Charles Dela Cruz, MD, PhD

2025

• Research Priorities for Noninvasive Sampling of the Lower Respiratory Tract during Acute Respiratory Failure: An Official American Thoracic Society Workshop Report

  Bain W, Sarma A, Morales-Nebreda L, Rizzo A, Herron M, Wright S, Hagan R, Vigeland C, Mwizerwa E, Pickens C, Toth S, Nonoyama M, Cao B, Luna C, Rubin E, Torres A, Bos L, McVerry B, Restrepo M, Baron R, Ware L, Kulkarni H, Calfee C, Rogers A, Wunderink R, Varisco B, Dela Cruz C, Kitsios G, Mock J, Morrell E, McElvaney N, Bastarache J. Research Priorities for Noninvasive Sampling of the Lower Respiratory Tract during Acute Respiratory Failure: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2025, 22: 1101-1114. PMID: 40748053, PMCID: PMC12329329, DOI: 10.1513/annalsats.202505-543st.

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• Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report

  Samarasinghe A, Randell S, Kulkarni H, Weiser J, Quinton L, Dickson R, Mizgerd J, Orihuela C, Parker D, Robinson K, Prince A, Evans S, Kolls J, Lee J, Jeyaseelan S, Torres A, Miller L, Hamilton D, Gómez M, Moore B, Walker R, Barkal L, Hook J, Lau G, Sharma J, Witzenrath M, Dela Cruz C. Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 178-199. PMID: 40748059, PMCID: PMC12334885, DOI: 10.1165/rcmb.2025-0322st.

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• Clinician Prediction of Hyperinflammatory Acute Respiratory Distress Syndrome Subphenotypes: Overestimated but Prognostic.

  Kitsios G, Haque M, Bain W, Dela Cruz C, McVerry B, Shah F, Evankovich J, Prendergast N, Hensley M, Suber T, Inman K, Schaefer C, Lenkey N, Lee J, Rizzo A, Qin S, Mehdi Nouraie S, Zhang Y, Morris A. Clinician Prediction of Hyperinflammatory Acute Respiratory Distress Syndrome Subphenotypes: Overestimated but Prognostic. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 1294-1297. PMID: 40173283, PMCID: PMC12264653, DOI: 10.1164/rccm.202409-1816rl.

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• Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort

  Jayavelu N, Qi J, Milliren C, Ozonoff A, Liu S, Levy O, Baden L, Melamed E, McComsey G, Cairns C, Schaenman J, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Geng L, Sesma A, Simon V, Krammer F, Bime C, Calfee C, Bosinger S, Eckalbar W, Steen H, Maecker H, Becker P, Augustine A, Holland S, Rosen L, Lee S, Vaysman T, Ozonoff A, Diray-Arce J, Chen J, Kho A, Milliren C, Hoch A, Chang A, McEnaney K, Barton B, Lentucci C, Murphy M, Saluvan M, Shaheen T, Liu S, Syphurs C, Albert M, Hayati A, Bryant R, Abraham J, Thomas S, Cooney M, Karoly M, Altman M, Jayavelu N, Presnell S, Kohr B, Jancsyk T, Arnett A, Peters B, Overton J, Vita R, Westendorf K, Overton J, Levy O, Steen H, van Zalm P, Fatou B, Smolen K, Viode A, van Haren S, Jha M, Stevenson D, Odumade O, Baden L, Mendez K, Lasky-Su J, Tong A, Rooks R, Desjardins M, Sherman A, Walsh S, Mitre X, Cauley J, Li X, Evans B, Montesano C, Licona J, Krauss J, Issa N, Chang J, Izaguirre N, Hutton S, Michelotti G, Wong K, Tebbutt S, Shannon C, Sekaly R, Fourati S, McComsey G, Harris P, Sieg S, Ribeiro S, Cairns C, Haddad E, Kutzler M, Bernui M, Cusimano G, Connors J, Woloszczuk K, Joyner D, Edwards C, Lee E, Lin E, Melnyk N, Powell D, Kim J, Goonewardene I, Simmons B, Smith C, Martens M, Croen B, Semenza N, Bell M, Furukawa S, McLin R, Tegos G, Rogowski B, Mege N, Ulring K, Schearer P, Sheidy J, Nagle C, Seyfert-Margolis V, Rouphael N, Bosinger S, Boddapati A, Tharp G, Pellegrini K, Johnson B, Panganiban B, Huerta C, Anderson E, Samaha H, Sevransky J, Bristow L, Beagle E, Cowan D, Hamilton S, Hodder T, Bechnak A, Cheng A, Mehta A, Ciric C, Spainhour C, Carter E, Scherer E, Usher J, Hellmeister K, Hussaini L, Hewitt L, Mcnair N, Ribeiro S, Wimalasena S, Fernandez-Sesma A, Simon V, Krammer F, Van Bakel H, Kim-Schulze S, Reiche A, Qi J, Lee B, Carreño J, Singh G, Raskin A, Tcheou J, Khalil Z, van de Guchte A, Farrugia K, Khan Z, Kelly G, Srivastava K, Eaker L, Bermúdez-González M, Mulder L, Beach K, Saksena M, Altman D, Kojic E, Sominsky L, Azad A, Bielak D, Kawabata H, Yellin T, Fried M, Sullivan L, Morris S, Kleiner G, Stadlbauer D, Dutta J, Xie H, Patel M, Nie K, Rahman A, Messer W, Hough C, Siegel S, Sullivan P, Lu Z, Brunton A, Strand M, Lyski Z, Coulter F, Micheleti C, Maecker H, Pulendran B, Nadeau K, Rosenberg-Hasson Y, Leipold M, Sigal N, Rogers A, Fernandes A, Manohar M, Do E, Chang I, Lee A, Blish C, Din H, Roque J, Geng L, Artandi M, Davis M, Ahuja N, Yang S, Chinthrajah S, Hagan T, Reed E, Schaenman J, Salehi-Rad R, Rivera A, Pickering H, Sen S, Elashoff D, Ward D, Brook J, Sanchez E, Llamas M, Perdomo C, Magyar C, Fulcher J, Erle D, Calfee C, Hendrickson C, Kangelaris K, Nguyen V, Lee D, Chak S, Ghale R, Gonzalez A, Jauregui A, Leroux C, Altamirano L, Rashid A, Willmore A, Woodruff P, Krummel M, Carrillo S, Ward A, Langelier C, Patel R, Wilson M, Dandekar R, Alvarenga B, Rajan J, Eckalbar W, Schroeder A, Fragiadakis G, Tsitsiklis A, Mick E, Guerrero Y, Love C, Maliskova L, Adkisson M, Leligdowicz A, Beagle A, Rao A, Sigman A, Samad B, Curiel C, Shaw C, Tietje-Ulrich G, Milush J, Singer J, Vasquez J, Tang K, Betancourt L, Santhosh L, Pierce L, Paz M, Matthay M, Thakur N, Rodriguez N, Sutter N, Jones N, Sinha P, Prasad P, Lota R, Rashid S, Asthana S, Bhide S, Lea T, Abe-Jones Y, Hafler D, Montgomery R, Shaw A, Kleinstein S, Gygi J, Pawar S, Konstorum A, Chen E, Cotsapas C, Wang X, Xu L, Dela Cruz C, Iwasaki A, Mohanty S, Nelson A, Zhao Y, Farhadian S, Asashima H, Chaudhary O, Coppi A, Fournier J, Muenker M, Nelson A, Raddassi K, Rainone M, Ruff W, Salahuddin S, Shulz W, Vijayakumar P, Wang H, Wunder E, Young H, Ko A, Wang X, Duchen D, Esserman D, Guan L, Brito A, Rothman J, Grubaugh N, Corry D, Kheradmand F, Song L, Nelson E, Metcalf J, Higuita N, Sinko L, Booth J, Drevets D, Brown B, Kraft M, Bime C, Mosier J, Erickson H, Schunk R, Kimura H, Conway M, Francisco D, Molzahn A, Wilson C, Schunk R, Hughes T, Sierra B, Atkinson M, Brakenridge S, Ungaro R, Manning B, Moldawer L, Oberhaus J, Guirgis F, Borresen B, Anderson M, Ehrlich L, Melamed E, Maguire C, Wylie D, Rousseau J, Hurley K, Geltman J, Siles N, Rogers J, Augustine A, Diray-Arce J, Haddad E, Sekaly R, Kraft M, Woodruff P, Erle D, Ehrlich L, Montgomery R, Becker P, Altman M, Fourati S. Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort. Journal Of Allergy And Clinical Immunology Global 2025, 4: 100515. PMID: 40709330, PMCID: PMC12284355, DOI: 10.1016/j.jacig.2025.100515.

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• Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID

  Grady C, Bhattacharjee B, Silva J, Jaycox J, Lee L, Silva Monteiro V, Sawano M, Massey D, Caraballo C, Gehlhausen J, Tabachnikova A, Mao T, Lucas C, Peña-Hernandez M, Xu L, Tzeng T, Takahashi T, Herrin J, Güthe D, Akrami A, Assaf G, Davis H, Harris K, McCorkell L, Schulz W, Griffin D, Wei H, Ring A, Guan L, Dela Cruz C, Krumholz H, Iwasaki A. Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID. Communications Medicine 2025, 5: 163. PMID: 40346201, PMCID: PMC12064684, DOI: 10.1038/s43856-025-00829-3.

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• Questions and Answers about Measles

  Pasnick S, Keller J, Dela Cruz C, Gross J, Carlos W, Maves R, Jamil S, Collins B, Sundar K. Questions and Answers about Measles. American Journal Of Respiratory And Critical Care Medicine 2025, 211: p5-p6. DOI: 10.1164/rccm.v211i5p5.

  Peer-Reviewed Original Research

• Epidermal Growth Factor Protects Lung Epithelial Cells After Injury

  Tolman N, Chen K, Shi J, Shiva S, Dela Cruz C, Kliment C, Alder J, Lee J, Bain W. Epidermal Growth Factor Protects Lung Epithelial Cells After Injury. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a1084-a1084. DOI: 10.1164/ajrccm.2025.211.abstracts.a1084.

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• Lower Respiratory Tract C. Albicans Induces Lung Injury in Mice and Associates With Lung Injury Endpoints in Humans

  Tolman N, Choi W, Alder J, Tabary M, Qin S, Wang X, Zhang Y, Tu Y, Sharma L, Bon J, Robinson K, Snyder M, Dela Cruz C, Nguyen M, Morris A, Biswas P, Bain W, Kitsios G. Lower Respiratory Tract C. Albicans Induces Lung Injury in Mice and Associates With Lung Injury Endpoints in Humans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2825-a2825. DOI: 10.1164/ajrccm.2025.211.abstracts.a2825.

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• Probabilities Over Binaries: Refining Inflammatory Sub-phenotypes in Acute Respiratory Failure

  Venkatesan N, Shah F, Nouraie M, Bain W, Dela Cruz C, Mcverry B, Kitsios G. Probabilities Over Binaries: Refining Inflammatory Sub-phenotypes in Acute Respiratory Failure. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3138-a3138. DOI: 10.1164/ajrccm.2025.211.abstracts.a3138.

  Peer-Reviewed Original Research

• Dichotomous Effects of TLR9 on Early Inflammation and Viral Clearance Dictates Recovery From Influenza Infection

  Kim J, Yuan Y, Agaronyan K, Zhao A, Bain W, Evankovich J, Dela Cruz C, Ryu C, Sharma L. Dichotomous Effects of TLR9 on Early Inflammation and Viral Clearance Dictates Recovery From Influenza Infection. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4707-a4707. DOI: 10.1164/ajrccm.2025.211.abstracts.a4707.

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