PMC11704535, DOI: 10.1016/j.xjon.2024.09.031.Peer-Reviewed Original ResearchProlonged mechanical ventilationStandard of care groupRisk of prolonged mechanical ventilationMechanical ventilationCardiac surgeryDiaphragmatic pacingDiaphragm pacingTreatment groupsRandomized trialsHistory of chronic obstructive pulmonary diseaseLeft ventricular ejection fractionIntra-aortic balloon pumpDecrease mechanical ventilationCardiac surgery patientsVentricular ejection fractionHigh-risk patientsMulticenter randomized trialCare groupEnhanced recoveryChronic obstructive pulmonary diseaseRelative risk reductionIntensive care unitStandard of carePredictive enrichment strategiesObstructive pulmonary diseaseThe prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review
Shah A, Ding Y, Walji D, Rabinovich G, Pelletier M, El-Diasty M. The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review. Biomarkers 2024, 29: 485-493. PMID: 39422445, DOI: 10.1080/1354750x.2024.2415073.Peer-Reviewed Original ResearchConceptsAssociated with acute kidney injuryPostoperative atrial fibrillationGal-3 levelsLeft ventricular reverse remodelingCardiac surgeryAdverse outcomesGal-3Clinical risk prediction scorePreoperative plasma levelsVentricular reverse remodelingEuroSCORE II modelPlasma Gal-3 levelsPostoperative adverse outcomesAcute kidney injuryGalectin-3Group of patientsPredicting adverse outcomesRisk prediction scorePostoperative morbidityReverse remodelingPostoperative mortalityElectronic database searchPrognostic utilityAdult patientsKidney injuryCurrent Role of Cardiac Magnetic Resonance for the Clinical Decision-Making Process in Transcatheter Aortic Valve Replacement
Dallan L, Feroze R, Jarrett C, Yoon S, Rajagopalan V, Walker J, Baeza C, Pelletier M, Al-Kindi S, Ukaigwe A, Filby S, Rajagopalan S, Attizzani G, Rashid I. Current Role of Cardiac Magnetic Resonance for the Clinical Decision-Making Process in Transcatheter Aortic Valve Replacement. Cardiovascular Revascularization Medicine 2024, 65: 58. DOI: 10.1016/j.carrev.2024.04.130.Peer-Reviewed Original ResearchElevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement
Feroze R, Kang P, Dallan L, Akula N, Galo J, Yoon S, Ukaigwe A, Filby S, Baeza C, Pelletier M, Rushing G, Rajagopalan S, AlāKindi S, Rashid I, Attizzani G. Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2024, 104: 1119-1128. PMID: 38952304, DOI: 10.1002/ccd.31136.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedAged, 80 and overAortic ValveAortic Valve StenosisArea Under CurveAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialFemaleFibrosisHeart Conduction SystemHumansMagnetic Resonance Imaging, CineMaleMyocardiumPacemaker, ArtificialPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementCardiac magnetic resonance imagingLate gadolinium enhancementRight bundle branch blockArea under the receiver operating characteristic curveAortic valve replacementReceiver operating curveMyocardial fibrosisPost-TAVRConduction defectsBundle branch blockAssociations of myocardial fibrosisExtracellular volumeConduction diseaseValve replacementGadolinium enhancementPermanent pacemakerConduction abnormalitiesConduction deficitsHeart blockBranch blockRisk of heart blockSeptal late gadolinium enhancementMyocardial extracellular volume fractionBaseline conduction diseasePericardial fluid troponin in cardiac surgery
Fatehi Hassanabad A, El-Sherbini A, Cherif I, Ahmad B, Gonzalez A, Pelletier M, Fedak P, El-Diasty M. Pericardial fluid troponin in cardiac surgery. Clinica Chimica Acta 2024, 559: 119722. PMID: 38734224, DOI: 10.1016/j.cca.2024.119722.Peer-Reviewed Original ResearchConceptsCardiac surgeryPericardial fluidTroponin levelsLevels of cardiac troponinPF levelsCardiac troponin levelsTroponin changesGoogle Scholar databasesTroponin concentrationsCardiac troponinProcedure typeClinical significancePrimary outcomeSurgerySecondary outcomesBiologically active factorsBlinded reviewersPreferred Reporting ItemsFull-text reviewTroponinInclusion criteriaPatientsPathological changesScholar databasesSystematic review(514) Diaphragm Dysfunction from Phrenic Nerve Injuries During LVAD or Heart Transplants: Positive Role of Diaphragm Pacing
Onders R, Elmo M, Carl N, Abu-Omar Y, Elgudin Y, Aorora R, Gray K, Pelletier M. (514) Diaphragm Dysfunction from Phrenic Nerve Injuries During LVAD or Heart Transplants: Positive Role of Diaphragm Pacing. The Journal Of Heart And Lung Transplantation 2024, 43: s254. DOI: 10.1016/j.healun.2024.02.1159.Peer-Reviewed Original Research(721) Current Utilization of Diaphragm Pacing in Lung Transplant Patients: Identifying and Treating Phrenic and Diaphragm Function Abnormalities
Onders R, Elmo M, Carl N, Elgudin Y, Abu-Omar Y, Gray K, Pelletier M, Arora R, Kilaru S, Schilz R. (721) Current Utilization of Diaphragm Pacing in Lung Transplant Patients: Identifying and Treating Phrenic and Diaphragm Function Abnormalities. The Journal Of Heart And Lung Transplantation 2024, 43: s344-s345. DOI: 10.1016/j.healun.2024.02.537.Peer-Reviewed Original Research
Clinical Care
Overview
Marc Pelletier, MD, MSc, is chief of cardiac surgery for Yale Medicine and Yale New Haven Hospital, and physician-in-chief of cardiac surgery for the Heart and Vascular Center of Yale New Haven Health System. He leads a large team of surgeons including a variety of heart subspecialists with an increasing focus on minimally invasive approaches, robotic surgery techniques, and the use of artificial intelligence in surgery to improve care and outcomes for patients.
A practicing cardiac surgeon himself, Dr. Pelletierās areas of specialty include transcatheter aortic valve replacement (TAVR) procedures, minimally invasive valve surgery, aortic valve and aortic root surgery, surgery for heart failure, and minimally invasive coronary bypass surgery.
Teamwork is the key to success for all cardiac surgeries, Dr. Pelletier says. āWe do this work well at Yale because we have the right supporting structures, and that means the anesthesiologists, nurses, perfusionists, technicians, and others in the operating room who are specially trained in the different cardiac surgery subspecialties. The cardiac surgeon may lead the team but is also one part of the equation,ā he says.
Dr. Pelletier joined Yale Medicine from University Hospitals in Cleveland, Ohio, where he served as division chief in cardiac surgery and held the Jay L. Ankeney Professorship in Cardiothoracic Surgery at Case Western Reserve University. Prior to that, he served as surgical director of the TAVR program at Brigham and Women's Hospital and Harvard Medical School. He joined the Brigham group in 2016 after nine years as head of cardiac surgery at the New Brunswick Heart Centre in Canada, which followed a period as assistant professor of cardiac surgery at Stanford University.
In addition to his work as a clinician, Dr. Pelletier is a national leader, serving as program chair of the 2026 annual meeting of the Society of Thoracic Surgeons (STS) and serving on multiple workforces for the STS, including the Council on Education and the Workforce on Cardiac and Vascular Surgery.
He is a prolific researcher who has authored over 130 peer-reviewed publications in journals including Circulation and The New England Journal of Medicine. āIn the last few years, my research interests have shifted toward clinical outcomes research,ā he says. āThat can mean using existing databases to get additional insights into such questions as what's the best way to do this operation? Should we be using this medication after surgery or another medication?ā
The most important focus in heart surgeryāand in medicineāis patients, Dr. Pelletier says. āIt's never lost on me that each patient I interact with is trusting me with one of the most important events in their life. In fact, they often will divide their life between ābefore heart surgeryā and āafter heart surgery,āā he says. āThe interaction I have with them before surgery may be brief, but in that moment, I want to make sure that they trust me, that they know I'm going to do the best job that I can, and that our team will do their best job and not leave any stone unturned.ā
Clinical Specialties
Board Certifications
Thoracic & Cardiac Surgery
- Certification Organization
- Royal College of Physicians & Surgeons of CANADA
- Original Certification Date
- 2000
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