Chenxiang Lin, PhD

Professor of Cell Biology and of Biomedical Engineering

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Appointments

Cell Biology

Primary

Additional Titles

Associate Director, Nanobiology Institute

Contact Info

chenxiang.lin@yale.edu

203.737.3924

About

Titles

Professor of Cell Biology and of Biomedical Engineering

Associate Director, Nanobiology Institute

Appointments

Cell Biology
Professor
Primary
Cell Biology

Education & Training

Research Fellow: Harvard Medical School (2012)

PhD: Arizona State University (2009)

BS: Peking University (2004)

Research

Overview

Medical Research Interests

Biophysics; Biosensing Techniques; Cell Biology; Cell Membrane; DNA; Lipid Bilayers; Membrane Fusion; Membranes, Artificial; Nanostructures; Nanotechnology; Nuclear Pore; Nucleic Acid Probes; Reference Standards

ORCID
0000-0001-7041-1946
Chenxiang Lin Lab
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Research at a Glance

Yale Co-Authors

Frequent collaborators of Chenxiang Lin's published research.

Publications

2026

Conformations and sequence determinants in the lipid binding of an adhesive peptide derived from Vibrio cholerae biofilms
Huang X, Prasad R, Saluja S, Yang Y, Yan Q, Shuster S, Karatekin E, Olson R, Lin C, Davis C, Jiang X, Zhou H, Yan J. Conformations and sequence determinants in the lipid binding of an adhesive peptide derived from Vibrio cholerae biofilms. PLOS Pathogens 2026, 22: e1013990. PMID: 41712669, PMCID: PMC12965690, DOI: 10.1371/journal.ppat.1013990.
Peer-Reviewed Original Research
This study investigates how a peptide from Vibrio cholerae biofilms binds lipid membranes via a conserved β-hairpin structure, providing insights into bacterial adhesion and potential biomedical applications.
Full Summary
Expanding DNA alphabet adds a previously unknown dimension to nanostructures
Zhou K, Hoshika S, Cheng J, Lin C, Benner S, Ke Y. Expanding DNA alphabet adds a previously unknown dimension to nanostructures. Science Advances 2026, 12: eaeb6713. PMID: 41564190, PMCID: PMC12822630, DOI: 10.1126/sciadv.aeb6713.
Peer-Reviewed Original Research
MeSH Keywords

2025

DNA nanodevice for analysis of force-activated protein extension and interactions
Zhou K, Chung M, Pandey S, Cheng J, Powell J, Yan Q, Liu J, Xiong Y, Schwartz M, Lin C. DNA nanodevice for analysis of force-activated protein extension and interactions. Nature Nanotechnology 2025, 21: 259-267. PMID: 41398070, PMCID: PMC12815478, DOI: 10.1038/s41565-025-02086-w.
Peer-Reviewed Original Research
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier
Kozai T, Fernandez-Martinez J, Kapinos L, Gallardo P, van Eeuwen T, Saladin M, Eliasian R, Mazur A, Zhang W, Tempkin J, Panatala R, Delgado-Izquierdo M, Escribano-Marin R, Feng Q, Lin C, Sali A, Chait B, Raveh B, Veenhoff L, Rout M, Lim R. Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier. Nature Cell Biology 2025, 27: 2089-2101. PMID: 41331088, PMCID: PMC12717009, DOI: 10.1038/s41556-025-01812-9.
Peer-Reviewed Original Research
MeSH Keywords

2024

Channel width modulates the permeability of DNA origami–based nuclear pore mimics
Feng Q, Saladin M, Wu C, Cao E, Zheng W, Zhang A, Bhardwaj P, Li X, Shen Q, Kapinos L, Kozai T, Mariappan M, Lusk C, Xiong Y, Lim R, Lin C. Channel width modulates the permeability of DNA origami–based nuclear pore mimics. Science Advances 2024, 10: eadq8773. PMID: 39536094, PMCID: PMC11559598, DOI: 10.1126/sciadv.adq8773.
Peer-Reviewed Original Research
MeSH Keywords
DNA-Based Molecular Clamp for Probing Protein Interactions and Structure under Force
Chung M, Zhou K, Powell J, Lin C, Schwartz M. DNA-Based Molecular Clamp for Probing Protein Interactions and Structure under Force. ACS Nano 2024, 18: 27590-27596. PMID: 39344156, PMCID: PMC11518680, DOI: 10.1021/acsnano.4c08663.
Peer-Reviewed Original Research
MeSH Keywords
DNA nanoswitches pack an anti-cancer punch
Zhou K, Lin C. DNA nanoswitches pack an anti-cancer punch. Nature Nanotechnology 2024, 19: 1765-1766. PMID: 39209995, DOI: 10.1038/s41565-024-01749-4.
Peer-Reviewed Original Research
Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow
Zhang Y, Lin C. Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow. Current Opinion In Cell Biology 2024, 88: 102377. PMID: 38823338, PMCID: PMC11193448, DOI: 10.1016/j.ceb.2024.102377.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

2023

Recent Advances in DNA Origami-Engineered Nanomaterials and Applications
Zhan P, Peil A, Jiang Q, Wang D, Mousavi S, Xiong Q, Shen Q, Shang Y, Ding B, Lin C, Ke Y, Liu N. Recent Advances in DNA Origami-Engineered Nanomaterials and Applications. Chemical Reviews 2023, 123: 3976-4050. PMID: 36990451, PMCID: PMC10103138, DOI: 10.1021/acs.chemrev.3c00028.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores
Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick R, Levintov L, Xiong Q, Wu C, Devarkar S, Tian T, Tripler T, Hu Y, Yuan S, Temple J, Feng Q, Lusk C, Aiken C, Engelman A, Perilla J, Pathak V, Lin C, Xiong Y. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2202815120. PMID: 36943880, PMCID: PMC10068764, DOI: 10.1073/pnas.2202815120.
Peer-Reviewed Original Research
MeSH Keywords

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Academic Achievements & Community Involvement

Honors

honor
Odyssey Award
09/01/2020Regional AwardRichard and Susan Smith Family Foundation
Details
honor
Director's New Innovator Award
09/30/2014National AwardNational Institutes of Health
Details

News

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Get In Touch

Contacts

chenxiang.lin@yale.edu

Academic Office Number

203.737.3924

Office Fax Number

203.737.3212

Administrative Support

Dae Blackman
Senior Administrative Assistant

Locations

Chenxiang Lin Lab
Lab
West Campus Integrative Science & Technology Center
850 West Campus Drive, Rm 213
West Haven, CT 06516
Get Directions

Appointments

Additional Titles

Contact Info

Titles

Appointments

Cell Biology

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

Chenxiang Lin Lab

Research at a Glance

Yale Co-Authors

Qi Shen

Qiancheng Xiong

C. Patrick Lusk, PhD

Longfei Liu

Qingzhou Feng

Yong Xiong, PhD

Publications

2026

2025

2024

2023

Honors

Odyssey Award

Director's New Innovator Award

News

Tiny Device Illuminates the Big Impact Force Has on the Body

Modeling HIV-1 nuclear entry with DNA-origami nuclear pore mimics

A better way to PAINT your sample for super-resolution imaging

DNA helps sort out liposomes and biophysical problems

Contacts

Administrative Support

Locations

Chenxiang Lin Lab