Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsCarolina Maciel, MD
About
Research
Publications
2025
Practice Patterns and Trends in Temperature Control After Cardiac Arrest: A Multi-Specialty Survey
Carr C, Eckert M, Bhakta N, Guirgis F, Hopson C, Maciel C, Becker T. Practice Patterns and Trends in Temperature Control After Cardiac Arrest: A Multi-Specialty Survey. Journal Of Clinical Medicine 2025, 14: 8592. PMID: 41375895, PMCID: PMC12693480, DOI: 10.3390/jcm14238592.Peer-Reviewed Original ResearchPost-cardiac arrest careCardiac arrestPractice patternsResults:Attending-level physiciansEmergency Medicine SocietyPost-cardiac arrest managementWeb-based surveyTargeted temperature managementLocal practice environmentCommunity cliniciansPhysicians' knowledgePhysician specialtyArrest etiologyPractice environmentCritical careMethods:TTM2-trialPractice variabilityPilot testIntensive care medicineInstitutional protocolMedicine SocietyCareCare medicineEarly Markers of Systemic Inflammation are not Related to Pain Burden After Aneurysmal Subarachnoid Hemorrhage: A Multicenter Observational Study
Kardon A, Ren H, Gerard E, Pomar-Forero D, Pop R, Ahmad B, Ciryam P, Parikh G, Badjatia N, Maciel C, Busl K, Chen C, Morris N. Early Markers of Systemic Inflammation are not Related to Pain Burden After Aneurysmal Subarachnoid Hemorrhage: A Multicenter Observational Study. Neurocritical Care 2025, 1-9. PMID: 41125902, DOI: 10.1007/s12028-025-02396-w.Peer-Reviewed Original ResearchIntensive care unitChronic opioid useAneurysmal subarachnoid hemorrhagePain burdenMulticenter observational studySubarachnoid hemorrhagePain scoresOpioid useOpioid-sparing pain management strategySensitivity analysis restricted to patientsObservational studyMarkers of systemic inflammationICU courseAnalysis restricted to patientsEarly markersEffective analgesic treatmentHunt-Hess scoreSubgroup of patientsBlood inflammatory biomarkersPain management strategiesBlood-brain barrier breakdownRestricted to patientsInflammatory blood biomarkersRefractory headacheAbortion managementCOMPRESSIVE DATA STORAGE FOR LONG-TERM EEG: VALIDATION BY VISUAL ANALYSIS
Kalamangalam G, Venkatesan S, Bruzzone M, Wang Y, Maciel C, Mitropanopoulos S, Cibula J, Patel K, Babajani-Feremi A. COMPRESSIVE DATA STORAGE FOR LONG-TERM EEG: VALIDATION BY VISUAL ANALYSIS. Clinical Neurophysiology Practice 2025, 10: 331-339. PMID: 40809319, PMCID: PMC12344260, DOI: 10.1016/j.cnp.2025.07.005.Peer-Reviewed Original ResearchDiscrete cosine transformSingular value decompositionCompression ratioData analytics pipelineMassive data volumesData analytics techniquesLong-term EEG monitoringCosine transformLatent spaceData sizeData compressionData volumeBiomedical dataData storageDimension reductionValue decompositionCompressed dataSVD componentsVisual analysisHigh-variabilityRun lengthOriginal recordsDatasetEEGBest Practices for Hospital-Based Donor Care Unit Operations Part 2
Vail E, Goyal V, McGinity A, Sarge T, Heimbach J, Mielke A, Tompeck A, Maciel C, Busl K, Leventhal T, Sanghavi D, Kumar R, Sommer P, Olthoff K, Martin N, Windham S, Bakhru R. Best Practices for Hospital-Based Donor Care Unit Operations Part 2. CHEST Critical Care 2025, 3: 100144. DOI: 10.1016/j.chstcc.2025.100144.Commentaries, Editorials and LettersSubarachnoid Haemorrhage
Busl K, Akkus S, Maciel C. Subarachnoid Haemorrhage. 2025, 225-242. DOI: 10.1093/med/9780198864714.003.0017.ChaptersSubarachnoid haemorrhageDegree of neurological impairmentDelayed cerebral ischaemiaCulprit aneurysmRescue therapyEarly complicationsPrompt diagnosisSystemic complicationsCardiac dysfunctionSevere headacheSurgical clippingRespiratory compromiseEndovascular interventionCerebral ischaemiaDay 4Improve outcomesNeurological impairmentInfluence outcomesNeuroprotective agentsComplicationsPatientsVariable degreesHæmorrhageTreatmentOutcomes
2024
Prolonged Monitoring of Brain Electrical Activity in the Intensive Care Unit
Carneiro T, Goswami S, Smith C, Giraldez M, Maciel C. Prolonged Monitoring of Brain Electrical Activity in the Intensive Care Unit. Neurologic Clinics 2024, 43: 31-50. PMID: 39547740, DOI: 10.1016/j.ncl.2024.08.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEarly vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus
Maciel C, Ahmad B, Jose Bruzzone Giraldez M, Eisenschenk S, Ramsay E, Maranchick N, Peloquin C, Hirsch L, Busl K. Early vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus. Epilepsy & Behavior 2024, 160: 110082. PMID: 39393141, DOI: 10.1016/j.yebeh.2024.110082.Peer-Reviewed Original ResearchStatus epilepticusGamma-aminobutyric acidGABAergic pathwayHypoxic-ischemic brain injuryPost-cardiac arrest periodHypoxic-ischemic insultOutcomes of patientsEffective adjunctive therapyInhibition of gamma-aminobutyric acidLondon-Innsbruck ColloquiumAdjunctive therapyAcute seizuresEffective therapyPoor outcomeEpilepticusExclusion criteriaEarly inhibitionSynergistic augmentationGamma-aminobutyric acid catabolismArrest periodTherapeutic nihilismSeizuresClinal trialsAllosteric modulatorsVigabatrinCyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury
Comparan H, Khaliq A, Frota L, Pomar-Forero D, Ahmad B, Marnet E, Teixeira F, Thomas A, Patel P, Brunkal H, Singireddy S, Lucke-Wold B, Maciel C, Busl K. Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury. Neurocritical Care 2024, 42: 680-689. PMID: 39266865, DOI: 10.1007/s12028-024-02114-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIntervention groupSystematic reviewHeadache managementCyclooxygenase 2 inhibitorsAcute brain injuryElective cranial neurosurgeryPain scoresRandomized Controlled TrialsHospital length of stayRetrospective cohort studyLength of stayModerate to mild severityBrain injuryIndependent reviewersDescriptive statisticsCohort studyStudy heterogeneityInclusion criteriaControlled TrialsArticle selectionObservational studyInterventionMeta-analysisElective cranial surgeryHospital lengthRationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design
Busl K, Smith C, Troxel A, Fava M, Illenberger N, Pop R, Yang W, Frota L, Gao H, Shan G, Hoh B, Maciel C. Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design. Neurocritical Care 2024, 42: 290-300. PMID: 39138719, PMCID: PMC11810580, DOI: 10.1007/s12028-024-02078-z.Peer-Reviewed Original ResearchSequential parallel comparison designDouble-blindPain controlPterygopalatine fossaClinical trialsPlacebo-controlled clinical trialPrimary tolerability end pointEnd pointsVerbal pain scoresEfficacy end pointOpen-label phaseTolerability end pointsPhase III trialsPost-subarachnoid hemorrhagePhase IIIII trialsPain scoresAcute headacheAneurysmal SAHSevere headachePeriprocedural monitoringPost-SAHHeadache phenotypeUltrasound guidanceAwake patientsLeveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery
Malnik S, Porche K, Mehkri Y, Yue S, Maciel C, Lucke-Wold B, Robicsek S, Decker M, Busl K. Leveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery. Frontiers In Neurology 2024, 15: 1386802. PMID: 38988605, PMCID: PMC11233696, DOI: 10.3389/fneur.2024.1386802.Peer-Reviewed Original ResearchPostoperative urinary retentionLumbar spine surgerySpine surgeryUrinary retentionPatient demographicsIncidence of postoperative urinary retentionRetrospective observational cohort studyTertiary academic medical centerIndwelling catheter placementIncreased patient morbidityReceiver operating characteristic curveArea under the receiver operating characteristic curveObservational cohort studyAcademic medical centerBody mass indexPostoperative prediction modelLogistic regression modelsIntraoperative variablesIntraoperative factorsCatheter placementAnesthesia variablesPatient morbidityMass indexSurgical proceduresCohort study